List of works - Ignacio Moriyón

A review of the basis of the immunological diagnosis of ruminant brucellosis

scientific article published on 10 February 2016

A systematic review of current immunological tests for the diagnosis of cattle brucellosis.

scientific article published on 31 January 2018

A two-component regulatory system playing a critical role in plant pathogens and endosymbionts is present in Brucella abortus and controls cell invasion and virulence.

scientific article published in July 1998

An ELISA with Brucella lipopolysaccharide antigen for the diagnosis of B. melitensis infection in sheep and for the evaluation of serological responses following subcutaneous or conjunctival B. melitensis strain Rev 1 vaccination

scientific article published in February 1992

Biophysical investigations into the interaction of lipopolysaccharide with polymyxins

Brucella CβG induces a dual pro- and anti-inflammatory response leading to a transient neutrophil recruitment

scientific article

Brucella Genital Tropism: What's on the Menu

scientific article published on 28 March 2017

Brucella abortus and its closest phylogenetic relative, Ochrobactrum spp., differ in outer membrane permeability and cationic peptide resistance

scientific article published on June 2000

Brucella abortus depends on pyruvate phosphate dikinase and malic enzyme but not on Fbp and GlpX fructose-1,6-bisphosphatases for full virulence in laboratory models.

scientific article

Brucella abortus ornithine lipids are dispensable outer membrane components devoid of a marked pathogen-associated molecular pattern

scientific article

Brucella abortus uses a stealthy strategy to avoid activation of the innate immune system during the onset of infection

scientific article

Brucella central carbon metabolism: an update.

scientific article

Brucella evolution and taxonomy

scientific article

Brucella lipopolysaccharide acts as a virulence factor.

scientific article published in February 2005

Brucella melitensis: a nasty bug with hidden credentials for virulence

scientific article

Brucella β 1,2 cyclic glucan is an activator of human and mouse dendritic cells

scientific article

Brucella, nitrogen and virulence.

scientific article

Brucellosis and One Health: Inherited and Future Challenges

scientific article published in 2023

Brucellosis as an emerging threat in developing economies: lessons from Nigeria

scientific article

Brucellosis at the animal/ecosystem/human interface at the beginning of the 21st century.

scientific article published on 14 May 2011

Brucellosis in Sub-Saharan Africa: Current challenges for management, diagnosis and control

scientific article

Brucellosis seroprevalence in livestock in Uganda from 1998 to 2008: a retrospective study

scientific article published on 17 November 2010

Brucellosis vaccines: assessment of Brucella melitensis lipopolysaccharide rough mutants defective in core and O-polysaccharide synthesis and export

scientific article published on 23 July 2008

BvrR/BvrS-controlled outer membrane proteins Omp3a and Omp3b are not essential for Brucella abortus virulence

scientific article

Characterization of Brucella abortus lipopolysaccharide macrodomains as mega rafts

scientific article published on February 2006

Clinical and histological features of brucellin skin test responses in Brucella suis biovar 2 infected pigs

scientific article

Comparative analysis of selected methods for the assessment of antimicrobial and membrane-permeabilizing activity: a case study for lactoferricin derived peptides

scientific article

Comparative genomics of early-diverging Brucella strains reveals a novel lipopolysaccharide biosynthesis pathway

scientific article

Comparative genomics of early-diverging Brucella strains reveals a novel lipopolysaccharide biosynthesis pathway

scientific article published in 2012

Comparative performance of lateral flow immunochromatography, iELISA and Rose Bengal tests for the diagnosis of cattle, sheep, goat and swine brucellosis

scientific article published on 19 June 2019

Convergent evolution of zoonotic Brucella species toward the selective use of the pentose phosphate pathway

scientific article published on 05 October 2020

Corrigendum to phenotypic and genotypic characterization of Brucella strains isolated from autochthonous livestock reveals the dominance of B . abortus biovar 3a in Nigeria [Vet. Microbiol. 180 (2015) 103–108]

scholarly article published in Veterinary Microbiology

Corrigendum: Genetic and Phenotypic Characterization of the Etiological Agent of Canine Orchiepididymitis Smooth Brucella sp. BCCN84.3.

