List of works - Johan Gabrielsson

A dynamical systems analysis of the indirect response model with special emphasis on time to peak response

scientific article published in August 2005

A flexible nonlinear feedback system that captures diverse patterns of adaptation and rebound.

scientific article published on 22 February 2008

A modeling approach for compounds affecting body composition

scientific article published on 25 October 2013

A nonlinear feedback model capturing different patterns of tolerance and rebound

scientific article published on 13 June 2007

A novel approach to data processing of the QT interval response in the conscious telemetered beagle dog.

scientific article

A pharmacodynamic turnover model capturing asymmetric circadian baselines of body temperature, heart rate and blood pressure in rats: challenges in terms of tolerance and animal-handling effects

scientific article

A pharmacokinetic model of intravenously administered hyaluronan in sheep

scientific article published on 01 August 1989

A physiological pharmacokinetic model for morphine disposition in the pregnant rat

scientific article published on 01 April 1983

A physiologically based pharmacokinetic model for theophylline disposition in the pregnant and nonpregnant rat.

scientific article published in April 1984

A quantitative approach to analysing cortisol response in the horse

scientific article

An extended physiological pharmacokinetic model of methadone disposition in the rat: validation and sensitivity analysis

scientific article published on 01 April 1988

Analysis of methadone disposition in the pregnant rat by means of a physiological flow model

scientific article published in August 1985

Analysis of pethidine disposition in the pregnant rat by means of a physiological flow model

scientific article published in August 1986

Animal Health Modeling & Simulation Society: a new society promoting model-based approaches in veterinary pharmacology

scientific article published on 29 May 2013

Challenges of a mechanistic feedback model describing nicotinic acid-induced changes in non-esterified fatty acids in rats

scientific article published on 04 July 2013

Clinical pharmacokinetics of clozapine in chronic schizophrenic patients

scientific article published on 01 January 1988

Comparison of the QT interval response during sinus and paced rhythm in conscious and anesthetized beagle dogs

scientific article

Constant rate of infusion--improvement of tests for teratogenicity and embryotoxicity

scientific article published in December 1985

Constant-rate infusion of nicotine and cotinine. I. A physiological pharmacokinetic analysis of the cotinine disposition, and effects on clearance and distribution in the rat.

scientific article

Do teratogenicity tests serve their objectives?

scientific article published on 01 August 1982

Dose-response-time data analysis involving nonlinear dynamics, feedback and delay

scientific article

Dose-response-time modelling: Second-generation turnover model with integral feedback control.

scientific article published on 31 October 2015

Dosing profile profoundly influences nicotinic acid's ability to improve metabolic control in rats

scientific article

Dynamics of target-mediated drug disposition

scientific article published on 26 September 2009

Dynamics of target-mediated drug disposition: characteristic profiles and parameter identification ⬇️

scientific article published on August 1, 2012

Early integration of pharmacokinetic and dynamic reasoning is essential for optimal development of lead compounds: strategic considerations

scientific article published on 20 January 2009

Effects of dietary sodium selenite supplementation on salicylate-induced embryo- and fetotoxicity in the rat

scientific article published on 01 April 1990

Feedback modeling of non-esterified fatty acids in obese Zucker rats after nicotinic acid infusions.

scientific article

Feedback modeling of non-esterified fatty acids in rats after nicotinic acid infusions.

scientific article published on 4 November 2010

Gastric acid secretion in the dog: a mechanism-based pharmacodynamic model for histamine stimulation and irreversible inhibition by omeprazole

scientific article

Influence of CYP2D6 polymorphism on the pharmacokinetics and pharmacodynamic of tolterodine

scientific article published in May 1998

Joint feedback analysis modeling of nonesterified fatty acids in obese Zucker rats and normal Sprague-Dawley rats after different routes of administration of nicotinic acid

scientific article published on July 2014

MDMA: on the translation from rodent to human dosing

scientific article published on 13 January 2009

Mathematical modeling and simulation in animal health. Part I: Moving beyond pharmacokinetics.

scientific article

Maxsim2 - Real-time interactive simulations for computer-assisted teaching of pharmacokinetics and pharmacodynamics

scientific article published on 25 December 2013

Mechanistic model of acute autoinhibitory feedback action after administration of SSRIs in rats: application to escitalopram-induced effects on brain serotonin levels

scientific article published on 12 August 2006

Mixed Effects Modeling Using Stochastic Differential Equations: Illustrated by Pharmacokinetic Data of Nicotinic Acid in Obese Zucker Rats

scientific article

Mixture dynamics: dual action of inhibition and stimulation

scientific article published on 04 July 2013

Modeling and design of challenge tests: Inflammatory and metabolic biomarker study examples.

