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List of works by Ralf P. Brandes

A Buttery Taste to Vascular Biology

scientific article published on 01 August 2016

A New PIXel in the Puzzle

scientific article published on 21 September 2009

A gp91phox Containing NADPH Oxidase Selectively Expressed in Endothelial Cells Is a Major Source of Oxygen Radical Generation in the Arterial Wall

scientific article published on 01 July 2000

A pirinixic acid derivative (LP105) inhibits murine 5-lipoxygenase activity and attenuates vascular remodelling in a murine model of aortic aneurysm

scientific article

A radical adventure: the quest for specific functions and inhibitors of vascular NAPDH oxidases

scientific article published in April 2003

AT1 receptor agonistic antibodies from preeclamptic patients stimulate NADPH oxidase

scientific article published on 24 February 2003

Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase

scientific article

Activating SIRT1: a new strategy to prevent atherosclerosis?

scientific article published on 10 September 2008

Activation of Rac-1 and RhoA contributes to podocyte injury in chronic kidney disease

scientific article

Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice.

scientific article published on 31 January 2012

Activation of thromboxane receptor modulates interleukin-1β-induced monocyte adhesion―A novel role of Nox1 ⬇️

scientific article published on March 9, 2012

Aged spontaneously hypertensive rats exhibit a selective loss of EDHF-mediated relaxation in the renal artery

scientific article published on 18 August 2003

Aging impairs the neurovascular interface in the heart

scientific article published on 24 August 2023

Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction

scientific article published on 27 April 2020

An endothelium-derived hyperpolarizing factor distinct from NO and prostacyclin is a major endothelium-dependent vasodilator in resistance vessels of wild-type and endothelial NO synthase knockout mice.

scientific article

Analysis of Endothelial Adherence of Bartonella henselae and Acinetobacter baumannii Using a Dynamic Human Ex Vivo Infection Model

scientific article published on 28 December 2015

Analysis of dichlorodihydrofluorescein and dihydrocalcein as probes for the detection of intracellular reactive oxygen species.

scientific article published on December 2004

Anatomic heterogeneity of vascular aging: role of nitric oxide and endothelin.

scientific article published on October 1997

And What About the Endothelium?

scientific article published on 01 July 2004

Angiotensin-converting enzyme is involved in outside-in signaling in endothelial cells

scientific article

Anti-atherosclerotic mechanisms of statin therapy ⬇️

scientific article published on 09 February 2013

Antioxidant-oxidant balance in the glomerulus and proximal tubule of the rat kidney

scientific article published on 01 June 1998

Antioxidative stress-associated genes in circulating progenitor cells: evidence for enhanced resistance against oxidative stress

scientific article published on 25 May 2004

Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant.

scientific article published on 17 December 2007

Author Correction: NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD

scientific article published on 01 July 2020

Avoiding Vicious Circles

scientific article published on 17 September 2007

Beneficial cardiovascular effects of endothelin ET(A) receptor blockade in established long-term heart failure after myocardial infarction

scientific article published on 01 June 2006

Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants.

scientific article published on 09 March 2017

Bimodal role of NADPH oxidases in the regulation of biglycan-triggered IL-1β synthesis.

scientific article published on 12 December 2015

CD40 ligand+ microparticles from human atherosclerotic plaques stimulate endothelial proliferation and angiogenesis a potential mechanism for intraplaque neovascularization

scientific article

CRISPR/Cas9-mediated knockout of p22phox leads to loss of Nox1 and Nox4, but not Nox5 activity

scientific article published on 24 August 2016

Cardiovascular pharmacology in the post-blockbuster era

scientific article published on 02 March 2010

Cell-to-Cell Connection of Endothelial Progenitor Cells With Cardiac Myocytes by Nanotubes

scientific article published on 05 May 2005

Chronic intratracheal application of the soluble guanylyl cyclase stimulator BAY 41-8543 ameliorates experimental pulmonary hypertension

