List of works - Rudolf Martini

5th Workshop of the European CMT Consortium, 69th ENMC International Workshop: therapeutic approaches in CMT neuropathies and related disorders 23-25 April 1999, Soestduinen, The Netherlands.

scientific article

A key role for gp130 expressed on peripheral sensory nerves in pathological pain.

scientific article

Absence of the myelin-associated glycoprotein (MAG) and the neural cell adhesion molecule (N-CAM) interferes with the maintenance, but not with the formation of peripheral myelin

scientific article published on 01 January 1997

Accelerated course of experimental autoimmune encephalomyelitis in PD-1-deficient central nervous system myelin mutants

scientific article

Accelerated demyelination of peripheral nerves in mice deficient in connexin 32 and protein zero

scientific article published on 01 September 1998

Aging-associated changes in motor axon voltage-gated Na(+) channel function in mice

scientific article

Altered expression of ion channel isoforms at the node of Ranvier in P0-deficient myelin mutants

scientific article published in January 2004

Animal models for inherited peripheral neuropathies.

scientific article published on October 1997

Antibodies to the mammalian adhesion molecule J1/tenascin and its carbohydrate epitope L2/HNK-1 label the receptor lymph cavities of insect sensilla

scientific article published in January 1989

Attenuated demyelination in the absence of the macrophage-restricted adhesion molecule sialoadhesin (Siglec-1) in mice heterozygously deficient in P0.

scientific article published on 3 February 2006

Attenuation of MCP-1/CCL2 expression ameliorates neuropathy in a mouse model for Charcot-Marie-Tooth 1X

scientific article published on 30 June 2010

Bone marrow transfer from wild-type mice reverts the beneficial effect of genetically mediated immune deficiency in myelin mutants.

scientific article published in June 2001

CNTF is a major protective factor in demyelinating CNS disease: A neurotrophic cytokine as modulator in neuroinflammation

scientific article published on 01 June 2002

CSF-1-activated macrophages are target-directed and essential mediators of Schwann cell dedifferentiation and dysfunction in Cx32-deficient mice

scientific article published on 27 January 2015

Caspr1/Paranodin/Neurexin IV is most likely not a common disease-causing gene for inherited peripheral neuropathies.

scientific article

Cell degeneration during early development of hymenopteran olfactory sensilla

scientific article published in January 1983

Cell-Surface and Secreted Isoforms of CSF-1 Exert Opposing Roles in Macrophage-Mediated Neural Damage in Cx32-Deficient Mice.

scientific article published on February 2016

Changes in expression of mRNA specific for cell adhesion molecules (L1 and NCAM) in the transected peripheral nerve of the adult rat

scientific article published on 01 December 1990

Characterization of Ighmbp2 in motor neurons and implications for the pathomechanism in a mouse model of human spinal muscular atrophy with respiratory distress type 1 (SMARD1)

scientific journal article

Clonal expansions of pathogenic CD8+ effector cells in the CNS of myelin mutant mice

scientific article published on 15 August 2007

Colony-stimulating factor-1 mediates macrophage-related neural damage in a model for Charcot–Marie–Tooth disease type 1X ⬇️

scientific article published on November 16, 2011

Complex expression pattern of tenascin during innervation of the posterior limb buds of the developing chicken

scientific article published in February 1991

Crucial role for the myelin-associated glycoprotein in the maintenance of axon-myelin integrity

scientific article published on 01 March 1995

Cytochalasin D disrupts the restricted localization of N-CAM, but not of L1, at sites of Schwann cell-neurite and Schwann cell-Schwann cell contact in culture

scientific article published on 01 June 1998

Disruption of the gene for the myelin-associated glycoprotein improves axonal regrowth along myelin in C57BL/Wlds mice.

scientific article published in June 1996

Disruption of the mouse L1 gene leads to malformations of the nervous system ⬇️

scientific article published on November 1, 1997

Ectopic T-cell specificity and absence of perforin and granzyme B alleviate neural damage in oligodendrocyte mutant mice

scientific article

Effective gene transfer of lacZ and P0 into Schwann cells of P0-deficient mice

article

Endogenous antibodies contribute to macrophage-mediated demyelination in a mouse model for CMT1B.

