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List of works by Ana Fortuna

A Critical Review of Microextraction by Packed Sorbent as A Sample Preparation Approach in Drug Bioanalysis ⬇️

scientific article published on June 1, 2013

A chiral HPLC‐UV method for the quantification of dibenz[b,f]azepine‐5‐carboxamide derivatives in mouse plasma and brain tissue: Eslicarbazepine acetate, carbamazepine and main metabolites ⬇️

scientific article published on 09 May 2011

A chiral liquid chromatography method for the simultaneous determination of oxcarbazepine, eslicarbazepine, R-licarbazepine and other new chemical derivatives BIA 2-024, BIA 2-059 and BIA 2-265, in mouse plasma and brain

scientific article

A combo-strategy to improve brain delivery of antiepileptic drugs: Focus on BCRP and intranasal administration

scientific article published on 08 December 2020

A new PAMPA model using an in-house brain lipid extract for screening the blood-brain barrier permeability of drug candidates

scientific article published on 30 January 2016

A single- and multiple-dose study to investigate the pharmacokinetics and pharmacodynamics of opicapone, a novel COMT inhibitor, in rat.

scientific article published on 19 July 2017

ABC transporters in drug-resistant epilepsy: mechanisms of upregulation and therapeutic approaches

scientific article published on 30 April 2019

An HPLC-DAD method for the simultaneous quantification of opicapone (BIA 9-1067) and its active metabolite in human plasma

scientific article

Analytical methods for determination of new fluoroquinolones in biological matrices and pharmaceutical formulations by liquid chromatography: a review

scientific article published on 10 February 2012

Antidepressants and nose-to-brain delivery: drivers, restraints, opportunities and challenges

scientific article published on 07 June 2019

Binding of licarbazepine enantiomers to mouse and human plasma proteins

scientific article published in July 2010

Blood-brain barrier models and their relevance for a successful development of CNS drug delivery systems: a review

scientific article published on 28 March 2014

Chiral chromatographic resolution of antiepileptic drugs and their metabolites: a challenge from the optimization to the application

scientific article

Comparison of ELISA and HPLC-MS methods for the determination of exenatide in biological and biotechnology-based formulation matrices

scientific article published on 26 February 2019

Cystic fibrosis: physiopathology and the latest pharmacological treatments

scientific article published on 27 October 2020

Determination of catecholamines and endogenous related compounds in rat brain tissue exploring their native fluorescence and liquid chromatography

scientific article published on 27 February 2017

Development and full validation of an innovative HPLC-diode array detection technique to simultaneously quantify lacosamide, levetiracetam and zonisamide in human plasma.

scientific article published on 21 March 2018

Development and validation of a fast isocratic liquid chromatography method for the simultaneous determination of norfloxacin, lomefloxacin and ciprofloxacin in human plasma

scientific article

Development and validation of an HPLC-UV method for the simultaneous quantification of carbamazepine, oxcarbazepine, eslicarbazepine acetate and their main metabolites in human plasma

scientific article published on 18 April 2010

Development of a liquid chromatography assay for the determination of opicapone and BIA 9-1079 in rat matrices

scientific article published on 6 July 2015

Direct nose-to-brain delivery of lamotrigine following intranasal administration to mice

scientific article

Drug-metabolizing Enzymes and Efflux Transporters in Nasal Epithelium: Influence on the Bioavailability of Intranasally Administered Drugs.

scientific article published on 6 April 2016

Elucidation of the Impact of P-glycoprotein and Breast Cancer Resistance Protein on the Brain Distribution of Catechol-O-Methyltransferase Inhibitors

scientific article

Enantioselective HPLC-UV method for determination of eslicarbazepine acetate (BIA 2-093) and its metabolites in human plasma

scientific article

Enantioselective assay for therapeutic drug monitoring of eslicarbazepine acetate: no interference with carbamazepine and its metabolites

scientific article published in August 2010

Erratum to: Analytical methods for determination of new fluoroquinolones in biological matrices and pharmaceutical formulations by liquid chromatography: a review

scholarly article published in Analytical and Bioanalytical Chemistry

Evaluation of the permeability and P‐glycoprotein efflux of carbamazepine and several derivatives across mouse small intestine by the Ussing chamber technique ⬇️

scientific article published on 01 March 2012

First HPLC–UV method for rapid and simultaneous quantification of phenobarbital, primidone, phenytoin, carbamazepine, carbamazepine-10,11-epoxide, 10,11-trans-dihydroxy-10,11-dihydrocarbamazepine, lamotrigine, oxcarbazepine and licarbazepine in hum

