List of works - Diana Karpman

A classification of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura and related disorders

scientific article

A common origin of the 4143insA ADAMTS13 mutation

scientific article

A genetic basis of susceptibility to acute pyelonephritis

scientific article

A mutation in factor I that is associated with atypical hemolytic uremic syndrome does not affect the function of factor I in complement regulation

scientific article

A novel C3 mutation causing increased formation of the C3 convertase in familial atypical hemolytic uremic syndrome

scientific article

A novel mechanism of bacterial toxin transfer within host blood cell-derived microvesicles

scientific article

A novel mutation in the complement regulator clusterin in recurrent hemolytic uremic syndrome.

scientific article

ADAMTS13 phenotype in plasma from normal individuals and patients with thrombotic thrombocytopenic purpura

scientific article

An audit analysis of a guideline for the investigation and initial therapy of diarrhea negative (atypical) hemolytic uremic syndrome

scientific article

An international consensus approach to the management of atypical hemolytic uremic syndrome in children

scientific article

An outbreak of Escherichia coli O157:H7 infection in southern Sweden associated with consumption of fermented sausage; aspects of sausage production that increase the risk of contamination.

scientific article published on 20 April 2007

Anguish over angiopathy: hemolytic uremic syndrome

scientific article

Annexin Induces Cellular Uptake of Extracellular Vesicles and Delays Disease in Escherichia coli O157:H7 Infection

scientific article published in 2021

Antibodies to intimin and Escherichia coli secreted proteins A and B in patients with enterohemorrhagic Escherichia coli infections

scientific article

Antibody response to IgA-binding streptococcal M proteins in children with IgA nephropathy

scientific article published on 17 June 2010

Apoptosis of Renal Cortical Cells in the Hemolytic-Uremic Syndrome: In Vivo and In Vitro Studies ⬇️

scientific article published on February 1, 1998

Bernard-Soulier syndrome Karlstad: Trp 498Stop mutation resulting in a truncated glycoprotein Ibalpha that contains part of the transmembranous domain

scientific article published on 01 July 1997

Biologically active ADAMTS13 is expressed in renal tubular epithelial cells.

scientific article

CYTOKINE REPERTOIRE OF EPITHELIAL CELLS LINING THE HUMAN URINARY TRACT

scientific article published on 01 June 1998

Characterization of mutations in complement factor I (CFI) associated with hemolytic uremic syndrome

scientific article

Complement Interactions with Blood Cells, Endothelial Cells and Microvesicles in Thrombotic and Inflammatory Conditions

scientific article

Complement activation associated with ADAMTS13 deficiency in human and murine thrombotic microangiopathy

scientific article

Complement activation in thrombotic microangiopathy

scientific article

Complement activation on platelet-leukocyte complexes and microparticles in enterohemorrhagic Escherichia coli-induced hemolytic uremic syndrome

scientific article

Complement contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome.

scientific article

Contact-system activation in children with vasculitis

scientific article published in The Lancet

Correct evaluation of renal glomerular filtration rate requires clearance assays

scientific article published on 8 August 2002

Cross-reactive protection against enterohemorrhagic Escherichia coli infection by enteropathogenic E. coli in a mouse model

scientific article

Early Terminal Complement Blockade and C6 Deficiency Are Protective in Enterohemorrhagic Escherichia coli-Infected Mice

scientific article published on 15 July 2016

Eculizumab in an anephric patient with atypical haemolytic uraemic syndrome and advanced vascular lesions

scientific article

Eculizumab treatment for rescue of renal function in IgA nephropathy

scientific article published on 13 June 2014

Editorial Commentary: Escherichia coli O104:H4 and Hemolytic Uremic Syndrome: The Analysis Begins

scientific article published on 05 June 2012

Enterohemorrhagic Escherichia coli Pathogenesis and the Host Response

scientific article

Enzyme-linked immunosorbent assay for detection of Shiga toxin-producing Escherichia coli infection by antibodies to Escherichia coli secreted protein B in children with hemolytic uremic syndrome.

scientific article

Epidemiology, clinical presentation, and pathophysiology of atypical and recurrent hemolytic uremic syndrome

scientific article

Exosomes and microvesicles in normal physiology, pathophysiology, and renal diseases.

scientific article published on 27 November 2017

Factor H binds to washed human platelets.

scientific article

Factor H dysfunction in patients with atypical hemolytic uremic syndrome contributes to complement deposition on platelets and their activation

scientific article

Guideline for the investigation and initial therapy of diarrhea-negative hemolytic uremic syndrome.