scientific article

Enhanced expression of the extracellular matrix molecule J1/tenascin in the regenerating adult mouse sciatic nerve ⬇️

scientific article published on August 1, 1990

Evidence for macrophage-mediated myelin disruption in an animal model for Charcot-Marie-Tooth neuropathy type 1A.

scientific article published in September 2005

Expression of J1/tenascin in the crypt-villus unit of adult mouse small intestine: implications for its role in epithelial cell shedding ⬇️

scientific article published on June 1, 1990

Expression of carbohydrate epitopes L2/HNK-1 and L3 in the larva and imago of Drosophila melanogaster and Calliphora vicina.

scientific article published in September 1991

Expression of the adhesion molecules L1, N-CAM and J1/tenascin during development of the murine small intestine

scientific article published in July 1990

Fine structure and development of the large sensilla basiconica on the antennae of sphecid wasps

scientific article published on 01 January 1986

Formation and maintenance of the myelin sheath in the peripheral nerve: roles of cell adhesion molecules and the gap junction protein connexin 32.

scientific article published in June 1998

Functional abnormalities in P0-deficient mice resemble human hereditary neuropathies linked to P0 gene mutations

scientific article published on 01 August 1996

Functions of the L2/HNK-1 carbohydrate in the nervous system.

scientific article

Glycans and the modulation of neural-recognition molecule function.

scientific article published on April 1995

Heterozygous P0 deficiency protects mice from vincristine-induced polyneuropathy

scientific article published on 01 July 2006

Hypermyelination and demyelinating peripheral neuropathy in Pmp22-deficient mice

scientific article published on 01 November 1995

Immune cells contribute to myelin degeneration and axonopathic changes in mice overexpressing proteolipid protein in oligodendrocytes

scientific article published on 01 August 2006

Immune cells perturb axons and impair neuronal survival in a mouse model of infantile neuronal ceroid lipofuscinosis.

scientific article

Immune deficiency in mouse models for inherited peripheral neuropathies leads to improved myelin maintenance

scientific article published on 01 January 2000

Immunocytochemical localization of the L1 and N-CAM cell adhesion molecules and their shared carbohydrate epitope L2/HNK-1 in the developing and differentiated gustatory papillae of the mouse tongue

scientific article published on January 1, 1992

Immunocytochemical localization of the neural cell adhesion molecules L1, N-CAM, and J1 in Pacinian corpuscles of the mouse during development, in the adult and during regeneration

scientific article published in December 1989

Immunocytological localization of the major peripheral nervous system glycoprotein P0 and the L2/HNK-1 and L3 carbohydrate structures in developing and adult mouse sciatic nerve

scientific article published in October 1988

Immunological evidence that the neural adhesion molecule L1 is expressed in fish brain and optic nerve: possible association with optic nerve regeneration

scientific article

Impaired differentiation of Schwann cells in transgenic mice with increased PMP22 gene dosage

scientific article published on 01 September 1996

Impaired sensory function in heterozygous P0 knockout mice is associated with nodal changes in sensory nerves

scientific article published on 01 January 2002

Increase of MCP-1 (CCL2) in myelin mutant Schwann cells is mediated by MEK-ERK signaling pathway.

scientific article

Inherited demyelinating neuropathies: from gene to disease

scientific article published on 01 October 1998

Interactions between Schwann cells and macrophages in injury and inherited demyelinating disease

scientific article

Introduction to myelin formation and maintenance ⬇️

scientific article published on 01 June 1998

Lack of evidence for a pathogenic role of T-lymphocytes in an animal model for Charcot-Marie-Tooth disease 1A.

scientific article published on 11 January 2010

Localization and functional roles of PMP22 in peripheral nerves of P0-deficient mice

scientific article published on 01 December 1999

Long-lasting significant functional improvement in chronic severe spinal cord injury following scar resection and polyethylene glycol implantation

scientific article (publication date: July 2014)

