List of works - Aengus Mac Sweeney

Crystal structure of delta-chymotrypsin bound to a peptidyl chloromethyl ketone inhibitor

scientific article

Crystallization and preliminary crystallographic analysis of an NADH oxidase that functions in peroxide reduction in Thermus aquaticus YT-1.

scientific article published in January 1999

Discovery and structure-based optimization of adenain inhibitors.

scientific article published on 20 June 2014

Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases

scientific article published on 19 February 2020

Discovery of Novel Inhibitors of LpxC Displaying Potent in Vitro Activity against Gram-Negative Bacteria

scientific article published on 24 December 2019

High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine

scientific article

Insights into the regulatory mechanism for caspase-8 activation

scientific journal article

Modified microbatch and seeding in protein crystallization experiments.

scientific article published on 28 November 2003

Practical aspects of using the microbatch method in screening conditions for protein crystallization

scientific article published in November 2004

Small-molecule factor B inhibitor for the treatment of complement-mediated diseases

scientific article published on 29 March 2019

Small-molecule factor D inhibitors targeting the alternative complement pathway

scientific article

Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases

scientific article

Structure-based design and optimization of potent inhibitors of the adenoviral protease

scientific article

The 1.15A crystal structure of the Staphylococcus aureus methionyl-aminopeptidase and complexes with triazole based inhibitors

scientific article

The advantages of using a modified microbatch method for rapid screening of protein crystallization conditions

scientific article published on 23 January 2003

The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation

scientific article published in January 2005

The crystallization additive hexatungstotellurate promotes the crystallization of the HSP70 nucleotide binding domain into two different crystal forms.

scientific article published on 27 June 2018

Using natural seeding material to generate nucleation in protein crystallization experiments

scientific article published on 27 June 2003

List of works by Aengus Mac Sweeney

Crystal structure of delta-chymotrypsin bound to a peptidyl chloromethyl ketone inhibitor

Crystallization and preliminary crystallographic analysis of an NADH oxidase that functions in peroxide reduction in Thermus aquaticus YT-1.

Discovery and structure-based optimization of adenain inhibitors.

Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases

Discovery of Novel Inhibitors of LpxC Displaying Potent in Vitro Activity against Gram-Negative Bacteria

High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine

Insights into the regulatory mechanism for caspase-8 activation

Modified microbatch and seeding in protein crystallization experiments.

Practical aspects of using the microbatch method in screening conditions for protein crystallization

Small-molecule factor B inhibitor for the treatment of complement-mediated diseases

Small-molecule factor D inhibitors targeting the alternative complement pathway

Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases

Structure-based design and optimization of potent inhibitors of the adenoviral protease

The 1.15A crystal structure of the Staphylococcus aureus methionyl-aminopeptidase and complexes with triazole based inhibitors

The advantages of using a modified microbatch method for rapid screening of protein crystallization conditions

The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation

The crystallization additive hexatungstotellurate promotes the crystallization of the HSP70 nucleotide binding domain into two different crystal forms.

Using natural seeding material to generate nucleation in protein crystallization experiments