List of works - Mark R. Hutchinson

"Listening" and "talking" to neurons: implications of immune activation for pain control and increasing the efficacy of opioids

scientific article

(+)-naloxone, an opioid-inactive toll-like receptor 4 signaling inhibitor, reverses multiple models of chronic neuropathic pain in rats

scientific article

(S)-(+)-methadone is more immunosuppressive than the potent analgesic (R)-(--)-methadone

scientific article

A concern on comparing 'apples' and 'oranges' when differences between microglia used in human and rodent studies go far, far beyond simply species: comment on Smith and Dragunow

scientific article published on 4 March 2014

A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity

scientific article published on 25 June 2010

A novel animal model of graded neuropathic pain: Utility to investigate mechanisms of population heterogeneity

article

A peptide antagonist of the TLR4-MD2 interaction

scientific article

Activation of adult rat CNS endothelial cells by opioid-induced toll-like receptor 4 (TLR4) signaling induces proinflammatory, biochemical, morphological, and behavioral sequelae

scientific article

Adoptive transfer of peripheral immune cells potentiates allodynia in a graded chronic constriction injury model of neuropathic pain

article

Alcohol-induced sedation and synergistic interactions between alcohol and morphine: a key mechanistic role for Toll-like receptors and MyD88-dependent signaling

scientific article

Amitriptyline pharmacologically preconditions rat hearts against cardiac ischemic-reperfusion injury

scientific article published on 18 April 2015

An MD2 hot-spot-mimicking peptide that suppresses TLR4-mediated inflammatory response in vitro and in vivo

scientific article

Application of a novel in silico high-throughput screen to identify selective inhibitors for protein-protein interactions

scientific article

Are the effects of alcohol on the CNS influenced by Toll-like receptor signaling? ⬇️

scientific article published on March 1, 2012

Are the protective benefits of vitamin D in neurodegenerative disease dependent on route of administration? A systematic review

scientific article published on 09 July 2018

Association of IL-1B genetic polymorphisms with an increased risk of opioid and alcohol dependence

scientific article published in November 2009

Association of innate immune single-nucleotide polymorphisms with the electroencephalogram during desflurane general anaesthesia

scientific article published on 19 December 2013

Attenuation of microglial and IL-1 signaling protects mice from acute alcohol-induced sedation and/or motor impairment

scientific article

BrainPhys neuronal medium optimized for imaging and optogenetics in vitro

scientific article published on 03 November 2020

CYP2B6*6 allele and age substantially reduce steady-state ketamine clearance in chronic pain patients: impact on adverse effects

scientific article

CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes.

scientific article

Can neuroimmune mechanisms explain the link between ultraviolet light (UV) exposure and addictive behavior?

scientific article published on 17 July 2018

Challenges and opportunities in neurophotonics discussed at the International Conference on Biophotonics 2017

scientific article published on 30 October 2018

Characterisation of the in vitro modulation of splenocyte proliferation by non-4,5-epoxymorphinan opioids

scientific article published in November 2005

Chemotherapy-induced gut toxicity and pain: involvement of TLRs

scientific article published on 19 November 2015

Commentary on Landry et al.: “Propentofylline, a CNS glial modulator, does not decrease pain in post-herpetic neuralgia patients: In vitro evidence for differential responses in human and rodent microglia and macrophages”

article

Constriction of the buccal branch of the facial nerve produces unilateral craniofacial allodynia

scientific article published on 16 December 2016

DAT isn't all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling

scientific article published on 3 February 2015

Diacetylmorphine degradation to 6-monoacetylmorphine and morphine in cell culture: implications for in vitro studies

scientific article published in October 2002

Differential effect of morphine on gastrointestinal transit, colonic contractions and nerve-evoked relaxations in Toll-Like Receptor deficient mice.

scientific article published on 12 April 2018

Discovery of a novel site of opioid action at the innate immune pattern-recognition receptor TLR4 and its role in addiction

scientific article published on January 2014

Drug addiction: targeting dynamic neuroimmune receptor interactions as a potential therapeutic strategy

scientific article

Early-life experience decreases drug-induced reinstatement of morphine CPP in adulthood via microglial-specific epigenetic programming of anti-inflammatory IL-10 expression

scientific article published on December 2011

Effect of chronic delivery of the Toll-like receptor 4 antagonist (+)-naltrexone on incubation of heroin craving.

scientific article published on 4 February 2013

Enduring reversal of neuropathic pain by a single intrathecal injection of adenosine 2A receptor agonists: a novel therapy for neuropathic pain

scientific article

Ethnicity-dependent influence of innate immune genetic markers on morphine PCA requirements and adverse effects in postoperative pain

scientific article published on 14 July 2016

Evidence that opioids may have toll-like receptor 4 and MD-2 effects

scientific article

Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity

scientific article

Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia

scientific article

Fluorescence brightness and photostability of individual copper (I) oxide nanocubes.

scientific article published on 4 December 2017

Glia: novel counter-regulators of opioid analgesia

scientific article

Glial Attenuation With Ibudilast in the Treatment of Medication Overuse Headache: A Double-Blind, Randomized, Placebo-Controlled Pilot Trial of Efficacy and Safety

scientific article published on 14 September 2015

Glial TLR4 signaling does not contribute to opioid-induced depression of respiration

scientific article

Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced pain

scientific article

Graphene quantum dot based "switch-on" nanosensors for intracellular cytokine monitoring

scientific article published on 3 April 2017

Harnessing pain heterogeneity and RNA transcriptome to identify blood-based pain biomarkers: a novel correlational study design and bioinformatics approach in a graded chronic constriction injury model

scientific article

Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes

scientific article

Ibudilast reduces oxaliplatin-induced tactile allodynia and cognitive impairments in rats

scientific article published on 21 July 2017

Immune priming and experimental glaucoma: the effect of prior systemic lipopolysaccharide challenge on tissue outcomes after optic nerve injury

scientific article

Implications of central immune signaling caused by drugs of abuse: mechanisms, mediators and new therapeutic approaches for prediction and treatment of drug dependence

scientific article published on February 2012

In vitro opioid induced proliferation of peripheral blood immune cells correlates with in vivo cold pressor pain tolerance in humans: a biological marker of pain tolerance

scientific article

In vivo veritas: (+)-Naltrexone's actions define translational importance

scientific article published on 07 August 2014

Increased responsiveness of peripheral blood mononuclear cells to in vitro TLR 2, 4 and 7 ligand stimulation in chronic pain patients

scientific article

Inflammatory mediators in mastitis and lactation insufficiency

scientific article published on 25 June 2014

Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice ⬇️

scientific article

Irinotecan-Induced Gastrointestinal Dysfunction and Pain Are Mediated by Common TLR4-Dependent Mechanisms

scientific article

Local and Systemic Inflammation in Localized, Provoked Vestibulodynia: A Systematic Review

scientific article

Low-dose endotoxin potentiates capsaicin-induced pain in man: evidence for a pain neuroimmune connection

scientific article published on 14 March 2013

Medication-overuse headache and opioid-induced hyperalgesia: A review of mechanisms, a neuroimmune hypothesis and a novel approach to treatment

scientific article

Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia

scientific article published on 31 July 2008

Morphine activates neuroinflammation in a manner parallel to endotoxin

scientific article published on 2 April 2012

Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury

scientific article

Mouse models of mastitis - how physiological are they?

scientific article

Naloxone-precipitated morphine withdrawal behavior and brain IL-1β expression: comparison of different mouse strains

scientific article

Naturally-diverse airborne environmental microbial exposures modulate the gut microbiome and may provide anxiolytic benefits in mice

scientific article published on 28 October 2019

Nitroxidative Signaling Mechanisms in Pathological Pain

scientific article published on 11 November 2016

Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4)

scientific article

Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids

scientific article published on 18 December 2006

Novel Toll-like receptor-4 antagonist (+)-naloxone protects mice from inflammation-induced preterm birth

scientific article published on 7 November 2016

Novel imaging tools for investigating the role of immune signalling in the brain.