scientific article published on 28 November 2014

Modeling drug- and system-related changes in body temperature: application to clomethiazole-induced hypothermia, long-lasting tolerance development, and circadian rhythm in rats

scientific article published on 8 December 2005

Modeling energy intake by adding homeostatic feedback and drug intervention

scientific article published on 12 November 2014

Neuroprotective efficacy of AR-A008055, a clomethiazole analogue, in a global model of acute ischaemic stroke and its effect on ischaemia-induced glutamate and GABA efflux in vitro.

scientific article published in August 2001

Nonlinear turnover models for systems with physiological limits

scientific article published on 30 December 2008

Optimising in vivo pharmacology studies--Practical PKPD considerations.

scientific article published on 11 February 2010

Pattern Recognition in Pharmacodynamic Data Analysis

scientific article

Pattern Recognition in Pharmacokinetic Data Analysis

scientific article

Pharmacodynamic modelling of reversible gastric acid pump inhibition in dog and man.

scientific article published in December 2001

Pharmacodynamic-pharmacokinetic integration as a guide to medicinal chemistry

scientific article published on January 2011

Pharmacokinetic-pharmacodynamic modeling of drug-induced effect on the QT interval in conscious telemetered dogs

scientific article

Pharmacokinetic-pharmacodynamic reasoning in drug discovery and early development

scientific article published in November 2009

Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteine

scientific article published on 01 January 1988

Pharmacokinetics of i.v. and rectal methohexitone in children

scientific article published in December 1987

Plasma concentration-dependent suppression of endogenous hydrocortisone in the horse after intramuscular administration of dexamethasone-21-isonicotinate.

scientific article published on 3 November 2014

Quantitative analysis of rate and extent of tolerance of biomarkers: application to nicotinic acid-induced changes in non-esterified fatty acids in rats

scientific article published on 11 August 2011

Quantitative pharmacology or pharmacokinetic pharmacodynamic integration should be a vital component in integrative pharmacology

scientific article published on 24 September 2009

Rapid and long-lasting tolerance to clomethiazole-induced hypothermia in the rat.

scientific article

Role of variability in explaining ethanol pharmacokinetics: research and forensic applications

scientific article

Studies of drug binding to plasma proteins using a variant of equilibrium dialysis

scientific article published on 24 February 2005

The influence of drug input rate on the development of tolerance to frusemide

scientific article published on November 1998

Time course of enzyme induction in humans: effect of pentobarbital on nortriptyline metabolism

scientific article published in July 1998

Tissue uptake, distribution and elimination of (14)C-PFOA in zebrafish (Danio rerio).

scientific article published on 3 April 2015

Translational neuropharmacology and the appropriate and effective use of animal models.

scientific article published in October 2011

Utilization of physiologically based models in extrapolating pharmacokinetic data among species.

scientific article

Volume turnover kinetics of fluid shifts after hemorrhage, fluid infusion, and the combination of hemorrhage and fluid infusion in sheep

scientific article published in May 2005

Within- and between-subject variations in pharmacokinetic parameters of ethanol by analysis of breath, venous blood and urine

scientific article

List of works by Johan Gabrielsson

A dynamical systems analysis of the indirect response model with special emphasis on time to peak response

A flexible nonlinear feedback system that captures diverse patterns of adaptation and rebound.

A modeling approach for compounds affecting body composition

A nonlinear feedback model capturing different patterns of tolerance and rebound

A novel approach to data processing of the QT interval response in the conscious telemetered beagle dog.

A pharmacodynamic turnover model capturing asymmetric circadian baselines of body temperature, heart rate and blood pressure in rats: challenges in terms of tolerance and animal-handling effects

A pharmacokinetic model of intravenously administered hyaluronan in sheep

A physiological pharmacokinetic model for morphine disposition in the pregnant rat

A physiologically based pharmacokinetic model for theophylline disposition in the pregnant and nonpregnant rat.

A quantitative approach to analysing cortisol response in the horse

An extended physiological pharmacokinetic model of methadone disposition in the rat: validation and sensitivity analysis

Analysis of methadone disposition in the pregnant rat by means of a physiological flow model

Analysis of pethidine disposition in the pregnant rat by means of a physiological flow model

Animal Health Modeling & Simulation Society: a new society promoting model-based approaches in veterinary pharmacology

Challenges of a mechanistic feedback model describing nicotinic acid-induced changes in non-esterified fatty acids in rats

Clinical pharmacokinetics of clozapine in chronic schizophrenic patients

Comparison of the QT interval response during sinus and paced rhythm in conscious and anesthetized beagle dogs

Constant rate of infusion--improvement of tests for teratogenicity and embryotoxicity

Constant-rate infusion of nicotine and cotinine. I. A physiological pharmacokinetic analysis of the cotinine disposition, and effects on clearance and distribution in the rat.

