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List of works by Changshun Shao

A human cell-based reporter detects microhomology-mediated end joining

scientific article published on 14 December 2011

A missense mutation in SLC33A1, which encodes the acetyl-CoA transporter, causes autosomal-dominant spastic paraplegia (SPG42)

scientific article

A novel deletion mutation in GJB1 causes X-linked Charcot-Marie-Tooth disease in a Han Chinese family

scientific article published on 01 December 2010

APRT: a versatile in vivo resident reporter of local mutation and loss of heterozygosity

scientific article published on 01 January 1996

Accelerated hepatocellular carcinoma development in CUL4B transgenic mice

scientific article

Adipose-derived mesenchymal stromal cells promote corneal wound healing by accelerating the clearance of neutrophils in cornea

scientific article published on 26 August 2020

Altered gene expression in kidneys of mice with 2,8-dihydroxyadenine nephrolithiasis

scientific article published on 01 August 2000

An osteopontin-integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells

scientific article published on February 2014

Artesunate sensitizes ovarian cancer cells to cisplatin by downregulating RAD51.

scientific article

Automatic Classification of Label-Free Cells from Small Cell Lung Cancer and Poorly Differentiated Lung Adenocarcinoma with 2D Light Scattering Static Cytometry and Machine Learning

scientific article published on 03 December 2018

Autophagy Contributes to the Maintenance of Genomic Integrity by Reducing Oxidative Stress

scientific article published on 25 August 2020

Berberine downregulates CDC6 and inhibits proliferation via targeting JAK-STAT3 signaling in keratinocytes

scientific article published on 20 March 2019

Berberine induces oxidative DNA damage and impairs homologous recombination repair in ovarian cancer cells to confer increased sensitivity to PARP inhibition

scientific article published on 5 October 2017

Berberine induces p53-dependent cell cycle arrest and apoptosis of human osteosarcoma cells by inflicting DNA damage

scientific article published on 31 December 2008

Berberine induces senescence of human glioblastoma cells by downregulating the EGFR-MEK-ERK signaling pathway.

scientific article published on 12 December 2014

Berberine radiosensitizes human esophageal cancer cells by downregulating homologous recombination repair protein RAD51

scientific article

Berberine, a genotoxic alkaloid, induces ATM-Chk1 mediated G2 arrest in prostate cancer cells ⬇️

scientific article published on April 26, 2012

Brief report: interferon-gamma induces expansion of Lin(-)Sca-1(+)C-Kit(+) Cells

scientific article published in January 2010

CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFα

scientific article

COVID-19 infection: the perspectives on immune responses

scientific article published on 23 March 2020

CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis

scientific article

CRL4B interacts with and coordinates the SIN3A-HDAC complex to repress CDKN1A and drive cell cycle progression

scientific article published on 4 September 2014

CUL4B activates Wnt/β-catenin signalling in hepatocellular carcinoma by repressing Wnt antagonists.

scientific article published on 23 January 2015

CUL4B contributes to cancer stemness by repressing tumor suppressor miR34a in colorectal cancer

scientific article published on 13 February 2020

CUL4B impedes stress-induced cellular senescence by dampening a p53-reactive oxygen species positive feedback loop

scientific article

CUL4B negatively regulates Toll-like receptor-triggered proinflammatory responses by repressing Pten transcription

scientific article published on 15 November 2019

CUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade.

scientific article published on 11 March 2013

Characterization of nuclear localization signal in the N terminus of CUL4B and its essential role in cyclin E degradation and cell cycle progression.

scientific article published on 02 October 2009

Chemokine receptor CXCR2 is transactivated by p53 and induces p38-mediated cellular senescence in response to DNA damage.

scientific article published on 8 September 2013

Chromosome instability contributes to loss of heterozygosity in mice lacking p53

scientific article

Cul4a promotes zebrafish primitive erythropoiesis via upregulating scl and gata1 expression

scientific article published on 17 May 2019

Differentiation of normal and leukemic cells by 2D light scattering label-free static cytometry

scientific article published on 01 September 2016

Disrupted mitochondrial homeostasis coupled with mitotic arrest generates antineoplastic oxidative stress

scientific article published on 12 November 2021

Dysregulation of the miR-194-CUL4B negative feedback loop drives tumorigenesis in non-small-cell lung carcinoma.

scientific article published on 6 February 2017

Embryonic stem cells and somatic cells differ in mutation frequency and type

scientific article

Emerging predictors of the response to the blockade of immune checkpoints in cancer therapy

scientific article published on 12 July 2018

Exome sequencing reveals a heterozygous DLX5 mutation in a Chinese family with autosomal-dominant split-hand/foot malformation.

