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List of works by Wei-Guo Zhu

5-Aza-2'-deoxycytidine reactivates gene expression via degradation of pRb pocket proteins

scientific article published on 11 October 2011

5-Fluorouracil targets histone acetyltransferases p300/CBP in the treatment of colorectal cancer.

scientific article published on 29 April 2017

5-aza-2'-deoxycytidine activates the p53/p21Waf1/Cip1 pathway to inhibit cell proliferation.

scientific article published on 13 January 2004

A SIRT1-centered circuitry regulates breast cancer stemness and metastasis

scientific article published on 23 July 2018

A comprehensive search for DNA amplification in lung cancer identifies inhibitors of apoptosis cIAP1 and cIAP2 as candidate oncogenes.

scientific article published on April 2003

A novel acridine derivative, LS-1-10 inhibits autophagic degradation and triggers apoptosis in colon cancer cells

scientific article published on 5 October 2017

ATM-mediated KDM2A phosphorylation is required for the DNA damage repair.

scientific article

Acetylation of 53BP1 dictates the DNA double strand break repair pathway.

scientific article published on 28 November 2017

Acetylation of PHF5A Modulates Stress Responses and Colorectal Carcinogenesis through Alternative Splicing-Mediated Upregulation of KDM3A

scientific article published on 01 May 2019

Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1).

scientific article

Advances in effector protein of histone methylation

scientific article published on 01 April 2011

An ATM- and Rad3-related (ATR) signaling pathway and a phosphorylation-acetylation cascade are involved in activation of p53/p21Waf1/Cip1 in response to 5-aza-2'-deoxycytidine treatment

scientific article published on 31 October 2007

Angiotensin II reduces cardiac AdipoR1 expression through AT1 receptor/ROS/ERK1/2/c-Myc pathway

scientific journal article

Anti-neoplastic activity of the cytosolic FoxO1 results from autophagic cell death.

scientific article published on 9 October 2010

Applications of post-translational modifications of FoxO family proteins in biological functions ⬇️

scientific article published on June 13, 2011

Autophagy Regulates Chromatin Ubiquitination in DNA Damage Response through Elimination of SQSTM1/p62.

scientific article published on 21 June 2016

Autophagy process is associated with anti-neoplastic function.

scientific article published on 26 April 2011

Autophagy regulates DNA repair by modulating histone ubiquitination

scientific article published on 26 July 2016

Autophagy substrate SQSTM1/p62 regulates chromatin ubiquitination during the DNA damage response

scientific article published on 28 October 2016

Autophagy-deficient tumor cells rely on extracellular amino acids to survive upon glutamine deprivation

scientific article published on 04 August 2018

Biological function and regulation of histone and non-histone lysine methylation in response to DNA damage.

scientific article published on 23 May 2016

Bone morphogenetic protein 3B silencing in non-small-cell lung cancer.

scientific article published on April 2004

C1QBP Promotes Homologous Recombination by Stabilizing MRE11 and Controlling the Assembly and Activation of MRE11/RAD50/NBS1 Complex

scientific article published on 25 July 2019

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

scientific article

DNA Methylation in the Exon 1 Region and Complex Regulation of Twist1 Expression in Gastric Cancer Cells

scientific article published on 22 December 2015

DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors.

scientific article published in February 2001

DNA methyltransferases: the role in regulation of gene expression and biological processes

article

Deficiency of hepatocystin induces autophagy through an mTOR-dependent pathway.

scientific article published in July 2011

Dependence of induction of interphase death of Chinese hamster ovary cells exposed to accelerated heavy ions on linear energy transfer

article

Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair.

scientific article

Downregulation of SIRT7 by 5-fluorouracil induces radiosensitivity in human colorectal cancer

scientific article

EZH2 supports nasopharyngeal carcinoma cell aggressiveness by forming a co-repressor complex with HDAC1/HDAC2 and Snail to inhibit E-cadherin.

scientific article published on 20 June 2011

Enhancement of hyperthermic killing in L5178Y cells by protease inhibitors

scientific article published on 01 February 1995

Epigenetic modification of PKMζ rescues aging-related cognitive impairment.

scientific article published on March 2016

Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway

scientific journal article

Erratum: ATM-mediated KDM2A phosphorylation is required for the DNA damage repair

scientific article published on 01 January 2016

Expression of Pirh2, a newly identified ubiquitin protein ligase, in lung cancer.

