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List of works by Marco Falasca

3-Phosphoinositide-dependent protein kinase-1 as an emerging target in the management of breast cancer.

scientific article published on 23 August 2013

A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion

scientific article (publication date: 2016)

A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling

scientific journal article

A novel regulatory mechanism links PLCγ1 to PDK1

scientific article

A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation

scientific article

A sodium channel opener inhibits stimulation of human peripheral blood mononuclear cells

scientific article published on April 1, 1992

ABC Transporters in Cancer Stem Cells: Beyond Chemoresistance.

scientific article published on 8 November 2017

ABC transporters as cancer drivers: Potential functions in cancer development

scientific article published on 27 September 2018

ATP-binding cassette transporters in progression and clinical outcome of pancreatic cancer: What is the way forward?

Activation of phosphatidylinositol 3-kinase β by the platelet collagen receptors integrin α2β1 and GPVI: The role of Pyk2 and c-Cbl.

scientific article

Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.

scientific article published in January 1998

Adenosine deaminase from Saccharomyces cerevisiae: kinetics and interaction with transition and ground state inhibitors

scientific article published on 01 August 1992

Aging impairs membrane potential responsiveness as well as opening of voltage and ligand gated Na+ channels in human lymphocytes

scientific article published on 01 March 1992

Akt/protein kinase B in skeletal muscle physiology and pathology.

scientific article published on January 2011

Analysis, regulation, and roles of endosomal phosphoinositides

scientific article published on 01 January 2014

Antiplatelet Drug Ticagrelor Enhances Chemotherapeutic Efficacy by Targeting the Novel P2Y12-AKT Pathway in Pancreatic Cancer Cells

scientific article published on 20 January 2020

Bile Acids and Microbiota Interplay in Pancreatic Cancer

scientific article published in 2023

Blood-brain barrier disturbances in diabetes-associated dementia: Therapeutic potential for cannabinoids

scientific article published on 04 January 2019

Boyden chamber.

scientific article published on January 2011

Bretylium-induced voltage-gated sodium current in human lymphocytes

scientific article published on 01 October 1992

CD31 signals confer immune privilege to the vascular endothelium

scientific article

Caffeine and the analog CGS 15943 inhibit cancer cell growth by targeting the phosphoinositide 3-kinase/Akt pathway

scientific article

Cancer chemoprevention with nuts

scientific article published on 10 September 2014

Cancer-Associated Fibroblasts: Epigenetic Regulation and Therapeutic Intervention in Breast Cancer

scientific article published on 13 October 2020

Changes in the levels of glycerophosphoinositols during differentiation of hepatic and neuronal cells.

scientific article published on October 1996

Cholesterol-rich rabbit serum modulates beta-adrenergic receptor density of human lymphocytes. A possible role of LDL-cholesterol

scientific article published on 01 April 1992

Class II Phosphoinositide 3-Kinases as Novel Drug Targets.

scientific article

Class II phosphoinositide 3-kinase C2β regulates a novel signaling pathway involved in breast cancer progression.

scientific article published on 26 February 2016

Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration.

scientific article

Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells

scientific journal article

Correction: A novel regulatory mechanism links PLCγ1 to PDK1.

scientific article published in March 2017

Defining the Anti-Cancer Activity of Tricarbonyl Rhenium Complexes: Induction of G2/M Cell Cycle Arrest and Blockade of Aurora-A Kinase Phosphorylation

scientific article published on 23 March 2017

Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme

scientific article published on 22 October 2015

Diet and Pancreatic Cancer Prevention

scientific article

Diet restriction, body temperature and physicochemical properties of cell membranes

scientific article published on 01 March 1991

Diet restriction: a tool to prolong the lifespan of experimental animals. Model and current hypothesis of action

scientific article published on 01 November 1992

Different subcellular localization and phosphoinositides binding of insulin receptor substrate protein pleckstrin homology domains

scientific article published on 01 June 2000

Dissecting the Physiology and Pathophysiology of Glucagon-Like Peptide-1

scientific article published on 11 October 2018

Dual PDK1/Aurora Kinase A Inhibitors Reduce Pancreatic Cancer Cell Proliferation and Colony Formation

scientific article published on 31 October 2019

Elevated levels and mitogenic activity of lysophosphatidylinositol in k-ras-transformed epithelial cells.

