List of works by Karen Keeshan

A Trib2-p38 axis controls myeloid leukaemia cell cycle and stress response signalling.

scientific article published on 18 April 2018

Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias

scientific article published in Nature Communications

Bcr‐Abl upregulates cytosolic p21WAF‐1/CIP‐1 by a phosphoinositide‐3‐kinase (PI3K)‐independent pathway ⬇️

scientific article published on October 1, 2003

Co-operative leukemogenesis in acute myeloid leukemia and acute promyelocytic leukemia reveals C/EBPα as a common target of TRIB1 and PML/RARA.

scientific article published on 06 July 2016

Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells.

scientific article published on 25 September 2018

Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia

scientific article

Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1.

scientific article

Elevated TRIB2 with NOTCH1 activation in paediatric/adult T-ALL.

scientific article published on 6 July 2012

Harnessing the potential of epigenetic therapies for childhood acute myeloid leukemia

scientific article published on 30 March 2018

High Bcr-Abl expression prevents the translocation of Bax and Bad to the mitochondrion

scientific article published in September 2002

Human TRIB2 Oscillates during the Cell Cycle and Promotes Ubiquitination and Degradation of CDC25C

scientific article

Insights into cell ontogeny, age, and acute myeloid leukemia

scientific article published on 04 June 2015

Inverse and correlative relationships between TRIBBLES genes indicate non-redundant functions during normal and malignant hemopoiesis

article

Knockdown of interleukin-1 receptor 1 is not neuroprotective in the 6-hydroxydopamine striatal lesion rat model of Parkinson's disease

scientific article published on 14 April 2014

Leukemogenesis induced by wild-type and STI571-resistant BCR/ABL is potently suppressed by C/EBPalpha.

scientific article published on 2 May 2006

Negative regulation of TLX by IL-1β correlates with an inhibition of adult hippocampal neural precursor cell proliferation.

scientific article

Nfix expression critically modulates early B lymphopoiesis and myelopoiesis

scientific article published on 17 March 2015

Pseudokinases: a tribble-edged sword

scientific article published on 16 October 2019

Regulation of NF-κB by PML and PML-RARα.

scientific article published on 20 March 2017

Regulation of Trib2 by an E2F1-C/EBPα feedback loop in AML cell proliferation

scientific article published on 10 February 2014

Repurposing covalent EGFR/HER2 inhibitors for on-target degradation of human Tribbles 2 (TRIB2) pseudokinase

TRIB2 and the ubiquitin proteasome system in cancer.

scientific article

TRIB2 regulates normal and stress-induced thymocyte proliferation.

scientific article published on 15 March 2016

The Tribble with APL: A New Road to Therapy

scientific article published on May 2017

The deubiquitinase USP7 uses a distinct ubiquitin-like domain to deubiquitinate NF-κB subunits

scientific article published on 25 June 2020

The functionally diverse roles of tribbles

scientific article published on August 2013

The presence of C/EBPα and its degradation are both required for TRIB2-mediated leukaemia.

scientific article

The requirement for Notch signaling at the beta-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor.

scientific article

The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression

scientific article

Transcription activation function of C/EBPalpha is required for induction of granulocytic differentiation.

scientific article published on 17 April 2003

Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding

scientific article

Trib2 expression in granulocyte-monocyte progenitors drives a highly drug resistant acute myeloid leukaemia linked to elevated Bcl2.

scientific article

Tribbles homolog 2 (Trib2) and HoxA9 cooperate to accelerate acute myelogenous leukemia

scientific article published on 7 November 2007

Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia

scientific article

Tribbles in acute leukemia

scientific article

Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease

scientific article

Unlocking the potential of anti-CD33 therapy in adult and childhood acute myeloid leukemia.

scientific article published on 28 June 2017

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