scientific article

Haemolytic uraemic syndrome

scientific article

Hyperfiltration evaluated by glomerular filtration rate at diagnosis in children with cancer

scientific article published on 16 January 2011

IgA nephropathy associated with a novel N-terminal mutation in factor H.

scientific article

Inherited Susceptibility to Acute Pyelonephritis: A Family Study of Urinary Tract Infection

scientific article published on 12 March 2007

Innate defences and resistance to gram negative mucosal infection.

scientific article

Ins405AsnPro mutation in the von Willebrand factor propeptide in recessive type 2A (IIC) von Willebrand's disease

scientific article published on 01 April 1998

Interleukin 8 receptor deficiency confers susceptibility to acute experimental pyelonephritis and may have a human counterpart.

scientific article

Interleukin‐8 Receptor Deficiency Confers Susceptibility to Acute Pyelonephritis

scientific article published on 01 March 2001

Intestinal damage in enterohemorrhagic Escherichia coli infection.

scientific article

Kinin system activation in vasculitis

scientific article published on 08 April 2011

Lipopolysaccharide from enterohemorrhagic Escherichia coli binds to platelets through TLR4 and CD62 and is detected on circulating platelets in patients with hemolytic uremic syndrome

scientific article

Management of Shiga toxin-associated Escherichia coli-induced haemolytic uraemic syndrome: randomized clinical trials are needed

scientific article

Microvesicle Involvement in Shiga Toxin-Associated Infection

scientific article published on 19 November 2017

Molecular basis of ADAMTS13 dysfunction in thrombotic thrombocytopenic purpura

scientific article

Multimeric alpha-lactalbumin from human milk induces apoptosis through a direct effect on cell nuclei

scientific article

Mutation analysis and clinical implications of von Willebrand factor-cleaving protease deficiency

scientific article

Neonatal onset atypical hemolytic uremic syndrome successfully treated with eculizumab

scientific article

Neutrophil Protease Cleavage of Von Willebrand Factor in Glomeruli - An Anti-thrombotic Mechanism in the Kidney

scientific article

Neutrophil-Derived Proteinase 3 Induces Kallikrein-Independent Release of a Novel Vasoactive Kinin

article published in 2009

Orphan drug policies and use in pediatric nephrology

scientific article

Ouabain protects against Shiga toxin-triggered apoptosis by reversing the imbalance between Bax and Bcl-xL.

scientific article published on 06 June 2013

Pathogen specific, IRF3-dependent signaling and innate resistance to human kidney infection.

scientific article

Pathogenesis of Shiga toxin-associated hemolytic uremic syndrome.

scientific article

Pathophysiology of typical hemolytic uremic syndrome

scientific article

Phenotypic expression of ADAMTS13 in glomerular endothelial cells

scientific article

Phenotypic expression of factor H mutations in patients with atypical hemolytic uremic syndrome.

scientific article

Platelet activation by Shiga toxin and circulatory factors as a pathogenetic mechanism in the hemolytic uremic syndrome.

scientific article

Platelet activation in hemolytic uremic syndrome

scientific article

Podocytes express ADAMTS13 in normal renal cortex and in patients with thrombotic thrombocytopenic purpura

scientific article

Recurrent mutation Asn45-->Ser of glycoprotein IX in Bernard-Soulier syndrome

scientific article published on 01 August 1996

Reduced toll-like receptor 4 expression in children with asymptomatic bacteriuria.

scientific article published on 21 June 2007

Shiga Toxin Uptake and Sequestration in Extracellular Vesicles Is Mediated by Its B-Subunit

scientific article published on 10 July 2020

Shiga toxin and lipopolysaccharide induce platelet-leukocyte aggregates and tissue factor release, a thrombotic mechanism in hemolytic uremic syndrome

scientific article

Shiga toxin pathogenesis: kidney complications and renal failure

scientific article

Shiga toxin signals via ATP and its effect is blocked by purinergic receptor antagonism

scientific article published on 07 October 2019

Shiga toxin-induced complement-mediated hemolysis and release of complement-coated red blood cell-derived microvesicles in hemolytic uremic syndrome

scientific article

Shiga toxin-mediated disease in MyD88-deficient mice infected with Escherichia coli O157:H7.

scientific article

Successful management of a planned pregnancy in severe congenital thrombotic thrombocytopaenic purpura: the Upshaw-Schulman syndrome

scientific article published on 11 January 2011

Successful thrombolysis of neonatal bilateral renal vein thrombosis originating in the IVC.

