List of works - Sílvia Beà

A B-cell epigenetic signature defines three biologic subgroups of chronic lymphocytic leukemia with clinical impact.

scientific article published on 25 August 2014

A cyclin D1-dependent transcriptional program predicts clinical outcome in mantle cell lymphoma

scientific article published on 12 October 2020

A gene signature that distinguishes conventional and leukemic nonnodal mantle cell lymphoma helps predict outcome

article

ATM gene inactivation in mantle cell lymphoma mainly occurs by truncating mutations and missense mutations involving the phosphatidylinositol-3 kinase domain and is associated with increasing numbers of chromosomal imbalances

scientific article published in January 2002

Amplifications and target genes in diffuse large B-cell lymphoma: real targets or consequences of structural features of the genome?

scientific article published in May 2010

Analysis of Aurora-A and hMPS1 mitotic kinases in mantle cell lymphoma

scientific article

Assessment of SOX11 expression in routine lymphoma tissue sections: characterization of new monoclonal antibodies for diagnosis of mantle cell lymphoma.

scientific article

CCND2 and CCND3 hijack immunoglobulin light-chain enhancers in cyclin D1- mantle cell lymphoma

scientific article published on 11 December 2018

CCND2 rearrangements are the most frequent genetic events in cyclin D1(-) mantle cell lymphoma

scientific article published on 18 December 2012

CDK4andMDM2Gene Alterations Mainly Occur in Highly Proliferative and Aggressive Mantle Cell Lymphomas with Wild-typeINK4a/ARFLocus

article

CHK2-decreased protein expression and infrequent genetic alterations mainly occur in aggressive types of non-Hodgkin lymphomas

scientific article published in August 2002

Check'-ing DLBCL

scientific article published on 8 February 2015

Checkpoint kinase 1 (CHK1) protein and mRNA expression is downregulated in aggressive variants of human lymphoid neoplasms

scientific article published in January 2005

Chromosomal alterations detected by comparative genomic hybridization in subgroups of gene expression-defined Burkitt's lymphoma

article

Clinical impact of clonal and subclonal TP53, SF3B1, BIRC3, NOTCH1, and ATM mutations in chronic lymphocytic leukemia.

scientific article

Clinicopathologic significance and prognostic value of chromosomal imbalances in diffuse large B-cell lymphomas

scientific article published in September 2004

Clinicopathological characteristics and genomic profile of primary sinonasal tract diffuse large B cell lymphoma (DLBCL) reveals gain at 1q31 and RGS1 encoding protein; high RGS1 immunohistochemical expression associates with poor overall survival i

scientific article

Comprehensive characterization of complex structural variations in cancer by directly comparing genome sequence reads

scientific article

Cyclin D1 transcriptional activation in MCL

scientific article published on 01 March 2014

Decoding the DNA Methylome of Mantle Cell Lymphoma in the Light of the Entire B Cell Lineage.

scientific article published on November 2016

Detection of chromothripsis-like patterns with a custom array platform for chronic lymphocytic leukemia.

scientific article published on 25 August 2015

Diffuse large B-cell lymphoma subgroups have distinct genetic profiles that influence tumor biology and improve gene-expression-based survival prediction

scientific article published on 26 July 2005

Diffuse large B-cell lymphoma: clinical and biological characterization and outcome according to the nodal or extranodal primary origin

scientific article

Disregulation of p16MTS1/CDK4I protein and mRNA expression is associated with gene alterations in squamous-cell carcinoma of the larynx

article

Dynamics of genome architecture and chromatin function during human B cell differentiation and neoplastic transformation

scientific article published on 28 January 2021

Epigenetic activation of SOX11 in lymphoid neoplasms by histone modifications.

scientific article

Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia.

