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List of works by Takeo Usui

4-isoavenaciolide covalently binds and inhibits VHR, a dual-specificity phosphatase.

scientific article published in August 2002

A K-252a-resistance gene, sks1+, encodes a protein similar to the Caenorhabditis elegans F37 A4.5 gene product and confers multidrug resistance in Schizosaccharomyces pombe

scientific article

A novel action of terpendole E on the motor activity of mitotic Kinesin Eg5.

scientific article published in February 2003

Actin- and microtubule-targeting bioprobes: their binding sites and inhibitory mechanisms.

scientific article published on 7 February 2007

Amphidinolide h, a potent cytotoxic macrolide, covalently binds on actin subdomain 4 and stabilizes actin filament.

scientific article published in September 2004

Antiproliferating activity of the mitotic inhibitor pironetin against vindesine- and paclitaxel-resistant human small cell lung cancer H69 cells.

scientific article

Apoptosis induction via microtubule disassembly by an antitumour compound, pironetin.

scientific article published on June 1999

Application of proteomic profiling based on 2D-DIGE for classification of compounds according to the mechanism of action

scientific article published in May 2010

Bafilomycin L, a new inhibitor of cholesteryl ester synthesis in mammalian cells, produced by marine-derived Streptomyces sp. OPMA00072. ⬇️

scientific article published on 6 August 2014

Biochemical Differences between Staurosporine-Induced Apoptosis and Premature Mitosis

scientific article published on 01 May 1997

Bitungolides A-F, new polyketides from the Indonesian sponge Theonella cf. swinhoei

scientific article

Cell cycle arrest and antitumor activity of pironetin and its derivatives

scientific article published on 01 April 1998

Chemical modification of reveromycin A and its biological activities.

scientific article published on December 2002

Construction of a genetic analysis-available multidrug sensitive yeast strain by disruption of the drug efflux system and conditional repression of the membrane barrier system

scientific article published in January 2014

Construction of multidrug-sensitive yeast with high sporulation efficiency

scientific article published on 07 August 2011

Design and synthesis of a dimeric derivative of RK-682 with increased inhibitory activity against VHR, a dual-specificity ERK phosphatase: implications for the molecular mechanism of the inhibition

scientific article published in December 2001

Design and synthesis of the penta(acetoxymethyl) ester of dioctanoyl phosphatidylinositol-3,5-bisphosphate.

scientific article published on 15 October 2016

Design, synthesis, and biological evaluation of the analogues of glaziovianin A, a potent antitumor isoflavone

scientific article published on 16 August 2012

Discovery of O6-benzyl glaziovianin A, a potent cytotoxic substance and a potent inhibitor of α,β-tubulin polymerization

scientific article published on 13 September 2016

Discovery of natural products possessing selective eukaryotic readthrough activity: 3-epi-deoxynegamycin and its leucine adduct

scientific article published on 09 July 2014

Effect of dehydroaltenusin-C12 derivative, a selective DNA polymerase alpha inhibitor, on DNA replication in cultured cells.

scientific article

Effects of tryprostatin derivatives on microtubule assembly in vitro and in situ

scientific article published on 01 August 1998

Epoxyquinol B shows antiangiogenic and antitumor effects by inhibiting VEGFR2, EGFR, FGFR, and PDGFR.

scientific article published in January 2008

Epoxyquinol B, a naturally occurring pentaketide dimer, inhibits NF-kappaB signaling by crosslinking TAK1.

scientific article published on 7 July 2008

Eudistomin C, an Antitumor and Antiviral Natural Product, Targets 40S Ribosome and Inhibits Protein Translation.

scientific article published on 15 June 2016

Fungal metabolite, epoxyquinol B, crosslinks proteins by epoxy-thiol conjugation

scientific article published in February 2008

Fusaramin, an antimitochondrial compound produced by Fusarium sp., discovered using multidrug-sensitive Saccharomyces cerevisiae ⬇️

scientific article published on 17 June 2019

Garbled messages and corrupted translations

scientific article

Glaziovianin A prevents endosome maturation via inhibiting microtubule dynamics

scientific article

High-throughput platform for yeast morphological profiling predicts the targets of bioactive compounds

scientific article published on 27 January 2022

Highly synchronous culture of fibroblasts from G2 block caused by staurosporine, a potent inhibitor of protein kinases

article

Identification of Saccharomyces cerevisiae isoleucyl-tRNA synthetase as a target of the G1-specific inhibitor Reveromycin A.

