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List of works by Gilberto Alves

A Critical Review of Microextraction by Packed Sorbent as A Sample Preparation Approach in Drug Bioanalysis ⬇️

scientific article published on June 1, 2013

A Rapid and Sensitive HPLC-DAD Assay to Quantify Lamotrigine, Phenytoin and Its Main Metabolite in Samples of Cultured HepaRG Cells

scientific article published on 18 May 2016

A chiral HPLC‐UV method for the quantification of dibenz[b,f]azepine‐5‐carboxamide derivatives in mouse plasma and brain tissue: Eslicarbazepine acetate, carbamazepine and main metabolites ⬇️

scientific article published on 09 May 2011

A chiral liquid chromatography method for the simultaneous determination of oxcarbazepine, eslicarbazepine, R-licarbazepine and other new chemical derivatives BIA 2-024, BIA 2-059 and BIA 2-265, in mouse plasma and brain

scientific article

A combo-strategy to improve brain delivery of antiepileptic drugs: Focus on BCRP and intranasal administration

scientific article published on 08 December 2020

A new PAMPA model using an in-house brain lipid extract for screening the blood-brain barrier permeability of drug candidates

scientific article published on 30 January 2016

A novel HPLC method for the determination of zonisamide in human plasma using microextraction by packed sorbent optimised by experimental design

article by Dina Lourenço et al published 2017 in Analytical Methods

A rapid HPLC method for the simultaneous determination of amiodarone and its major metabolite in rat plasma and tissues: a useful tool for pharmacokinetic studies

scientific article

A single- and multiple-dose study to investigate the pharmacokinetics and pharmacodynamics of opicapone, a novel COMT inhibitor, in rat.

scientific article published on 19 July 2017

ABC transporters in drug-resistant epilepsy: mechanisms of upregulation and therapeutic approaches

scientific article published on 30 April 2019

An easy-to-use liquid chromatography assay for the analysis of lamotrigine in rat plasma and brain samples using microextraction by packed sorbent: Application to a pharmacokinetic study

scientific article published on 27 September 2016

An easy-to-use liquid chromatography method with fluorescence detection for the simultaneous determination of five neuroactive amino acids in different regions of rat brain.

scientific article published on 6 February 2018

Analytical methods for determination of new fluoroquinolones in biological matrices and pharmaceutical formulations by liquid chromatography: a review

scientific article published on 10 February 2012

Antioxidant Status, Antidiabetic Properties and Effects on Caco-2 Cells of Colored and Non-Colored Enriched Extracts of Sweet Cherry Fruits

scientific article published on 05 November 2018

Authentication of honeys from Caramulo region (Portugal): Pollen spectrum, physicochemical characteristics, mineral content, and phenolic profile

scientific article published on 27 January 2020

Binding of licarbazepine enantiomers to mouse and human plasma proteins

scientific article published in July 2010

Bioanalytical chromatographic methods for the determination of catechol-O-methyltransferase inhibitors in rodents and human samples: a review

scientific article published on 20 October 2011

Blood-brain barrier models and their relevance for a successful development of CNS drug delivery systems: a review

scientific article published on 28 March 2014

Can the CEIBA Cocktail Designed for Human Cytochrome P450 Enzymes be Used in the Rat for Drug Interaction Studies?

scientific article published on October 2016

Characterization of a Parkinson's disease rat model using an upgraded paraquat exposure paradigm

scientific article published on 20 January 2020

Chiral chromatographic resolution of antiepileptic drugs and their metabolites: a challenge from the optimization to the application

scientific article

Clinical drug-drug interactions: focus on venlafaxine.

scientific article published on March 2015

Clinical pharmacists´ interventions in the management of type 2 diabetes mellitus: a systematic review

scientific article published on 01 July 2020

Considerations and Pitfalls in Selecting the Drug Vehicles for Evaluation of New Drug Candidates: Focus on in vivo Pharmaco-Toxicological Assays Based on the Rotarod Performance Test

scientific article published in January 2018

Determination of catecholamines and endogenous related compounds in rat brain tissue exploring their native fluorescence and liquid chromatography

scientific article published on 27 February 2017

Development and application of an ex vivo fosphenytoin nasal bioconversion/permeability evaluation method

scientific article

Development and full validation of an innovative HPLC-diode array detection technique to simultaneously quantify lacosamide, levetiracetam and zonisamide in human plasma.

