List of works - Stewart O. Sage

A key role for dense granule secretion in potentiation of the Ca2+ signal arising from store-operated calcium entry in human platelets

scientific article published on 13 March 2009

A key role for reverse Na+/Ca2+ exchange influenced by the actin cytoskeleton in store-operated Ca2+ entry in human platelets: evidence against the de novo conformational coupling hypothesis.

scientific article published on 23 March 2007

A role for SNAP-25 but not VAMPs in store-mediated Ca2+ entry in human platelets.

scientific article published on 30 April 2004

A role for TRPV1 in agonist-evoked activation of human platelets.

scientific article published on 20 November 2008

A role for cofilin in the activation of store-operated calcium entry by de novo conformational coupling in human platelets

scientific article published on 18 October 2005

A role for hTRPC1 and lipid raft domains in store-mediated calcium entry in human platelets

scientific article

A role for the actin cytoskeleton in the initiation and maintenance of store-mediated calcium entry in human platelets. Evidence for conformational coupling

scientific article published in March 2000

A role for the intracellular protease calpain in the activation of store-operated calcium entry in human platelets

scientific article published on 01 August 2006

Actin polymerisation regulates thrombin-evoked Ca2+signalling after activation of PAR-4 but not PAR-1 in human platelets

scientific article published on 01 May 2006

Biochemical and functional properties of the store-operated Ca2+ channels.

scientific article

Bradykinin-evoked changes in cytosolic calcium and membrane currents in cultured bovine pulmonary artery endothelial cells

scientific article published on 01 December 1989

Calcium influx evoked by Ca2+ store depletion in human platelets is more susceptible to cytochrome P-450 inhibitors than receptor-mediated calcium entry

scientific article published on 01 October 1992

Calcium signalling in platelets and other cells

scientific article published in January 1994

Cleavage of SNAP-25 and VAMP-2 impairs store-operated Ca2+ entry in mouse pancreatic acinar cells

scientific article published on 8 September 2004

Conventional protein kinase C isoforms differentially regulate ADP- and thrombin-evoked Ca²⁺ signalling in human platelets.

scientific article

Coupling between inositol 1,4,5-trisphosphate receptors and human transient receptor potential channel 1 when intracellular Ca2+ stores are depleted

scientific article

Cyclic nucleotides modulate store-mediated calcium entry through the activation of protein-tyrosine phosphatases and altered actin polymerization in human platelets

scientific article

Cytosolic calcium concentration in resting and stimulated endothelium of excised intact rat aorta

scientific article published on 01 December 1995

Cytosolic calcium elevation in response to Fc receptor cross-linking in undifferentiated and differentiated U937 cells.

scientific article published on July 1994

Dual role of tubulin-cytoskeleton in store-operated calcium entry in human platelets.

scientific article published on 28 June 2007

Effects of U73122 and U73343 on human platelet calcium signalling and protein tyrosine phosphorylation

scientific article published on 01 January 1997

Effects of ionic substitution on [Ca2+]i rises evoked by thrombin and PAF in human platelets

scientific article published on 01 August 1986

Electrical properties of resting and acetylcholine-stimulated endothelium in intact rat aorta

scientific article published on 01 March 1993

Endogenously expressed Trp1 is involved in store-mediated Ca2+ entry by conformational coupling in human platelets

scientific article published on 23 August 2002

Farnesylcysteine analogues inhibit store-regulated Ca2+ entry in human platelets: evidence for involvement of small GTP-binding proteins and actin cytoskeleton

scientific article

Fibrinogen binding to the integrin alpha(IIb)beta(3) modulates store-mediated calcium entry in human platelets

scientific article published in May 2001

Function of intracellular [Ca2+]i in exocytosis and transbilayer movement in human platelets surface-labeled with the fluorescent probe 1-(4-trimethylammonio)phenyl)-6-phenyl-1,3,5-hexatriene.

scientific article

Human platelet activation is inhibited upstream of the activation of phospholipase A2 by U73343

scientific article published on 01 May 1997

Hydrogen peroxide generation induces pp60src activation in human platelets: evidence for the involvement of this pathway in store-mediated calcium entry

scientific article published on 27 October 2003

Identification of a P2X1 purinoceptor expressed on human platelets

scientific article published on 01 January 1998

Increased capacity for store regulated calcium influx in U937 cells differentiated by treatment with dibutyryl cAMP.