scientific article published on 24 March 2009

Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome

scientific article

The 'innate' host response protects and damages the infected urinary tract.

scientific article

The antimicrobial peptide cathelicidin protects mice from Escherichia coli O157:H7-mediated disease.

scientific article

The combined role of galactose-deficient IgA1 and streptococcal IgA-binding M Protein in inducing IL-6 and C3 secretion from human mesangial cells: implications for IgA nephropathy

scientific article

The council for new therapies should immediately revoke their decision on eculizumab

scientific article

The host response to urinary tract infection.

scientific article

The role of lipopolysaccharide and Shiga-like toxin in a mouse model of Escherichia coli O157:H7 infection.

scientific article

Thrombotic microangiopathy mimicking membranoproliferative glomerulonephritis.

scientific article

Tissue deposits of IgA-binding streptococcal M proteins in IgA nephropathy and Henoch-Schonlein purpura

scientific article

Toll-like receptor 4 promoter polymorphisms: common TLR4 variants may protect against severe urinary tract infection

scientific article

Uropathogenic Escherichia coli as a model of host-parasite interaction

scientific article

[23 physicians comments on circumcision of small boys: The Swedish Medical Association should take a more humble approach].

scientific article published in March 2014

[The council for new therapies position on eculizumab is unacceptable]

scientific article published on 09 June 2015

von Willebrand factor mediates increased platelet retention in recurrent thrombotic thrombocytopenic purpura

scientific article published on December 1, 1997

List of works by Diana Karpman

A classification of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura and related disorders

A common origin of the 4143insA ADAMTS13 mutation

A genetic basis of susceptibility to acute pyelonephritis

A mutation in factor I that is associated with atypical hemolytic uremic syndrome does not affect the function of factor I in complement regulation

A novel C3 mutation causing increased formation of the C3 convertase in familial atypical hemolytic uremic syndrome

A novel mechanism of bacterial toxin transfer within host blood cell-derived microvesicles

A novel mutation in the complement regulator clusterin in recurrent hemolytic uremic syndrome.

ADAMTS13 phenotype in plasma from normal individuals and patients with thrombotic thrombocytopenic purpura

An audit analysis of a guideline for the investigation and initial therapy of diarrhea negative (atypical) hemolytic uremic syndrome

An international consensus approach to the management of atypical hemolytic uremic syndrome in children

An outbreak of Escherichia coli O157:H7 infection in southern Sweden associated with consumption of fermented sausage; aspects of sausage production that increase the risk of contamination.

Anguish over angiopathy: hemolytic uremic syndrome

Annexin Induces Cellular Uptake of Extracellular Vesicles and Delays Disease in Escherichia coli O157:H7 Infection

Antibodies to intimin and Escherichia coli secreted proteins A and B in patients with enterohemorrhagic Escherichia coli infections

Antibody response to IgA-binding streptococcal M proteins in children with IgA nephropathy

Apoptosis of Renal Cortical Cells in the Hemolytic-Uremic Syndrome: In Vivo and In Vitro Studies ⬇️

Bernard-Soulier syndrome Karlstad: Trp 498Stop mutation resulting in a truncated glycoprotein Ibalpha that contains part of the transmembranous domain

Biologically active ADAMTS13 is expressed in renal tubular epithelial cells.

CYTOKINE REPERTOIRE OF EPITHELIAL CELLS LINING THE HUMAN URINARY TRACT

Characterization of mutations in complement factor I (CFI) associated with hemolytic uremic syndrome

Complement Interactions with Blood Cells, Endothelial Cells and Microvesicles in Thrombotic and Inflammatory Conditions

Complement activation associated with ADAMTS13 deficiency in human and murine thrombotic microangiopathy

Complement activation in thrombotic microangiopathy

Complement activation on platelet-leukocyte complexes and microparticles in enterohemorrhagic Escherichia coli-induced hemolytic uremic syndrome

Complement contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome.

Contact-system activation in children with vasculitis

Correct evaluation of renal glomerular filtration rate requires clearance assays

Cross-reactive protection against enterohemorrhagic Escherichia coli infection by enteropathogenic E. coli in a mouse model

Early Terminal Complement Blockade and C6 Deficiency Are Protective in Enterohemorrhagic Escherichia coli-Infected Mice

Eculizumab in an anephric patient with atypical haemolytic uraemic syndrome and advanced vascular lesions

Eculizumab treatment for rescue of renal function in IgA nephropathy

Editorial Commentary: Escherichia coli O104:H4 and Hemolytic Uremic Syndrome: The Analysis Begins

Enterohemorrhagic Escherichia coli Pathogenesis and the Host Response

Enzyme-linked immunosorbent assay for detection of Shiga toxin-producing Escherichia coli infection by antibodies to Escherichia coli secreted protein B in children with hemolytic uremic syndrome.