scientific article published on 21 March 2018

Development and validation of a fast isocratic liquid chromatography method for the simultaneous determination of norfloxacin, lomefloxacin and ciprofloxacin in human plasma

scientific article

Development and validation of an HPLC-FLD technique for colistin quantification and its plasma monitoring in hospitalized patients

article

Development and validation of an HPLC-UV method for the simultaneous quantification of carbamazepine, oxcarbazepine, eslicarbazepine acetate and their main metabolites in human plasma

scientific article published on 18 April 2010

Development of a liquid chromatography assay for the determination of opicapone and BIA 9-1079 in rat matrices

scientific article published on 6 July 2015

Development, validation and application of a new HPLC-DAD method for simultaneous quantification of apixaban, dabigatran, edoxaban and rivaroxaban in human plasma

scientific article published on 14 January 2020

Direct nose-to-brain delivery of lamotrigine following intranasal administration to mice

scientific article

Disposition of eslicarbazepine acetate in the mouse after oral administration

scientific article published on 15 August 2008

Drug-induced Epistaxis: An Often-Neglected Adverse Effect

scientific article published on 12 February 2018

Drug-metabolizing Enzymes and Efflux Transporters in Nasal Epithelium: Influence on the Bioavailability of Intranasally Administered Drugs.

scientific article published on 6 April 2016

Early preclinical evaluation of dihydropyrimidin(thi)ones as potential anticonvulsant drug candidates

scientific article published on 14 March 2017

Effects of Hypericum perforatum extract and its main bioactive compounds on the cytotoxicity and expression of CYP1A2 and CYP2D6 in hepatic cells

scientific article published on 20 November 2015

Effects of Hypericum perforatum hydroalcoholic extract, hypericin, and hyperforin on cytotoxicity and CYP3A4 mRNA expression in hepatic cell lines: a comparative study

Effects of Paullinia cupana extract on lamotrigine pharmacokinetics in rats: A herb-drug interaction on the gastrointestinal tract with potential clinical impact.

scientific article published on 10 March 2018

Elucidation of the Impact of P-glycoprotein and Breast Cancer Resistance Protein on the Brain Distribution of Catechol-O-Methyltransferase Inhibitors

scientific article

Enantioselective HPLC-UV method for determination of eslicarbazepine acetate (BIA 2-093) and its metabolites in human plasma

scientific article

Enantioselective assay for therapeutic drug monitoring of eslicarbazepine acetate: no interference with carbamazepine and its metabolites

scientific article published in August 2010

Evaluation of the effects of Citrus aurantium (bitter orange) extract on lamotrigine pharmacokinetics: Insights from in vivo studies in rats

scientific article published on 30 August 2018

Evaluation of the permeability and P‐glycoprotein efflux of carbamazepine and several derivatives across mouse small intestine by the Ussing chamber technique ⬇️

scientific article published on 01 March 2012

Exploring the phenolic profile, antioxidant, antidiabetic and anti-hemolytic potential of Prunus avium vegetal parts

scientific article published on 02 September 2018

First HPLC–UV method for rapid and simultaneous quantification of phenobarbital, primidone, phenytoin, carbamazepine, carbamazepine-10,11-epoxide, 10,11-trans-dihydroxy-10,11-dihydrocarbamazepine, lamotrigine, oxcarbazepine and licarbazepine in hum

scientific article published on 27 February 2013

First MEPS/HPLC assay for the simultaneous determination of venlafaxine and O-desmethylvenlafaxine in human plasma

scientific article published on 01 January 2014

First liquid chromatographic method for the simultaneous determination of amiodarone and desethylamiodarone in human plasma using microextraction by packed sorbent (MEPS) as sample preparation procedure

scientific article published on 7 December 2012

First liquid chromatography method for the simultaneous determination of levofloxacin, pazufloxacin, gatifloxacin, moxifloxacin and trovafloxacin in human plasma

scientific article published on 4 May 2013

Flavonoid compounds as reversing agents of the P-glycoprotein-mediated multidrug resistance: An in vitro evaluation with focus on antiepileptic drugs

scientific article

Gastrodia elata and epilepsy: Rationale and therapeutic potential

scientific article

HepaRG cell line as an in vitro model for screening drug-drug interactions mediated by metabolic induction: amiodarone used as a model substance

scientific article published on 27 August 2014

Herb-Drug Interaction of Paullinia cupana (Guarana) Seed Extract on the Pharmacokinetics of Amiodarone in Rats

scientific article published on 5 December 2012

Herb–drug interaction of Fucus vesiculosus extract and amiodarone in rats: A potential risk for reduced bioavailability of amiodarone in clinical practice ⬇️

scientific article published on November 20, 2012

Histamine induces microglia activation and dopaminergic neuronal toxicity via H1 receptor activation

scientific article

Histopathological and in vivo evidence of regucalcin as a protective molecule in mammary gland carcinogenesis.

scientific article published on 13 August 2014

In vitro and in vivo experimental models employed in the discovery and development of antiepileptic drugs for pharmacoresistant epilepsy

scientific article published on 21 July 2018

In vitro assessment of the interactions of dopamine β-hydroxylase inhibitors with human P-glycoprotein and Breast Cancer Resistance Protein.

scientific article published on 8 February 2018

In vitro screening of dual flavonoid combinations for reversing P-glycoprotein-mediated multidrug resistance: Focus on antiepileptic drugs

scientific article published on 6 November 2017

Influence of the dual combination of silymarin and (-)-epigallocatechin gallate, natural dietary flavonoids, on the pharmacokinetics of oxcarbazepine in rats

scientific article

Intranasal Delivery of Topically-Acting Levofloxacin to Rats: a Proof-of-Concept Pharmacokinetic Study

scientific article

Intranasal administration of carbamazepine to mice: a direct delivery pathway for brain targeting

scientific article published on 9 May 2014

Intranasal delivery of ciprofloxacin to rats: A topical approach using a thermoreversible in situ gel.

scientific article published on 31 October 2016

Intranasal delivery of systemic-acting drugs: small-molecules and biomacromolecules

scientific article published on 28 March 2014

Investigating herb–drug interactions: The effect of Citrus aurantium fruit extract on the pharmacokinetics of amiodarone in rats ⬇️

scientific article published on July 22, 2013

Liquid chromatographic assay based on microextraction by packed sorbent for therapeutic drug monitoring of carbamazepine, lamotrigine, oxcarbazepine, phenobarbital, phenytoin and the active metabolites carbamazepine-10,11-epoxide and licarbazepine

scientific article published on 16 September 2014

Liquid chromatographic methods for the determination of direct oral anticoagulant drugs in biological samples: A critical review

scientific article published on 08 April 2019

Liquid chromatographic methods for the quantification of catecholamines and their metabolites in several biological samples—A review ⬇️

scientific article published on December 27, 2012

Medication Evaluation in Portuguese Elderly Patients According to Beers, STOPP/START Criteria and EU(7)-PIM List - An Exploratory Study

scientific article published on 05 May 2020

Multitarget protection of Pterospartum tridentatum phenolic-rich extracts against a wide range of free radical species, antidiabetic activity and effects on human colon carcinoma (Caco-2) cells

scientific article published on 29 October 2020

Nanoemulsions and thermosensitive nanoemulgels of phenytoin and fosphenytoin for intranasal administration: Formulation development and in vitro characterization

scientific article published on 28 October 2019

Nanoformulations for the Delivery of Dietary Anthocyanins for the Prevention and Treatment of Diabetes Mellitus and Its Complications

scientific article published in 2023

Nose-to-brain Delivery of Natural Compounds for the Treatment of Central Nervous System Disorders

scientific article published on 01 January 2020

Nose-to-brain delivery of levetiracetam after intranasal administration to mice

scientific article published on 20 April 2019

Novel bioanalytical method for the quantification of rufinamide in mouse plasma and tissues using HPLC-UV: A tool to support pharmacokinetic studies

