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List of works by James M. McDonnell

A Mass-Spectrometry-Based Modelling Workflow for Accurate Prediction of IgG Antibody Conformations in the Gas Phase.

scientific article

Allergen specificity of IgG4-expressing B cells in patients with grass pollen allergy undergoing immunotherapy

scientific article published on 13 May 2012

Antibodies and superantibodies in patients with chronic rhinosinusitis with nasal polyps

scientific article published on 19 September 2016

Basis of the intrinsic flexibility of the Cε3 domain of IgE

scientific article published on 05 May 2011

Ca2+-dependent Structural Changes in the B-cell Receptor CD23 Increase Its Affinity for Human Immunoglobulin E

scientific article

Calreticulin binding affinity for glycosylated laminin

scientific article published on 01 April 1996

Cancer-associated glycoforms of gelatinase B exhibit a decreased level of binding to galectin-3.

scientific article published on 6 December 2006

Catalytic folding of the Cepsilon3 domain by its high affinity receptor

scientific article

Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI.

scientific article

Conformational plasticity at the IgE-binding site of the B-cell receptor CD23

scientific article

Cross-reactivity of antiidiotypic antibodies with DNA in systemic lupus erythematosus

scientific article published on 01 February 2000

Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor Fc RI

scientific article

Crystal structure of the human IgG4 CH3 dimer reveals the role of Arg409 in the mechanism of Fab-arm exchange ⬇️

scientific article published on November 17, 2012

Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization

scientific article published on 02 March 2020

Exploiting structural principles to design cyclin-dependent kinase inhibitors.

scientific article

Human immunoglobulin E flexes between acutely bent and extended conformations.

scientific article

Identification of Contact Residues in the IgE Binding Site of Human FcεRIα†

scientific article published on 01 December 1997

IgE binds asymmetrically to its B cell receptor CD23

scientific article

Inhibition of allergen-dependent IgE activity by antibodies of the same specificity but different class

scientific article published on 28 March 2015

Inhibitors of MDM2 and MDMX: a structural perspective.

scientific article published on September 2009

Interplay between Affinity and Valency in Effector Cell Degranulation: A Model System with Polcalcin Allergens and Human Patient-Derived IgE Antibodies

scientific article published on 28 August 2019

Isoindolinone inhibitors of the murine double minute 2 (MDM2)-p53 protein-protein interaction: structure-activity studies leading to improved potency

scientific article published on 11 February 2011

MDM2-p53 protein-protein interaction inhibitors: a-ring substituted isoindolinones.

scientific article

Mapping of the CD23 Binding Site on Immunoglobulin E (IgE) and Allosteric Control of the IgE-FcϵRI Interaction ⬇️

scientific article published on July 19, 2012

NMR backbone assignment of the Cε4 domain of immunoglobulin E

scientific article published on 27 February 2020

NMR determination that an extended BH3 motif of pro-apoptotic BID is specifically bound to BCL-XL.

scientific article published in July 2006

Ontogeny of human IgE-expressing B cells and plasma cells

scientific article published on 08 April 2016

Participation of the N-Terminal Region of Cε3 in the Binding of Human IgE to Its High-Affinity Receptor FcεRI ⬇️

scientific article published on December 16, 1997

Recombinant complement receptor 2 radiolabeled with [99mTc(CO)3]+: a potential new radiopharmaceutical for imaging activated complement

scientific article

Soluble CD23 controls IgE synthesis and homeostasis in human B cells.

scientific article

Solution Structures of FcεRI α-Chain Mimics: A β-Hairpin Peptide and Its Retroenantiomer

scientific article published in 1997

Solution structure and dynamics of the bioactive retroviral M domain from Rous sarcoma virus

scientific article

Stromal cell-derived receptor 2 and cytochrome b561 are functional ferric reductases

scientific article

Structural and Functional Studies on the N-terminal Domain of the Shigella Type III Secretion Protein MxiG

scientific article

Structural and functional characterization of a novel T cell receptor co-regulatory protein complex, CD97-CD55

scientific article

Structural basis for selective inhibition of immunoglobulin E-receptor interactions by an anti-IgE antibody

scientific article published in Scientific Reports

Structural characterization of Ca2+/CaM in complex with the phosphorylase kinase PhK5 peptide

scientific article published on 01 March 2005

Structure based design and characterization of peptides that inhibit IgE binding to its high-affinity receptor

article

The CD46-Jagged1 interaction is critical for human TH1 immunity

scientific article

The intrinsic flexibility of IgE and its role in binding FcepsilonRI.

scientific article published on 8 December 2006

The key role of protein flexibility in modulating IgE interactions

scientific article

The structure of human CD23 and its interactions with IgE and CD21.

scientific article published on September 2005

The structure of the IgE Cepsilon2 domain and its role in stabilizing the complex with its high-affinity receptor FcepsilonRIalpha

scientific article

Understanding small-molecule binding to MDM2: insights into structural effects of isoindolinone inhibitors from NMR spectroscopy

scientific article published on March 2011

Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches

scientific article

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