MAG-deficient Schwann cells myelinate dorsal root ganglion neurons in culture

scientific article published on 01 March 1998

MCP-1/CCL2 modifies axon properties in a PMP22-overexpressing mouse model for Charcot-Marie-tooth 1A neuropathy.

scientific article published on 21 January 2010

Macrophage colony stimulating factor is a crucial factor for the intrinsic macrophage response in mice heterozygously deficient for the myelin protein P0.

scientific article published on 8 September 2006

Macrophage-related demyelination in peripheral nerves of mice deficient in the gap junction protein connexin 32.

scientific article published in March 2002

Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin.

scientific article

Mice doubly deficient in the genes for P0 and myelin basic protein show that both proteins contribute to the formation of the major dense line in peripheral nerve myelin

scientific article published on 01 June 1995

Monocyte chemoattractant protein-1 is a pathogenic component in a model for a hereditary peripheral neuropathy.

scientific article published in February 2008

Mouse P0 gene disruption leads to hypomyelination, abnormal expression of recognition molecules, and degeneration of myelin and axons

scientific article published in November 1992

Mutation of the TBCE gene causes disturbance of microtubules in the auditory nerve and cochlear outer hair cell degeneration accompanied by progressive hearing loss in the pmn/pmn mouse.

scientific article published on 10 October 2013

Myelin and macrophages in the PNS: An intimate relationship in trauma and disease.

scientific article

Myelin formation by Schwann cells in the absence of beta4 integrin.

scientific article published on September 1999

Myelin-associated glycoprotein is not detectable in perikaryal myelin of spiral ganglion neurons of adult mice

scientific article published on 01 April 1994

Na(v)1.8 channelopathy in mutant mice deficient for myelin protein zero is detrimental to motor axons

scientific article published on 17 December 2010

Neuregulin-1 alleviates Charcot-Marie-Tooth disease in rats

scientific article published in September 2014

Neuroinflammation as modifier of genetically caused neurological disorders of the central nervous system: Understanding pathogenesis and chances for treatment.

scientific article published on June 2017

Neuroinflammation by cytotoxic T-lymphocytes impairs retrograde axonal transport in an oligodendrocyte mutant mouse

scientific article

Neuroinflammation in the peripheral nerve: Cause, modulator, or bystander in peripheral neuropathies?

scientific article

Neuromyotonia in mice with hereditary myelinopathies

scientific article published on 01 May 2000

Neuroprotective effect of the immune system in a mouse model of severe dysmyelinating hereditary neuropathy: enhanced axonal degeneration following disruption of the RAG-1 gene

scientific article published in January 2005

Non-invasive assessment of retinal alterations in mouse models of infantile and juvenile neuronal ceroid lipofuscinosis by spectral domain optical coherence tomography

scientific article

Nonuniform molecular features of myelinating Schwann cells in models for CMT1: distinct disease patterns are associated with NCAM and c-Jun upregulation

scientific article published on 13 February 2014

Origin of CD11b+ macrophage-like cells in the CNS of PLP-overexpressing mice: low influx of haematogenous macrophages and unchanged blood-brain-barrier in the optic nerve.

scientific article published on 2 May 2008

Origin of pathogenic macrophages and endoneurial fibroblast-like cells in an animal model of inherited neuropathy

scientific article published on 01 July 2003

P(0) glycoprotein overexpression causes congenital hypomyelination of peripheral nerves

scientific article published on March 2000

P0-deficient knockout mice as tools to understand pathomechanisms in Charcot-Marie-Tooth 1B and P0-related Déjérine-Sottas syndrome.

scientific article

PD-1 regulates neural damage in oligodendroglia-induced inflammation

scientific article

Pathology of a mouse mutation in peripheral myelin protein P0 is characteristic of a severe and early onset form of human Charcot-Marie-Tooth type 1B disorder

scientific article published on 17 May 2004

Preserved myelin integrity and reduced axonopathy in connexin32-deficient mice lacking the recombination activating gene-1.

scientific article published in April 2003

Progression of motor axon dysfunction and ectopic Nav1.8 expression in a mouse model of Charcot-Marie-Tooth disease 1B.