scientific article

FOXO3 induces FOXO1-dependent autophagy by activating the AKT1 signaling pathway.

scientific article published on 29 August 2012

Global methylation profiling of lung cancer identifies novel methylated genes

scientific article

Glucose-derived acetate and ACSS2 as key players in cisplatin resistance in bladder cancer

scientific article published on 05 June 2018

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

HDAC inhibitors act with 5-aza-2'-deoxycytidine to inhibit cell proliferation by suppressing removal of incorporated abases in lung cancer cells

scientific article

HDAC8 cooperates with SMAD3/4 complex to suppress SIRT7 and promote cell survival and migration

scientific article published on 01 April 2020

Heat-induced modulation of lamin B content in two different cell lines

scientific article published in December 1999

Histone deacetylase inhibitor depsipeptide activates silenced genes through decreasing both CpG and H3K9 methylation on the promoter.

scientific article published on 10 March 2008

Histone modifications in DNA damage response

scientific article published on 29 January 2016

Identifying Human SIRT1 Substrates by Integrating Heterogeneous Information from Various Sources.

scientific article

Increased Amino Acid Uptake Supports Autophagy-Deficient Cell Survival upon Glutamine Deprivation

scientific article published on 01 June 2018

Increased expression of unmethylated CDKN2D by 5-aza-2'-deoxycytidine in human lung cancer cells

scientific article published in November 2001

Kindlin 2 forms a transcriptional complex with β-catenin and TCF4 to enhance Wnt signalling

scientific article

Lamin A buffers CK2 kinase activity to modulate aging in a progeria mouse model

scientific article published on 20 March 2019

Lamin B is a prompt heat shock protein

scientific article published on 01 January 1999

Linker Histone in Diseases.

scientific article published on 18 July 2017

Long-term tumor resistance induced by laser photo-immunotherapy.

scientific article

Loss of FOXO1 Cooperates with TMPRSS2-ERG Overexpression to Promote Prostate Tumorigenesis and Cell Invasion

scientific article

Lung-specific expression of human mutant p53-273H is associated with a high frequency of lung adenocarcinoma in transgenic mice.

scientific article

MDM2-mediated degradation of WRN promotes cellular senescence in a p53-independent manner

scientific article published on 07 December 2018

Mechanism of regulating deacetylase SIRT1 expression and activity

scientific article published on 01 October 2010

Mechanisms controlling the anti-neoplastic functions of FoxO proteins.

scientific article published on 16 November 2017

Methylation of FoxO3 regulates neuronal cell death ⬇️

scientific article published on May 1, 2012

Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability

scientific article

Methylation of adjacent CpG sites affects Sp1/Sp3 binding and activity in the p21(Cip1) promoter

scientific article

Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1).

scientific article

Molecular mechanisms of epigenetic regulators as activatable targets in cancer theranostics

scientific article published on 20 September 2017

Novel link between E2F1 and Smac/DIABLO: proapoptotic Smac/DIABLO is transcriptionally upregulated by E2F1.

scientific article

P21 response to DNA damage induced by genistein and etoposide in human lung cancer cells.

scientific article published on June 2003

PCAF-mediated acetylation of transcriptional factor HOXB9 suppresses lung adenocarcinoma progression by targeting oncogenic protein JMJD6.

scientific article published on 08 September 2016

PCAF/GCN5-Mediated Acetylation of RPA1 Promotes Nucleotide Excision Repair

scientific article published in August 2017

PTK2-mediated degradation of ATG3 impedes cancer cells susceptible to DNA damage treatment

scientific article

Phosphate-induced autophagy counteracts vascular calcification by reducing matrix vesicle release

scientific article published on 30 January 2013

Phosphorylation of LSD1 by PLK1 promotes its chromatin release during mitosis.

scientific article published on 23 March 2017

Phosphorylation of Pirh2 by calmodulin-dependent kinase II impairs its ability to ubiquitinate p53

scientific article

Post-irradiation exposure to HBSS enhances apoptosis in FM3A cells.