scientific article published on April 1994

Emerging role of the KRAS-PDK1 axis in pancreatic cancer

scientific article

Emerging roles of phosphatidylinositol 3-monophosphate as a dynamic lipid second messenger.

scientific article published on October 2006

Epithelial-mesenchymal transition as a therapeutic target for overcoming chemoresistance in pancreatic cancer.

scientific article published on January 2017

Fast receptor-induced formation of glycerophosphoinositol-4-phosphate, a putative novel intracellular messenger in the Ras pathway.

scientific article published on March 1997

Food restriction in female Wistar rats, IV. Morphometric parameters of cerebellar synapses

scientific article published on 01 September 1991

Food restriction in female Wistar rats. I. Survival characteristics, membrane microviscosity and proliferative response in lymphocytes.

scientific article published in September 1990

Food restriction in female Wistar rats. II. Beta-adrenoceptor density in the cerebellum and in the splenic lymphocytes

scientific article published on 01 September 1990

Food restriction in female Wistar rats. III. Thermotropic transition of membrane lipid and 5'-nucleotidase activity in hepatocytes

scientific article published on 01 September 1990

Food restriction in female Wistar rats: V. Lipid peroxidation and antioxidant enzymes in the liver

scientific article published on 01 January 1992

GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine

scientific article published on 30 July 2018

Genetic and Epigenetic Regulation of Phosphoinositide 3-kinase Isoforms

scientific article published on January 1, 2013

Inhibition of the Lysophosphatidylinositol Transporter ABCC1 Reduces Prostate Cancer Cell Growth and Sensitizes to Chemotherapy

scientific article published on 23 July 2020

Inositol Polyphosphate-Based Compounds as Inhibitors of Phosphoinositide 3-Kinase-Dependent Signaling

scientific article published on 29 September 2020

Insulin induces phosphatidylinositol-3-phosphate formation through TC10 activation.

scientific article

Introduction of WT-TP53 into pancreatic cancer cells alters sensitivity to chemotherapeutic drugs, targeted therapeutics and nutraceuticals

scientific article published on 28 June 2018

Investigational ABC transporter inhibitors ⬇️

scientific article published on May 1, 2012

Large-Scale Plasma Analysis Revealed New Mechanisms and Molecules Associated with the Host Response to SARS-CoV-2

scientific article published on 16 November 2020

Lysophosphatidylinositol Signalling and Metabolic Diseases

scientific article

Lysophosphatidylinositol signalling: new wine from an old bottle.

scientific article

Lysophosphatidylinositol: a novel link between ABC transporters and G-protein-coupled receptors.

scientific article

Modulation of oncogenic DBL activity by phosphoinositol phosphate binding to pleckstrin homology domain.

scientific article published on 26 February 2001

Molecular and cellular mechanisms of chemoresistance in pancreatic cancer.

scientific article published on 22 November 2017

New insight into the intracellular roles of class II phosphoinositide 3-kinases.

scientific article

Novel roles for class II Phosphoinositide 3-Kinase C2β in signalling pathways involved in prostate cancer cell invasion.

scientific article published on 17 March 2016

Oleoyl-lysophosphatidylinositol enhances glucagon-like peptide-1 secretion from enteroendocrine L-cells through GPR119

scientific article published on 05 June 2018

Overexpression of activated phospholipase Cγ1 is a risk factor for distant metastases in T1-T2, N0 breast cancer patients undergoing adjuvant chemotherapy.

scientific article published in September 2012

PI3K class IB controls the cell cycle checkpoint promoting cell proliferation in hepatocellular carcinoma

scientific article published on 24 January 2012

PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function

scientific article

PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling

scientific article published on 23 June 2015

PI3K/Akt signalling pathway specific inhibitors: a novel strategy to sensitize cancer cells to anti-cancer drugs.