scientific article

Protein zero (P0)-deficient mice show myelin degeneration in peripheral nerves characteristic of inherited human neuropathies

scientific article published on 01 November 1995

Proteolipid protein modulates preservation of peripheral axons and premature death when myelin protein zero is lacking

scientific article published on 22 September 2015

Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies

scientific journal article

Restricted localization of L1 and N-CAM at sites of contact between Schwann cells and neurites in culture

scientific article published on 01 January 1994

Sialoadhesin deficiency ameliorates myelin degeneration and axonopathic changes in the CNS of PLP overexpressing mice

scientific article published on 24 October 2006

Sialoadhesin promotes neuroinflammation-related disease progression in two mouse models of CLN disease.

scientific article published on 17 January 2016

Structural abnormalities and deficient maintenance of peripheral nerve myelin in mice lacking the gap junction protein connexin 32

scientific article published on 01 June 1997

Subtle roles of neural cell adhesion molecule and myelin-associated glycoprotein during Schwann cell spiralling in P0-deficient mice

scientific article published on 01 September 1999

Tacrolimus (FK506) causes disease aggravation in models for inherited peripheral myelinopathies

scientific article published on 5 November 2008

Targeting microglia attenuates neuroinflammation-related neural damage in mice carrying human PLP1 mutations

scientific article published on 22 November 2018

Targeting the colony stimulating factor 1 receptor alleviates two forms of Charcot-Marie-Tooth disease in mice

scientific article published on 21 August 2015

Tenascin-C expression during wallerian degeneration in C57BL/Wlds mice: possible implications for axonal regeneration

scientific article published on 01 January 1995

The L2/HNK-1 Carbohydrate Epitope is Involved in the Preferential Outgrowth of Motor Neurons on Ventral Roots and Motor Nerves

scientific article published on 01 January 1992

The L2/HNK-1 carbohydrate is carried by the myelin associated glycoprotein and sulphated glucuronyl glycolipids in muscle but not cutaneous nerves of adult mice

scientific article published on 01 December 1994

The L2/HNK-1 carbohydrate is preferentially expressed by previously motor axon-associated Schwann cells in reinnervated peripheral nerves

scientific article published on 01 November 1994

The Wlds mutation delays robust loss of motor and sensory axons in a genetic model for myelin-related axonopathy.

scientific article published in April 2003

The co-inhibitory molecule PD-1 modulates disease severity in a model for an inherited, demyelinating neuropathy

scientific article published on 15 October 2008

The effect of myelinating Schwann cells on axons.

scientific article

The extracellular matrix molecule, tenascin is associated with adult rat CNS axons regenerating into peripheral nerve grafts.

scientific article published in January 1994

Triple knock-out of CNTF, LIF, and CT-1 defines cooperative and distinct roles of these neurotrophic factors for motoneuron maintenance and function

scientific journal article

Visualization of degenerating axons in a dysmyelinating mouse mutant with axonal loss

scientific article published on 23 February 2007

[The role of the immune system in hereditary demyelinating neuropathies]

scientific article published on 01 June 2005

List of works by Rudolf Martini

5th Workshop of the European CMT Consortium, 69th ENMC International Workshop: therapeutic approaches in CMT neuropathies and related disorders 23-25 April 1999, Soestduinen, The Netherlands.

A key role for gp130 expressed on peripheral sensory nerves in pathological pain.

Absence of the myelin-associated glycoprotein (MAG) and the neural cell adhesion molecule (N-CAM) interferes with the maintenance, but not with the formation of peripheral myelin

Accelerated course of experimental autoimmune encephalomyelitis in PD-1-deficient central nervous system myelin mutants

Accelerated demyelination of peripheral nerves in mice deficient in connexin 32 and protein zero

Aging-associated changes in motor axon voltage-gated Na(+) channel function in mice

Altered expression of ion channel isoforms at the node of Ranvier in P0-deficient myelin mutants

Animal models for inherited peripheral neuropathies.

