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List of works by Ping-Yee Law

A major species of mouse mu-opioid receptor mRNA and its promoter-dependent functional polyadenylation signal

scientific article

A novel noncanonical signaling pathway for the μ-opioid receptor

scientific article published on 23 September 2013

A proteomics approach for identification of single strand DNA-binding proteins involved in transcriptional regulation of mouse mu opioid receptor gene

scientific article published on 2 May 2008

Action of NF-kappaB on the delta opioid receptor gene promoter

scientific article published on 27 November 2006

Activation of protein kinase C (PKC)α or PKCε as an approach to increase morphine tolerance in respiratory depression and lethal overdose

scientific article

Adenylyl cyclase superactivation induced by long-term treatment with opioid agonist is dependent on receptor localized within lipid rafts and is independent of receptor internalization

scientific article published on 13 January 2006

Agonist-dependent mu-opioid receptor signaling can lead to heterologous desensitization

scientific article

Agonist-dependent postsynaptic effects of opioids on miniature excitatory postsynaptic currents in cultured hippocampal neurons

scientific article published on 22 November 2006

Agonist-selective signaling is determined by the receptor location within the membrane domains.

scholarly article

Agonist-selective signaling of G protein-coupled receptor: mechanisms and implications

scientific article

Analysis of epigenetic mechanisms regulating opioid receptor gene transcription

scientific article published in January 2015

Antagonist efficacy in MORS196L mutant is affected by the interaction between transmembrane domains of the opioid receptor

scientific article published on 3 December 2004

Antinociceptive effects of morphine and naloxone in mu-opioid receptor knockout mice transfected with the MORS196A gene.

scientific article

Assembly of a beta2-adrenergic receptor--GluR1 signalling complex for localized cAMP signalling

scientific journal article

Association of a lower molecular weight protein to the mu-opioid receptor demonstrated by (125)I-beta-endorphin cross-linking studies

scientific article published in July 2000

Beta-arrestin-dependent mu-opioid receptor-activated extracellular signal-regulated kinases (ERKs) Translocate to Nucleus in Contrast to G protein-dependent ERK activation

scientific article

Bidirectional effects of fentanyl on dendritic spines and AMPA receptors depend upon the internalization of mu opioid receptors

scientific article published on 18 March 2009

Cholesterol level influences opioid signaling in cell models and analgesia in mice and humans.

scientific article

Cholesterol regulates micro-opioid receptor-induced beta-arrestin 2 translocation to membrane lipid rafts

scientific article

Chronic opioid treatment may uncouple opioid receptors and G-proteins: evidence from radiation inactivation analysis

scientific article

Covalently induced activation of the delta opioid receptor by a fluorogenic affinity label, 7'-(phthalaldehydecarboxamido)naltrindole (PNTI).

scientific article published in March 2001

DNA methylation-related chromatin modification in the regulation of mouse delta-opioid receptor gene

scientific article

Decrease in delta-opioid receptor density in rat brain after chronic [D-Ala2,D-Leu5]enkephalin treatment

scientific article

Differential gene expression activity among species-specific polypyrimidine/polypurine motifs in mu opioid receptor gene promoters

scientific article published on October 12, 2010

Differential use of an in-frame translation initiation codon regulates human mu opioid receptor (OPRM1).

scientific article

Discovery, structure-activity relationship studies, and anti-nociceptive effects of 1-phenyl-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one as novel opioid receptor agonists.

scientific article published on 16 July 2014

Distinct effects of individual opioids on the morphology of spines depend upon the internalization of mu opioid receptors

scientific article published on 4 May 2007

Dynamic association of p300 with the promoter of the G protein-coupled rat delta opioid receptor gene during NGF-induced neuronal differentiation

scientific journal article

Effect of aldosterone on incorporation of amino acids into renal medullary proteins

scientific article

Effect of naltrexone on neuropathic pain in mice locally transfected with the mutant μ-opioid receptor gene in spinal cord

scientific article

Effect of opioid receptor ligands on the mu-S196A knock-in and mu knockout mouse vas deferens

scientific article

Effects of cycloheximide and tunicamycin on opiate receptor activities in neuroblastoma X glioma NG108-15 hybrid cells.

scientific article published in January 1985

Effects of dextromethorphan and oxycodone on treatment of neuropathic pain in mice.

scientific article

Epigenetic programming of mu-opioid receptor gene in mouse brain is regulated by MeCP2 and Brg1 chromatin remodelling factor

scientific article

Evidence of endogenous mu opioid receptor regulation by epigenetic control of the promoters

scientific article published on 23 April 2007

Evidence of the neuron-restrictive silencer factor (NRSF) interaction with Sp3 and its synergic repression to the mu opioid receptor (MOR) gene

scientific article

FK506-binding protein 12 modulates μ-opioid receptor phosphorylation and protein kinase C(ε)-dependent signaling by its direct interaction with the receptor.

scientific article published on 10 October 2013

Functional expression of adrenergic and opioid receptors in Xenopus oocytes: interaction between alpha 2- and beta 2-adrenergic receptors

scientific article

GRIN1 regulates micro-opioid receptor activities by tethering the receptor and G protein in the lipid raft

scientific article published on 27 October 2009

Heterodimerization of mu- and delta-opioid receptors occurs at the cell surface only and requires receptor-G protein interactions.

scientific article

Identification of serine 356 and serine 363 as the amino acids involved in etorphine-induced down-regulation of the mu-opioid receptor.

scientific article published on December 1998

Immunohistochemical evidence of down-regulation of mu-opioid receptor after chronic PL-017 in rats

scientific article published in March 1998

In vivo activation of a mutant mu-opioid receptor by antagonist: future direction for opiate pain treatment paradigm that lacks undesirable side effects

scholarly article

Induction of citrate synthase by aldosterone in the rat kidney

scientific article published on June 22, 1978

Inhibition of c-Jun NH2-terminal kinase stimulates mu opioid receptor expression via p38 MAPK-mediated nuclear NF-κB activation in neuronal and non-neuronal cells.

scientific article published on 26 February 2013

Inhibition of specific opiate binding to synaptic membrane by cerebroside sulfatase

scientific article published on September 1, 1979

Intrathecal delivery of a mutant micro-opioid receptor activated by naloxone as a possible antinociceptive paradigm.

scientific article

Irreversible binding of cis-(+)-3-methylfentanyl isothiocyanate to the delta opioid receptor and determination of its binding domain

scientific article

Isolation of a novel cDNA encoding a putative membrane receptor with high homology to the cloned mu, delta, and kappa opioid receptors.

scientific article published on November 1994

Isosteric replacement of acidic with neutral residues in extracellular loop-2 of the kappa-opioid receptor does not affect dynorphin A(1-13) affinity and function.

scientific article

Ligand-selective activation of mu-oid receptor: demonstrated with deletion and single amino acid mutations of third intracellular loop domain

scientific article published on 6 March 2003

Long-term morphine treatment decreases the association of mu-opioid receptor (MOR1) mRNA with polysomes through miRNA23b

scientific article

Loss of morphine reward and dependence in mice lacking G protein-coupled receptor kinase 5.

scientific article

MicroRNA 339 down-regulates μ-opioid receptor at the post-transcriptional level in response to opioid treatment

scientific article published on 19 October 2012

MicroRNAs in opioid pharmacology

scientific article published on 9 November 2011

Mobilization of Ca2+ from intracellular stores in transfected neuro2a cells by activation of multiple opioid receptor subtypes.

scientific article

Modification of opioid receptor activity by acid phosphatase in neuroblastoma x glioma NG108-15 hybrid cells

scientific article

Modulating micro-opioid receptor phosphorylation switches agonist-dependent signaling as reflected in PKCepsilon activation and dendritic spine stability.

scientific article

Modulation of adenylate cyclase activity by a cytosolic factor following chronic opiate exposure in neuroblastoma x glioma NG108-15 hybrid cells.

scientific article published in January 1983

Modulation of mTOR Activity by μ-Opioid Receptor is Dependent upon the Association of Receptor and FK506-Binding Protein 12

scientific article published on July 2015

Modulations of NeuroD activity contribute to the differential effects of morphine and fentanyl on dendritic spine stability.

scientific article

Morphine Promotes Astrocyte-Preferential Differentiation of Mouse Hippocampal Progenitor Cells via PKCε-Dependent ERK Activation and TRBP Phosphorylation

scientific article

Morphine drives internal ribosome entry site-mediated hnRNP K translation in neurons through opioid receptor-dependent signaling

scientific article

Morphine induces AMPA receptor internalization in primary hippocampal neurons via calcineurin-dependent dephosphorylation of GluR1 subunits.

