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List of works by John M. Luk

96 weeks combination of adefovir dipivoxil plus emtricitabine vs. adefovir dipivoxil monotherapy in the treatment of chronic hepatitis B.

scientific article

A protein-based set of reference markers for liver tissues and hepatocellular carcinoma

scientific article published on 2 September 2009

AXL receptor kinase is a mediator of YAP-dependent oncogenic functions in hepatocellular carcinoma.

scientific article published on 15 November 2010

Acrosome-specific gene AEP1: identification, characterization and roles in spermatogenesis

scientific journal article

Activation of interleukin-6-induced glycoprotein 130/signal transducer and activator of transcription 3 pathway in mesenchymal stem cells enhances hepatic differentiation, proliferation, and liver regeneration

scientific article published on October 2010

Altered E-cadherin expression and p120 catenin localization in esophageal squamous cell carcinoma

scientific article published on 24 July 2007

An alternative DNA damage pathway to apoptosis in hematological cancers

scientific article

An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer

scientific article

An update on targeting Hippo-YAP signaling in liver cancer

scientific article published on 16 February 2012

Applicability of intraoperative parathyroid hormone assay during thyroidectomy

scientific article published on 01 November 2002

Applicability of tissue aspirate for quick parathyroid hormone assay to confirm parathyroid tissue identity during parathyroidectomy for primary hyperparathyroidism.

scientific article

Artificial neural networks and decision tree model analysis of liver cancer proteomes.

scientific article published on 10 July 2007

Association of mortalin (HSPA9) with liver cancer metastasis and prediction for early tumor recurrence.

scientific article

Biomarkers for early detection of liver cancer: focus on clinical evaluation.

scientific article published on January 2009

Biotinylated lipopolysaccharide binds to endotoxin receptor in endothelial and monocytic cells

scientific article published in December 1995

Blockage of testicular connexins induced apoptosis in rat seminiferous epithelium.

scientific article

CDX2 co-localizes with liver-intestine cadherin in intestinal metaplasia and adenocarcinoma of the stomach

scientific article published on 01 April 2005

Celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade in vitro and in vivo

scientific article published on 27 February 2012

Changes in liver histology as a "surrogate" end point of antiviral therapy for chronic HBV can predict progression to liver complications

scientific article

Characterization of an acrosome protein VAD1.2/AEP2 which is differentially expressed in spermatogenesis

scientific journal article

Characterization of two novel LPS-binding sites in leukocyte integrin betaA domain

scientific article published on 23 May 2007

Circulating Lamin B1 (LMNB1) biomarker detects early stages of liver cancer in patients

scientific article published on 01 January 2010

Circulating markers for prognosis of hepatocellular carcinoma ⬇️

scientific article published on 06 May 2013

Circulating miR-15b and miR-130b in serum as potential markers for detecting hepatocellular carcinoma: a retrospective cohort study ⬇️

scientific article published on March 8, 2012

Circulating mortalin autoantibody--a new serological marker of liver cirrhosis

scientific article published on 24 April 2015

Clinical correlation of nuclear survivin in esophageal squamous cell carcinoma.

scientific article

Clinical significance of SOD2 and GSTP1 gene polymorphisms in Chinese patients with gastric cancer

scientific article published on 19 April 2012

Clinicopathologic and gene expression parameters predict liver cancer prognosis.

scientific article

Clinicopathological and prognostic significance of serum and tissue Dickkopf-1 levels in human hepatocellular carcinoma.

scientific article published on 4 August 2011

Clinicopathological roles of alterations of tumor suppressor gene p16 in papillary thyroid carcinoma

scientific article published on 31 December 2006

Comparative proteomic analysis of mouse livers from embryo to adult reveals an association with progression of hepatocellular carcinoma

scientific article

Comparison of real-time PCR assays for monitoring serum hepatitis B virus DNA levels during antiviral therapy

scientific article

Cytoplasmic Forkhead box M1 (FoxM1) in esophageal squamous cell carcinoma significantly correlates with pathological disease stage

scientific article published on January 2012

DLK1-DIO3 Genomic Imprinted MicroRNA Cluster at 14q32.2 Defines a Stemlike Subtype of Hepatocellular Carcinoma Associated with Poor Survival ⬇️

scientific article (publication date: 2 September 2011)

