List of works by Ruud F Toonen

A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons

scientific article published on 01 May 2019

A closer look at FBXO41 as a Parkinson's disease risk factor

scientific article published on 06 September 2013

Automated analysis of neuronal morphology, synapse number and synaptic recruitment

scientific article published on 15 December 2010

Automated quantification of cellular traffic in living cells.

scientific article

CAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neurons

scientific journal article

CAPS-1 requires its C2, PH, MHD1 and DCV domains for dense core vesicle exocytosis in mammalian CNS neurons

scientific article published on 7 September 2017

Ca(2+)-induced recruitment of the secretory vesicle protein DOC2B to the target membrane.

scientific article published on 21 March 2004

CaMKII controls neuromodulation via neuropeptide gene expression and axonal targeting of neuropeptide vesicles

scientific article published on 10 August 2020

Correction: Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling.

scientific article

Crashpilot underachieves due to acetylation at the nerve terminal

scientific article published on 01 December 2011

Deletion of Munc18-1 in 5-HT neurons results in rapid degeneration of the 5-HT system and early postnatal lethality.

scientific article

Dendritic position is a major determinant of presynaptic strength.

scientific article published on 9 April 2012

Dense-core vesicle biogenesis and exocytosis in neurons lacking chromogranins A and B.

scientific article published on 27 November 2017

Detection of silent cells, synchronization and modulatory activity in developing cellular networks

scientific article

Differential Maturation of the Two Regulated Secretory Pathways in Human iPSC-Derived Neurons.

scientific article

Dissecting docking and tethering of secretory vesicles at the target membrane.

scientific article published on 10 August 2006

Early Golgi Abnormalities and Neurodegeneration upon Loss of Presynaptic Proteins Munc18-1, Syntaxin-1, or SNAP-25.

scientific article published on 27 March 2017

Fbxo41 Promotes Disassembly of Neuronal Primary Cilia.

scientific article

Functional characterization of the PCLO p.Ser4814Ala variant associated with major depressive disorder reveals cellular but not behavioral differences

scientific article published on June 2015

Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia.

scientific article

Homozygous STXBP1 variant causes encephalopathy and gain-of-function in synaptic transmission

scientific article published on 01 February 2020

Interdependence of PKC-dependent and PKC-independent pathways for presynaptic plasticity

scientific article

Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission

scientific article published on June 2013

Matrix-dependent local retention of secretory vesicle cargo in cortical neurons

scientific article published in January 2009

Multi-level characterization of balanced inhibitory-excitatory cortical neuron network derived from human pluripotent stem cells.

scientific article

Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles

scientific article

Munc18-1 expression levels control synapse recovery by regulating readily releasable pool size

scientific journal article

Munc18-1 in secretion: lonely Munc joins SNARE team and takes control.

scientific article published on 22 October 2007

Munc18-1 is a dynamically regulated PKC target during short-term enhancement of transmitter release

scientific article

Munc18-1 mutations that strongly impair SNARE-complex binding support normal synaptic transmission.

scientific article

Munc18-1 phosphorylation by protein kinase C potentiates vesicle pool replenishment in bovine chromaffin cells.

scientific article published on 25 September 2006

Munc18-1: sequential interactions with the fusion machinery stimulate vesicle docking and priming.

scientific article published on August 2007

Phosphorylation of synaptotagmin-1 controls a post-priming step in PKC-dependent presynaptic plasticity

scientific article published on 18 April 2016

Pool size estimations for dense-core vesicles in mammalian CNS neurons

scientific article published on 05 September 2018

Presynaptic inhibition upon CB1 or mGlu2/3 receptor activation requires ERK/MAPK phosphorylation of Munc18-1.

scientific article published on 07 April 2016

Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling.

scientific article published on 16 January 2018

Regulated exocytosis: merging ideas on fusing membranes.

scientific article published on 16 July 2007

SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering

scientific article published on 01 August 2019

SNAP-25 gene family members differentially support secretory vesicle fusion.

scientific article published on 12 April 2017

SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse

scientific article published on 03 June 2019

Synapse associated protein 102 (SAP102) binds the C-terminal part of the scaffolding protein neurobeachin.

scientific article

Synaptic Effects of Munc18-1 Alternative Splicing in Excitatory Hippocampal Neurons

scientific article published on 25 September 2015

The RAB3-RIM Pathway Is Essential for the Release of Neuromodulators

scientific article published on 31 October 2019

The role of Rab3a in secretory vesicle docking requires association/dissociation of guanidine phosphates and Munc18-1.

scientific article

Tyrosine phosphorylation of Munc18-1 inhibits synaptic transmission by preventing SNARE assembly.

scientific article published on 17 November 2017

Unfolded protein response activates glycogen synthase kinase-3 via selective lysosomal degradation.

scientific article published on 14 February 2013

Vesicle trafficking: pleasure and pain from SM genes.

scientific article

Vesicular trafficking of semaphorin 3A is activity-dependent and differs between axons and dendrites.

scientific article

Vti Proteins: Beyond Endolysosomal Trafficking

scientific article published on 22 November 2018

Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi

scientific article published in Nature Communications

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