scientific article published on 31 March 2017

Conditional Transgenic Expression of Fibroblast Growth Factor 9 in the Adult Mouse Heart Reduces Heart Failure Mortality After Myocardial Infarction

scientific article published on 24 January 2011

Critical role for p47phox in renin-angiotensin system activation and blood pressure regulation

scientific article

Cytochrome P450 enzymes but not NADPH oxidases are the source of the NADPH-dependent lucigenin chemiluminescence in membrane assays

scientific article published on 15 November 2016

Deficient angiogenesis in redox-dead Cys17Ser PKARIα knock-in mice

scientific article published on 10 August 2015

Dietary L-arginine normalizes endothelin-induced vascular contractions in cholesterol-fed rabbits

scientific article published in August 1998

Dietary l -Arginine Reduces the Progression of Atherosclerosis in Cholesterol-Fed Rabbits

scientific article published on 01 August 1997

Dietary l-arginine and α-tocopherol reduce vascular oxidative stress and preserve endothelial function in hypercholesterolemic rabbits via different mechanisms

scientific article published on 01 November 1998

Differential effect of p47phox and gp91phox deficiency on the course of Pneumococcal Meningitis

scientific article

Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase

scientific article

Do Not Overcharge the System or It Will Explode!

scientific article published on 01 September 2013

Dynamic modulation of interendothelial gap junctional communication by 11,12-epoxyeicosatrienoic acid

scientific article published in April 2002

Effects of dimethylarginine dimethylaminohydrolase-1 overexpression on the response of the pulmonary vasculature to hypoxia.

scientific article published on September 2013

Elevated heart rate triggers action potential alternans and sudden death. translational study of a homozygous KCNH2 mutation

scientific article

Endo-PDI is required for TNFα-induced angiogenesis.

scientific article

Endothelial Progenitor Cells=EPC=Elemental Pernicious Complexity ⬇️

scientific article published on April 26, 2011

Endothelial dysfunction and hypertension

scientific article

Endothelial dysfunction in heart transplanted patients with graft vasculopathy

scientific article published on 01 October 1995

Endothelium-dependent vasodilatation in Sprague-Dawley rats with postinfarction hypertrophy: Lack of endothelial dysfunction in vitro

scientific article published on 01 December 1998

Endothelium-derived hyperpolarizing factor synthase (Cytochrome P450 2C9) is a functionally significant source of reactive oxygen species in coronary arteries.

scientific article

Epigenetic Regulation of Angiogenesis by JARID1B-Induced Repression of HOXA5.

scientific article published on 28 May 2015

Epigenetic control of microsomal prostaglandin E synthase-1 by HDAC-mediated recruitment of p300.

scientific article published on 2 December 2016

Estradiol regulates human QT-interval: acceleration of cardiac repolarization by enhanced KCNH2 membrane trafficking

scientific article published on 12 August 2015

Evidence Against a Role for NADPH Oxidase Modulating Hepatic Vascular Tone in Cirrhosis

scientific article published on 20 June 2007

Ex vivo pretreatment of bone marrow mononuclear cells with endothelial NO synthase enhancer AVE9488 enhances their functional activity for cell therapy

scientific article published on 18 September 2006

Extracellular signal-regulated kinase-2 phosphorylates RORα4 in vitro

scientific article published on 11 May 2007

Extracellular superoxide dismutase is a major determinant of nitric oxide bioavailability: in vivo and ex vivo evidence from ecSOD-deficient mice

scientific article published on 21 August 2003

First evidence for a crosstalk between mitochondrial and NADPH oxidase-derived reactive oxygen species in nitroglycerin-triggered vascular dysfunction.

scientific article

Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells

scientific article

Function of NADPH oxidase 1 in pulmonary arterial smooth muscle cells after monocrotaline-induced pulmonary vascular remodeling

scientific article published on 20 July 2013

Gender differences in the generation of superoxide anions in the rat aorta

scientific article published in January 1997

Glucocorticoids inhibit superoxide anion production and p22 phox mRNA expression in human aortic smooth muscle cells.

