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List of works by James C Hardwick

5-Aminosalicylic acid inhibits cell cycle progression in a phospholipase D dependent manner in colorectal cancer.

scientific article

A Meta-Analysis of SMAD4 Immunohistochemistry as a Prognostic Marker in Colorectal Cancer

scientific article

A thirty-year follow-up surveillance study for neoplasia of a dutch ulcerative colitis cohort

scientific article published on 28 November 2013

Activation of the canonical beta-catenin pathway by histamine

scientific article published on 16 October 2003

Altered bone morphogenetic protein signalling in theHelicobacter pylori-infected stomach

scientific article published on 01 June 2006

Bidirectional tumor/stroma crosstalk promotes metastasis in mesenchymal colorectal cancer

scientific article published on 23 January 2020

Blimp1 regulates the transition of neonatal to adult intestinal epithelium

scientific article

Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon.

scientific article published on January 2004

Bone morphogenetic protein signaling suppresses tumorigenesis at gastric epithelial transition zones in mice

scientific article

Bone morphogenetic protein signalling in colorectal cancer.

scientific article published on 29 August 2008

Cholesterol metabolism and colorectal cancers.

scientific article

Clinical evaluation of endoscopic trimodal imaging for the detection and differentiation of colonic polyps

scientific article published on 30 October 2008

Combining autofluorescence imaging and narrow-band imaging for the differentiation of adenomas from non-neoplastic colonic polyps among experienced and non-experienced endoscopists

scientific article published on 28 April 2009

Depletion of the colonic epithelial precursor cell compartment upon conditional activation of the hedgehog pathway

scientific article published on 6 March 2009

Double balloon endoscopy for detection of small-bowel adenomas in familial adenomatous polyposis after pancreaticoduodenectomy according to Whipple

scientific article published on 20 August 2008

ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response

scientific article published on 28 March 2013

Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A

scientific article (publication date: 19 October 2006)

Endoscopic tri-modal imaging for surveillance in ulcerative colitis: randomised comparison of high-resolution endoscopy and autofluorescence imaging for neoplasia detection; and evaluation of narrow-band imaging for classification of lesions.

scientific article published on 26 March 2008

Evaluation of the prognostic value of pSMAD immunohistochemistry in colorectal cancer.

scientific article published in September 2013

Extracellular BMP Antagonists, Multifaceted Orchestrators in the Tumor and Its Microenvironment

scientific article published on 29 May 2020

Hedgehog signalling stimulates precursor cell accumulation and impairs epithelial maturation in the murine oesophagus.

scientific article

Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation

scientific article (publication date: March 2004)

Influence of combination therapy with immune modulators on anti-TNF trough levels and antibodies in patients with IBD.

scientific article published in December 2014

Intestinal tumorigenesis is not affected by progesterone signaling in rodent models

scientific article (publication date: 2011)

Intraoperative fluorescence imaging to localize tumors and sentinel lymph nodes in rectal cancer.

scientific article published on 7 May 2015

Leptin Signaling in Human Peripheral Blood Mononuclear Cells, Activation of p38 and p42/44 Mitogen-Activated Protein (MAP) Kinase and p70 S6 Kinase

scientific article published on 01 September 2000

Leptin is a growth factor for colonic epithelial cells

scientific article published in July 2001

Loss of Indian Hedgehog activates multiple aspects of a wound healing response in the mouse intestine

scientific article published on August 2010

Loss of SMAD4 alters BMP signaling to promote colorectal cancer cell metastasis via activation of Rho and ROCK.

scientific article published on 3 April 2014

Low molecular weight protein tyrosine phosphatase (LMWPTP) upregulation mediates malignant potential in colorectal cancer.

scientific article published on April 2015

Luminescence-based Imaging Approaches in the Field of Interventional Molecular Imaging.

scientific article published on July 2015

MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients.

scientific article published in April 2012

NF-kappaB, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps

scientific article published on 01 February 2001

Narrow-band imaging compared with conventional colonoscopy for the detection of dysplasia in patients with longstanding ulcerative colitis

scientific article

Oestrogens promote tumorigenesis in a mouse model for colitis-associated cancer.

scientific article published on 13 February 2013

One to 2-year surveillance intervals reduce risk of colorectal cancer in families with Lynch syndrome

scientific article published on 2 March 2010

Putting the Wnt up colon cancer.

scientific article

Quality of web-based information on inflammatory bowel diseases

scientific article published on 21 May 2009

Rage signalling promotes intestinal tumourigenesis

scientific article published on 2 April 2012

Simultaneous correlative scanning electron and high-NA fluorescence microscopy

scientific article

Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract.

scientific article published in June 2003

Sonic hedgehog regulates gastric gland morphogenesis in man and mouse.

scientific article

Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell 'stemness' via the bone morphogenetic protein pathway.

scientific article published on 6 May 2011

Targeting endoglin expressing regulatory T cells in the tumor microenvironment enhances the effect of PD1 checkpoint inhibitor immunotherapy

scientific article published on 24 April 2020

Targeting of the Cancer-Associated Fibroblast-T-Cell Axis in Solid Malignancies

scientific article published on 15 November 2019

The BMP pathway either enhances or inhibits the Wnt pathway depending on the SMAD4 and p53 status in CRC.

scientific article published on 13 November 2014

The absence of functional PI3Kgamma prevents leukocyte recruitment and ameliorates DSS-induced colitis in mice.

scientific article published on 27 March 2010

The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer

scientific article published in January 2008

The effect of statins in colorectal cancer is mediated through the bone morphogenetic protein pathway

scientific article published on 14 August 2007

The impact of sexual abuse in patients undergoing colonoscopy.

scientific article published on 15 January 2014

The role of EZH2 and DNA methylation in the silencing of the tumour suppressor RUNX3 in colorectal cancer

scientific article published on 14 July 2010

Transanal endoscopic microsurgery versus endoscopic mucosal resection for large rectal adenomas (TREND-study)

scientific article

Tumour-stroma ratio has poor prognostic value in non-pedunculated T1 colorectal cancer: A multi-centre case-cohort study

scientific article published on 19 November 2020

Value-based healthcare in Lynch syndrome

scientific article published in June 2013

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