scientific article

Morphine modulates mouse hippocampal progenitor cell lineages by upregulating miR-181a level.

scientific article

Morphine regulates dopaminergic neuron differentiation via miR-133b

scientific article

Morphine-induced mu-opioid receptor rapid desensitization is independent of receptor phosphorylation and beta-arrestins

scientific article published on 18 May 2008

Mu-opioid receptor desensitization: role of receptor phosphorylation, internalization, and representation

scientific article

Mu-opioid receptors modulate the stability of dendritic spines

scientific article

NGF/PI3K signaling-mediated epigenetic regulation of delta opioid receptor gene expression

scientific article

NTI4F: a non-peptide fluorescent probe selective for functional delta opioid receptors.

scientific article published on June 1998

Naloxone Facilitates Contextual Learning and Memory in a Receptor-Independent and Tet1-Dependent Manner

scientific article published on 28 September 2020

Naloxone can act as an analgesic agent without measurable chronic side effects in mice with a mutant mu-opioid receptor expressed in different sites of pain pathway

scientific article

Naltrexone Facilitates Learning and Delays Extinction by Increasing AMPA Receptor Phosphorylation and Membrane Insertion.

scientific article

Neurite outgrowth is dependent on the association of c-Src and lipid rafts.

scientific article

Neuroblastoma Neuro2A cells stably expressing a cloned mu-opioid receptor: a specific cellular model to study acute and chronic effects of morphine.

scientific article published on June 1995

Neuroblastoma X glioma NG108-15 hybrid cells cultured in a serum-free chemically defined medium: effects on acute and chronic opiate regulation of adenylate cyclase activity.

scientific article published on December 1985

Neurod1 modulates opioid antinociceptive tolerance via two distinct mechanisms

scientific article published on 2 June 2014

Neuron-glial cell communication in the traumatic stress-induced immunomodulation.

scientific article

Neuron-restrictive silencer factor (NRSF) functions as a repressor in neuronal cells to regulate the mu opioid receptor gene

scientific article published on 18 August 2004

Non-Coding RNAs Regulating Morphine Function: With Emphasis on the In vivo and In vitro Functions of miR-190

scientific article published on 15 June 2012

Novel dual-binding function of a poly (C)-binding protein 3, transcriptional factor which binds the double-strand and single-stranded DNA sequence

scientific journal article

Novel function of neuron-restrictive silencer factor (NRSF) for posttranscriptional regulation.

scientific article

Novel function of the poly(C)-binding protein alpha CP3 as a transcriptional repressor of the mu opioid receptor gene

scientific article

Novel function of the poly(c)-binding protein α-CP2 as a transcriptional activator that binds to single-stranded DNA sequences.

scientific article

Nuclear factor kappaB signaling in opioid functions and receptor gene expression

scientific article

Opioid properties of β-lipotropin fragment 60–65, HArgTryGlyGlyPheMetOH

scientific article published on January 15, 1977

Opioid receptors: toward separation of analgesic from undesirable effects

scientific article

Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series

scholarly article

Oxycodone in the Opioid Epidemic: High 'Liking', 'Wanting', and Abuse Liability

scientific article published on 27 November 2020

Palmitoylation and membrane cholesterol stabilize μ-opioid receptor homodimerization and G protein coupling.

scientific article

Pertussis toxin treatment modifies opiate action in the rat brain striatum

scientific article published in March 1985

Phosphorylation of Ser363, Thr370, and Ser375 residues within the carboxyl tail differentially regulates mu-opioid receptor internalization.

