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List of works by Erick Strauss

3-Fluoroaspartate and pyruvoyl-dependant aspartate decarboxylase: exploiting the unique characteristics of fluorine to probe reactivity and binding

scientific article published on September 2010

A miniaturized assay for measuring small molecule phosphorylation in the presence of complex matrices

scientific article published on 12 December 2013

A pantetheinase-resistant pantothenamide with potent, on-target, and selective antiplasmodial activity

scientific article published on 6 April 2015

An enzyme-initiated Smiles rearrangement enables the development of an assay of MshB, the GlcNAc-Ins deacetylase of mycothiol biosynthesis

scientific article published on 7 June 2012

Antiplasmodial Mode of Action of Pantothenamides: Pantothenate Kinase Serves as a Metabolic Activator Not as a Target

scientific article published on 24 April 2017

Biocatalytic Production of Coenzyme A Analogues

article

Characterization of a new pantothenate kinase isoform from Helicobacter pylori

scientific article (publication date: 27 May 2005)

Coenzyme A: to make it or uptake it?

scientific article published on 24 August 2016

Complex stability and dynamic subunit interchange modulates the disparate activities of the yeast moonlighting proteins Hal3 and Vhs3

scientific article

Creating Cellulose-Binding Domain Fusions of the Coenzyme A Biosynthetic Enzymes to Enable Reactor-Based Biotransformations

Crystal structure of a type III pantothenate kinase: insight into the mechanism of an essential coenzyme A biosynthetic enzyme universally distributed in bacteria

scientific article

Developing Pantetheinase-Resistant Pantothenamide Antibacterials: Structural Modification Impacts on PanK Interaction and Mode of Action.

scientific article published on 14 January 2018

Development of a method for the parallel synthesis and purification of N-substituted pantothenamides, known inhibitors of coenzyme A biosynthesis and utilization

scientific article

Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the Product

scientific article published on 3 August 2016

Functional copper at the acetyl-CoA synthase active site

scholarly article

Functional mapping of the disparate activities of the yeast moonlighting protein Hal3.

scientific article published in March 2012

Grand Challenge Commentary: Exploiting single-cell variation for new antibiotics ⬇️

scientific article published on December 1, 2010

Mechanistic studies on phosphopantothenoylcysteine decarboxylase

scientific article

Mechanistic studies on phosphopantothenoylcysteine decarboxylase: trapping of an enethiolate intermediate with a mechanism-based inactivating agent

scientific article published in December 2004

Metabolism: Jump-starting CoA biosynthesis

scientific article published in September 2015

Michael acceptor-containing coenzyme A analogues as inhibitors of the atypical coenzyme A disulfide reductase from Staphylococcus aureus

scientific article published on September 2010

Modular Enzymatic Cascade Synthesis of Vitamin B5 and Its Derivatives

scientific article published on 30 October 2018

Moonlighting proteins Hal3 and Vhs3 form a heteromeric PPCDC with Ykl088w in yeast CoA biosynthesis

scientific article

Mutations at the hydrophobic core affect Hal3 trimer stability, reducing its Ppz1 inhibitory capacity but not its PPCDC moonlighting function

scientific article published in Scientific Reports

Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues

scientific article published on 3 April 2018

One-pot preparation of coenzyme A analogues via an improved chemo-enzymatic synthesis of pre-CoA thioester synthons

scientific article

Overcoming synthetic challenges in targeting coenzyme A biosynthesis with the antimicrobial natural product CJ-15,801

scientific article published on 17 October 2019

Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated

scientific article

Probing the ligand preferences of the three types of bacterial pantothenate kinase

scientific article published on 02 November 2018

Recent advances in targeting coenzyme A biosynthesis and utilization for antimicrobial drug development

scientific article

Role of allosteric switches and adaptor domains in long-distance cross-talk and transient tunnel formation

scientific article published on 03 April 2020

Stereochemical studies on phosphopantothenoylcysteine decarboxylase from Escherichia coli

scientific article

Structural basis for substrate binding and the catalytic mechanism of type III pantothenate kinase

scientific article

Structural modification of pantothenamides counteracts degradation by pantetheinase and improves antiplasmodial activity

scientific article

Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution

scientific article

The Schizosaccharomyces pombe fusion gene hal3 encodes three distinct activities.

scientific article published on 10 September 2013

The antibiotic CJ-15,801 is an antimetabolite that hijacks and then inhibits CoA biosynthesis

scientific article

The antibiotic activity of N-pentylpantothenamide results from its conversion to ethyldethia-coenzyme a, a coenzyme a antimetabolite

scientific article published on 7 October 2002

The selectivity for cysteine over serine in coenzyme A biosynthesis

scientific article published in February 2005

Top down characterization of larger proteins (45 kDa) by electron capture dissociation mass spectrometry

scientific article published in January 2002

Turnover-Dependent Covalent Inactivation of Staphylococcus aureus Coenzyme A-Disulfide Reductase by Coenzyme A-Mimetics: Mechanistic and Structural Insights

scientific article

Variation in pantothenate kinase type determines the pantothenamide mode of action and impacts on coenzyme A salvage biosynthesis.

scientific article

Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity

scientific article published on 23 July 2018

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