scientific article published on 02 August 2019

Cyclic β-1,2-glucan is a brucella virulence factor required for intracellular survival

scientific article published on 08 May 2005

Deletion of the GI-2 integrase and the wbkA flanking transposase improves the stability of Brucella melitensis Rev 1 vaccine

scientific article

Determination of the O-specific polysaccharide structure in the lipopolysaccharide of Ochrobactrum anthropi LMG 3331

scientific article published on 01 June 1996

Diagnostic performance of serological tests for swine brucellosis in the presence of false positive serological reactions

scientific article

Differential inductions of TNF-alpha and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharides

scientific article published on March 2006

Efficacy of several serological tests and antigens for diagnosis of bovine brucellosis in the presence of false-positive serological results due to Yersinia enterocolitica O:9.

scientific article

Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide

scientific article published on January 2005

Eradication of bovine brucellosis in the Azores, Portugal--outcome of a 5-year programme (2002-2007) based on test-and-slaughter and RB51 vaccination

scientific article

Erythritol Availability in Bovine, Murine and Human Models Highlights a Potential Role for the Host Aldose Reductase during Brucella Infection

scientific article

Erythritol feeds the pentose phosphate pathway via three new isomerases leading to D-erythrose-4-phosphate in Brucella

scientific article

Evaluation of whole cell and subcellular vaccines against Brucella ovis in rams

article

Extensive Cell Envelope Modulation Is Associated with Virulence inBrucella abortus

Genetic and Phenotypic Characterization of the Etiological Agent of Canine Orchiepididymitis Smooth Brucella sp. BCCN84.3.

scientific article

Genomic island 2 is an unstable genetic element contributing to Brucella lipopolysaccharide spontaneous smooth-to-rough dissociation

scientific article published on 15 October 2010

Hospital-based evidence on cost-effectiveness of brucellosis diagnostic tests and treatment in Kenyan hospitals

scientific article published on 07 January 2021

Identification and functional analysis of the cyclopropane fatty acid synthase of Brucella abortus

scientific article

Identification of lptA, lpxE, and lpxO, Three Genes Involved in the Remodeling of Brucella Cell Envelope.

scientific article published in January 2017

Immunization with Brucella melitensis Rev 1 against Brucella ovis infection of rams

scientific article published on 01 September 1987

Immunological identity of brucella native hapten, polysaccharide B, and yersinia enterocolitica serotype 9 native hapten ⬇️

scientific article published on November 1, 1982

Immunomodulatory properties of Brucella melitensis lipopolysaccharide determinants on mouse dendritic cells in vitro and in vivo.

scientific article

In vitro interactions between lipopolysaccharides and heterologous outer membrane porin proteins

Increases of efficacy as vaccine against Brucella abortus infection in mice by simultaneous inoculation with avirulent smooth bvrS/bvrR and rough wbkA mutants

scientific article published on 06 January 2006

Interactions of lipopolysaccharide with lipid membranes, raft models - a solid state NMR study.

scientific article published on 6 April 2013

Is Brucella an enteric pathogen?

scientific article published on 27 January 2009

Lipopolysaccharide as a target for brucellosis vaccine design.

scientific article published on 05 December 2012

Lipopolysaccharides with acylation defects potentiate TLR4 signaling and shape T cell responses

scientific article

Mechanism of interaction of optimized Limulus-derived cyclic peptides with endotoxins: thermodynamic, biophysical and microbiological analysis

scientific article published on September 2007

Molecular recognition of lipopolysaccharide by the lantibiotic nisin

scientific article published on 05 October 2018

Mutants in the lipopolysaccharide of Brucella ovis are attenuated and protect against B. ovis infection in mice

scientific article

New antiseptic peptides to protect against endotoxin-mediated shock

scientific article

Pathogenic Yersinia enterocolitica strains increase the outer membrane permeability in response to environmental stimuli by modulating lipopolysaccharide fluidity and lipid A structure

scientific article

Performance of skin tests with allergens from B. melitensis B115 and rough B. abortus mutants for diagnosing swine brucellosis.

scientific article

Phenotypic and genotypic characterization of Brucella strains isolated from autochthonous livestock reveals the dominance of B. abortus biovar 3a in Nigeria

scientific article

Poor performance of the rapid test for human brucellosis in health facilities in Kenya.

