List of works - Iván Peñuelas

(13)N-ammonia PET as a measurement of hindlimb perfusion in a mouse model of peripheral artery occlusive disease

scientific article published on 15 June 2007

18F-FDG metabolism in a rat model of chronic infarction

scientific article published on 01 January 2007

A fully automated one pot synthesis of 9-(4-[18F]fluoro-3-hydroxymethylbutyl) guanine for gene therapy studies

scientific article published in November 2002

A phase I clinical trial of thymidine kinase-based gene therapy in advanced hepatocellular carcinoma.

scientific article published on 6 August 2010

A synthetic peptide from transforming growth factor beta type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury

scientific article published in April 2003

Adeno-associated virus liver transduction efficiency measured by in vivo [18F]FHBG positron emission tomography imaging in rodents and nonhuman primates.

scientific article published on 6 April 2011

Adipose stromal vascular fraction improves cardiac function in chronic myocardial infarction through differentiation and paracrine activity.

scientific article published on 2 February 2012

Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment of activated T lymphocytes.

scientific article published on 25 January 2011

Antitumor and antiangiogenic effect of the dual EGFR and HER-2 tyrosine kinase inhibitor lapatinib in a lung cancer model

scientific article

Assessment of biliary bicarbonate secretion in humans by positron emission tomography

scientific article published on 01 July 1999

Assessment of metabolic patterns and new antitumoral treatment in osteosarcoma xenograft models by [F]FDG and sodium [F]fluoride PET

scientific article published on 29 November 2018

Automated analysis of FDG PET as a tool for single-subject probabilistic prediction and detection of Alzheimer's disease dementia.

scientific article published on 29 May 2013

Bioadhesive properties and biodistribution of cyclodextrin-poly(anhydride) nanoparticles.

scientific article published on 28 February 2009

Conjunctival vaccination against Brucella ovis in mice with mannosylated nanoparticles

scientific article published on 28 July 2012

Cyclodextrin-poly(anhydride) nanoparticles as new vehicles for oral drug delivery.

scientific article published on 04 April 2011

Decreased carbon-11-flumazenil binding in early Alzheimer's disease.

scientific article published in September 2012

Deletion of inducible nitric-oxide synthase in leptin-deficient mice improves brown adipose tissue function

scientific article

Dendritic cells delivered inside human carcinomas are sequestered by interleukin-8.

scientific article

Design and performance evaluation of single-use whole-sterile "plug & play" kits for routine automated production of [(11)C]choline and [(11)C]methionine with radiopharmaceutical quality.

scientific article published on 22 July 2010

Dual tracer 11C-choline and FDG-PET in the diagnosis of biochemical prostate cancer relapse after radical treatment.

scientific article published on 19 June 2009

European regulations for the introduction of novel radiopharmaceuticals in the clinical setting.

scientific article

Functional neuroanatomy of sustained attention in schizophrenia: contribution of parietal cortices.

scientific article published in October 2002

Gene therapy imaging in patients for oncological applications.

scientific article

Glucose metabolism during fasting is altered in experimental porphobilinogen deaminase deficiency.

scientific article

Guidance on current good radiopharmacy practice (cGRPP) for the small-scale preparation of radiopharmaceuticals

scientific article

Imaging studies for evaluating gene therapy in translational research

scientific article published on January 2005

Impact of time-of-flight and point-spread-function in SUV quantification for oncological PET.

scientific article published in February 2013

In vivo monitoring of Staphylococcus aureus biofilm infections and antimicrobial therapy by [18F]fluoro-deoxyglucose-MicroPET in a mouse model.

scientific article

In vivo study of the mucus-permeating properties of PEG-coated nanoparticles following oral administration

scientific article published on 23 December 2014

Infiltration of plasma rich in growth factors enhances in vivo angiogenesis and improves reperfusion and tissue remodeling after severe hind limb ischemia

scientific article published on 24 January 2015

Intensive pharmacological immunosuppression allows for repetitive liver gene transfer with recombinant adenovirus in nonhuman primates

scientific article

Levodopa induces long-lasting modification in the functional activity of the nigrostriatal pathway.

scientific article published on 27 September 2013

MAPC transplantation confers a more durable benefit than AC133+ cell transplantation in severe hind limb ischemia.

scientific article published on 17 August 2010

Meox2/Tcf15 heterodimers program the heart capillary endothelium for cardiac fatty acid uptake

scientific article published on 5 January 2015

Molecular imaging techniques to study the biodistribution of orally administered (99m)Tc-labelled naive and ligand-tagged nanoparticles.