Deregulation of E-cadherin-catenin complex in precancerous lesions of gastric adenocarcinoma.

scientific article

Dickkopf 4 (DKK4) acts on Wnt/β-catenin pathway by influencing β-catenin in hepatocellular carcinoma ⬇️

scientific article published on January 16, 2012

Different testicular gene expression patterns in the first spermatogenic cycle of postnatal and vitamin A-deficient rat testis

scientific article

Differential suppression by Tripterygium wilfordii extracts (traditional Chinese medicine) in the allogeneic rat mixed lymphocyte reaction

scientific article published on 01 November 2000

Discovery of lamin B1 and vimentin as circulating biomarkers for early hepatocellular carcinoma.

scientific article

Dysregulated expression of dickkopfs for potential detection of hepatocellular carcinoma.

scientific article published on 09 May 2014

Efficient production of mouse and rat monoclonal antibodies against the O antigens of Salmonella serogroup C1, using LPS-coated bacteria as immunogen

scientific article published in May 1990

Embryotrophic factor-3 from human oviductal cells affects the messenger RNA expression of mouse blastocyst.

scientific article published on February 2003

Embryotrophic factor-3 from human oviductal cells enhances proliferation, suppresses apoptosis and stimulates the expression of the beta1 subunit of sodium-potassium ATPase in mouse embryos.

scientific article published on 30 September 2004

Enhanced detection of early hepatocellular carcinoma by serum SELDI-TOF proteomic signature combined with alpha-fetoprotein marker.

scientific article

Expression of hepatocyte-like phenotypes in bone marrow stromal cells after HGF induction

scientific article published in July 2004

Fibrosis progression in chronic hepatitis C patients with occult hepatitis B co-infection

scientific article published on 15 August 2005

Gene signatures derived from a c-MET-driven liver cancer mouse model predict survival of patients with hepatocellular carcinoma

scientific article (publication date: 2011)

Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma

scientific article published on 27 May 2012

Genomic and proteomic biomarkers for diagnosis and prognosis of hepatocellular carcinoma

scientific article published on 01 August 2007

Global regulation on microRNA in hepatitis B virus-associated hepatocellular carcinoma

scientific article published on 14 February 2011

HNF1α and CDX2 transcriptional factors bind to cadherin-17 (CDH17) gene promoter and modulate its expression in hepatocellular carcinoma

scientific article published on 01 October 2010

Hepatic potential of bone marrow stromal cells: development of in vitro co-culture and intra-portal transplantation models

scientific article

Hepatic stellate cell-targeted delivery of M6P-HSA-glycyrrhetinic acid attenuates hepatic fibrogenesis in a bile duct ligation rat model.

scientific article published on May 2007

Hepatic tight junctions: from viral entry to cancer metastasis

scientific article published on January 2010

Hepatocyte growth factor promotes cancer cell migration and angiogenic factors expression: a prognostic marker of human esophageal squamous cell carcinomas

scientific article published on 01 September 2005

High prevalence of cyclooxygenase 2 expression in papillary thyroid carcinoma

scientific article published on 01 April 2005

Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

scientific article

Identification of liver-intestine cadherin in hepatocellular carcinoma--a potential disease marker.

scientific article published on November 2003

Identification of novel genes expressed during spermatogenesis in stage-synchronized rat testes by differential display

scientific article published in August 2003

Immunochemical characterization of the functional constituents of Tripterygium wilfordii contributing to its anti-inflammatory property

scientific article published in January 2008

Immunosuppressive effects of Tripterygium wilfordii polysaccharide on LPS-stimulated human monocytes.

scientific article

In situ gene transfer into rat auxiliary liver transplant.

scientific article published in December 1997

Increased expression of vascular endothelial growth factor C in papillary thyroid carcinoma correlates with cervical lymph node metastases

scientific article published on 01 November 2005

Increased solubility of integrin betaA domain using maltose-binding protein as a fusion tag

scientific article published on 01 January 2006

Induction of mutant p53-dependent apoptosis in human hepatocellular carcinoma by targeting stress protein mortalin.

