List of works - Hideo Kigoshi

6-Amidopyrene as a label-assisted laser desorption/ionization (LA-LDI) enhancing tag: development of photoaffinity pyrene derivative.

scientific article published on 15 December 2015

A wrench-shaped synthetic molecule that modulates a transcription factor-coactivator interaction.

scientific article

Analysis of the aplyronine A-induced protein-protein interaction between actin and tubulin by surface plasmon resonance.

scientific article published on 24 April 2016

Anti-inflammatory marine cyclic peptide stylissatin A and its derivatives inhibit differentiation of murine preadipocytes

scientific article published on 01 May 2019

Aplaminal: a novel cytotoxic aminal isolated from the sea hare Aplysia kurodai

scientific article published on 10 January 2008

Aplyronine A, a potent antitumour macrolide of marine origin, and the congeners aplyronines B-H: chemistry and biology.

scientific article published on January 2009

Aplysiasecosterol A: A 9,11-Secosteroid with an Unprecedented Tricyclic γ-Diketone Structure from the Sea Hare Aplysia kurodai

scientific article published on 29 April 2015

Apoptosis-inducing activity of the actin-depolymerizing agent aplyronine A and its side-chain derivatives

scientific article

Aurisides A and B, Cytotoxic Macrolide Glycosides from the Japanese Sea Hare Dolabella auricularia

scientific article published on 01 December 1996

Binding position analysis of target proteins with the use of amidopyrene probes as LA-LDI enhancing tags.

scientific article

Construction of the [6-7-5-5] tetracyclic core of all the carbocyclic frameworks of yuzurimine-type alkaloids

scientific article published on 22 June 2015

Cyclohaliclonamines A-E: dimeric, trimeric, tetrameric, pentameric, and hexameric 3-alkyl pyridinium alkaloids from a marine sponge Haliclona sp.

scientific article published in January 2006

Cytotoxic substances from two species of Japanese sea hares: chemistry and bioactivity

scientific article

Design, synthesis, and biological evaluation of the analogues of glaziovianin A, a potent antitumor isoflavone.

scientific article published on 16 August 2012

Design, synthesis, and biological evaluations of aplyronine A-mycalolide B hybrid compound

scientific article published on 22 February 2012

Development of a novel inducer of protein-protein interactions based on aplyronine A

scientific article published on 01 August 2018

Development of highly cytotoxic and actin-depolymerizing biotin derivatives of aplyronine A

scientific article published on 27 September 2011

Development of photoaffinity derivatives of the antitumor macrolide aplyronine A, a PPI-inducer between actin and tubulin.

scientific article published on 4 October 2017

Discovery of 1-oxa-4,9-diazaspiro[5.5]undecane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase inhibitors and orally active drug candidates for treating of chronic kidney diseases

scientific article published on 10 December 2013

Discovery of G Protein-Biased EP2 Receptor Agonists.

scientific article published on 4 January 2016

Discovery of O6-benzyl glaziovianin A, a potent cytotoxic substance and a potent inhibitor of α,β-tubulin polymerization

scientific article published on 13 September 2016

Enantioselective synthesis of 15-epi-haterumalide NA methyl ester and revised structure of haterumalide NA

scientific article published on 01 March 2003

Formal synthesis of optically active ingenol via ring-closing olefin metathesis

scientific article published on 01 November 2004

Glaziovianin A prevents endosome maturation via inhibiting microtubule dynamics.

scientific article

Inhibition of microtubule assembly by a complex of actin and antitumor macrolide aplyronine A.

scientific article published on 21 November 2013

Interactions of the antitumor macrolide aplyronine A with actin and actin-related proteins established by its versatile photoaffinity derivatives

scientific article published on 06 December 2012

Isolation and Synthesis of Azuriaplysins A and B, Bromoditerpenes with an α-Methylene Carbonyl from the Sea Hare <i>Aplysia kurodai</i>

scientific article published on 14 July 2022

Isolation and structure of korolkoside, a bis-iridoid glucoside from Lonicera korolkovii

scientific article (publication date: August 2001)

Isotheasaponins B1-B3 from Camellia sinensis var. sinensis tea leaves

scientific article published on 30 June 2006

Marine natural product aurilide activates the OPA1-mediated apoptosis by binding to prohibitin

scientific article

Marine natural products that interfere with multiple cytoskeletal protein interactions.

scientific article

New Cytotoxic Norditerpenes from the Australian Nudibranchs Goniobranchus Splendidus and Goniobranchus Daphne

article

Quantitative analysis of saponins in a tea-leaf extract and their antihypercholesterolemic activity.