scientific article

Prevalence of bovine brucellosis in slaughtered cattle and barriers to better protection of abattoir workers in Ibadan, South-Western Nigeria

scientific article published on 22 September 2017

Properties of the outer membrane of Brucella

scientific article published on January 1987

Protection of Brucella abortus RB51 revaccinated cows

scientific article published on 22 September 2005

Proteomics-based confirmation of protein expression and correction of annotation errors in the Brucella abortus genome

scientific article

Raising the political profile of the neglected zoonotic diseases: three complementary European commission-funded projects to streamline research, build capacity and advocate for control

scientific article

Rationale for the design of shortened derivatives of the NK-lysin-derived antimicrobial peptide NK-2 with improved activity against Gram-negative pathogens.

scientific article published on 27 March 2007

Regulation of Brucella virulence by the two-component system BvrR/BvrS.

scientific article

Rev1 wbdR tagged vaccines against Brucella ovis

scientific article published on 15 November 2019

Rough mutants defective in core and O-polysaccharide synthesis and export induce antibodies reacting in an indirect ELISA with smooth lipopolysaccharide and are less effective than Rev 1 vaccine against Brucella melitensis infection of sheep.

scientific article published on 30 January 2009

Rough vaccines in animal brucellosis: structural and genetic basis and present status.

scientific article published on January 2004

Spontaneous excision of the O-polysaccharide wbkA glycosyltranferase gene is a cause of dissociation of smooth to rough Brucella colonies

scientific article published on 10 February 2012

Structural Studies of Lipopolysaccharide-defective Mutants from Brucella melitensis Identify a Core Oligosaccharide Critical in Virulence.

scientific article published on 11 February 2016

Structural features governing the activity of lactoferricin-derived peptides that act in synergy with antibiotics against Pseudomonas aeruginosa in vitro and in vivo

scientific article

Structural prerequisites for endotoxic activity in the Limulus test as compared to cytokine production in mononuclear cells

scientific article published on 30 June 2009

Structural studies on the lipopolysaccharide from a rough strain of Ochrobactrum anthropi containing a 2,3-diamino-2,3-dideoxy- d -glucose disaccharide lipid A backbone

scientific article published on 01 January 1998

Synthesis of phosphatidylcholine, a typical eukaryotic phospholipid, is necessary for full virulence of the intracellular bacterial parasite Brucella abortus

scientific article published on 01 August 2006

The CO-dependence of Brucella ovis and Brucella abortus biovars is caused by defective carbonic anhydrases

scientific article published on 05 September 2018

The Fast-Growing Brucella suis Biovar 5 Depends on Phosphoenolpyruvate Carboxykinase and Pyruvate Phosphate Dikinase but Not on Fbp and GlpX Fructose-1,6-Bisphosphatases or Isocitrate Lyase for Full Virulence in Laboratory Models.

scientific article

The Rose Bengal Test in human brucellosis: a neglected test for the diagnosis of a neglected disease

scientific article

The acyl group as the central element of the structural organization of antimicrobial lipopeptide

scientific article

The characterization of Brucella strains isolated from cattle in Algeria reveals the existence of a B. abortus lineage distinct from European and Sub-Saharan Africa strains

scientific article

The differential interaction of Brucella and ochrobactrum with innate immunity reveals traits related to the evolution of stealthy pathogens

scientific article

The epitopic and structural characterization of Brucella suis biovar 2 O-polysaccharide demonstrates the existence of a new M-negative C-negative smooth Brucella serovar

scientific article

The identification of wadB, a new glycosyltransferase gene, confirms the branched structure and the role in virulence of the lipopolysaccharide core of Brucella abortus

scientific article published on 11 June 2014

The interaction of rough and smooth form lipopolysaccharides with polymyxins as studied by titration calorimetry

The lipopolysaccharide core of Brucella abortus acts as a shield against innate immunity recognition

scientific article

The lipopolysaccharide of Brucella abortus BvrS/BvrR mutants contains lipid A modifications and has higher affinity for bactericidal cationic peptides

scientific article published on August 2005

The prevalence of brucellosis and bovine tuberculosis in ruminants in Sidi Kacem Province, Morocco

scientific article published in PLoS ONE

The two-component system BvrR/BvrS essential for Brucella abortus virulence regulates the expression of outer membrane proteins with counterparts in members of the Rhizobiaceae

scientific article

Thermodynamic analysis of the lipopolysaccharide-dependent resistance of gram-negative bacteria against polymyxin B.

scientific article published on 19 January 2007

Torulopsis navarrensis sp. nov. A new species of yeast isolated from an acid washed brown soil in the province of Navarra, Spain

article

Vaccine development targeting lipopolysaccharide structure modification

scientific article

List of works by Ignacio Moriyón

A review of the basis of the immunological diagnosis of ruminant brucellosis

A systematic review of current immunological tests for the diagnosis of cattle brucellosis.