Epidemiology, clinical presentation, and pathophysiology of atypical and recurrent hemolytic uremic syndrome

Exosomes and microvesicles in normal physiology, pathophysiology, and renal diseases.

Factor H binds to washed human platelets.

Factor H dysfunction in patients with atypical hemolytic uremic syndrome contributes to complement deposition on platelets and their activation

Guideline for the investigation and initial therapy of diarrhea-negative hemolytic uremic syndrome.

Haemolytic uraemic syndrome

Hyperfiltration evaluated by glomerular filtration rate at diagnosis in children with cancer

IgA nephropathy associated with a novel N-terminal mutation in factor H.

Inherited Susceptibility to Acute Pyelonephritis: A Family Study of Urinary Tract Infection

Innate defences and resistance to gram negative mucosal infection.

Ins405AsnPro mutation in the von Willebrand factor propeptide in recessive type 2A (IIC) von Willebrand's disease

Interleukin 8 receptor deficiency confers susceptibility to acute experimental pyelonephritis and may have a human counterpart.

Interleukin‐8 Receptor Deficiency Confers Susceptibility to Acute Pyelonephritis

Intestinal damage in enterohemorrhagic Escherichia coli infection.

Kinin system activation in vasculitis

Lipopolysaccharide from enterohemorrhagic Escherichia coli binds to platelets through TLR4 and CD62 and is detected on circulating platelets in patients with hemolytic uremic syndrome

Management of Shiga toxin-associated Escherichia coli-induced haemolytic uraemic syndrome: randomized clinical trials are needed

Microvesicle Involvement in Shiga Toxin-Associated Infection

Molecular basis of ADAMTS13 dysfunction in thrombotic thrombocytopenic purpura

Multimeric alpha-lactalbumin from human milk induces apoptosis through a direct effect on cell nuclei

Mutation analysis and clinical implications of von Willebrand factor-cleaving protease deficiency

Neonatal onset atypical hemolytic uremic syndrome successfully treated with eculizumab

Neutrophil Protease Cleavage of Von Willebrand Factor in Glomeruli - An Anti-thrombotic Mechanism in the Kidney

Neutrophil-Derived Proteinase 3 Induces Kallikrein-Independent Release of a Novel Vasoactive Kinin

Orphan drug policies and use in pediatric nephrology

Ouabain protects against Shiga toxin-triggered apoptosis by reversing the imbalance between Bax and Bcl-xL.

Pathogen specific, IRF3-dependent signaling and innate resistance to human kidney infection.

Pathogenesis of Shiga toxin-associated hemolytic uremic syndrome.

Pathophysiology of typical hemolytic uremic syndrome

Phenotypic expression of ADAMTS13 in glomerular endothelial cells

Phenotypic expression of factor H mutations in patients with atypical hemolytic uremic syndrome.

Platelet activation by Shiga toxin and circulatory factors as a pathogenetic mechanism in the hemolytic uremic syndrome.

Platelet activation in hemolytic uremic syndrome

Podocytes express ADAMTS13 in normal renal cortex and in patients with thrombotic thrombocytopenic purpura

Recurrent mutation Asn45-->Ser of glycoprotein IX in Bernard-Soulier syndrome

Reduced toll-like receptor 4 expression in children with asymptomatic bacteriuria.

Shiga Toxin Uptake and Sequestration in Extracellular Vesicles Is Mediated by Its B-Subunit

Shiga toxin and lipopolysaccharide induce platelet-leukocyte aggregates and tissue factor release, a thrombotic mechanism in hemolytic uremic syndrome

Shiga toxin pathogenesis: kidney complications and renal failure

Shiga toxin signals via ATP and its effect is blocked by purinergic receptor antagonism

Shiga toxin-induced complement-mediated hemolysis and release of complement-coated red blood cell-derived microvesicles in hemolytic uremic syndrome

Shiga toxin-mediated disease in MyD88-deficient mice infected with Escherichia coli O157:H7.

Successful management of a planned pregnancy in severe congenital thrombotic thrombocytopaenic purpura: the Upshaw-Schulman syndrome

Successful thrombolysis of neonatal bilateral renal vein thrombosis originating in the IVC.

Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome