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List of works by Nicola Simola

A new ethyladenine antagonist of adenosine A(2A) receptors: behavioral and biochemical characterization as an antiparkinsonian drug

scientific article published on 4 December 2009

A(2A) Receptor Antagonism and Dyskinesia in Parkinson's Disease

scientific article

Activation of adenosine A₂A receptors suppresses the emission of pro-social and drug-stimulated 50-kHz ultrasonic vocalizations in rats: possible relevance to reward and motivation

scientific article

Acute perinatal asphyxia impairs non-spatial memory and alters motor coordination in adult male rats

scientific article published on 8 November 2007

Adenosine A2A Receptors: Localization and Function

Adenosine A2A receptor antagonists and Parkinson's disease: state of the art and future directions

scientific article

Alteration in the progression of dopamine neuron degeneration: May caffeine offer new perspective? ⬇️

scientific article published on June 9, 2012

Amphetamine Usage, Misuse, and Addiction Processes

Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms

scientific article published on 08 October 2015

Antidyskinetic effect of A2A and 5HT1A/1B receptor ligands in two animal models of Parkinson's disease

scientific article

Anxiolytic properties of a 2-phenylindolglyoxylamide TSPO ligand: Stimulation of in vitro neurosteroid production affecting GABAA receptor activity

article

Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis

scientific article

Assessment of symptomatic and neuroprotective efficacy of Mucuna pruriens seed extract in rodent model of Parkinson's disease

scientific article published on 20 February 2009

Behavioral and biochemical correlates of the dyskinetic potential of dopaminergic agonists in the 6-OHDA lesioned rat.

scientific article published in July 2008

Blockade of adenosine A2A receptors antagonizes parkinsonian tremor in the rat tacrine model by an action on specific striatal regions

scientific article

Blockade of globus pallidus adenosine A(2A) receptors displays antiparkinsonian activity in 6-hydroxydopamine-lesioned rats treated with D(1) or D(2) dopamine receptor agonists

scientific article

Can dietary substances protect against Parkinson's disease? The case of caffeine

scientific article published on 24 July 2010

Characterization of the antiparkinsonian effects of the new adenosine A2A receptor antagonist ST1535: acute and subchronic studies in rats

scientific article

Direct and long-lasting effects elicited by repeated drug administration on 50-kHz ultrasonic vocalizations are regulated differently: implications for the study of the affective properties of drugs of abuse

article published in 2013

Dopamine and adenosine receptor interaction as basis for the treatment of Parkinson's disease

scientific article

Dual target strategy: combining distinct non-dopaminergic treatments reduces neuronal cell loss and synergistically modulates L-DOPA-induced rotational behavior in a rodent model of Parkinson's disease

scientific article published on 4 June 2015

Dyskinesia in Parkinson's disease: mechanisms and current non-pharmacological interventions

scientific article published on 07 June 2014

Effect of crowding, temperature and age on glia activation and dopaminergic neurotoxicity induced by MDMA in the mouse brain

scientific article published on 21 July 2016

Effect of long-term administration of antiretroviral drugs (Tenofovir and Nevirapine) on neuroinflammation and neuroplasticity in mouse hippocampi

article

Elevation of striatal urate in experimental models of Parkinson's disease: a compensatory mechanism triggered by dopaminergic nigrostriatal degeneration?

scientific article published on 30 July 2014

Emission of categorized 50-kHz ultrasonic vocalizations in rats repeatedly treated with amphetamine or apomorphine: Possible relevance to drug-induced modifications in the emotional state

Erratum to: MDMA administration during adolescence exacerbates MPTP-induced cognitive impairment and neuroinflammation in the hippocampus and prefrontal cortex

scholarly article published in Psychopharmacology

Increase of dopamine D2(High) receptors in the striatum of rats sensitized to caffeine motor effects

scientific article

Influence of acute caffeine on 50-kHz ultrasonic vocalizations in male adult rats and relevance to caffeine-mediated psychopharmacological effects.

scientific article published on 23 June 2009

Involvement of Glutamate NMDA Receptors in the Acute, Long-Term, and Conditioned Effects of Amphetamine on Rat 50 kHz Ultrasonic Vocalizations

scientific article

Involvement of globus pallidus in the antiparkinsonian effects of adenosine A(2A) receptor antagonists

scientific article published on 30 June 2006

L-DOPA disrupts adenosine A(2A)-cannabinoid CB(1)-dopamine D(2) receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: biochemical and behavioral studies

scientific article published on 9 January 2014

MDMA administration during adolescence exacerbates MPTP-induced cognitive impairment and neuroinflammation in the hippocampus and prefrontal cortex

scholarly article by Giulia Costa et al published 1 April 2014 in Psychopharmacology