scientific article published in May 1995

Indirect regulation of Ca2+ entry by cAMP-dependent and cGMP-dependent protein kinases and phospholipase C in rat platelets

scientific article published on 01 July 1994

Inhibition by forskolin of cytosolic calcium rise, shape change and aggregation in quin2-loaded human platelets

scientific article published on 01 August 1985

Is calcium-independent phospholipase A2 required for store-operated calcium entry in human platelets?

scientific article

Kinetic differences between thrombin-induced and ADP-induced calcium influx and release from internal stores in fura-2-loaded human platelets

scientific article published on 01 May 1986

Lack of evidence for a role for the lipoxygenase pathway in increases in cytosolic calcium evoked by ADP and arachidonic acid in human platelets.

scientific article published on November 1991

Monitoring the intracellular store Ca2+ concentration in agonist-stimulated, intact human platelets by using Fluo-5N

scientific article published on 01 March 2011

Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation.

scientific article published on 8 October 2009

PAR-1-dependent pp60src activation is dependent on protein kinase C and increased [Ca2+]: evidence that pp60src does not regulate PAR-1-dependent Ca2+ entry in human platelets

scientific article published on 11 September 2006

Phorbol ester-evoked Ca2+ signaling in human platelets is via autocrine activation of P(2X1) receptors, not a novel non-capacitative Ca2+ entry

scientific article published on 23 March 2010

Phosphoinositides are required for store-mediated calcium entry in human platelets

scientific article published on 01 March 2000

Ragged spiking of free calcium in ADP-stimulated human platelets: regulation of puff-like calcium signals in vitro and ex vivo

scientific article

Rapid agonist-evoked coupling of type II Ins(1,4,5)P3 receptor with human transient receptor potential (hTRPC1) channels in human platelets

scientific article published in November 2003

Real-time detection of activation patterns in individual platelets during thromboembolism in vivo: differences between thrombus growth and embolus formation

scientific article

Resting and ADP-evoked changes in cytosolic free sodium concentration in human platelets loaded with the indicator SBFI.

scientific article published on September 1991

Role of the ERK pathway in the activation of store-mediated calcium entry in human platelets

scientific article

SERCA2b and 3 play a regulatory role in store-operated calcium entry in human platelets.

scientific article published on 26 October 2007

STIM1 tyrosine-phosphorylation is required for STIM1-Orai1 association in human platelets

scientific article published on 25 February 2012

Shedding of procoagulant microparticles from unstimulated platelets by integrin-mediated destabilization of actin cytoskeleton.

scientific article

Sodium-calcium exchange in cultured bovine pulmonary artery endothelial cells.

scientific article published on January 1991

Src family tyrosine kinases activate thrombin-induced non-capacitative cation entry in human platelets

scientific article published in January 2010

Stimulated calcium efflux from fura-2-loaded human platelets.

scientific article published on December 1987

Stimulation of Ca2+ efflux from fura-2-loaded platelets activated by thrombin or phorbol myristate acetate

scientific article published on 01 January 1987

Store-operated Ca2+ entry: vesicle fusion or reversible trafficking and de novo conformational coupling?

scientific article

TRP channels and calcium entry in human platelets

scientific article published on 01 December 2002

The TRPV1 ion channel is expressed in human but not mouse platelets.

scientific article

The imidazole antimycotics econazole and miconazole reduce agonist-evoked protein-tyrosine phosphorylation and evoke membrane depolarisation in human platelets: cautions for their use in studying Ca2+ signalling pathways

scientific article published on 01 November 1994

The inositol trisphosphate receptor antagonist 2-aminoethoxydiphenylborate (2-APB) blocks Ca2+ entry channels in human platelets: cautions for its use in studying Ca2+ influx.

scientific article

The roles of P(2X1)and P(2T AC)receptors in ADP-evoked calcium signalling in human platelets

scientific article published on 01 August 2000

The tyrosine kinase inhibitors methyl 2,5-dihydroxycinnamate and genistein reduce thrombin-evoked tyrosine phosphorylation and Ca2+ entry in human platelets

scientific article published on 01 January 1993

Three routes for receptor-mediated Ca2+ entry

scientific article published on 01 June 1992

Thromboxane receptor stimulation inhibits adenylate cyclase and reduces cyclic AMP-mediated inhibition of ADP-evoked responses in fura-2-loaded human platelets

scientific article

Transient receptor potential protein subunit assembly and membrane distribution in human platelets

scientific article published on 01 October 2005

Two pathways for store-mediated calcium entry differentially dependent on the actin cytoskeleton in human platelets

scientific article

Tyrosine kinases activate store-mediated Ca2+ entry in human platelets through the reorganization of the actin cytoskeleton.