Antibodies to the mammalian adhesion molecule J1/tenascin and its carbohydrate epitope L2/HNK-1 label the receptor lymph cavities of insect sensilla

Attenuated demyelination in the absence of the macrophage-restricted adhesion molecule sialoadhesin (Siglec-1) in mice heterozygously deficient in P0.

Attenuation of MCP-1/CCL2 expression ameliorates neuropathy in a mouse model for Charcot-Marie-Tooth 1X

Bone marrow transfer from wild-type mice reverts the beneficial effect of genetically mediated immune deficiency in myelin mutants.

CNTF is a major protective factor in demyelinating CNS disease: A neurotrophic cytokine as modulator in neuroinflammation

CSF-1-activated macrophages are target-directed and essential mediators of Schwann cell dedifferentiation and dysfunction in Cx32-deficient mice

Caspr1/Paranodin/Neurexin IV is most likely not a common disease-causing gene for inherited peripheral neuropathies.

Cell degeneration during early development of hymenopteran olfactory sensilla

Cell-Surface and Secreted Isoforms of CSF-1 Exert Opposing Roles in Macrophage-Mediated Neural Damage in Cx32-Deficient Mice.

Changes in expression of mRNA specific for cell adhesion molecules (L1 and NCAM) in the transected peripheral nerve of the adult rat

Characterization of Ighmbp2 in motor neurons and implications for the pathomechanism in a mouse model of human spinal muscular atrophy with respiratory distress type 1 (SMARD1)

Clonal expansions of pathogenic CD8+ effector cells in the CNS of myelin mutant mice

Colony-stimulating factor-1 mediates macrophage-related neural damage in a model for Charcot–Marie–Tooth disease type 1X ⬇️

Complex expression pattern of tenascin during innervation of the posterior limb buds of the developing chicken

Crucial role for the myelin-associated glycoprotein in the maintenance of axon-myelin integrity

Cytochalasin D disrupts the restricted localization of N-CAM, but not of L1, at sites of Schwann cell-neurite and Schwann cell-Schwann cell contact in culture

Disruption of the gene for the myelin-associated glycoprotein improves axonal regrowth along myelin in C57BL/Wlds mice.

Disruption of the mouse L1 gene leads to malformations of the nervous system ⬇️

Ectopic T-cell specificity and absence of perforin and granzyme B alleviate neural damage in oligodendrocyte mutant mice

Effective gene transfer of lacZ and P0 into Schwann cells of P0-deficient mice

Endogenous antibodies contribute to macrophage-mediated demyelination in a mouse model for CMT1B.

Enhanced expression of the extracellular matrix molecule J1/tenascin in the regenerating adult mouse sciatic nerve ⬇️

Evidence for macrophage-mediated myelin disruption in an animal model for Charcot-Marie-Tooth neuropathy type 1A.

Expression of J1/tenascin in the crypt-villus unit of adult mouse small intestine: implications for its role in epithelial cell shedding ⬇️

Expression of carbohydrate epitopes L2/HNK-1 and L3 in the larva and imago of Drosophila melanogaster and Calliphora vicina.

Expression of the adhesion molecules L1, N-CAM and J1/tenascin during development of the murine small intestine

Fine structure and development of the large sensilla basiconica on the antennae of sphecid wasps

Formation and maintenance of the myelin sheath in the peripheral nerve: roles of cell adhesion molecules and the gap junction protein connexin 32.

Functional abnormalities in P0-deficient mice resemble human hereditary neuropathies linked to P0 gene mutations

Functions of the L2/HNK-1 carbohydrate in the nervous system.

Glycans and the modulation of neural-recognition molecule function.

Heterozygous P0 deficiency protects mice from vincristine-induced polyneuropathy

Hypermyelination and demyelinating peripheral neuropathy in Pmp22-deficient mice

Immune cells contribute to myelin degeneration and axonopathic changes in mice overexpressing proteolipid protein in oligodendrocytes

Immune cells perturb axons and impair neuronal survival in a mouse model of infantile neuronal ceroid lipofuscinosis.