Methylxanthines and Drug Dependence

article

Methylxanthines and Drug Dependence: A Focus on Interactions with Substances of Abuse ⬇️

scientific article published on January 1, 2011

Microglial and astroglial activation by 3,4-methylenedioxymethamphetamine (MDMA) in mice depends on S(+) enantiomer and is associated with an increase in body temperature and motility

scientific article published on 15 November 2012

Modulation of Rat 50-kHz Ultrasonic Vocalizations by Glucocorticoid Signaling: Possible Relevance to Reward and Motivation

scientific article published on 22 November 2017

Neurochemical and Behavioral Characterization after Acute and Repeated Exposure to Novel Synthetic Cannabinoid Agonist 5-MDMB-PICA

scientific article published on 18 December 2020

New therapies for the treatment of Parkinson's disease: adenosine A2A receptor antagonists

scientific article

Nicotinamide prevents the long-term effects of perinatal asphyxia on apoptosis, non-spatial working memory and anxiety in rats

scientific article

Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease

scientific article published on 21 July 2015

Performance of movement in hemiparkinsonian rats influences the modifications induced by dopamine agonists in striatal efferent dynorphinergic neurons ⬇️

scientific article published on March 13, 2013

Perinatal asphyxia: CNS development and deficits with delayed onset

scientific article published on 26 March 2014

Perinatal asphyxia: current status and approaches towards neuroprotective strategies, with focus on sentinel proteins

scientific article published on 20 July 2010

Pharmacological characterization of 50-kHz ultrasonic vocalizations in rats: comparison of the effects of different psychoactive drugs and relevance in drug-induced reward

scientific article published on 23 March 2012

Pharmacological therapy of Parkinson's disease: current options and new avenues

scientific article

Potentiation of amphetamine-mediated responses in caffeine-sensitized rats involves modifications in A2A receptors and zif-268 mRNAs in striatal neurons

scientific article published on 12 June 2006

Priming of rotational behavior by a dopamine receptor agonist in Hemiparkinsonian rats: movement-dependent induction

scientific article

Progression and Persistence of Neurotoxicity Induced by MDMA in Dopaminergic Regions of the Mouse Brain and Association with Noradrenergic, GABAergic, and Serotonergic Damage

scientific article

Protective Agents in Parkinson's Disease: Caffeine and Adenosine A2A Receptor Antagonists

scholarly article published 2014

Rat 50-kHz ultrasonic vocalizations as a tool in studying neurochemical mechanisms that regulate positive emotional states

Rat Ultrasonic Vocalizations and Behavioral Neuropharmacology: From the Screening of Drugs to the Study of Disease

scientific article

Repeated amphetamine administration and long-term effects on 50-kHz ultrasonic vocalizations: possible relevance to the motivational and dopamine-stimulating properties of the drug

scientific article

Role of Adenosine in the Basal Ganglia

article

Role of Adenosine in the Basal Ganglia

Role of movement in long-term basal ganglia changes: implications for abnormal motor responses

scientific article published on 23 October 2013

Sensitization to caffeine and cross-sensitization to amphetamine: influence of individual response to caffeine

scientific article

Strain dependence of adolescent Cannabis influence on heroin reward and mesolimbic dopamine transmission in adult Lewis and Fischer 344 rats

scientific article published on 20 August 2013

Striatal neuroprotection with methylene blue

scientific article

Subchronic-intermittent caffeine amplifies the motor effects of amphetamine in rats

scientific article published on 02 August 2006

Symptomatic and Neuroprotective Effects of A2A Receptor Antagonists in Parkinson’s Disease

scholarly article published 23 July 2012

The 6-hydroxydopamine model of Parkinson's disease

scientific article published on April 2007

The novel psychoactive substance methoxetamine induces persistent behavioral abnormalities and neurotoxicity in rats

scientific article published on 23 October 2018

Ultrasonic vocalizations as a tool in studying emotional states in rodent models of social behavior and brain disease

scientific article published on 13 November 2018

Widespread reduction of dopamine cell bodies and terminals in adult rats exposed to a low dose regimen of MDMA during adolescence

scientific article

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