scientific article published on January 2010

Pancreatic Ductal Adenocarcinoma: Current and Evolving Therapies

scientific article

Pancreatic cancer: Current research and future directions.

scientific article

Parameters to monitor aging with a possible perspective for intervention - an immunological approach

scientific article published on 01 March 1991

Phosphatidylinositol 3-kinase mediates epidermal growth factor-induced activation of the c-Jun N-terminal kinase signaling pathway.

scientific article published on October 1997

Phosphoinositide 3-kinase pathway inhibitors: pharmacology, metabolism & drug development

scientific article published on 01 January 2011

Phosphoinositide 3-kinase-dependent regulation of phospholipase Cgamma

scientific article published on 01 April 2007

Phospholipase Cgamma1 is required for metastasis development and progression

scientific article

Properties and prospects for rhenium(i) tricarbonyl N-heterocyclic carbene complexes

article

Regulation and cellular functions of class II phosphoinositide 3-kinases.

scientific article published on May 2012

Release of the mitogen lysophosphatidylinositol from H-Ras-transformed fibroblasts; a possible mechanism of autocrine control of cell proliferation.

scientific article published in May 1998

Rhenium N-heterocyclic carbene complexes block growth of aggressive cancers by inhibiting FGFR- and SRC-mediated signalling

scientific article published on 07 December 2020

Role and regulation of phosphatidylinositol 3-kinase β in platelet integrin α2β1 signaling.

scientific article

Role of class II phosphoinositide 3-kinase in cell signalling

scientific article

Role of pleckstrin homology domain in regulating membrane targeting and metabolic function of insulin receptor substrate 3.

scientific article published on 8 May 2003

Role of the lysophosphatidylinositol/GPR55 axis in cancer

scientific article published on 28 October 2015

Signalling Properties of Inositol Polyphosphates

scientific article published on 12 November 2020

Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains

scientific journal article

Specificity in pleckstrin homology (PH) domain membrane targeting: a role for a phosphoinositide-protein co-operative mechanism.

scientific article

Studies on cell membrane properties in food restricted rats ⬇️

scientific article published on December 1, 1991

Synthesis of Novel 3,5-Disubstituted-2-oxindole Derivatives As Antitumor Agents against Human Nonsmall Cell Lung Cancer

scientific article

Targeting PDK1 for Chemosensitization of Cancer Cells

scientific article published on 24 October 2017

Targeting PDK1 in Cancer ⬇️

scientific article published on January 1, 2011

Targeting Platelets for the Treatment of Cancer.

scientific article

Targeting p110gamma in gastrointestinal cancers: attack on multiple fronts

scientific article

Targeting phosphoinositide 3-kinase pathways in pancreatic cancer--from molecular signalling to clinical trials.

scientific article published on June 2011

The Role of Phosphoinositide 3-Kinase C2α in Insulin Signaling

scientific article published in Journal of Biological Chemistry

The Role of Platelet-Derived ADP and ATP in Promoting Pancreatic Cancer Cell Survival and Gemcitabine Resistance

scientific article published on 24 October 2017

The focal adhesion kinase Pyk2 links Ca2+ signalling to Src family kinase activation and protein tyrosine phosphorylation in thrombin-stimulated platelets.

scientific article published on 13 May 2015

The mechanism involved in the regulation of phospholipase Cgamma1 activity in cell migration.

scientific article

The proline‐rich tyrosine kinase Pyk2 regulates platelet integrin αIIbβ3 outside‐in signaling ⬇️

scientific article published on February 1, 2013

The putative cannabinoid receptor GPR55 defines a novel autocrine loop in cancer cell proliferation ⬇️

scientific article published on September 13, 2010

The role of phospholipase Cγ1 in breast cancer and its clinical significance

scientific article published on 22 August 2017

The role of the pleckstrin homology domain in membrane targeting and activation of phospholipase Cbeta(1).

scientific article published on May 2000

mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate.

scientific article

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