scientific article published on 7 July 2009

Reproduction of progressive retinal degeneration (bright blindness) in sheep by administration of ptaquiloside contained in bracken

scientific article published on 01 December 1993

Second-generation total synthesis of aplyronine A featuring Ni/Cr-mediated coupling reactions

scientific article published on 01 December 2016

Second-generation total synthesis of haterumalide NA using B-alkyl Suzuki-Miyaura coupling

scientific article published on 09 April 2008

Separation of carcinogenic fraction of bracken fern.

scientific article

Specific protein-labeling and ligand-binding position analysis with amidopyrene probes as LDI MS tags

scientific article published on 01 October 2018

Stereocontrolled total synthesis (-)-picrotoxinin and (+)-coriamyrtin via a common isotwistane intermediate

scientific article published in 1984

Stereocontrolled total synthesis of (+)-tutin and (+)-asteromurin a, toxic picrotoxane sesquiterpenes

article

Stereocontrolled total synthesis of (+)-tutin, a toxic sesquiterpene of picrotoxane-type

article

Structure basis for antitumor effect of aplyronine a.

scientific article published on 27 December 2005

Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells

scientific article published on August 2010

Studies on Pteridium aquilinum var. latiusculum, IV. Isolation of three p-hydroxystyrene glycosides and an efficient method for the isolation of ptaquiloside, an unstable bracken carcinogen.

scientific article

Study of the interaction between actin and antitumor substance aplyronine A with a novel fluorescent photoaffinity probe

scientific article published in March 2006

Synthesis and cytotoxicity of aurilide analogs

scientific article published on 14 June 2008

Synthesis and structure-activity relationships for cytotoxicity and apoptosis-inducing activity of (+)-halichonine B.

scientific article published on 19 August 2015

Synthesis of actin-depolymerizing compounds.

scientific article published on 21 February 2009

Synthesis of ustalic acid, an inhibitor of Na+,K+-ATPase

Synthetic studies toward 13-oxyingenol: construction of the fully substituted tetracyclic compound

scientific article published on 29 March 2011

The γ-tubulin-specific inhibitor gatastatin reveals temporal requirements of microtubule nucleation during the cell cycle.

scientific article published on 27 October 2015

Total Synthesis of Biselide E, a Marine Polyketide

scientific article published on 11 October 2017

Total Synthesis of Mycalolides A and B through Olefin Metathesis

scientific article published on 09 October 2015

Total synthesis and cytotoxicity of haterumalides NA and B and their artificial analogues

scientific article published on 01 May 2009

Total synthesis of (-)-13-oxyingenol and its natural derivative

scientific article published on 05 April 2012

Total synthesis of natural derivatives and artificial analogs of 13-oxyingenol and their biological evaluation.

scientific article published on 22 November 2016

Toward the Synthesis of Yuzurimine-Type Alkaloids: Stereoselective Construction of the Heterocyclic Portions of Deoxyyuzurimine and Macrodaphnine

scientific article published on 30 July 2019

Toward the second generation synthesis of aplyronine A: stereocontrolled assembly of the C1-C19 segment by using an asymmetric Nozaki-Hiyama-Kishi coupling

scientific article published on 26 January 2011

List of works by Hideo Kigoshi

6-Amidopyrene as a label-assisted laser desorption/ionization (LA-LDI) enhancing tag: development of photoaffinity pyrene derivative.

A wrench-shaped synthetic molecule that modulates a transcription factor-coactivator interaction.

Analysis of the aplyronine A-induced protein-protein interaction between actin and tubulin by surface plasmon resonance.

Anti-inflammatory marine cyclic peptide stylissatin A and its derivatives inhibit differentiation of murine preadipocytes

Aplaminal: a novel cytotoxic aminal isolated from the sea hare Aplysia kurodai

Aplyronine A, a potent antitumour macrolide of marine origin, and the congeners aplyronines B-H: chemistry and biology.

Aplysiasecosterol A: A 9,11-Secosteroid with an Unprecedented Tricyclic γ-Diketone Structure from the Sea Hare Aplysia kurodai

Apoptosis-inducing activity of the actin-depolymerizing agent aplyronine A and its side-chain derivatives

Aurisides A and B, Cytotoxic Macrolide Glycosides from the Japanese Sea Hare Dolabella auricularia

Binding position analysis of target proteins with the use of amidopyrene probes as LA-LDI enhancing tags.

Construction of the [6-7-5-5] tetracyclic core of all the carbocyclic frameworks of yuzurimine-type alkaloids

Cyclohaliclonamines A-E: dimeric, trimeric, tetrameric, pentameric, and hexameric 3-alkyl pyridinium alkaloids from a marine sponge Haliclona sp.

