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List of works by Alexander J. Whitworth

A SCA7 CAG/CTG repeat expansion is stable in Drosophila melanogaster despite modulation of genomic context and gene dosage

scientific article

A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit

scientific article published on 17 February 2022

Antioxidant Therapy in Parkinson's Disease: Insights from Drosophila melanogaster

scientific article published on 07 January 2020

Basal mitophagy is widespread in Drosophila but minimally affected by loss of Pink1 or parkin.

scientific article

Characterization of Drosophila ATPsynC mutants as a new model of mitochondrial ATP synthase disorders

scientific article published in PLoS ONE

DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron  depletion

scientific article published on 12 April 2022

Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations.

scientific article published on November 2011

Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease

scientific article published in September 2005

Drosophila Models of Parkinson's Disease

scientific article published on January 1, 2011

Drosophila models pioneer a new approach to drug discovery for Parkinson's disease

scientific article

Drosophila phosphatidylinositol-4 kinase fwd promotes mitochondrial fission and can suppress Pink1/parkin phenotypes

scientific article published on 21 October 2020

Effects of five Ayurvedic herbs on locomotor behaviour in a Drosophila melanogaster Parkinson's disease model

scientific article

Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis

scientific article published on 2 February 2005

Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

How could Parkin-mediated ubiquitination of mitofusin promote mitophagy?

scientific article published on July 2010

Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease

scientific article

Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations

scientific article

Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction

scientific article published on 15 April 2019

Mitochondrial defects and neuromuscular degeneration caused by altered expression of Drosophila Gdap1: implications for the Charcot-Marie-Tooth neuropathy

scientific article published on 13 August 2014

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

scientific article (publication date: April 2003)

Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila

scientific article published on 23 July 2019

Modeling pathogenic mutations of human twinkle in Drosophila suggests an apoptosis role in response to mitochondrial defects

scientific article

Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1.

scientific article

Molecular mechanisms of PINK1-related neurodegeneration

scientific article published on June 2011

PINK1 cleavage at position A103 by the mitochondrial protease PARL.

scientific article

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss.

scientific article published on 16 August 2009

Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin

scientific article

SREBF1 links lipogenesis to mitophagy and sporadic Parkinson disease

scientific article published on 27 June 2014

SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits

scientific article

Superoxide dismutating molecules rescue the toxic effects of PINK1 and parkin loss.

scientific article published in May 2018

TRAP1 rescues PINK1 loss-of-function phenotypes

scientific article published on 21 March 2013

Temporally dynamic response to Wingless directs the sequential elaboration of the proximodistal axis of the Drosophila wing

scientific article published in February 2003

The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy

scientific article published on 22 June 2016

The PINK1/Parkin pathway: a mitochondrial quality control system?

scientific article published on December 2009

The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy

scientific article

The STING pathway does not contribute to behavioural or mitochondrial phenotypes in Drosophila Pink1/parkin or mtDNA mutator models

scientific article published on 14 February 2020

The complex I subunit NDUFA10 selectively rescues Drosophila pink1 mutants through a mechanism independent of mitophagy

scientific article

The many faces of mitophagy

scientific article published in January 2014

VPS35 pathogenic mutations confer no dominant toxicity but partial loss of function in Drosophila and genetically interact with parkin

scientific article published on 6 August 2015

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