scientific article published in December 2011

Monoaminergic PET imaging and histopathological correlation in unilateral and bilateral 6-hydroxydopamine lesioned rat models of Parkinson's disease: a longitudinal in-vivo study.

scientific article published on 12 February 2015

Multipotent adult progenitor cells sustain function of ischemic limbs in mice.

scientific article

New MRI, 18F-DOPA and 11C-(+)-alpha-dihydrotetrabenazine templates for Macaca fascicularis neuroimaging: advantages to improve PET quantification.

scientific article published on 5 May 2009

Non-invasive in vivo imaging of cardiac stem/progenitor cell biodistribution and retention after intracoronary and intramyocardial delivery in a swine model of chronic ischemia reperfusion injury

scientific article

PET Tracers for Clinical Imaging of Breast Cancer.

scientific article

PET imaging of thymidine kinase gene expression in the liver of non-human primates following systemic delivery of an adenoviral vector.

scientific article

PET optimization for improved assessment and accurate quantification of 90Y-microsphere biodistribution after radioembolization

scientific article published in September 2014

Pilot clinical trial of type 1 dendritic cells loaded with autologous tumor lysates combined with GM-CSF, pegylated IFN, and cyclophosphamide for metastatic cancer patients.

scientific article published on 2 November 2011

Positron emission tomography and gene therapy: basic concepts and experimental approaches for in vivo gene expression imaging.

scientific article published in July 2004

Positron emission tomography imaging of adenoviral-mediated transgene expression in liver cancer patients

scientific article

Progression of dopaminergic depletion in a model of MPTP-induced Parkinsonism in non-human primates. An (18)F-DOPA and (11)C-DTBZ PET study

scientific article published on 19 March 2010

Quantitative volumetric analysis of gliomas with sequential MRI and ¹¹C-methionine PET assessment: patterns of integration in therapy planning.

scientific article

Quick and simple synthesis of (11)C-(+)-alpha-dihydrotetrabenazine to be used as a PET radioligand of vesicular monoamine transporters

scientific article published in January 2008

Radiation dosimetry and biodistribution in non-human primates of the sodium/iodide PET ligand [(18)F]-tetrafluoroborate

scientific article

Radiopharmaceuticals are special, but is this recognized? The possible impact of the new Clinical Trials Regulation on the preparation of radiopharmaceuticals.

scientific article published in November 2014

Role of positron emission tomography in urological oncology.

scientific article published on December 2010

Simple automated system for simultaneous production of 11C-labeled tracers by solid supported methylation

scientific article published on 18 April 2006

Statistical parametric maps of ¹⁸F-FDG PET and 3-D autoradiography in the rat brain: a cross-validation study.

scientific article published on 27 August 2011

Study of the neutron field in the vicinity of an unshielded PET cyclotron

scientific article published on 19 October 2005

Sustained attention in a counting task: normal performance and functional neuroanatomy.

scientific article published in September 2002

Synthesis of S-[13N]nitrosoglutathione (13N-GSNO) as a new potential PET imaging agent.

scientific article published on 15 October 2008

The HIF-1α Hypoxia Response in Tumor-Infiltrating T Lymphocytes Induces Functional CD137 (4-1BB) for Immunotherapy

scientific article published on 19 June 2012

The nigrostriatal system in the presymptomatic and symptomatic stages in the MPTP monkey model: a PET, histological and biochemical study.

scientific article published on 5 June 2012

The specific case of radiopharmaceuticals and GMP—activities of the Radiopharmacy Committee

scientific article published on 15 May 2008

Toxicity studies of poly(anhydride) nanoparticles as carriers for oral drug delivery

scientific article published on 26 May 2012

Transplantation of Mesenchymal Stem Cells Exerts a Greater Long-Term Effect than Bone Marrow Mononuclear Cells in a Chronic Myocardial Infarction Model in Rat

scientific article published on 16 November 2009

Transplantation of adipose derived stromal cells is associated with functional improvement in a rat model of chronic myocardial infarction.

scientific article published on 24 April 2008

Twelve automated thresholding methods for segmentation of PET images: a phantom study.

scientific article published on 31 May 2012

Untangling the web of European regulations for the preparation of unlicensed radiopharmaceuticals: a concise overview and practical guidance for a risk-based approach.

scientific article

Use of 11C-(+)-alpha -dihydrotetrabenazine for the assessment of dopaminergic innervation in animal models of Parkinson's disease

scientific article published in March 2008

Validation of segmentation techniques for positron emission tomography using ex-vivo images of oncological surgical specimens

scientific article published on 13 August 2013

Voxel-based analysis of dual-time-point 18F-FDG PET images for brain tumor identification and delineation.

