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List of works by Malcolm Lyon

A general method for the detection and mapping of submicrogram quantities of glycosaminoglycan oligosaccharides on polyacrylamide gels by sequential staining with azure A and ammoniacal silver

scientific article published on 01 February 1990

A new map of glycosaminoglycan and C3b binding sites on factor H

scientific article

A new model for the domain structure of heparan sulfate based on the novel specificity of K5 lyase.

scientific article published on 26 March 2004

A rapid purification of bovine testicular hyaluronidase by chromatography on dermatan sulphate-substituted 1,6-diaminohexane--sepharose 4B.

scientific article published on November 1981

A simplified and sensitive fluorescent method for disaccharide analysis of both heparan sulfate and chondroitin/dermatan sulfates from biological samples

scientific article

An evaluation of cytosolic erythrocyte carbonic anhydrase and catalase in carcinoma patients: An elevation of carbonic anhydrase activity

scientific article published on 19 April 2006

Binding of endostatin to endothelial heparan sulphate shows a differential requirement for specific sulphates.

scientific article

Binding of perlecan to transthyretin qin vitro ⬇️

scientific article published on September 15, 1997

Bio-specific sequences and domains in heparan sulphate and the regulation of cell growth and adhesion

scientific article published on 01 November 1998

Characterization and binding activity of the chondroitin/dermatan sulfate chain from Endocan, a soluble endothelial proteoglycan

scientific article published on 24 June 2010

Conformation of glycosaminoglycans by ion mobility mass spectrometry and molecular modelling.

scientific article

DMT-MM mediated functionalisation of the non-reducing end of glycosaminoglycans

scientific article

Determination of the Disaccharide Composition of Glycosaminoglycans: Comparison of Chemical and Enzymatic Scission

article

Disease-associated sequence variations congregate in a polyanion recognition patch on human factor H revealed in three-dimensional structure

scientific article

Distinct substrate specificities of bacterial heparinases against N-unsubstituted glucosamine residues in heparan sulfate

scientific article published on 10 February 2005

Elucidation of the structural features of heparan sulfate important for interaction with the Hep-2 domain of fibronectin.

scientific article published on February 2000

Endocan or endothelial cell specific molecule-1 (ESM-1): a potential novel endothelial cell marker and a new target for cancer therapy.

scientific article

Fibroblast Growth Factor-2 Stimulation of p42/44MAPKPhosphorylation and IκB Degradation Is Regulated by Heparan Sulfate/Heparin in Rat Mammary Fibroblasts

scientific article published in Journal of Biological Chemistry

HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1.

scientific article

Heparan Sulfate

Heparan sulfate undergoes specific structural changes during the progression from human colon adenoma to carcinoma in vitro

scientific article published in January 1998

Heparan sulphate-degrading endoglycosidase in liver plasma membranes ⬇️

scientific article published on March 1988

Hepatocyte growth factor/scatter factor binds to small heparin-derived oligosaccharides and stimulates the proliferation of human HaCaT keratinocytes

scientific article

Hepatocyte growth factor/scatter factor binds with high affinity to dermatan sulfate

scientific article

Hepatocyte growth factor/scatter factor stimulates migration of rat mammary fibroblasts through both mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt pathways.

scientific article

Hepatocyte growth factor/scatter factor: a heparan sulphate-binding pleiotropic growth factor

scientific article published on 01 May 1994

Highly sensitive sequencing of the sulfated domains of heparan sulfate.

scientific article published on June 1999

Insights into the structure/function of hepatocyte growth factor/scatter factor from studies with individual domains

scientific article published on 26 January 2007

Interaction of human β-defensin 2 (HBD2) with glycosaminoglycans.

scientific article

Interactions of hepatocyte growth factor/scatter factor with various glycosaminoglycans reveal an important interplay between the presence of iduronate and sulfate density.

scientific article published on 21 December 2007

Isolation and characterization of high-buoyant-density proteoglycans from bovine femoral-head cartilage.

scientific article published on August 1983

Isolation and characterization of the integral glycosaminoglycan constituents of human amyloid A and monoclonal light-chain amyloid fibrils.

scientific article published on April 1991

Lysine and arginine side chains in glycosaminoglycan-protein complexes investigated by NMR, cross-linking, and mass spectrometry: a case study of the factor H-heparin interaction.

scientific article published on May 2010

Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration

scientific article

Novel heparin/heparan sulfate mimics as inhibitors of HGF/SF-induced MET activation

scientific article published on 4 September 2007

Patterns of sulphation in heparan sulphate: polymorphism based on a common structural theme

scientific article (publication date: April 1992)

Preparation of heparin/heparan sulfate oligosaccharides with internal N-unsubstituted glucosamine residues for functional studies

scientific article

Proteoglycans

Proteoglycans of human T lymphocytes: differences between helper and suppressor subsets

article

Purification and partial characterization of the major cell-associated heparan sulphate proteoglycan of rat liver ⬇️

scientific article published on January 15, 1991

Quantitative and qualitative alterations of heparan sulfate in fibrogenic liver diseases and hepatocellular cancer

scientific article

Residual dipolar coupling investigation of a heparin tetrasaccharide confirms the limited effect of flexibility of the iduronic acid on the molecular shape of heparin

scientific article published on 31 July 2009

Specific chemical modifications of link protein and their effect on binding to hyaluronate and cartilage proteoglycan.

scientific article published in March 1986

Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism

scientific article

The binding properties of minimal oligosaccharides reveal a common heparan sulfate/dermatan sulfate-binding site in hepatocyte growth factor/scatter factor that can accommodate a wide variety of sulfation patterns

scientific article

The heparin/heparan sulfate sequence that interacts with cyclophilin B contains a 3-O-sulfated N-unsubstituted glucosamine residue.

scientific article

The interaction of the transforming growth factor-betas with heparin/heparan sulfate is isoform-specific.

scientific article

The interactions of hepatocyte growth factor/scatter factor and its NK1 and NK2 variants with glycosaminoglycans using a modified gel mobility shift assay. Elucidation of the minimal size of binding and activatory oligosaccharides

scientific article

The isolation of membrane proteoglycans

scientific article published on 01 January 1993

The mode of action of heparan and dermatan sulfates in the regulation of hepatocyte growth factor/scatter factor

scientific article (publication date: 11 January 2002)

The molecular phenotype of heparan sulfate in the Hs2st-/- mutant mouse

scientific journal article

The synthesis of proteoglycans by human T lymphocytes

scientific article published on May 1990

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