scientific article

Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice.

scientific article published on 14 April 2015

Hepatocyte growth factor induces a proangiogenic phenotype and mobilizes endothelial progenitor cells by activating Nox2.

scientific article

Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707.

scientific article published on July 2003

Hyperthyroidism enhances endothelium-dependent relaxation in the rat renal artery

scientific article

Hypoxia induces Kv channel current inhibition by increased NADPH oxidase-derived reactive oxygen species

scientific article published on 16 December 2011

Hypoxia-dependent reactive oxygen species signaling in the pulmonary circulation: focus on ion channels

scientific article published on February 2015

Identification of structural elements in Nox1 and Nox4 controlling localization and activity.

scientific article

Inactivation of Extracellular Superoxide Dismutase Contributes to the Development of High-Volume Hypertension

article

Increased nitrovasodilator sensitivity in endothelial nitric oxide synthase knockout mice: role of soluble guanylyl cyclase.

scientific article

Increased sensitivity to endothelial nitric oxide (NO) contributes to arterial normotension in mice with vascular smooth muscle-selective deletion of the atrial natriuretic peptide (ANP) receptor

scientific article published on 11 March 2003

Inhalation of the BK(Ca)-opener NS1619 attenuates right ventricular pressure and improves oxygenation in the rat monocrotaline model of pulmonary hypertension.

scientific article published on 31 January 2014

Inhibition of the soluble epoxide hydrolase attenuates monocrotaline-induced pulmonary hypertension in rats

scientific article

Inhibition of the soluble epoxide hydrolase by tyrosine nitration.

scientific article published on 24 August 2009

Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal disease

scientific article

L-type calcium channel inhibitor diltiazem prevents aneurysm formation by blood pressure-independent anti-inflammatory effects.

scientific article published on 30 September 2013

Laminar shear stress regulates mitochondrial dynamics, bioenergetics responses and PRX3 activation in endothelial cells.

scientific article published on 17 July 2014

Left ventricular remodeling after myocardial infarction in mice with targeted deletion of the NADPH oxidase subunit gp91PHOX.

scientific article published on 10 November 2005

Leptin Potentiates Endothelium-Dependent Relaxation by Inducing Endothelial Expression of Neuronal NO Synthase

scientific article published on 10 May 2012

Levosimendan attenuates pulmonary vascular remodeling

scientific article published on 31 May 2011

Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo.

scientific article

Loss of Nrf2 in bone marrow-derived macrophages impairs antigen-driven CD8(+) T cell function by limiting GSH and Cys availability.

scientific article

Lovastatin maintains nitric oxide—but not EDHF-mediated endothelium-dependent relaxation in the hypercholesterolemic rabbit carotid artery

scientific article published on 01 January 1999

Mepivacaine for spinal anesthesia in parturients undergoing elective cesarean delivery: maternal and neonatal plasma concentrations and neonatal outcome.

scientific article

Metabolism Regulates Cellular Functions of Bone Marrow-Derived Cells used for Cardiac Therapy

scientific article

Micro-CT Technique Is Well Suited for Documentation of Remodeling Processes in Murine Carotid Arteries

scientific article published on 18 June 2015

MicroRNA-29 in Aortic Dilation: Implications for Aneurysm Formation

scientific article published on 08 September 2011

Mitochondrial Complex IV Subunit 4 Isoform 2 Is Essential for Acute Pulmonary Oxygen Sensing

scientific article published on 15 June 2017

Monoamine oxidases are mediators of endothelial dysfunction in the mouse aorta

scientific article published on 13 May 2013

NADPH Oxidase-4 Maintains Neuropathic Pain after Peripheral Nerve Injury

scientific article published on 01 July 2012

NADPH oxidase 4 is not involved in hypoxia-induced pulmonary hypertension.