A two-component regulatory system playing a critical role in plant pathogens and endosymbionts is present in Brucella abortus and controls cell invasion and virulence.

An ELISA with Brucella lipopolysaccharide antigen for the diagnosis of B. melitensis infection in sheep and for the evaluation of serological responses following subcutaneous or conjunctival B. melitensis strain Rev 1 vaccination

Biophysical investigations into the interaction of lipopolysaccharide with polymyxins

Brucella CβG induces a dual pro- and anti-inflammatory response leading to a transient neutrophil recruitment

Brucella Genital Tropism: What's on the Menu

Brucella abortus and its closest phylogenetic relative, Ochrobactrum spp., differ in outer membrane permeability and cationic peptide resistance

Brucella abortus depends on pyruvate phosphate dikinase and malic enzyme but not on Fbp and GlpX fructose-1,6-bisphosphatases for full virulence in laboratory models.

Brucella abortus ornithine lipids are dispensable outer membrane components devoid of a marked pathogen-associated molecular pattern

Brucella abortus uses a stealthy strategy to avoid activation of the innate immune system during the onset of infection

Brucella central carbon metabolism: an update.

Brucella evolution and taxonomy

Brucella lipopolysaccharide acts as a virulence factor.

Brucella melitensis: a nasty bug with hidden credentials for virulence

Brucella β 1,2 cyclic glucan is an activator of human and mouse dendritic cells

Brucella, nitrogen and virulence.

Brucellosis and One Health: Inherited and Future Challenges

Brucellosis as an emerging threat in developing economies: lessons from Nigeria

Brucellosis at the animal/ecosystem/human interface at the beginning of the 21st century.

Brucellosis in Sub-Saharan Africa: Current challenges for management, diagnosis and control

Brucellosis seroprevalence in livestock in Uganda from 1998 to 2008: a retrospective study

Brucellosis vaccines: assessment of Brucella melitensis lipopolysaccharide rough mutants defective in core and O-polysaccharide synthesis and export

BvrR/BvrS-controlled outer membrane proteins Omp3a and Omp3b are not essential for Brucella abortus virulence

Characterization of Brucella abortus lipopolysaccharide macrodomains as mega rafts

Clinical and histological features of brucellin skin test responses in Brucella suis biovar 2 infected pigs

Comparative analysis of selected methods for the assessment of antimicrobial and membrane-permeabilizing activity: a case study for lactoferricin derived peptides

Comparative genomics of early-diverging Brucella strains reveals a novel lipopolysaccharide biosynthesis pathway

Comparative genomics of early-diverging Brucella strains reveals a novel lipopolysaccharide biosynthesis pathway

Comparative performance of lateral flow immunochromatography, iELISA and Rose Bengal tests for the diagnosis of cattle, sheep, goat and swine brucellosis

Convergent evolution of zoonotic Brucella species toward the selective use of the pentose phosphate pathway

Corrigendum to phenotypic and genotypic characterization of Brucella strains isolated from autochthonous livestock reveals the dominance of B . abortus biovar 3a in Nigeria [Vet. Microbiol. 180 (2015) 103–108]

Corrigendum: Genetic and Phenotypic Characterization of the Etiological Agent of Canine Orchiepididymitis Smooth Brucella sp. BCCN84.3.

Cyclic β-1,2-glucan is a brucella virulence factor required for intracellular survival

Deletion of the GI-2 integrase and the wbkA flanking transposase improves the stability of Brucella melitensis Rev 1 vaccine

Determination of the O-specific polysaccharide structure in the lipopolysaccharide of Ochrobactrum anthropi LMG 3331

Diagnostic performance of serological tests for swine brucellosis in the presence of false positive serological reactions

Differential inductions of TNF-alpha and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharides

Efficacy of several serological tests and antigens for diagnosis of bovine brucellosis in the presence of false-positive serological results due to Yersinia enterocolitica O:9.

Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide

Eradication of bovine brucellosis in the Azores, Portugal--outcome of a 5-year programme (2002-2007) based on test-and-slaughter and RB51 vaccination

Erythritol Availability in Bovine, Murine and Human Models Highlights a Potential Role for the Host Aldose Reductase during Brucella Infection

Erythritol feeds the pentose phosphate pathway via three new isomerases leading to D-erythrose-4-phosphate in Brucella

Evaluation of whole cell and subcellular vaccines against Brucella ovis in rams

Extensive Cell Envelope Modulation Is Associated with Virulence inBrucella abortus

Genetic and Phenotypic Characterization of the Etiological Agent of Canine Orchiepididymitis Smooth Brucella sp. BCCN84.3.

Genomic island 2 is an unstable genetic element contributing to Brucella lipopolysaccharide spontaneous smooth-to-rough dissociation

Hospital-based evidence on cost-effectiveness of brucellosis diagnostic tests and treatment in Kenyan hospitals

Identification and functional analysis of the cyclopropane fatty acid synthase of Brucella abortus

Identification of lptA, lpxE, and lpxO, Three Genes Involved in the Remodeling of Brucella Cell Envelope.

Immunization with Brucella melitensis Rev 1 against Brucella ovis infection of rams

Immunological identity of brucella native hapten, polysaccharide B, and yersinia enterocolitica serotype 9 native hapten ⬇️

Immunomodulatory properties of Brucella melitensis lipopolysaccharide determinants on mouse dendritic cells in vitro and in vivo.

In vitro interactions between lipopolysaccharides and heterologous outer membrane porin proteins

Increases of efficacy as vaccine against Brucella abortus infection in mice by simultaneous inoculation with avirulent smooth bvrS/bvrR and rough wbkA mutants

Interactions of lipopolysaccharide with lipid membranes, raft models - a solid state NMR study.

Is Brucella an enteric pathogen?

Lipopolysaccharide as a target for brucellosis vaccine design.

Lipopolysaccharides with acylation defects potentiate TLR4 signaling and shape T cell responses

Mechanism of interaction of optimized Limulus-derived cyclic peptides with endotoxins: thermodynamic, biophysical and microbiological analysis

Molecular recognition of lipopolysaccharide by the lantibiotic nisin

Mutants in the lipopolysaccharide of Brucella ovis are attenuated and protect against B. ovis infection in mice

New antiseptic peptides to protect against endotoxin-mediated shock

Pathogenic Yersinia enterocolitica strains increase the outer membrane permeability in response to environmental stimuli by modulating lipopolysaccharide fluidity and lipid A structure

Performance of skin tests with allergens from B. melitensis B115 and rough B. abortus mutants for diagnosing swine brucellosis.

Phenotypic and genotypic characterization of Brucella strains isolated from autochthonous livestock reveals the dominance of B. abortus biovar 3a in Nigeria

Poor performance of the rapid test for human brucellosis in health facilities in Kenya.

Prevalence of bovine brucellosis in slaughtered cattle and barriers to better protection of abattoir workers in Ibadan, South-Western Nigeria

Properties of the outer membrane of Brucella

Protection of Brucella abortus RB51 revaccinated cows

Proteomics-based confirmation of protein expression and correction of annotation errors in the Brucella abortus genome

Raising the political profile of the neglected zoonotic diseases: three complementary European commission-funded projects to streamline research, build capacity and advocate for control

Rationale for the design of shortened derivatives of the NK-lysin-derived antimicrobial peptide NK-2 with improved activity against Gram-negative pathogens.

Regulation of Brucella virulence by the two-component system BvrR/BvrS.

Rev1 wbdR tagged vaccines against Brucella ovis

Rough mutants defective in core and O-polysaccharide synthesis and export induce antibodies reacting in an indirect ELISA with smooth lipopolysaccharide and are less effective than Rev 1 vaccine against Brucella melitensis infection of sheep.

Rough vaccines in animal brucellosis: structural and genetic basis and present status.

Spontaneous excision of the O-polysaccharide wbkA glycosyltranferase gene is a cause of dissociation of smooth to rough Brucella colonies

Structural Studies of Lipopolysaccharide-defective Mutants from Brucella melitensis Identify a Core Oligosaccharide Critical in Virulence.