scientific article published on October 2000

Tyrosine phosphorylation and Ca2+ influx. A further mechanism for store-dependent Ca2+ entry?

scientific article published on 01 August 1994

Voltage-gated potassium channels and the control of membrane potential in human platelets

scientific article published on 01 September 1990

Wortmannin inhibits store-mediated calcium entry and protein tyrosine phosphorylation in human platelets

scientific article published on 01 March 1996

Zinc is a transmembrane agonist that induces platelet activation in a tyrosine phosphorylation-dependent manner.

scientific article

List of works by Stewart O. Sage

A key role for dense granule secretion in potentiation of the Ca2+ signal arising from store-operated calcium entry in human platelets

A key role for reverse Na+/Ca2+ exchange influenced by the actin cytoskeleton in store-operated Ca2+ entry in human platelets: evidence against the de novo conformational coupling hypothesis.

A role for SNAP-25 but not VAMPs in store-mediated Ca2+ entry in human platelets.

A role for TRPV1 in agonist-evoked activation of human platelets.

A role for cofilin in the activation of store-operated calcium entry by de novo conformational coupling in human platelets

A role for hTRPC1 and lipid raft domains in store-mediated calcium entry in human platelets

A role for the actin cytoskeleton in the initiation and maintenance of store-mediated calcium entry in human platelets. Evidence for conformational coupling

A role for the intracellular protease calpain in the activation of store-operated calcium entry in human platelets

Actin polymerisation regulates thrombin-evoked Ca2+signalling after activation of PAR-4 but not PAR-1 in human platelets

Biochemical and functional properties of the store-operated Ca2+ channels.

Bradykinin-evoked changes in cytosolic calcium and membrane currents in cultured bovine pulmonary artery endothelial cells

Calcium influx evoked by Ca2+ store depletion in human platelets is more susceptible to cytochrome P-450 inhibitors than receptor-mediated calcium entry

Calcium signalling in platelets and other cells

Cleavage of SNAP-25 and VAMP-2 impairs store-operated Ca2+ entry in mouse pancreatic acinar cells

Conventional protein kinase C isoforms differentially regulate ADP- and thrombin-evoked Ca²⁺ signalling in human platelets.

Coupling between inositol 1,4,5-trisphosphate receptors and human transient receptor potential channel 1 when intracellular Ca2+ stores are depleted

Cyclic nucleotides modulate store-mediated calcium entry through the activation of protein-tyrosine phosphatases and altered actin polymerization in human platelets

Cytosolic calcium concentration in resting and stimulated endothelium of excised intact rat aorta

Cytosolic calcium elevation in response to Fc receptor cross-linking in undifferentiated and differentiated U937 cells.

Dual role of tubulin-cytoskeleton in store-operated calcium entry in human platelets.

Effects of U73122 and U73343 on human platelet calcium signalling and protein tyrosine phosphorylation

Effects of ionic substitution on [Ca2+]i rises evoked by thrombin and PAF in human platelets

Electrical properties of resting and acetylcholine-stimulated endothelium in intact rat aorta

Endogenously expressed Trp1 is involved in store-mediated Ca2+ entry by conformational coupling in human platelets

Farnesylcysteine analogues inhibit store-regulated Ca2+ entry in human platelets: evidence for involvement of small GTP-binding proteins and actin cytoskeleton

Fibrinogen binding to the integrin alpha(IIb)beta(3) modulates store-mediated calcium entry in human platelets

Function of intracellular [Ca2+]i in exocytosis and transbilayer movement in human platelets surface-labeled with the fluorescent probe 1-(4-trimethylammonio)phenyl)-6-phenyl-1,3,5-hexatriene.

Human platelet activation is inhibited upstream of the activation of phospholipase A2 by U73343

Hydrogen peroxide generation induces pp60src activation in human platelets: evidence for the involvement of this pathway in store-mediated calcium entry

Identification of a P2X1 purinoceptor expressed on human platelets

Increased capacity for store regulated calcium influx in U937 cells differentiated by treatment with dibutyryl cAMP.