scientific article published on 4 March 2011

Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo

scientific article

Interleukin 17A promotes hepatocellular carcinoma metastasis via NF-kB induced matrix metalloproteinases 2 and 9 expression.

scientific article

Interleukin 23 promotes hepatocellular carcinoma metastasis via NF-kappa B induced matrix metalloproteinase 9 expression

scientific article

Intracellular levels of hepatitis B virus DNA and pregenomic RNA in peripheral blood mononuclear cells of chronically infected patients

scientific article published on 26 September 2008

Kinetics and risk of de novo hepatitis B infection in HBsAg-negative patients undergoing cytotoxic chemotherapy

scientific article published on 01 July 2006

Laparoscopic surgery induced interleukin-6 levels in serum and gut mucosa: implications of peritoneum integrity and gas factors.

scientific article

Liver as an ideal target for gene therapy: expression of CTLA4Ig by retroviral gene transfer

scientific article

Long-term liver allograft survival induced by combined treatment with rAAV-hCTLA4Ig gene transfer and low-dose FK506.

scientific article published in February 2003

Macrophage migration inhibitory factor expression correlates with inflammatory changes in human chronic hepatitis B infection.

scientific article published in June 2005

MicroRNA-375 targets Hippo-signaling effector YAP in liver cancer and inhibits tumor properties.

scientific article

Minimally invasive endoscopic-assisted parathyroidectomy for primary hyperparathyroidism

scientific article published on 28 October 2003

Molecular biology of gastric carcinoma: from laboratory to bedside.

scientific article

Monoclonal antibodies as targeting and therapeutic agents: prospects for liver transplantation, hepatitis and hepatocellular carcinoma.

scientific article

Mortalin-p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy

scientific article

Mutations in the tight-junction gene claudin 19 (CLDN19) are associated with renal magnesium wasting, renal failure, and severe ocular involvement

scientific article

Natural history of patients with recurrent chronic hepatitis C virus and occult hepatitis B co-infection after liver transplantation

scientific article published in July 2006

Oesophageal basaloid squamous cell carcinoma: a unique clinicopathological entity with telomerase activity as a prognostic indicator

scientific article published on 01 November 2001

Oncofetal gene SALL4 in aggressive hepatocellular carcinoma

scientific article

Oncoproteomics of hepatocellular carcinoma: from cancer markers' discovery to functional pathways.

scientific article

Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers

scientific article published in August 2012

Over-expression of inducible heat shock protein 70 in the gastric mucosa of partially sleep-deprived rats

scientific article

Overexpression of LI-cadherin in gastric cancer is associated with lymph node metastasis.

scientific article

Overexpression of Yes-associated protein confers doxorubicin resistance in hepatocellullar carcinoma ⬇️

scientific article published on December 10, 2012

Predicting prognosis in hepatocellular carcinoma after curative surgery with common clinicopathologic parameters.

scientific article

Predictive genes in adjacent normal tissue are preferentially altered by sCNV during tumorigenesis in liver cancer and may rate limiting

scientific article (publication date: 2011)

Preimplantation embryos cooperate with oviductal cells to produce embryotrophic inactivated complement-3b

scientific article published on 26 November 2007

Prognostic marker microRNA-125b inhibits tumorigenic properties of hepatocellular carcinoma cells via suppressing tumorigenic molecule eIF5A2.

scientific article published on 9 May 2014

Prognostic significance and therapeutic potential of eukaryotic translation initiation factor 5A (eIF5A) in hepatocellular carcinoma.

scientific article published on August 2010

Prognostic significance of phosphorylated RON in esophageal squamous cell carcinoma.

scientific article published on 16 November 2011

Proteomic expression signature distinguishes cancerous and nonmalignant tissues in hepatocellular carcinoma

scientific article

Proteomic identification of a monoclonal antibody recognizing caveolin-1 in hepatocellular carcinoma with metastatic potential.

