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Authors whose works are in public domain in at least one jurisdiction

List of works by Luigi Formisano

A Phase Ib Study of Alpelisib (BYL719), a PI3Kα-Specific Inhibitor, with Letrozole in ER+/HER2- Metastatic Breast Cancer

scientific article published on 28 April 2016

Aberrant FGFR signaling mediates resistance to CDK4/6 inhibitors in ER+ breast cancer

scientific article published on 26 March 2019

Activating PIK3CA Mutations Induce an Epidermal Growth Factor Receptor (EGFR)/Extracellular Signal-regulated Kinase (ERK) Paracrine Signaling Axis in Basal-like Breast Cancer

scientific article in 2015

An ERBB1-3 Neutralizing Antibody Mixture With High Activity Against Drug-Resistant HER2+ Breast Cancers With ERBB Ligand Overexpression.

scientific article

Animal models of Multiple Sclerosis.

scientific article published on 27 March 2015

Association of FGFR1 with ERαmaintains ligand-independent ER transcription and mediates resistance to estrogen deprivation in ER+ breast cancer.

scientific article

CDK 4/6 Inhibitors as Single Agent in Advanced Solid Tumors

scientific article published on 12 December 2018

CIKS/DDX3X interaction controls the stability of the Zc3h12a mRNA induced by IL-17

scientific article

Combination of a Toll-like receptor 9 agonist with everolimus interferes with the growth and angiogenic activity of renal cell carcinoma.

scientific article published on 28 May 2013

Combined blockade of activating mutations and ER results in synthetic lethality of ER+/HER2 mutant breast cancer

scientific article published on 12 October 2018

Combining Immune Checkpoint Inhibitors with Anti-Angiogenic Agents

scientific article published on 03 March 2020

Correction: Association of FGFR1 with ERα Maintains Ligand-Independent ER Transcription and Mediates Resistance to Estrogen Deprivation in ER+ Breast Cancer

scientific article published on 01 February 2019

Correction: ER+ Breast Cancers Resistant to Prolonged Neoadjuvant Letrozole Exhibit an E2F4 Transcriptional Program Sensitive to CDK4/6 Inhibitors

scientific article published on 01 February 2019

Correction: Kinome-Wide RNA Interference Screen Reveals a Role for PDK1 in Acquired Resistance to CDK4/6 Inhibition in ER-Positive Breast Cancer

scientific article published on 01 February 2019

Correction: Treatment of Triple-Negative Breast Cancer with TORC1/2 Inhibitors Sustains a Drug-Resistant and Notch-Dependent Cancer Stem Cell Population

scientific article published on 01 February 2019

Discovery of new small molecules inhibiting 67 kDa laminin receptor interaction with laminin and cancer cell invasion

scientific article

ER+ Breast Cancers Resistant to Prolonged Neoadjuvant Letrozole Exhibit an E2F4 Transcriptional Program Sensitive to CDK4/6 Inhibitors

scientific article published on 26 March 2018

ERK1/2, p38, and JNK regulate the expression and the activity of the three isoforms of the Na+ /Ca2+ exchanger, NCX1, NCX2, and NCX3, in neuronal PC12 cells.

scientific article

Epidermal growth factor-receptor activation modulates Src-dependent resistance to lapatinib in breast cancer models

scientific article

Everolimus induces Met inactivation by disrupting the FKBP12/Met complex

scientific article published on 20 May 2016

Everolimus plus long-acting somatostatin analogs in thymic epithelial malignancies

scientific article

Extended adjuvant therapy with neratinib plus fulvestrant blocks ER/HER2 crosstalk and maintains complete responses of ER+/HER2+ breast cancers: Implications to the ExteNET trial

article

Extracellular signal-related kinase 2/specificity protein 1/specificity protein 3/repressor element-1 silencing transcription factor pathway is involved in Aroclor 1254-induced toxicity in SH-SY5Y neuronal cells

scientific article

FGFR1 Amplification Mediates Endocrine Resistance but Retains TORC Sensitivity in Metastatic Hormone Receptor-Positive (HR+) Breast Cancer

scientific article published on 01 August 2019

From biology to therapy: Improvements of therapeutic options in Lung cancer.