scientific article

Proliferating cell nuclear antigen is protected from degradation by forming a complex with MutT Homolog2

scientific journal article

Promotion of Heat-Induced Apoptosis in FM3A Cells by Protease Inhibitors

scientific article published on 01 August 1996

Quantitative proteome-based systematic identification of SIRT7 substrates.

scientific article published on 27 May 2017

RT-PCR heteroduplex analysis permits differentiation of transgene and host gene expression in a transgenic animal model

article

Reduced expression of SET7/9, a histone mono-methyltransferase, is associated with gastric cancer progression

scientific article published on 19 December 2015

Regulation of histone acetyltransferase TIP60 function by histone deacetylase 3.

scientific article published on 9 October 2014

Regulation of p53 acetylation

Reply to Leithner et al.: Focus on phopshoenolpyruvate carboxykinase (PEPCK): a target of the p53-SIRT6-FoxO1 axis

scientific article published on 26 September 2014

SET7/9 regulates cancer cell proliferation by influencing β-catenin stability.

scientific article published on 26 June 2015

SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation.

scientific article published on 27 November 2017

SIRT3 regulates cancer cell proliferation through deacetylation of PYCR1 in proline metabolism

scientific article published on 17 May 2019

SIRT4 regulates PTEN stability through IDE in response to cellular stresses

scientific article published on 16 January 2019

SIRT5, functions in cellular metabolism with a multiple enzymatic activities.

scientific article published on 24 July 2015

SIRT6 coordinates with CHD4 to promote chromatin relaxation and DNA repair

scientific article published on 01 April 2020

SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis

scientific article

SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair

scientific article published on 27 March 2019

Serine/Threonine Kinase Unc-51-like Kinase-1 (Ulk1) Phosphorylates the Co-chaperone Cell Division Cycle Protein 37 (Cdc37) and Thereby Disrupts the Stability of Cdc37 Client Proteins

scientific article published on 10 January 2017

Sirtuin 7-mediated deacetylation of WD repeat domain 77 (WDR77) suppresses cancer cell growth by reducing WDR77/PRMT5 transmethylase complex activity

scientific article published in Journal of Biological Chemistry

Sirtuins in glucose and lipid metabolism.

scientific article published on 21 September 2016

Surf the post-translational modification network of p53 regulation

scientific article

Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice

scientific article published on 15 June 2020

Systematic identification of Class I HDAC substrates.

scientific article published on 23 August 2013

Targeting histone deacetylases for cancer therapy: from molecular mechanisms to clinical implications

scientific article

The Batten disease gene CLN3 confers resistance to endoplasmic reticulum stress induced by tunicamycin.

scientific article published on April 2014

The HDAC inhibitor depsipeptide transactivates the p53/p21 pathway by inducing DNA damage.

scientific article

The axis of MAPK1/3-XBP1u-FOXO1 controls autophagic dynamics in cancer cells ⬇️

scientific article published on February 20, 2013

The changing face of HDAC inhibitor depsipeptide.

scientific article published on February 2009

The expression of chemokine receptors CXCR3 and CXCR4 in predicting postoperative tumour progression in stages I-II colon cancer: a retrospective study.

scientific article

The interaction of histone deacetylase inhibitors and DNA methyltransferase inhibitors in the treatment of human cancer cells.

scientific article

The regulation of the autophagic network and its implications for human disease

scientific article

The transcription factor c-Fos coordinates with histone lysine-specific demethylase 2A to activate the expression of cyclooxygenase-2

scientific article published on 25 September 2015

Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses

scientific article

Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion.

scientific article

ULK1 phosphorylates Mad1 to regulate spindle assembly checkpoint

scientific article published on 01 September 2019

Ubiquitin-like modifications in the DNA damage response

scientific article

Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis

scientific article

XBP-1u suppresses autophagy by promoting the degradation of FoxO1 in cancer cells

scientific article published on January 2013

ZD6474 induces growth arrest and apoptosis of GIST-T1 cells, which is enhanced by concomitant use of sunitinib

article

[Advances in histone methyltransferases and histone demethylases]

article

[DNA damage and repair ]

scientific article published on 01 October 2005

[The role of histone acetyltransferase Tip60 in transcription and DNA damage response]

scientific article published on 01 February 2011

p53 cooperates with SIRT6 to regulate cardiolipin de novo biosynthesis

scientific article published on 20 September 2018

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