Do teratogenicity tests serve their objectives?

Dose-response-time data analysis involving nonlinear dynamics, feedback and delay

Dose-response-time modelling: Second-generation turnover model with integral feedback control.

Dosing profile profoundly influences nicotinic acid's ability to improve metabolic control in rats

Dynamics of target-mediated drug disposition

Dynamics of target-mediated drug disposition: characteristic profiles and parameter identification ⬇️

Early integration of pharmacokinetic and dynamic reasoning is essential for optimal development of lead compounds: strategic considerations

Effects of dietary sodium selenite supplementation on salicylate-induced embryo- and fetotoxicity in the rat

Feedback modeling of non-esterified fatty acids in obese Zucker rats after nicotinic acid infusions.

Feedback modeling of non-esterified fatty acids in rats after nicotinic acid infusions.

Gastric acid secretion in the dog: a mechanism-based pharmacodynamic model for histamine stimulation and irreversible inhibition by omeprazole

Influence of CYP2D6 polymorphism on the pharmacokinetics and pharmacodynamic of tolterodine

Joint feedback analysis modeling of nonesterified fatty acids in obese Zucker rats and normal Sprague-Dawley rats after different routes of administration of nicotinic acid

MDMA: on the translation from rodent to human dosing

Mathematical modeling and simulation in animal health. Part I: Moving beyond pharmacokinetics.

Maxsim2 - Real-time interactive simulations for computer-assisted teaching of pharmacokinetics and pharmacodynamics

Mechanistic model of acute autoinhibitory feedback action after administration of SSRIs in rats: application to escitalopram-induced effects on brain serotonin levels

Mixed Effects Modeling Using Stochastic Differential Equations: Illustrated by Pharmacokinetic Data of Nicotinic Acid in Obese Zucker Rats

Mixture dynamics: dual action of inhibition and stimulation

Modeling and design of challenge tests: Inflammatory and metabolic biomarker study examples.

Modeling drug- and system-related changes in body temperature: application to clomethiazole-induced hypothermia, long-lasting tolerance development, and circadian rhythm in rats

Modeling energy intake by adding homeostatic feedback and drug intervention

Neuroprotective efficacy of AR-A008055, a clomethiazole analogue, in a global model of acute ischaemic stroke and its effect on ischaemia-induced glutamate and GABA efflux in vitro.

Nonlinear turnover models for systems with physiological limits

Optimising in vivo pharmacology studies--Practical PKPD considerations.

Pattern Recognition in Pharmacodynamic Data Analysis

Pattern Recognition in Pharmacokinetic Data Analysis

Pharmacodynamic modelling of reversible gastric acid pump inhibition in dog and man.

Pharmacodynamic-pharmacokinetic integration as a guide to medicinal chemistry

Pharmacokinetic-pharmacodynamic modeling of drug-induced effect on the QT interval in conscious telemetered dogs

Pharmacokinetic-pharmacodynamic reasoning in drug discovery and early development

Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteine

Pharmacokinetics of i.v. and rectal methohexitone in children

Plasma concentration-dependent suppression of endogenous hydrocortisone in the horse after intramuscular administration of dexamethasone-21-isonicotinate.

Quantitative analysis of rate and extent of tolerance of biomarkers: application to nicotinic acid-induced changes in non-esterified fatty acids in rats

Quantitative pharmacology or pharmacokinetic pharmacodynamic integration should be a vital component in integrative pharmacology

Rapid and long-lasting tolerance to clomethiazole-induced hypothermia in the rat.

Role of variability in explaining ethanol pharmacokinetics: research and forensic applications

Studies of drug binding to plasma proteins using a variant of equilibrium dialysis

The influence of drug input rate on the development of tolerance to frusemide

Time course of enzyme induction in humans: effect of pentobarbital on nortriptyline metabolism

Tissue uptake, distribution and elimination of (14)C-PFOA in zebrafish (Danio rerio).

Translational neuropharmacology and the appropriate and effective use of animal models.

Utilization of physiologically based models in extrapolating pharmacokinetic data among species.

Volume turnover kinetics of fluid shifts after hemorrhage, fluid infusion, and the combination of hemorrhage and fluid infusion in sheep

Within- and between-subject variations in pharmacokinetic parameters of ethanol by analysis of breath, venous blood and urine