scientific article

NADPH oxidase 4 limits bone mass by promoting osteoclastogenesis

scientific article

NADPH oxidase 4 regulates homocysteine metabolism and protects against acetaminophen-induced liver damage in mice

scientific article

NADPH oxidase Nox1 contributes to ischemic injury in experimental stroke in mice

scientific article published on 23 May 2010

NADPH oxidase Nox2 is required for hypoxia-induced mobilization of endothelial progenitor cells

scientific article published on 13 August 2009

NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke

scientific article published on 4 October 2007

NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD

scientific article published on 08 June 2020

NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis.

scientific article

NADPH oxidase-derived overproduction of reactive oxygen species impairs postischemic neovascularization in mice with type 1 diabetes.

scientific article published on August 2006

NADPH oxidases as therapeutic targets in ischemic stroke.

scientific article published on 23 May 2012

NADPH oxidases in cardiovascular disease.

scientific article published on 02 May 2010

NG-nitro-l-arginine- and indomethacin-resistant endothelium-dependent relaxation in the rabbit renal artery: effect of hypercholesterolemia

scientific article published on 01 November 1997

NOX4 Regulates CCR2 and CCL2 mRNA Stability in Alcoholic Liver Disease.

scientific article published on 06 April 2017

NOX4-dependent Hydrogen peroxide promotes shear stress-induced SHP2 sulfenylation and eNOS activation.

scientific article published on 28 September 2015

NOXious phosphorylation: Smooth muscle reactive oxygen species production is facilitated by direct activation of the NADPH oxidase Nox1.

scientific article published in November 2014

Native LDL induces proliferation of human vascular smooth muscle cells via redox-mediated activation of ERK 1/2 mitogen-activated protein kinases

scientific article published in February 2002

Ncf1 provides a reactive oxygen species-independent negative feedback regulation of TLR9-induced IL-12p70 in murine dendritic cells

scientific article published in April 2009

Nebivolol inhibits superoxide formation by NADPH oxidase and endothelial dysfunction in angiotensin II-treated rats.

scientific article published on 28 August 2006

Nicotinamide adenine dinucleotide phosphate oxidase-4-dependent upregulation of nuclear factor erythroid-derived 2-like 2 protects the heart during chronic pressure overload

scientific article published on 22 December 2014

No Superoxide—No Stress?

scientific article published on 01 June 2011

Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells

scientific article

Novel Faces to Old Friends

scientific article published on 01 February 2006

Nox activator 1: a potential target for modulation of vascular reactive oxygen species in atherosclerotic arteries

scientific article

Nox family NADPH oxidases: Molecular mechanisms of activation

scientific article

Nox1 mediates basic fibroblast growth factor-induced migration of vascular smooth muscle cells.

scientific article

Nox2-dependent signaling between macrophages and sensory neurons contributes to neuropathic pain hypersensitivity

scientific article published on 17 August 2014

Nox4 acts as a switch between differentiation and proliferation in preadipocytes.

scientific article published on 4 December 2008

Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase

scientific article

Noxa1 is a central component of the smooth muscle NADPH oxidase in mice.

scientific article published on 30 January 2006

Optoinjection for efficient targeted delivery of a broad range of compounds and macromolecules into diverse cell types.

scientific article

Organizers and activators: Cytosolic Nox proteins impacting on vascular function.

scientific article published on 20 March 2017

Out of Balance

scientific article published on 01 December 2003

Oxidative stress and expression of p22phox are involved in the up-regulation of tissue factor in vascular smooth muscle cells in response to activated platelets

scientific article published on 01 August 2000

Oxidized low-density lipoprotein increases superoxide production by endothelial nitric oxide synthase by inhibiting PKCalpha

scientific article

PAFAH1B1 and the lncRNA NONHSAT073641 maintain an angiogenic phenotype in human endothelial cells.