scientific article published on 26 April 2016

Opioid activation of toll-like receptor 4 contributes to drug reinforcement

scientific article

Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward.

scientific article published on 2 November 2007

Pathological pain and the neuroimmune interface

scientific article

Peripheral immune contributions to the maintenance of central glial activation underlying neuropathic pain

scientific article published on 07 April 2011

Pharmacological characterization of the opioid inactive isomers (+)-naltrexone and (+)-naloxone as antagonists of toll-like receptor 4

scientific article published on 25 November 2015

Portable optical fiber probe for in vivo brain temperature measurements

scientific article published on 20 July 2016

Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences

scientific article

Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia

scientific article

Quantification of the O- and N-demethylated metabolites of hydrocodone and oxycodone in human liver microsomes using liquid chromatography with ultraviolet absorbance detection

scientific article published in February 2003

Recent advances in cytokine detection by immunosensing

scientific article

Reduced response to the thermal grill illusion in chronic pain patients.

scientific article published on 12 February 2014

Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast)

scientific article published on 04 October 2008

Relationship between 4,5-epoxymorphinan structure and in vitro modulation of cell proliferation

scientific article

Review: What innovations in pain measurement and control might be possible if we could quantify the neuroimmune synapse?

scientific article published on 13 August 2019

Role of microglia and toll-like receptor 4 in the pathophysiology of delirium

scientific article published on 10 September 2012

Select steroid hormone glucuronide metabolites can cause toll-like receptor 4 activation and enhanced pain

scientific article

Sensitive Cytokine Assay Based on Optical Fiber Allowing Localized and Spatially Resolved Detection of Interleukin-6.

scientific article published on 29 December 2016

Sex differences in mechanical allodynia: how can it be preclinically quantified and analyzed?

scientific article published on 13 February 2014

Spinal Glial Adaptations Occur in a Minimally Invasive Mouse Model of Endometriosis: Potential Implications for Lesion Etiology and Persistent Pelvic Pain

scientific article published on 06 May 2018

Study protocol: an observational study of distress, immune function and persistent pain in HIV

scientific article published on 3 June 2022

Targeting Toll-like receptor-4 to tackle preterm birth and fetal inflammatory injury

scientific article published on 14 April 2020

The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia

scientific article

The CYP2B6*6 allele significantly alters the N-demethylation of ketamine enantiomers in vitro

scientific article published on 2 April 2013

The Neuroimmunology of Chronic Pain: From Rodents to Humans

scientific article published on 24 November 2020

The cortical innate immune response increases local neuronal excitability leading to seizures

scientific article published on 30 June 2009

The effects of a single exposure to uncontrollable stress on the subsequent conditioned place preference responses to oxycodone, cocaine, and ethanol in rats

scientific article published on 9 January 2007

The effects of pregabalin and the glial attenuator minocycline on the response to intradermal capsaicin in patients with unilateral sciatica

scientific article

The efficacy of (+)-Naltrexone on alcohol preference and seeking behaviour is dependent on light-cycle.

scientific article published on 29 August 2017

The glial activation inhibitor AV411 reduces morphine-induced nucleus accumbens dopamine release

scientific article published on 3 February 2009

The role of Toll-like receptor 4 (TLR4) in cardiac ischaemic-reperfusion injury, cardioprotection and preconditioning

scientific article published on June 2016

Toll-Like Receptor 4 Is an Essential Upstream Regulator of On-Time Parturition and Perinatal Viability in Mice

scientific article

Toll-Like Receptor 4 Regulates Lipopolysaccharide-Induced Inflammation and Lactation Insufficiency in a Mouse Model of Mastitis1

article

Toll-Like Receptor Responsiveness of Peripheral Blood Mononuclear Cells in Young Women with Dysmenorrhea