scientific article

Fibrotic liver microenvironment promotes Dll4 and SDF-1-dependent T-cell lineage development

scientific article published on 05 June 2019

GSH-dependent antioxidant defense contributes to the acclimation of colon cancer cells to acidic microenvironment

scientific article published on 07 March 2016

HMGA2 overexpression-induced ovarian surface epithelial transformation is mediated through regulation of EMT genes

scientific article published on 11 January 2011

HSD11B1 is upregulated synergistically by IFNγ and TNFα and mediates TSG-6 expression in human UC-MSCs

scientific article published on 20 April 2020

Harnessing tumor-associated macrophages as aids for cancer immunotherapy

scientific article published on 05 December 2019

Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks

scientific article published on 24 April 2008

Human mesenchymal stem cells inhibit cancer cell proliferation by secreting DKK-1.

scientific article

IFNγ and TNFα synergistically induce apoptosis of mesenchymal stem/stromal cells via the induction of nitric oxide

scientific article published on 11 January 2019

IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-Dependent Anti-inflammatory Properties

scientific article published on 07 February 2019

Identification and functional analysis of a SLC33A1: c.339T>G (p.Ser113Arg) variant in the original SPG42 family

scientific article

Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases

scientific article published on 01 August 2018

In vivo loss of heterozygosity in T-cells of B6C3F1 Aprt(+/-) mice

scientific article

Increased oxidative stress mediates the antitumor effect of PARP inhibition in ovarian cancer.

scientific article published on 30 March 2018

Inhibition of DYRK1A-EGFR axis by p53-MDM2 cascade mediates the induction of cellular senescence

scientific article published on 25 March 2019

Ionizing radiation is a potent inducer of mitotic recombination in mouse embryonic stem cells

scientific article published on 23 July 2011

Irradiation induces cancer lung metastasis through activation of the cGAS-STING-CCL5 pathway in mesenchymal stromal cells

scientific article published on 07 May 2020

Isoliensinine induces apoptosis in triple-negative human breast cancer cells through ROS generation and p38 MAPK/JNK activation.

scientific article published on 29 July 2015

Label-free light-sheet microfluidic cytometry for the automatic identification of senescent cells.

scientific article

Lack of CUL4B in Adipocytes Promotes PPARγ-Mediated Adipose Tissue Expansion and Insulin Sensitivity.

scientific article published on 29 November 2016

Lack of CUL4B leads to increased abundance of GFAP-positive cells that is mediated by PTGDS in mouse brain.

scientific article

Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development

scientific article

Lack of interferon-γ receptor results in a microenvironment favorable for intestinal tumorigenesis

scientific article published on 07 June 2016

Lessons learned from the blockade of immune checkpoints in cancer immunotherapy.

scientific article published on 27 February 2018

Light-sheet-based 2D light scattering cytometry for label-free characterization of senescent cells.

scientific article

Localization of group IIc low molecular weight phospholipase A2 mRNA to meiotic cells in the mouse

scientific article published in March 1997

Loss of heterozygosity and point mutation at Aprt locus in T cells and fibroblasts of Pms2-/- mice

scientific article published on 01 April 2002

Lung mesenchymal stromal cells influenced by Th2 cytokines mobilize neutrophils and facilitate metastasis by producing complement C3

scientific article published on 27 October 2021

MIF produced by bone marrow-derived macrophages contributes to teratoma progression after embryonic stem cell transplantation

scientific article published on 29 March 2012

MYC-regulated pseudogene HMGA1P6 promotes ovarian cancer malignancy via augmenting the oncogenic HMGA1/2

scientific article published on 03 March 2020

Macrophages inhibit adipogenic differentiation of adipose tissue derived mesenchymal stem/stromal cells by producing pro-inflammatory cytokines

scientific article published on 20 July 2020

Mesenchymal stem/stromal cells induce the generation of novel IL-10-dependent regulatory dendritic cells by SOCS3 activation.

scientific article published on 2 July 2012

Mesenchymal stromal cells pretreated with pro-inflammatory cytokines promote skin wound healing through VEGFC-mediated angiogenesis

scientific article published on 13 June 2020

Metadherin enhances the invasiveness of breast cancer cells by inducing epithelial to mesenchymal transition.

scientific article published on 5 April 2011

MiR-182 overexpression in tumourigenesis of high-grade serous ovarian carcinoma.

scientific article

Mitotic recombination is suppressed by chromosomal divergence in hybrids of distantly related mouse strains

scientific article published on 01 June 2001

Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous mice.

scientific article published on August 1999

Mlh1 mediates tissue-specific regulation of mitotic recombination

scientific journal article

Modulation of DNA end joining by nuclear proteins

scientific article

Mutagenesis in vivo in T cells of p21-deficient mice

scientific article published on 08 September 2009

Mutation in CUL4B, which encodes a member of cullin-RING ubiquitin ligase complex, causes X-linked mental retardation

scientific article

NANOG has a role in mesenchymal stem cells' immunomodulatory effect

scientific article published on 26 February 2011

Neferine induces autophagy of human ovarian cancer cells via p38 MAPK/ JNK activation.