Cytotoxic substances from two species of Japanese sea hares: chemistry and bioactivity

Design, synthesis, and biological evaluation of the analogues of glaziovianin A, a potent antitumor isoflavone.

Design, synthesis, and biological evaluations of aplyronine A-mycalolide B hybrid compound

Development of a novel inducer of protein-protein interactions based on aplyronine A

Development of highly cytotoxic and actin-depolymerizing biotin derivatives of aplyronine A

Development of photoaffinity derivatives of the antitumor macrolide aplyronine A, a PPI-inducer between actin and tubulin.

Discovery of 1-oxa-4,9-diazaspiro[5.5]undecane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase inhibitors and orally active drug candidates for treating of chronic kidney diseases

Discovery of G Protein-Biased EP2 Receptor Agonists.

Discovery of O6-benzyl glaziovianin A, a potent cytotoxic substance and a potent inhibitor of α,β-tubulin polymerization

Enantioselective synthesis of 15-epi-haterumalide NA methyl ester and revised structure of haterumalide NA

Formal synthesis of optically active ingenol via ring-closing olefin metathesis

Glaziovianin A prevents endosome maturation via inhibiting microtubule dynamics.

Inhibition of microtubule assembly by a complex of actin and antitumor macrolide aplyronine A.

Interactions of the antitumor macrolide aplyronine A with actin and actin-related proteins established by its versatile photoaffinity derivatives

Isolation and Synthesis of Azuriaplysins A and B, Bromoditerpenes with an α-Methylene Carbonyl from the Sea Hare <i>Aplysia kurodai</i>

Isolation and structure of korolkoside, a bis-iridoid glucoside from Lonicera korolkovii

Isotheasaponins B1-B3 from Camellia sinensis var. sinensis tea leaves

Marine natural product aurilide activates the OPA1-mediated apoptosis by binding to prohibitin

Marine natural products that interfere with multiple cytoskeletal protein interactions.

New Cytotoxic Norditerpenes from the Australian Nudibranchs Goniobranchus Splendidus and Goniobranchus Daphne

Quantitative analysis of saponins in a tea-leaf extract and their antihypercholesterolemic activity.

Reproduction of progressive retinal degeneration (bright blindness) in sheep by administration of ptaquiloside contained in bracken

Second-generation total synthesis of aplyronine A featuring Ni/Cr-mediated coupling reactions

Second-generation total synthesis of haterumalide NA using B-alkyl Suzuki-Miyaura coupling

Separation of carcinogenic fraction of bracken fern.

Specific protein-labeling and ligand-binding position analysis with amidopyrene probes as LDI MS tags

Stereocontrolled total synthesis (-)-picrotoxinin and (+)-coriamyrtin via a common isotwistane intermediate

Stereocontrolled total synthesis of (+)-tutin and (+)-asteromurin a, toxic picrotoxane sesquiterpenes

Stereocontrolled total synthesis of (+)-tutin, a toxic sesquiterpene of picrotoxane-type

Structure basis for antitumor effect of aplyronine a.

Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells

Studies on Pteridium aquilinum var. latiusculum, IV. Isolation of three p-hydroxystyrene glycosides and an efficient method for the isolation of ptaquiloside, an unstable bracken carcinogen.

Study of the interaction between actin and antitumor substance aplyronine A with a novel fluorescent photoaffinity probe

Synthesis and cytotoxicity of aurilide analogs

Synthesis and structure-activity relationships for cytotoxicity and apoptosis-inducing activity of (+)-halichonine B.

Synthesis of actin-depolymerizing compounds.

Synthesis of ustalic acid, an inhibitor of Na+,K+-ATPase

Synthetic studies toward 13-oxyingenol: construction of the fully substituted tetracyclic compound

The γ-tubulin-specific inhibitor gatastatin reveals temporal requirements of microtubule nucleation during the cell cycle.

Total Synthesis of Biselide E, a Marine Polyketide

Total Synthesis of Mycalolides A and B through Olefin Metathesis

Total synthesis and cytotoxicity of haterumalides NA and B and their artificial analogues

Total synthesis of (-)-13-oxyingenol and its natural derivative

Total synthesis of natural derivatives and artificial analogs of 13-oxyingenol and their biological evaluation.

Toward the Synthesis of Yuzurimine-Type Alkaloids: Stereoselective Construction of the Heterocyclic Portions of Deoxyyuzurimine and Macrodaphnine

Toward the second generation synthesis of aplyronine A: stereocontrolled assembly of the C1-C19 segment by using an asymmetric Nozaki-Hiyama-Kishi coupling