scientific article published on 09 March 2020

Toll-Like Receptor-4 Antagonist (+)-Naloxone Confers Sexually Dimorphic Protection From Inflammation-Induced Fetal Programming in Mice

scientific article published on 01 November 2019

Toll-like receptor 4 in CNS pathologies

scientific article

Toll-like receptor 4: innate immune regulator of neuroimmune and neuroendocrine interactions in stress and major depressive disorder

scientific article

Toll-like receptors in chronic pain

scientific article published on 6 October 2011

Want more pain? Just add a dash of endotoxin to enhance your clinical pain model

scientific article published on 25 June 2014

Why is neuroimmunopharmacology crucial for the future of addiction research?

scientific article published on 11 June 2013

List of works by Mark R. Hutchinson

"Listening" and "talking" to neurons: implications of immune activation for pain control and increasing the efficacy of opioids

(+)-naloxone, an opioid-inactive toll-like receptor 4 signaling inhibitor, reverses multiple models of chronic neuropathic pain in rats

(S)-(+)-methadone is more immunosuppressive than the potent analgesic (R)-(--)-methadone

A concern on comparing 'apples' and 'oranges' when differences between microglia used in human and rodent studies go far, far beyond simply species: comment on Smith and Dragunow

A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity

A novel animal model of graded neuropathic pain: Utility to investigate mechanisms of population heterogeneity

A peptide antagonist of the TLR4-MD2 interaction

Activation of adult rat CNS endothelial cells by opioid-induced toll-like receptor 4 (TLR4) signaling induces proinflammatory, biochemical, morphological, and behavioral sequelae

Adoptive transfer of peripheral immune cells potentiates allodynia in a graded chronic constriction injury model of neuropathic pain

Alcohol-induced sedation and synergistic interactions between alcohol and morphine: a key mechanistic role for Toll-like receptors and MyD88-dependent signaling

Amitriptyline pharmacologically preconditions rat hearts against cardiac ischemic-reperfusion injury

An MD2 hot-spot-mimicking peptide that suppresses TLR4-mediated inflammatory response in vitro and in vivo

Application of a novel in silico high-throughput screen to identify selective inhibitors for protein-protein interactions

Are the effects of alcohol on the CNS influenced by Toll-like receptor signaling? ⬇️

Are the protective benefits of vitamin D in neurodegenerative disease dependent on route of administration? A systematic review

Association of IL-1B genetic polymorphisms with an increased risk of opioid and alcohol dependence

Association of innate immune single-nucleotide polymorphisms with the electroencephalogram during desflurane general anaesthesia

Attenuation of microglial and IL-1 signaling protects mice from acute alcohol-induced sedation and/or motor impairment

BrainPhys neuronal medium optimized for imaging and optogenetics in vitro

CYP2B6*6 allele and age substantially reduce steady-state ketamine clearance in chronic pain patients: impact on adverse effects

CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes.

Can neuroimmune mechanisms explain the link between ultraviolet light (UV) exposure and addictive behavior?

Challenges and opportunities in neurophotonics discussed at the International Conference on Biophotonics 2017

Characterisation of the in vitro modulation of splenocyte proliferation by non-4,5-epoxymorphinan opioids

Chemotherapy-induced gut toxicity and pain: involvement of TLRs

Commentary on Landry et al.: “Propentofylline, a CNS glial modulator, does not decrease pain in post-herpetic neuralgia patients: In vitro evidence for differential responses in human and rodent microglia and macrophages”

Constriction of the buccal branch of the facial nerve produces unilateral craniofacial allodynia

DAT isn't all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling

Diacetylmorphine degradation to 6-monoacetylmorphine and morphine in cell culture: implications for in vitro studies

Differential effect of morphine on gastrointestinal transit, colonic contractions and nerve-evoked relaxations in Toll-Like Receptor deficient mice.