scientific article published on 12 September 2017

Genomic profiling of ER+ breast cancers after short-term estrogen suppression reveals alterations associated with endocrine resistance.

scientific article published on August 2017

Hedgehog signalling pathway orchestrates angiogenesis in triple-negative breast cancers

scientific article

Histone deacetylase 4 promotes ubiquitin-dependent proteasomal degradation of Sp3 in SH-SY5Y cells treated with di(2-ethylhexyl)phthalate (DEHP), determining neuronal death.

scientific article

Hyperactivation of TORC1 Drives Resistance to the Pan-HER Tyrosine Kinase Inhibitor Neratinib in HER2-Mutant Cancers

scientific article published on 23 January 2020

Increased anaerobic metabolism is a distinctive signature in a colorectal cancer cellular model of resistance to antiepidermal growth factor receptor antibody.

scientific article

Inhibition of Hedgehog signalling by NVP-LDE225 (Erismodegib) interferes with growth and invasion of human renal cell carcinoma cells

scientific article published on 5 August 2014

Involvement of PI3'-K, mitogen-activated protein kinase and protein kinase B in the up-regulation of the expression of nNOSalpha and nNOSbeta splicing variants induced by PRL-receptor activation in GH3 cells.

scientific article published on March 2003

Ischemic insults promote epigenetic reprogramming of mu opioid receptor expression in hippocampal neurons

scholarly article

Kinome-Wide RNA Interference Screen Reveals a Role for PDK1 in Acquired Resistance to CDK4/6 Inhibition in ER-Positive Breast Cancer.

scientific article published in March 2017

Leptin-Induced mTOR Activation Defines a Specific Molecular and Transcriptional Signature Controlling CD4+ Effector T Cell Responses ⬇️

scientific article published on August 17, 2012

MC1568 Inhibits Thimerosal-Induced Apoptotic Cell Death by Preventing HDAC4 Up-Regulation in Neuronal Cells and in Rat Prefrontal Cortex.

scientific article published on 22 September 2016

MS-275 inhibits aroclor 1254-induced SH-SY5Y neuronal cell toxicity by preventing the formation of the HDAC3/REST complex on the synapsin-1 promoter

scientific article

Maintenance Treatment with Cetuximab and BAY86-9766 Increases Antitumor Efficacy of Irinotecan plus Cetuximab in Human Colorectal Cancer Xenograft Models

scientific article published on 27 May 2015

Mechanisms of lapatinib resistance in HER2-driven breast cancer.

scientific article published on 08 August 2015

Melanoma response to anti-PD-L1 immunotherapy requires JAK1 signaling, but not JAK2.

scientific article

Methylmercury upregulates RE-1 silencing transcription factor (REST) in SH-SY5Y cells and mouse cerebellum

scientific article published on 20 November 2015

MicroRNA-103-1 selectively downregulates brain NCX1 and its inhibition by anti-miRNA ameliorates stroke damage and neurological deficits

scientific article published on 23 June 2014

Molecular diagnostics for pharmacogenomic testing of fluoropyrimidine based-therapy: costs, methods and applications ⬇️

scientific article published on April 20, 2011

NCX1 is a new rest target gene: role in cerebral ischemia

scientific article published on 13 October 2012

Neoadjuvant Treatment in Locally Advanced Pancreatic Cancer (LAPC) Patients with FOLFIRINOX or Gemcitabine NabPaclitaxel: A Single-Center Experience and a Literature Review

scientific article published on 13 July 2019

Neuronal NOS activation during oxygen and glucose deprivation triggers cerebellar granule cell death in the later reoxygenation phase.

scientific article

Nitric oxide dysregulation in platelets from patients with advanced Huntington disease.

scientific article

PIK3CA and MAP3K1 alterations imply luminal A status and are associated with clinical benefit from pan-PI3K inhibitor buparlisib and letrozole in ER+ metastatic breast cancer

scientific article published on 23 September 2019

Paraneoplastic sensitive neuropathy associated with anti-hu antibodies in a neuroendocrine tumor of duodenum: a case report

scientific article published on 01 October 2010

Pentraxin 3 Induces Vascular Endothelial Dysfunction Through a P-selectin/Matrix Metalloproteinase-1 Pathway

scientific article published on 6 March 2015

Polychlorinated Biphenyls Induce Mitochondrial Dysfunction in SH-SY5Y Neuroblastoma Cells.