scientific article published on 27 February 2013

First liquid chromatography method for the simultaneous determination of levofloxacin, pazufloxacin, gatifloxacin, moxifloxacin and trovafloxacin in human plasma

scientific article published on 4 May 2013

First-time oral administration of resveratrol-loaded layer-by-layer nanoparticles to rats - a pharmacokinetics study

scientific article published on 06 February 2019

Flavonoid compounds as reversing agents of the P-glycoprotein-mediated multidrug resistance: An in vitro evaluation with focus on antiepileptic drugs

scientific article

Herb-drug pharmacokinetic interaction between carica papaya extract and amiodarone in rats

scientific article published on 01 January 2014

Impact of direct oral anticoagulant off-label doses on clinical outcomes of atrial fibrillation patients: A systematic review

scientific article published on 05 February 2020

In vitro and in vivo experimental models employed in the discovery and development of antiepileptic drugs for pharmacoresistant epilepsy

scientific article published on 21 July 2018

In vitro assessment of the interactions of dopamine β-hydroxylase inhibitors with human P-glycoprotein and Breast Cancer Resistance Protein.

scientific article published on 8 February 2018

Intranasal Delivery of Topically-Acting Levofloxacin to Rats: a Proof-of-Concept Pharmacokinetic Study

scientific article

Intranasal administration of carbamazepine to mice: a direct delivery pathway for brain targeting

scientific article published on 9 May 2014

Intranasal delivery of ciprofloxacin to rats: A topical approach using a thermoreversible in situ gel.

scientific article published on 31 October 2016

Intranasal delivery of systemic-acting drugs: small-molecules and biomacromolecules

scientific article published on 28 March 2014

Intranasal drug delivery: how, why and what for?

scientific article published on January 2009

Liquid chromatographic assay based on microextraction by packed sorbent for therapeutic drug monitoring of carbamazepine, lamotrigine, oxcarbazepine, phenobarbital, phenytoin and the active metabolites carbamazepine-10,11-epoxide and licarbazepine

scientific article published on 16 September 2014

Liquid chromatographic methods for the determination of direct oral anticoagulant drugs in biological samples: A critical review

scientific article published on 08 April 2019

Liquid chromatographic methods for the quantification of catecholamines and their metabolites in several biological samples—A review ⬇️

scientific article published on December 27, 2012

Nose-to-brain Delivery of Natural Compounds for the Treatment of Central Nervous System Disorders

scientific article published on 01 January 2020

Nose-to-brain delivery of levetiracetam after intranasal administration to mice

scientific article published on 20 April 2019

Optimization of a Parallel Artificial Membrane Permeability Assay for the Fast and Simultaneous Prediction of Human Intestinal Absorption and Plasma Protein Binding of Drug Candidates: Application to Dibenz[b,f]azepine-5-Carboxamide Derivatives

scientific article published on 03 November 2011

P-glycoprotein Mediated Efflux Modulators of Plant Origin: A Short Review

scientific article published on May 2016

Pharmacokinetics of opicapone, a third-generation COMT inhibitor, after single and multiple oral administration: A comparative study in the rat.

scientific article published on 16 March 2017

Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: new set of data for predictive in silico ADME models

scientific article

Pre-Clinical Assessment of the Nose-to-Brain Delivery of Zonisamide After Intranasal Administration

scientific article published on 25 March 2020

Real-world clinical characterization of subjects with depression treated with antidepressant drugs focused on (non-)genetic factors, pharmacokinetics, and clinical outcomes: GnG-PK/PD-AD study

scientific article published on 23 May 2019

Relevance of Breast Cancer Resistance Protein to Brain Distribution and Central Acting Drugs: A Pharmacokinetic Perspective

scientific article published on 01 January 2018

Rethinking carbamazepine oral delivery using polymer-lipid hybrid nanoparticles

scientific article published on 12 November 2018

Screening of pharmacokinetic properties of fifty dihydropyrimidin(thi)one derivatives using a combo of in vitro and in silico assays

scientific article published on 22 August 2017

Silymarin as a flavonoid-type P-glycoprotein inhibitor with impact on the pharmacokinetics of carbamazepine, oxcarbazepine and phenytoin in rats

scientific article published on 25 April 2019

Third and fourth generation fluoroquinolone antibacterials: a systematic review of safety and toxicity profiles

scientific article published on January 2014

Timing in drug absorption and disposition: The past, present, and future of chronopharmacokinetics

scientific article published on 13 February 2020

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