scientific article

[Contribution of time of flight and point spread function modeling to the performance characteristics of the PET/CT Biograph mCT scanner].

scientific article published on 18 September 2012

[Dual time point 18F-FDOPA PET as a tool for characterizing brain tumors].

scientific article

[Radiolabeling and biodistribution studies of polymeric nanoparticles as adjuvants for ocular vaccination against brucellosis]

scientific article published on 16 January 2013

[Translational molecular imaging: an investment for the future]

scientific article published on 03 January 2012

[¹⁸F]fluorothymidine-positron emission tomography in patients with locally advanced breast cancer under bevacizumab treatment: usefulness of different quantitative methods of tumor proliferation.

scientific article published on 23 July 2014

cAMP activates transcription of the human glucocorticoid receptor gene promoter

scientific article published on 01 October 1998

List of works by Iván Peñuelas

(13)N-ammonia PET as a measurement of hindlimb perfusion in a mouse model of peripheral artery occlusive disease

18F-FDG metabolism in a rat model of chronic infarction

A fully automated one pot synthesis of 9-(4-[18F]fluoro-3-hydroxymethylbutyl) guanine for gene therapy studies

A phase I clinical trial of thymidine kinase-based gene therapy in advanced hepatocellular carcinoma.

A synthetic peptide from transforming growth factor beta type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury

Adeno-associated virus liver transduction efficiency measured by in vivo [18F]FHBG positron emission tomography imaging in rodents and nonhuman primates.

Adipose stromal vascular fraction improves cardiac function in chronic myocardial infarction through differentiation and paracrine activity.

Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment of activated T lymphocytes.

Antitumor and antiangiogenic effect of the dual EGFR and HER-2 tyrosine kinase inhibitor lapatinib in a lung cancer model

Assessment of biliary bicarbonate secretion in humans by positron emission tomography

Assessment of metabolic patterns and new antitumoral treatment in osteosarcoma xenograft models by [F]FDG and sodium [F]fluoride PET

Automated analysis of FDG PET as a tool for single-subject probabilistic prediction and detection of Alzheimer's disease dementia.

Bioadhesive properties and biodistribution of cyclodextrin-poly(anhydride) nanoparticles.

Conjunctival vaccination against Brucella ovis in mice with mannosylated nanoparticles

Cyclodextrin-poly(anhydride) nanoparticles as new vehicles for oral drug delivery.

Decreased carbon-11-flumazenil binding in early Alzheimer's disease.

Deletion of inducible nitric-oxide synthase in leptin-deficient mice improves brown adipose tissue function

Dendritic cells delivered inside human carcinomas are sequestered by interleukin-8.

Design and performance evaluation of single-use whole-sterile "plug & play" kits for routine automated production of [(11)C]choline and [(11)C]methionine with radiopharmaceutical quality.

Dual tracer 11C-choline and FDG-PET in the diagnosis of biochemical prostate cancer relapse after radical treatment.

European regulations for the introduction of novel radiopharmaceuticals in the clinical setting.

Functional neuroanatomy of sustained attention in schizophrenia: contribution of parietal cortices.

Gene therapy imaging in patients for oncological applications.

Glucose metabolism during fasting is altered in experimental porphobilinogen deaminase deficiency.

Guidance on current good radiopharmacy practice (cGRPP) for the small-scale preparation of radiopharmaceuticals

Imaging studies for evaluating gene therapy in translational research

Impact of time-of-flight and point-spread-function in SUV quantification for oncological PET.

In vivo monitoring of Staphylococcus aureus biofilm infections and antimicrobial therapy by [18F]fluoro-deoxyglucose-MicroPET in a mouse model.

In vivo study of the mucus-permeating properties of PEG-coated nanoparticles following oral administration

Infiltration of plasma rich in growth factors enhances in vivo angiogenesis and improves reperfusion and tissue remodeling after severe hind limb ischemia

Intensive pharmacological immunosuppression allows for repetitive liver gene transfer with recombinant adenovirus in nonhuman primates

Levodopa induces long-lasting modification in the functional activity of the nigrostriatal pathway.

MAPC transplantation confers a more durable benefit than AC133+ cell transplantation in severe hind limb ischemia.

Meox2/Tcf15 heterodimers program the heart capillary endothelium for cardiac fatty acid uptake

Molecular imaging techniques to study the biodistribution of orally administered (99m)Tc-labelled naive and ligand-tagged nanoparticles.