scientific article published on 19 June 2019

Optimization of a Parallel Artificial Membrane Permeability Assay for the Fast and Simultaneous Prediction of Human Intestinal Absorption and Plasma Protein Binding of Drug Candidates: Application to Dibenz[b,f]azepine-5-Carboxamide Derivatives

scientific article published on 03 November 2011

Pharmacist Interventions in the Management of Type 2 Diabetes Mellitus: A Systematic Review of Randomized Controlled Trials

scientific article published on May 2016

Pharmacogenetics and therapeutic drug monitoring of fluoxetine in a real-world setting: A PK/PD analysis of the influence of (non-)genetic factors

scientific article published on 21 November 2019

Pharmacokinetics of opicapone, a third-generation COMT inhibitor, after single and multiple oral administration: A comparative study in the rat.

scientific article published on 16 March 2017

Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: new set of data for predictive in silico ADME models

scientific article

Potential Activity of Abrantes Pollen Extract: Biochemical and Cellular Model Studies

scientific article published on 15 November 2021

Potential antitumoral 3,4-dihydropyrimidin-2-(1H)-ones: synthesis, in vitro biological evaluation and QSAR studies

scholarly article in RSC Advances, vol. 6 no. 88, 2016

Proceedings of the 3rd IPLeiria's International Health Congress : Leiria, Portugal. 6-7 May 2016

scientific article

Real-world clinical characterization of subjects with depression treated with antidepressant drugs focused on (non-)genetic factors, pharmacokinetics, and clinical outcomes: GnG-PK/PD-AD study

scientific article published on 23 May 2019

Recent Highlights on Molecular Hybrids Potentially Useful in Central Nervous System Disorders

scientific article published on 11 November 2016

Relevance of Breast Cancer Resistance Protein to Brain Distribution and Central Acting Drugs: A Pharmacokinetic Perspective

scientific article published on 01 January 2018

Safety evidence on the administration of Fucus vesiculosus L. (bladderwrack) extract and lamotrigine: data from pharmacokinetic studies in the rat

article

Salting-out assisted liquid-liquid extraction method optimized by design of experiments for the simultaneous HPLC analysis of perampanel and stiripentol in mouse matrices

scientific article published on 30 September 2020

Screening of pharmacokinetic properties of fifty dihydropyrimidin(thi)one derivatives using a combo of in vitro and in silico assays

scientific article published on 22 August 2017

Short-term effects of Garcinia cambogia extract on the pharmacokinetics of lamotrigine given as a single-dose in Wistar rats

scientific article published on 30 March 2019

Silymarin as a flavonoid-type P-glycoprotein inhibitor with impact on the pharmacokinetics of carbamazepine, oxcarbazepine and phenytoin in rats

scientific article published on 25 April 2019

Simultaneous Quantification of Antidepressants and Metabolites in Urine and Plasma Samples by GC–MS for Therapeutic Drug Monitoring

Simultaneous and enantioselective liquid chromatographic determination of eslicarbazepine acetate, S-licarbazepine, R-licarbazepine and oxcarbazepine in mouse tissue samples using ultraviolet detection

scientific article

Stereoselective disposition of S- and R-licarbazepine in mice

scientific article

Steroidal oximes: useful compounds with antitumor activities

scientific article published on 3 October 2017

Synthesis, in vitro evaluation and QSAR modelling of potential antitumoral 3,4-dihydropyrimidin-2-(1H)-thiones

The maximal electroshock seizure (MES) model in the preclinical assessment of potential new antiepileptic drugs

scientific article published on 01 March 2009

Therapeutic Drug Monitoring of Fluoxetine, Norfluoxetine and Paroxetine: A New Tool Based on Microextraction by Packed Sorbent Coupled to Liquid Chromatography

scientific article published in September 2017

Thymus mastichina: Composition and Biological Properties with a Focus on Antimicrobial Activity

scientific article published on 19 December 2020

Timing in drug absorption and disposition: The past, present, and future of chronopharmacokinetics

scientific article published on 13 February 2020

Usefulness of factor II and factor X as therapeutic markers in patients under chronic warfarin therapy

scientific article published on 16 December 2009

Venlafaxine pharmacokinetics focused on drug metabolism and potential biomarkers

scientific article published on January 2014

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