scientific article published on 25 January 2001

Phosphorylation of the delta-opioid receptor regulates its beta-arrestins selectivity and subsequent receptor internalization and adenylyl cyclase desensitization

scientific article

Poly(C) binding protein family is a transcription factor in mu-opioid receptor gene expression

scientific article

Post-transcriptional regulation of mouse mu opioid receptor (MOR1) via its 3' untranslated region: a role for microRNA23b

scientific article published on 20 August 2008

Post-transcriptional regulation of mu-opioid receptor: role of the RNA-binding proteins heterogeneous nuclear ribonucleoprotein H1 and F

scientific article

Properties of a kappa-opioid receptor expressed in CHO cells: interaction with multiple G-proteins is not specific for any individual G alpha subunit and is similar to that of other opioid receptors

scientific article

Reporter affinity labels: an o-phthalaldehyde derivative of beta-naltrexamine as a fluorogenic ligand for opioid receptors

scientific article published in June 2000

Rescuing the traffic-deficient mutants of rat mu-opioid receptors with hydrophobic ligands

scientific article

Role for G protein-coupled receptor kinase in agonist-specific regulation of mu-opioid receptor responsiveness

scientific article published on June 1998

Role of FK506 binding protein 12 in morphine-induced μ-opioid receptor internalization and desensitization.

scientific article

Role of carboxyl terminus of mu-and delta-opioid receptor in agonist-induced down-regulation

scientific article published in February 1998

Short- and long-term regulation of adenylyl cyclase activity by delta-opioid receptor are mediated by Galphai2 in neuroblastoma N2A cells

scientific article published on 8 March 2006

Src phosphorylation of micro-receptor is responsible for the receptor switching from an inhibitory to a stimulatory signal.

scientific article

Src-dependent phosphorylation of μ-opioid receptor at Tyr(336) modulates opiate withdrawal

scientific article published on 17 August 2017

Studies on the mechanism of ethanolamine-ammonia lyase using 2-ethoxyethylamine as a substrate

scientific article published on 01 September 1973

Sustained activation of phosphatidylinositol 3-kinase/Akt/nuclear factor kappaB signaling mediates G protein-coupled delta-opioid receptor gene expression

scientific article

The first and third intracellular loops together with the carboxy terminal tail of the delta-opioid receptor contribute toward functional interaction with Galpha16.

scientific article

The interaction of the mu-opioid receptor and G protein is altered after chronic morphine treatment in rats

scientific article

The intracellular trafficking of opioid receptors directed by carboxyl tail and a di-leucine motif in Neuro2A cells

scientific article

The mechanism of cobalamin binding to hog intrinsic factor

scientific article published in December 1973

The opioid ligand binding of human mu-opioid receptor is modulated by novel splice variants of the receptor.

scientific article published on 23 March 2006

The other side of the opioid story: modulation of cell growth and survival signaling.

scientific article published on January 2008

The photolysis of 5′-deoxyadenosylcobalamin under anaerobic conditions

scientific article published on December 21, 1973

The polypyrimidine/polypurine motif in the mouse mu opioid receptor gene promoter is a supercoiling-regulatory element

scientific article published on 31 July 2011

The region in the mu opioid receptor conferring selectivity for sufentanil over the delta receptor is different from that over the kappa receptor

scientific article

Transcriptional regulation of mouse mu opioid receptor gene in neuronal cells by poly(ADP-ribose) polymerase-1.

scientific article published on 4 February 2008

Transcriptional regulation of mouse mu opioid receptor gene: Sp3 isoforms (M1, M2) function as repressors in neuronal cells to regulate the mu opioid receptor gene.

scientific article published on 9 February 2005

Translational repression of mouse mu opioid receptor expression via leaky scanning

scientific article published on 6 February 2007

Yin Yang 1 phosphorylation contributes to the differential effects of mu-opioid receptor agonists on microRNA-190 expression

scientific article

mu-Opioid receptor agonists differentially regulate the expression of miR-190 and NeuroD.

scientific article

mu-Opioid receptor cell surface expression is regulated by its direct interaction with Ribophorin I.

scientific article published on 16 March 2009

mu-opioid receptor regulates CFTR coexpressed in Xenopus oocytes in a cAMP independent manner

scientific article

p38 mitogen-activated protein kinase and PI3-kinase are involved in up-regulation of mu opioid receptor transcription induced by cycloheximide

scientific article

uAUG-mediated translational initiations are responsible for human mu opioid receptor gene expression

scientific article published on 06 March 2009

β-Endorphin: Structure-activity relationships in the guinea pig ileum and opiate receptor binding assays

scientific article published on January 24, 1977

μ-Opioid receptor attenuates Aβ oligomers-induced neurotoxicity through mTOR signaling

scientific article published on 21 August 2014