scientific article

Peroxisome proliferator-activated receptor alpha induces NADPH oxidase activity in macrophages, leading to the generation of LDL with PPAR-alpha activation properties

scientific article published on 11 November 2004

Phenotypic characterization of miR-92a-/- mice reveals an important function of miR-92a in skeletal development

scientific article

Pivotal role of xanthine oxidase in the initiation of tubulointerstitial renal injury in rats with hyperlipidemia

scientific article published in February 2006

Platelet-derived growth factor activates production of reactive oxygen species by NAD(P)H oxidase in smooth muscle cells through Gi1,2.

scientific article published in November 2002

Polarity Protein Scrib Facilitates Endothelial Inflammatory Signaling.

scientific article published on 23 July 2015

Reactive Oxygen Species Differentially Modulate the Metabolic and Transcriptomic Response of Endothelial Cells

scientific article published in 2022

Reactive oxygen species and antioxidant defense in puromycin aminonucleoside glomerulopathy.

scientific article published on November 1997

Redox-mediated signal transduction by cardiovascular Nox NADPH oxidases.

scientific article published on 19 February 2014

Regulation of proliferation of skeletal muscle precursor cells by NADPH oxidase

scientific article

Reprogramming of myeloid angiogenic cells by Bartonella henselae leads to microenvironmental regulation of pathological angiogenesis

scientific article

Response to Pagano et al.

scientific article

Response to Sympathoinhibitory Effect of Diltiazem and Prevention of Aneurysm Formation

scientific article published on 01 March 2014

Response to letter regarding article, "Vitamin D promotes vascular regeneration".

scientific article published in June 2015

Rho kinase contributes to basal vascular tone in humans: role of endothelium-derived nitric oxide

scientific article published on 23 March 2007

Roads to Dysfunction

scientific article published on 01 October 2006

Role of Increased Production of Superoxide Anions by NAD(P)H Oxidase and Xanthine Oxidase in Prolonged Endotoxemia

scientific article published on 01 May 1999

Role of Nox4 in murine models of kidney disease.

scientific article published on 27 June 2012

Role of Src tyrosine kinases in experimental pulmonary hypertension

scientific article published on 19 April 2012

Role of p22phox in angiotensin II and platelet-derived growth factor AA induced activator protein 1 activation in vascular smooth muscle cells

scientific article

Role of podocytes for reversal of glomerulosclerosis and proteinuria in the aging kidney after endothelin inhibition.

scientific article published on 15 November 2004

Role of reactive oxygen species and gp91phox in endothelial dysfunction of pulmonary arteries induced by chronic hypoxia

scientific article published on 22 May 2006

Roles of reactive oxygen species in angiopoietin-1/tie-2 receptor signaling.

scientific article published on 27 July 2005

SPARC, a Novel Regulator of Vascular Cell Function in Pulmonary Hypertension

scientific article published on 22 March 2022

SYNCRIP-dependent Nox2 mRNA destabilization impairs ROS formation in M2-polarized macrophages

scientific article published on 29 July 2014

Soluble epoxide hydrolase deficiency attenuates neointima formation in the femoral cuff model of hyperlipidemic mice.

scientific article

Soluble epoxide hydrolase is a main effector of angiotensin II-induced hypertension

scientific article published on 7 February 2005

Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation

scientific article published on 04 October 2011

Statin-Mediated Inhibition of Rho

scientific article published on 01 May 2005

Stimulation of soluble guanylate cyclase prevents cigarette smoke-induced pulmonary hypertension and emphysema

scientific article published in June 2014

Supplementation of hypercholesterolaemic rabbits with L-arginine reduces the vascular release of superoxide anions and restores NO production

scientific article published on 01 October 1995

Sympathoactivation and rho-kinase-dependent baroreflex function in experimental renovascular hypertension with reduced kidney mass

scientific article

Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2α-mediated stress signaling

scientific article published on 7 January 2016

Targeting inflammation and oxidative stress in atrial fibrillation: role of 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibition with statins.