scientific article

Proteomic profiling of hepatocellular carcinoma in Chinese cohort reveals heat-shock proteins (Hsp27, Hsp70, GRP78) up-regulation and their associated prognostic values

scientific article published in February 2006

Proteomics of Hepatocellular Carcinoma in Chinese Patients ⬇️

scientific article published on February 24, 2011

Quantitative analysis of the expression of TGF-alpha and EGFR in papillary thyroid carcinoma: clinicopathological relevance

scientific article

Rapid and sensitive detection of Salmonella (O:6,7) by immunomagnetic monoclonal antibody-based assays

scientific article published in March 1991

Recombinant adeno-associated virus vector: Is it ideal for gene delivery in liver transplantation?

scientific article published in April 2003

Reduced expression of chemokine receptors on peripheral blood lymphocytes in patients with hepatocellular carcinoma

scientific article published in June 2004

Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer

article

Regulators of mammalian Hippo pathway in cancer ⬇️

scientific article published on 07 June 2012

Regulatory role of vHL/HIF-1alpha in hypoxia-induced VEGF production in hepatic stellate cells.

scientific article published on April 2004

Serum adiponectin is increased in advancing liver fibrosis and declines with reduction in fibrosis in chronic hepatitis B.

scientific article

Serum soluble E-cadherin is a potential prognostic marker in esophageal squamous cell carcinoma

scientific article published on 30 August 2010

Serum vascular endothelial growth factor C correlates with lymph node metastases and high-risk tumor profiles in papillary thyroid carcinoma

scientific article

Signaling mechanisms of pertussis toxin-induced myelomonocytic cell adhesion: role of tyrosine phosphorylation

scientific article published on 01 July 1997

Sp1 site is crucial for the mouse claudin-19 gene expression in the kidney cells

scientific journal article

Specificity of monoclonal antibodies binding to the polysaccharide antigens (Vi, O9) of Salmonella typhi

scientific article published in October 1992

Suppression of cytokine production and cell adhesion molecule expression in human monocytic cell line THP-1 by Tripterygium wilfordii polysaccharide moiety.

scientific article published on January 2000

TNP-470 blockage of VEGF synthesis is dependent on MAPK/COX-2 signaling pathway in PDGF-BB-activated hepatic stellate cells.

scientific article published on 9 January 2006

Targeting Hippo pathway by specific interruption of YAP-TEAD interaction using cyclic YAP-like peptides

scientific article

Targeting cadherin-17 inactivates Wnt signaling and inhibits tumor growth in liver carcinoma

scientific article published in November 2009

Telomerase activity in small cell esophageal carcinoma

scientific article published on 01 January 2001

Telomerase activity in thyroid malignancy

scientific article published on 01 December 1999

The "3Ps" world--from disease markers to biological therapeutics

scientific article

The embryotrophic activity of oviductal cell-derived complement C3b and iC3b, a novel function of complement protein in reproduction.

scientific article

The gene expression of adrenomedullin, calcitonin-receptor-like receptor and receptor activity modifying proteins (RAMPs) in CCl4-induced rat liver cirrhosis

scientific article published on 19 May 2006

The healing effects of Centella extract and asiaticoside on acetic acid induced gastric ulcers in rats

scientific article published in March 2004

The kringle 1 domain of hepatocyte growth factor has antiangiogenic and antitumor cell effects on hepatocellular carcinoma.

scientific article published in January 2008

The potential clinical relevance of serum vascular endothelial growth factor (VEGF) and VEGF-C in recurrent papillary thyroid carcinoma

scientific article published on 01 December 2008

The use of small peptides in the diagnosis and treatment of hepatocellular carcinoma.

scientific article published on January 2009

Toward the proteomic identification of biomarkers for the prediction of HBV related hepatocellular carcinoma

scientific article

Traditional Chinese herbal medicines for treatment of liver fibrosis and cancer: from laboratory discovery to clinical evaluation.

scientific article published on September 2007

Tripterygium wilfordii bioactive compounds as anticancer and anti-inflammatory agents.

scientific article published on March 2012

Two-tiered approach identifies a network of cancer and liver disease-related genes regulated by miR-122.

scientific article

Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma

scientific article published on 20 June 2013

miR-122 targets pyruvate kinase M2 and affects metabolism of hepatocellular carcinoma

scientific article published on 23 January 2014

microRNA-122 as a regulator of mitochondrial metabolic gene network in hepatocellular carcinoma

scientific article

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