Monoaminergic PET imaging and histopathological correlation in unilateral and bilateral 6-hydroxydopamine lesioned rat models of Parkinson's disease: a longitudinal in-vivo study.

Multipotent adult progenitor cells sustain function of ischemic limbs in mice.

New MRI, 18F-DOPA and 11C-(+)-alpha-dihydrotetrabenazine templates for Macaca fascicularis neuroimaging: advantages to improve PET quantification.

Non-invasive in vivo imaging of cardiac stem/progenitor cell biodistribution and retention after intracoronary and intramyocardial delivery in a swine model of chronic ischemia reperfusion injury

PET Tracers for Clinical Imaging of Breast Cancer.

PET imaging of thymidine kinase gene expression in the liver of non-human primates following systemic delivery of an adenoviral vector.

PET optimization for improved assessment and accurate quantification of 90Y-microsphere biodistribution after radioembolization

Pilot clinical trial of type 1 dendritic cells loaded with autologous tumor lysates combined with GM-CSF, pegylated IFN, and cyclophosphamide for metastatic cancer patients.

Positron emission tomography and gene therapy: basic concepts and experimental approaches for in vivo gene expression imaging.

Positron emission tomography imaging of adenoviral-mediated transgene expression in liver cancer patients

Progression of dopaminergic depletion in a model of MPTP-induced Parkinsonism in non-human primates. An (18)F-DOPA and (11)C-DTBZ PET study

Quantitative volumetric analysis of gliomas with sequential MRI and ¹¹C-methionine PET assessment: patterns of integration in therapy planning.

Quick and simple synthesis of (11)C-(+)-alpha-dihydrotetrabenazine to be used as a PET radioligand of vesicular monoamine transporters

Radiation dosimetry and biodistribution in non-human primates of the sodium/iodide PET ligand [(18)F]-tetrafluoroborate

Radiopharmaceuticals are special, but is this recognized? The possible impact of the new Clinical Trials Regulation on the preparation of radiopharmaceuticals.

Role of positron emission tomography in urological oncology.

Simple automated system for simultaneous production of 11C-labeled tracers by solid supported methylation

Statistical parametric maps of ¹⁸F-FDG PET and 3-D autoradiography in the rat brain: a cross-validation study.

Study of the neutron field in the vicinity of an unshielded PET cyclotron

Sustained attention in a counting task: normal performance and functional neuroanatomy.

Synthesis of S-[13N]nitrosoglutathione (13N-GSNO) as a new potential PET imaging agent.

The HIF-1α Hypoxia Response in Tumor-Infiltrating T Lymphocytes Induces Functional CD137 (4-1BB) for Immunotherapy

The nigrostriatal system in the presymptomatic and symptomatic stages in the MPTP monkey model: a PET, histological and biochemical study.

The specific case of radiopharmaceuticals and GMP—activities of the Radiopharmacy Committee

Toxicity studies of poly(anhydride) nanoparticles as carriers for oral drug delivery

Transplantation of Mesenchymal Stem Cells Exerts a Greater Long-Term Effect than Bone Marrow Mononuclear Cells in a Chronic Myocardial Infarction Model in Rat

Transplantation of adipose derived stromal cells is associated with functional improvement in a rat model of chronic myocardial infarction.

Twelve automated thresholding methods for segmentation of PET images: a phantom study.

Untangling the web of European regulations for the preparation of unlicensed radiopharmaceuticals: a concise overview and practical guidance for a risk-based approach.

Use of 11C-(+)-alpha -dihydrotetrabenazine for the assessment of dopaminergic innervation in animal models of Parkinson's disease

Validation of segmentation techniques for positron emission tomography using ex-vivo images of oncological surgical specimens

Voxel-based analysis of dual-time-point 18F-FDG PET images for brain tumor identification and delineation.

[Contribution of time of flight and point spread function modeling to the performance characteristics of the PET/CT Biograph mCT scanner].

[Dual time point 18F-FDOPA PET as a tool for characterizing brain tumors].

[Radiolabeling and biodistribution studies of polymeric nanoparticles as adjuvants for ocular vaccination against brucellosis]

[Translational molecular imaging: an investment for the future]

[¹⁸F]fluorothymidine-positron emission tomography in patients with locally advanced breast cancer under bevacizumab treatment: usefulness of different quantitative methods of tumor proliferation.

cAMP activates transcription of the human glucocorticoid receptor gene promoter