List of works - Jani Saarela

APECED-causing mutations in AIRE reveal the functional domains of the protein

scientific article published in March 2004

Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins

scientific article published on 25 September 2017

Avian phospholipid transfer protein causes HDL conversion without affecting cholesterol efflux from macrophages

scientific article published on 22 April 2009

BRCA1-deficient breast cancer cell lines are resistant to MEK inhibitors and show distinct sensitivities to 6-thioguanine

scientific article

Combined gene essentiality scoring improves the prediction of cancer dependency maps

scientific article published on 12 November 2019

Dasatinib reversibly disrupts endothelial vascular integrity by increasing non-muscle myosin II contractility in a ROCK-dependent manner

scientific article

Development of FRET-based high-throughput screening for viral RNase III inhibitors

scientific article published on 21 May 2020

Discovery of MINC1, a GTPase-activating protein small molecule inhibitor, targeting MgcRacGAP.

scientific article

Glycosylation, transport, and complex formation of palmitoyl protein thioesterase 1 (PPT1)--distinct characteristics in neurons

scientific article

HOX gene expression predicts response to BCL-2 inhibition in acute myeloid leukemia.

scientific article published on 8 August 2016

High NRF2 Levels Correlate with Poor Prognosis in Colorectal Cancer Patients and with Sensitivity to the Kinase Inhibitor AT9283 In Vitro

scientific article published on 25 September 2020

High Throughput siRNA Screening Using Reverse Transfection

scientific article published on January 2016

High miR-30 Expression Associates with Improved Breast Cancer Patient Survival and Treatment Outcome

scientific article published on 10 June 2021

Identification of an aspartylglucosaminidase-like protein in the venom of the parasitic wasp Asobara tabida (Hymenoptera: Braconidae).

scientific article published in May 2004

Methods for High-throughput Drug Combination Screening and Synergy Scoring.

scientific article published in January 2018

Network pharmacology modeling identifies synergistic Aurora B and ZAK interaction in triple-negative breast cancer

scientific article published on 08 July 2019

Patient-derived organoids from multiple colorectal cancer liver metastases reveal moderate intra-patient pharmacotranscriptomic heterogeneity

scientific article published on 16 April 2020

Precision Cancer Medicine in the Acoustic Dispensing Era: Ex Vivo Primary Cell Drug Sensitivity Testing.

scientific article published on 2 December 2015

Relevance Rank Platform (RRP) for Functional Filtering of High Content Protein-Protein Interaction Data.

scientific article

Suppression of BRCA1 sensitizes cells to proteasome inhibitors

scientific article

Systematic Mapping of Kinase Addiction Combinations in Breast Cancer Cells by Integrating Drug Sensitivity and Selectivity Profiles.

scientific article published on 22 July 2015

TP53-based interaction analysis identifies cis-eQTL variants for TP53BP2, FBXO28, and FAM53A that associate with survival and treatment outcome in breast cancer

scientific article published on 5 February 2017

The high throughput biomedicine unit at the institute for molecular medicine Finland: high throughput screening meets precision medicine

scientific article published in May 2014

The patatin-like lipase family in Gallus gallus.

scientific article

Therapeutic targeting of KSP in preclinical models of high-risk neuroblastoma

scientific article published on 01 September 2020

List of works by Jani Saarela

APECED-causing mutations in AIRE reveal the functional domains of the protein

Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins

Avian phospholipid transfer protein causes HDL conversion without affecting cholesterol efflux from macrophages

BRCA1-deficient breast cancer cell lines are resistant to MEK inhibitors and show distinct sensitivities to 6-thioguanine

Combined gene essentiality scoring improves the prediction of cancer dependency maps

Dasatinib reversibly disrupts endothelial vascular integrity by increasing non-muscle myosin II contractility in a ROCK-dependent manner

Development of FRET-based high-throughput screening for viral RNase III inhibitors

Discovery of MINC1, a GTPase-activating protein small molecule inhibitor, targeting MgcRacGAP.

Glycosylation, transport, and complex formation of palmitoyl protein thioesterase 1 (PPT1)--distinct characteristics in neurons

HOX gene expression predicts response to BCL-2 inhibition in acute myeloid leukemia.

High NRF2 Levels Correlate with Poor Prognosis in Colorectal Cancer Patients and with Sensitivity to the Kinase Inhibitor AT9283 In Vitro

High Throughput siRNA Screening Using Reverse Transfection

High miR-30 Expression Associates with Improved Breast Cancer Patient Survival and Treatment Outcome

Identification of an aspartylglucosaminidase-like protein in the venom of the parasitic wasp Asobara tabida (Hymenoptera: Braconidae).

Methods for High-throughput Drug Combination Screening and Synergy Scoring.

Network pharmacology modeling identifies synergistic Aurora B and ZAK interaction in triple-negative breast cancer

Patient-derived organoids from multiple colorectal cancer liver metastases reveal moderate intra-patient pharmacotranscriptomic heterogeneity

Precision Cancer Medicine in the Acoustic Dispensing Era: Ex Vivo Primary Cell Drug Sensitivity Testing.

Relevance Rank Platform (RRP) for Functional Filtering of High Content Protein-Protein Interaction Data.

Suppression of BRCA1 sensitizes cells to proteasome inhibitors

Systematic Mapping of Kinase Addiction Combinations in Breast Cancer Cells by Integrating Drug Sensitivity and Selectivity Profiles.

TP53-based interaction analysis identifies cis-eQTL variants for TP53BP2, FBXO28, and FAM53A that associate with survival and treatment outcome in breast cancer

The high throughput biomedicine unit at the institute for molecular medicine Finland: high throughput screening meets precision medicine

The patatin-like lipase family in Gallus gallus.

Therapeutic targeting of KSP in preclinical models of high-risk neuroblastoma