scientific article published on 19 October 2013

The Cytosolic NADPH Oxidase Subunit NoxO1 Promotes an Endothelial Stalk Cell Phenotype

scientific article

The E-loop is involved in hydrogen peroxide formation by the NADPH oxidase Nox4

scientific article

The Endoplasmic Reticulum Chaperone Calnexin Is a NADPH Oxidase NOX4 Interacting Protein

scientific article published on 9 February 2016

The Histone Demethylase PHF8 Is Essential for Endothelial Cell Migration

scientific article published on 11 January 2016

The NADPH Oxidase Nox2 Mediates Vitamin D-Induced Vascular Regeneration in Male Mice.

scientific article

The NADPH organizers NoxO1 and p47phox are both mediators of diabetes-induced vascular dysfunction in mice

scientific article

The NADPH oxidase Nox4 has anti-atherosclerotic functions

scientific article published on 17 September 2015

The Nox family of NADPH oxidases: friend or foe of the vascular system?

scientific article published on February 2012

The basal and stimulated release of the endothelium-derived relaxing factor from isolated pig coronary arteries does not interfere with the vascular release of superoxide

scientific article published on 01 February 1994

The interaction between delayed rectifier channel alpha-subunits does not involve hetero-tetramer formation

scientific article published on 20 March 2015

The terminal complement complex C5b-9 stimulates interleukin-6 production in human smooth muscle cells through activation of transcription factors NF-kappa B and AP-1

scientific article published on 01 December 2000

The vascular NADPH oxidase subunit p47phox is involved in redox-mediated gene expression.

scientific article

Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension

scientific article

Thrombin-induced MCP-1 expression involves activation of the p22phox-containing NADPH oxidase in human vascular smooth muscle cells

scientific article published on 01 June 2001

Trafficking-deficient long QT syndrome mutation KCNQ1-T587M confers severe clinical phenotype by impairment of KCNH2 membrane localization: evidence for clinically significant IKr-IKs alpha-subunit interaction.

scientific article

Transdifferentiation of Blood-Derived Human Adult Endothelial Progenitor Cells Into Functionally Active Cardiomyocytes

scientific article published on 01 February 2003

Triggering mitochondrial radical release: a new function for NADPH oxidases

scientific article

Unchanged NADPH Oxidase Activity in Nox1-Nox2-Nox4 Triple Knockout Mice: What Do NADPH-Stimulated Chemiluminescence Assays Really Detect?

scientific article published on 23 April 2015

Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity: Evidence From Mouse and Human Studies.

scientific article published on 27 April 2017

Vascular NADPH oxidases: molecular mechanisms of activation.

scientific article

Vascular functions of NADPH oxidases

scientific article published on 17 May 2010

Vascular peroxidase 1/peroxidasin: a complex protein with a simple function?

scientific article published on 20 April 2011

Vascular release of superoxide radicals is enhanced in hypercholesterolemic rabbits

scientific article published on 01 December 1994

Vitamin D promotes vascular regeneration

scientific article published on 11 July 2014

Which NADPH oxidase isoform is relevant for ischemic stroke? The case for nox 2.

scientific article published on 20 August 2012

Withdrawal of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors elicits oxidative stress and induces endothelial dysfunction in mice

scientific article

Withdrawal of cerivastatin induces monocyte chemoattractant protein 1 and tissue factor expression in cultured vascular smooth muscle cells

scientific article published on 21 August 2003

Xanthine oxidase inhibitor tungsten prevents the development of atherosclerosis in ApoE knockout mice fed a Western-type diet.

scientific article

gp91phox-containing NADPH oxidase mediates endothelial dysfunction in renovascular hypertension

scientific article published on 22 March 2004

p47phox-dependent NADPH oxidase regulates flow-induced vascular remodeling

scientific article published on 18 August 2005

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