Immune deficiency in mouse models for inherited peripheral neuropathies leads to improved myelin maintenance

Immunocytochemical localization of the L1 and N-CAM cell adhesion molecules and their shared carbohydrate epitope L2/HNK-1 in the developing and differentiated gustatory papillae of the mouse tongue

Immunocytochemical localization of the neural cell adhesion molecules L1, N-CAM, and J1 in Pacinian corpuscles of the mouse during development, in the adult and during regeneration

Immunocytological localization of the major peripheral nervous system glycoprotein P0 and the L2/HNK-1 and L3 carbohydrate structures in developing and adult mouse sciatic nerve

Immunological evidence that the neural adhesion molecule L1 is expressed in fish brain and optic nerve: possible association with optic nerve regeneration

Impaired differentiation of Schwann cells in transgenic mice with increased PMP22 gene dosage

Impaired sensory function in heterozygous P0 knockout mice is associated with nodal changes in sensory nerves

Increase of MCP-1 (CCL2) in myelin mutant Schwann cells is mediated by MEK-ERK signaling pathway.

Inherited demyelinating neuropathies: from gene to disease

Interactions between Schwann cells and macrophages in injury and inherited demyelinating disease

Introduction to myelin formation and maintenance ⬇️

Lack of evidence for a pathogenic role of T-lymphocytes in an animal model for Charcot-Marie-Tooth disease 1A.

Localization and functional roles of PMP22 in peripheral nerves of P0-deficient mice

Long-lasting significant functional improvement in chronic severe spinal cord injury following scar resection and polyethylene glycol implantation

MAG-deficient Schwann cells myelinate dorsal root ganglion neurons in culture

MCP-1/CCL2 modifies axon properties in a PMP22-overexpressing mouse model for Charcot-Marie-tooth 1A neuropathy.

Macrophage colony stimulating factor is a crucial factor for the intrinsic macrophage response in mice heterozygously deficient for the myelin protein P0.

Macrophage-related demyelination in peripheral nerves of mice deficient in the gap junction protein connexin 32.

Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin.

Mice doubly deficient in the genes for P0 and myelin basic protein show that both proteins contribute to the formation of the major dense line in peripheral nerve myelin

Monocyte chemoattractant protein-1 is a pathogenic component in a model for a hereditary peripheral neuropathy.

Mouse P0 gene disruption leads to hypomyelination, abnormal expression of recognition molecules, and degeneration of myelin and axons

Mutation of the TBCE gene causes disturbance of microtubules in the auditory nerve and cochlear outer hair cell degeneration accompanied by progressive hearing loss in the pmn/pmn mouse.

Myelin and macrophages in the PNS: An intimate relationship in trauma and disease.

Myelin formation by Schwann cells in the absence of beta4 integrin.

Myelin-associated glycoprotein is not detectable in perikaryal myelin of spiral ganglion neurons of adult mice

Na(v)1.8 channelopathy in mutant mice deficient for myelin protein zero is detrimental to motor axons

Neuregulin-1 alleviates Charcot-Marie-Tooth disease in rats

Neuroinflammation as modifier of genetically caused neurological disorders of the central nervous system: Understanding pathogenesis and chances for treatment.

Neuroinflammation by cytotoxic T-lymphocytes impairs retrograde axonal transport in an oligodendrocyte mutant mouse

Neuroinflammation in the peripheral nerve: Cause, modulator, or bystander in peripheral neuropathies?

Neuromyotonia in mice with hereditary myelinopathies

Neuroprotective effect of the immune system in a mouse model of severe dysmyelinating hereditary neuropathy: enhanced axonal degeneration following disruption of the RAG-1 gene

Non-invasive assessment of retinal alterations in mouse models of infantile and juvenile neuronal ceroid lipofuscinosis by spectral domain optical coherence tomography

Nonuniform molecular features of myelinating Schwann cells in models for CMT1: distinct disease patterns are associated with NCAM and c-Jun upregulation

Origin of CD11b+ macrophage-like cells in the CNS of PLP-overexpressing mice: low influx of haematogenous macrophages and unchanged blood-brain-barrier in the optic nerve.