scientific article published on 23 June 2015

Powerful anti-tumor and anti-angiogenic activity of a new anti-vascular endothelial growth factor receptor 1 peptide in colorectal cancer models

scientific article published on April 2015

Predictors of Outcomes in Patients with EGFR-Mutated Non-Small Cell Lung Cancer Receiving EGFR Tyrosine Kinase Inhibitors: A Systematic Review and Meta-Analysis

scientific article published on 28 August 2019

Resveratrol treatment reduces the vulnerability of SH-SY5Y cells and cortical neurons overexpressing SOD1-G93A to Thimerosal toxicity through SIRT1/DREAM/PDYN pathway

scientific article published on 29 November 2018

Resveratrol via sirtuin-1 downregulates RE1-silencing transcription factor (REST) expression preventing PCB-95-induced neuronal cell death.

scientific article published on 22 August 2015

Risk factors and acute ischemic stroke subtypes

scientific article published on 15 January 2014

Role of adipokines signaling in the modulation of T cells function.

scientific article published on 18 October 2013

Role of metabolism in neurodegenerative disorders.

scientific article

Silencing or knocking out the Na(+)/Ca(2+) exchanger-3 (NCX3) impairs oligodendrocyte differentiation.

scientific article

Sirtuins: Possible Clinical Implications in Cardio and Cerebrovascular Diseases.

scientific article published on 18 October 2015

Sp3/REST/HDAC1/HDAC2 Complex Represses and Sp1/HIF-1/p300 Complex Activates ncx1 Gene Transcription, in Brain Ischemia and in Ischemic Brain Preconditioning, by Epigenetic Mechanism.

scientific article

Specification of skeletal muscle differentiation by repressor element-1 silencing transcription factor (REST)-regulated Kv7.4 potassium channels ⬇️

scientific article published on December 14, 2012

Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models ⬇️

scientific article published on November 19, 2012

Src inhibitors act through different mechanisms in Non-Small Cell Lung Cancer models depending on EGFR and RAS mutational status

scientific article

The dual PI3K/mTOR inhibitor PKI-587 enhances sensitivity to cetuximab in EGFR-resistant human head and neck cancer models.

scientific article published on 13 May 2014

The neurotoxicant PCB-95 by increasing the neuronal transcriptional repressor REST down-regulates caspase-8 and increases Ripk1, Ripk3 and MLKL expression determining necroptotic neuronal death

scientific article

The repressor element 1-silencing transcription factor is a novel molecular target for the neurotoxic effect of the polychlorinated biphenyl mixture aroclor 1254 in neuroblastoma SH-SY5Y cells.

scientific article published on 21 June 2011

The two isoforms of the Na+/Ca2+ exchanger, NCX1 and NCX3, constitute novel additional targets for the prosurvival action of Akt/protein kinase B pathway.

scientific article

Toll-like receptor 9 agonist IMO cooperates with everolimus in renal cell carcinoma by interfering with tumour growth and angiogenesis.

scientific article published on 9 April 2013

Treatment of Triple-Negative Breast Cancer with TORC1/2 Inhibitors Sustains a Drug-Resistant and Notch-Dependent Cancer Stem Cell Population

scientific article

Tumor-to-tumor metastasis: breast cancer metastatic to thymic epithelial tumor

scientific article published on 01 August 2013

Tumour Microenvironment and Immune Evasion in EGFR Addicted NSCLC: Hurdles and Possibilities

scientific article published on 24 September 2019

Urokinase-type plasminogen activator receptor (uPAR) expression enhances invasion and metastasis in RAS mutated tumors.

scientific article published on 24 August 2017

c-Src and EGFR Inhibition in Molecular Cancer Therapy: What Else Can We Improve?

scientific article published on 07 June 2020

ncx1, ncx2, and ncx3 gene product expression and function in neuronal anoxia and brain ischemia.

scientific article published on March 2007

p38/Sp1/Sp4/HDAC4/BDNF Axis Is a Novel Molecular Pathway of the Neurotoxic Effect of the Methylmercury

scientific article published on 19 January 2017

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