Indirect regulation of Ca2+ entry by cAMP-dependent and cGMP-dependent protein kinases and phospholipase C in rat platelets

Inhibition by forskolin of cytosolic calcium rise, shape change and aggregation in quin2-loaded human platelets

Is calcium-independent phospholipase A2 required for store-operated calcium entry in human platelets?

Kinetic differences between thrombin-induced and ADP-induced calcium influx and release from internal stores in fura-2-loaded human platelets

Lack of evidence for a role for the lipoxygenase pathway in increases in cytosolic calcium evoked by ADP and arachidonic acid in human platelets.

Monitoring the intracellular store Ca2+ concentration in agonist-stimulated, intact human platelets by using Fluo-5N

Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation.

PAR-1-dependent pp60src activation is dependent on protein kinase C and increased [Ca2+]: evidence that pp60src does not regulate PAR-1-dependent Ca2+ entry in human platelets

Phorbol ester-evoked Ca2+ signaling in human platelets is via autocrine activation of P(2X1) receptors, not a novel non-capacitative Ca2+ entry

Phosphoinositides are required for store-mediated calcium entry in human platelets

Ragged spiking of free calcium in ADP-stimulated human platelets: regulation of puff-like calcium signals in vitro and ex vivo

Rapid agonist-evoked coupling of type II Ins(1,4,5)P3 receptor with human transient receptor potential (hTRPC1) channels in human platelets

Real-time detection of activation patterns in individual platelets during thromboembolism in vivo: differences between thrombus growth and embolus formation

Resting and ADP-evoked changes in cytosolic free sodium concentration in human platelets loaded with the indicator SBFI.

Role of the ERK pathway in the activation of store-mediated calcium entry in human platelets

SERCA2b and 3 play a regulatory role in store-operated calcium entry in human platelets.

STIM1 tyrosine-phosphorylation is required for STIM1-Orai1 association in human platelets

Shedding of procoagulant microparticles from unstimulated platelets by integrin-mediated destabilization of actin cytoskeleton.

Sodium-calcium exchange in cultured bovine pulmonary artery endothelial cells.

Src family tyrosine kinases activate thrombin-induced non-capacitative cation entry in human platelets

Stimulated calcium efflux from fura-2-loaded human platelets.

Stimulation of Ca2+ efflux from fura-2-loaded platelets activated by thrombin or phorbol myristate acetate

Store-operated Ca2+ entry: vesicle fusion or reversible trafficking and de novo conformational coupling?

TRP channels and calcium entry in human platelets

The TRPV1 ion channel is expressed in human but not mouse platelets.

The imidazole antimycotics econazole and miconazole reduce agonist-evoked protein-tyrosine phosphorylation and evoke membrane depolarisation in human platelets: cautions for their use in studying Ca2+ signalling pathways

The inositol trisphosphate receptor antagonist 2-aminoethoxydiphenylborate (2-APB) blocks Ca2+ entry channels in human platelets: cautions for its use in studying Ca2+ influx.

The roles of P(2X1)and P(2T AC)receptors in ADP-evoked calcium signalling in human platelets

The tyrosine kinase inhibitors methyl 2,5-dihydroxycinnamate and genistein reduce thrombin-evoked tyrosine phosphorylation and Ca2+ entry in human platelets

Three routes for receptor-mediated Ca2+ entry

Thromboxane receptor stimulation inhibits adenylate cyclase and reduces cyclic AMP-mediated inhibition of ADP-evoked responses in fura-2-loaded human platelets

Transient receptor potential protein subunit assembly and membrane distribution in human platelets

Two pathways for store-mediated calcium entry differentially dependent on the actin cytoskeleton in human platelets

Tyrosine kinases activate store-mediated Ca2+ entry in human platelets through the reorganization of the actin cytoskeleton.

Tyrosine phosphorylation and Ca2+ influx. A further mechanism for store-dependent Ca2+ entry?

Voltage-gated potassium channels and the control of membrane potential in human platelets

Wortmannin inhibits store-mediated calcium entry and protein tyrosine phosphorylation in human platelets

Zinc is a transmembrane agonist that induces platelet activation in a tyrosine phosphorylation-dependent manner.