Discovery of a novel site of opioid action at the innate immune pattern-recognition receptor TLR4 and its role in addiction

Drug addiction: targeting dynamic neuroimmune receptor interactions as a potential therapeutic strategy

Early-life experience decreases drug-induced reinstatement of morphine CPP in adulthood via microglial-specific epigenetic programming of anti-inflammatory IL-10 expression

Effect of chronic delivery of the Toll-like receptor 4 antagonist (+)-naltrexone on incubation of heroin craving.

Enduring reversal of neuropathic pain by a single intrathecal injection of adenosine 2A receptor agonists: a novel therapy for neuropathic pain

Ethnicity-dependent influence of innate immune genetic markers on morphine PCA requirements and adverse effects in postoperative pain

Evidence that opioids may have toll-like receptor 4 and MD-2 effects

Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity

Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia

Fluorescence brightness and photostability of individual copper (I) oxide nanocubes.

Glia: novel counter-regulators of opioid analgesia

Glial Attenuation With Ibudilast in the Treatment of Medication Overuse Headache: A Double-Blind, Randomized, Placebo-Controlled Pilot Trial of Efficacy and Safety

Glial TLR4 signaling does not contribute to opioid-induced depression of respiration

Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced pain

Graphene quantum dot based "switch-on" nanosensors for intracellular cytokine monitoring

Harnessing pain heterogeneity and RNA transcriptome to identify blood-based pain biomarkers: a novel correlational study design and bioinformatics approach in a graded chronic constriction injury model

Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes

Ibudilast reduces oxaliplatin-induced tactile allodynia and cognitive impairments in rats

Immune priming and experimental glaucoma: the effect of prior systemic lipopolysaccharide challenge on tissue outcomes after optic nerve injury

Implications of central immune signaling caused by drugs of abuse: mechanisms, mediators and new therapeutic approaches for prediction and treatment of drug dependence

In vitro opioid induced proliferation of peripheral blood immune cells correlates with in vivo cold pressor pain tolerance in humans: a biological marker of pain tolerance

In vivo veritas: (+)-Naltrexone's actions define translational importance

Increased responsiveness of peripheral blood mononuclear cells to in vitro TLR 2, 4 and 7 ligand stimulation in chronic pain patients

Inflammatory mediators in mastitis and lactation insufficiency

Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice ⬇️

Irinotecan-Induced Gastrointestinal Dysfunction and Pain Are Mediated by Common TLR4-Dependent Mechanisms

Local and Systemic Inflammation in Localized, Provoked Vestibulodynia: A Systematic Review

Low-dose endotoxin potentiates capsaicin-induced pain in man: evidence for a pain neuroimmune connection

Medication-overuse headache and opioid-induced hyperalgesia: A review of mechanisms, a neuroimmune hypothesis and a novel approach to treatment

Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia

Morphine activates neuroinflammation in a manner parallel to endotoxin

Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury

Mouse models of mastitis - how physiological are they?

Naloxone-precipitated morphine withdrawal behavior and brain IL-1β expression: comparison of different mouse strains

Naturally-diverse airborne environmental microbial exposures modulate the gut microbiome and may provide anxiolytic benefits in mice

Nitroxidative Signaling Mechanisms in Pathological Pain

Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4)

Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids

Novel Toll-like receptor-4 antagonist (+)-naloxone protects mice from inflammation-induced preterm birth

Novel imaging tools for investigating the role of immune signalling in the brain.

Opioid activation of toll-like receptor 4 contributes to drug reinforcement

Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward.

Pathological pain and the neuroimmune interface

Peripheral immune contributions to the maintenance of central glial activation underlying neuropathic pain

Pharmacological characterization of the opioid inactive isomers (+)-naltrexone and (+)-naloxone as antagonists of toll-like receptor 4

Portable optical fiber probe for in vivo brain temperature measurements

Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences

Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia

Quantification of the O- and N-demethylated metabolites of hydrocodone and oxycodone in human liver microsomes using liquid chromatography with ultraviolet absorbance detection