scientific article published on 5 June 2002

Iejimalide C is a potent V-ATPase inhibitor, and induces actin disorganization.

scientific article published in January 2014

Iejimalides show anti-osteoclast activity via V-ATPase inhibition

scientific article published on 01 June 2006

Inhibition of microtubule assembly by a complex of actin and antitumor macrolide aplyronine A.

scientific article published on 21 November 2013

Irciniastatin A induces JNK activation that is involved in caspase-8-dependent apoptosis via the mitochondrial pathway.

scientific article published on December 2010

Irciniastatin A induces potent and sustained activation of extracellular signal-regulated kinase and thereby promotes ectodomain shedding of tumor necrosis factor receptor 1 in human lung carcinoma A549 cells.

scientific article published on January 2015

Irciniastatin A, a pederin-type translation inhibitor, promotes ectodomain shedding of cell-surface tumor necrosis factor receptor 1.

scientific article

Isolation of new protein phosphatase inhibitors from two cyanobacteria species, Planktothrix spp.

scientific article published in August 2001

MA026, an anti-hepatitis C virus compound, opens tight junctions of the epithelial cell membrane.

scientific article published on 18 January 2017

Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome

Modification of bafilomycin structure to efficiently synthesize solid-state NMR probes that selectively bind to vacuolar-type ATPase.

scientific article

Nordihydroguaiaretic acid, of a new family of microtubule-stabilizing agents, shows effects differentiated from paclitaxel.

scientific article

Pestiocandin, a new papulacandin class antibiotic isolated from Pestalotiopsis humus

scientific article published on 19 September 2018

Phenothiazine and carbazole-related compounds inhibit mitotic kinesin Eg5 and trigger apoptosis in transformed culture cells

scientific article published on 24 May 2006

Protective effects of Nitraria retusa extract and its constituent isorhamnetin against amyloid β-induced cytotoxicity and amyloid β aggregation

scientific article published on 12 May 2015

Regulating microtubule properties by modifying their organizing minus ends.

scientific article

Structural Revision of Natural Cyclic Depsipeptide MA026 Established by Total Synthesis and Biosynthetic Gene Cluster Analysis

scientific article published on 6 February 2021

Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells

scientific article published on August 2010

Synthesis and biological activities of reveromycin A and spirofungin A derivatives.

scientific article published on 17 May 2008

Synthesis and evaluation of microtubule assembly inhibition and cytotoxicity of prenylated derivatives of cyclo-L-Trp-L-Pro

scientific article published on 01 October 2000

Synthesis and evaluation of tryprostatin B and demethoxyfumitremorgin C analogues.

scientific article

Synthesis and structure-activity relationship study of FD-891: importance of the side chain and C8-C9 epoxide for cytotoxic activity against cancer cells

scientific article published on 27 January 2016

Synthesis and structure-activity relationship study of antimicrotubule agents phenylahistin derivatives with a didehydropiperazine-2,5-dione structure

scientific article published on 20 January 2012

Synthesis and structure-activity relationships of benzophenone-bearing diketopiperazine-type anti-microtubule agents

scientific article published on 4 June 2012

Terpendole E and its derivative inhibit STLC- and GSK-1-resistant Eg5

scientific article published on 19 March 2014

Tetrandrine induces lipid accumulation through blockade of autophagy in a hepatic stellate cell line.

scientific article published on 4 June 2016

The anticancer natural product pironetin selectively targets Lys352 of alpha-tubulin.

scientific article published on June 2004

The cytotoxic macrolide FD-891 induces caspase-8-dependent mitochondrial release of cytochrome c and subsequent apoptosis in human leukemia Jurkat cells

scientific article published on 10 July 2009

The reversible increase in tight junction permeability induced by capsaicin is mediated via cofilin-actin cytoskeletal dynamics and decreased level of occludin

scientific article

The γ-tubulin-specific inhibitor gatastatin reveals temporal requirements of microtubule nucleation during the cell cycle.

scientific article published on 27 October 2015

Total Synthesis and Biological Evaluation of Irciniastatin A (a.k.a. Psymberin) and Irciniastatin B.

scientific article published on 6 November 2015

Tryprostatin A, a specific and novel inhibitor of microtubule assembly

scientific article published on August 1998

Vicenistatin induces early endosome-derived vacuole formation in mammalian cells

scientific article published on February 2016

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