scientific article published on 7 January 2016

Neferine, an alkaloid ingredient in lotus seed embryo, inhibits proliferation of human osteosarcoma cells by promoting p38 MAPK-mediated p21 stabilization.

scientific article published on 29 December 2011

Oxidative stress preferentially induces a subtype of micronuclei and mediates the genomic instability caused by p53 dysfunction

scientific article

Oxidative stress-induced miRNAs modulate AKT signaling and promote cellular senescence in uterine leiomyoma

scientific article published on 10 August 2018

Pan-senescence transcriptome analysis identified RRAD as a marker and negative regulator of cellular senescence

scientific article published on 02 November 2018

Prdx1 deficiency in mice promotes tissue specific loss of heterozygosity mediated by deficiency in DNA repair and increased oxidative stress

scientific article

Prenatal diagnosis of autosomal dominant hereditary spastic paraplegia (SPG42) caused by SLC33A1 mutation in a Chinese kindred.

scientific article

Radiation-induced genetic instability in vivo depends on p53 status

scientific article published on 01 May 2002

Recurrence of the D100N mutation in a Chinese family with brachydactyly type A1: evidence for a mutational hot spot in the Indian hedgehog gene

scientific article published on 01 June 2007

Reduced apoptosis and increased deletion mutations at Aprt locus in vivo in mice exposed to repeated ionizing radiation

scientific article published on 01 March 2007

Replication stress induces micronuclei comprising of aggregated DNA double-strand breaks

scientific article

Resveratrol augments the canonical Wnt signaling pathway in promoting osteoblastic differentiation of multipotent mesenchymal cells.

scientific article

Resveratrol modulates angiogenesis through the GSK3β/β-catenin/TCF-dependent pathway in human endothelial cells

scientific article published on 7 August 2010

Resveratrol sequentially induces replication and oxidative stresses to drive p53-CXCR2 mediated cellular senescence in cancer cells.

scientific article

Role of the mismatch repair gene, Msh6, in suppressing genome instability and radiation-induced mutations

scientific article published on 30 April 2008

S113R mutation in SLC33A1 leads to neurodegeneration and augmented BMP signaling in a mouse model

scientific article

STC2 overexpression mediated by HMGA2 is a biomarker for aggressiveness of high-grade serous ovarian cancer.

scientific article

Sequential analysis of kidney stone formation in the Aprt knockout mouse

scientific article

Serum withdrawal up-regulates human SIRT1 gene expression in a p53-dependent manner.

scientific article published in October 2009

Skeletal muscle stem cells confer maturing macrophages anti-inflammatory properties through insulin-like growth factor-2

scientific article published on 16 March 2020

Small scale genetic alterations contribute to increased mutability at the X-linked Hprt locus in vivo in Blm hypomorphic mice

scientific article published on 17 March 2010

Somatic recombination redux.

scientific article

Specific deletion of TRAF3 in B lymphocytes leads to B-lymphoma development in mice.

scientific article

Splicing factor USP39 promotes ovarian cancer malignancy through maintaining efficient splicing of oncogenic HMGA2

scientific article published on 17 March 2021

The CUL4B/AKT/β-Catenin Axis Restricts the Accumulation of Myeloid-Derived Suppressor Cells to Prohibit the Establishment of a Tumor-Permissive Microenvironment.

scientific article

The critical role of T cells in glucocorticoid-induced osteoporosis

scientific article published on 14 December 2020

The tango of ROS and p53 in tissue stem cells.

scientific article published on 27 February 2018

Tumor resident mesenchymal stromal cells endow naïve stromal cells with tumor-promoting properties

scientific article published on 30 September 2013

Upregulation of IL-6 in CUL4B-deficient myeloid-derived suppressive cells increases the aggressiveness of cancer cells

scientific article published on 24 June 2019

Whole-exome sequencing identifies a variant in TMEM132E causing autosomal-recessive nonsyndromic hearing loss DFNB99.

scientific article published on 28 November 2014

X-linked intellectual disability gene CUL4B targets Jab1/CSN5 for degradation and regulates bone morphogenetic protein signaling

scientific article

X-rays induce distinct patterns of somatic mutation in fetal versus adult hematopoietic cells

scientific article

Zebrafish cul4a, but not cul4b, modulates cardiac and forelimb development by upregulating tbx5a expression.

scientific article published on 30 September 2014

miR-106a represses the Rb tumor suppressor p130 to regulate cellular proliferation and differentiation in high-grade serous ovarian carcinoma.

scientific article published on 17 September 2013

miR-130a upregulates mTOR pathway by targeting TSC1 and is transactivated by NF-κB in high-grade serous ovarian carcinoma

scientific article published on 11 August 2017

miR-17-5p and miR-106a are involved in the balance between osteogenic and adipogenic differentiation of adipose-derived mesenchymal stem cells

scientific article published on 3 December 2012

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