scientific article published on 14 October 2012

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

scientific article

Follicular lymphomas with and without translocation t(14;18) differ in gene expression profiles and genetic alterations

scientific article published on 26 May 2009

Gene expression profile and genomic changes in disease progression of early-stage chronic lymphocytic leukemia

article

Genetic Predisposition to Chronic Lymphocytic Leukemia Is Mediated by a BMF Super-Enhancer Polymorphism.

scientific article published on 10 August 2016

Genetic landscape and deregulated pathways in B-cell lymphoid malignancies

scientific article published on 20 June 2017

Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia

scientific article published on 06 February 2017

Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

scientific journal article

Genome-wide methylation analyses identify a subset of mantle cell lymphoma with a high number of methylated CpGs and aggressive clinicopathological features.

scientific article published on 16 July 2013

Genomic and Gene Expression Profiling Defines Indolent Forms of Mantle Cell Lymphoma

article

Genomic and immunohistochemical profiles of enteropathy-associated T-cell lymphoma in Japan

scientific article

Genomic complexity and IGHV mutational status are key predictors of outcome of chronic lymphocytic leukemia patients with TP53 disruption

scientific article published on 4 July 2014

Genomic imbalances and patterns of karyotypic variability in mantle-cell lymphoma cell lines

scientific article published on 31 January 2006

Genomic profiling reveals different genetic aberrations in systemic ALK-positive and ALK-negative anaplastic large cell lymphomas.

scientific article

Identification of methylated genes associated with aggressive clinicopathological features in mantle cell lymphoma

scientific article

IgCaller for reconstructing immunoglobulin gene rearrangements and oncogenic translocations from whole-genome sequencing in lymphoid neoplasms

scientific article published on 07 July 2020

Inactivation of RB1 in mantle-cell lymphoma detected by nonsense-mediated mRNA decay pathway inhibition and microarray analysis.

scientific article published on March 2007

Incidence and prognostic impact of secondary cytogenetic aberrations in a series of 145 patients with mantle cell lymphoma.

scientific article published in May 2010

Increased tumor cell proliferation in mantle cell lymphoma is associated with elevated insulin-like growth factor 2 mRNA-binding protein 3 expression

scientific article published on 4 May 2012

Insight into genetic predisposition to chronic lymphocytic leukemia from integrative epigenomics

scientific article published on 09 August 2019

Integrated genomic and expression profiling in mantle cell lymphoma: identification of gene-dosage regulated candidate genes.

scientific article

International network of cancer genome projects

scientific article

Is TCL1 overexpression a good or a bad player in mantle cell lymphoma?

scientific article published on 01 December 2015

Landscape of somatic mutations and clonal evolution in mantle cell lymphoma.

scientific article published on 21 October 2013

Leukemic involvement is a common feature in mantle cell lymphoma

scientific article published on 01 June 2007

Loss of major histocompatibility class II expression in non-immune-privileged site diffuse large B-cell lymphoma is highly coordinated and not due to chromosomal deletions.

scientific article published on 20 October 2005

MicroRNA expression, chromosomal alterations, and immunoglobulin variable heavy chain hypermutations in Mantle cell lymphomas.

scientific article

Molecular subsets of mantle cell lymphoma defined by the IGHV mutational status and SOX11 expression have distinct biologic and clinical features

scientific article published on 20 August 2012

Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma in Asia Frequently Shows <i>SETD2</i> Alterations

scientific article published on 27 November 2020

Multiple recurrent chromosomal breakpoints in mantle cell lymphoma revealed by a combination of molecular cytogenetic techniques

scientific article

Mutational Landscape and Tumor Burden Assessed by Cell-Free DNA in Diffuse Large B-Cell Lymphoma in a Population-based Study

scientific article published on 29 October 2020

NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome.

scientific article published on 6 December 2012

NOTCH1, TP53, and MAP2K1 Mutations in Splenic Diffuse Red Pulp Small B-cell Lymphoma Are Associated With Progressive Disease

scientific article published on 29 September 2015

Non-coding recurrent mutations in chronic lymphocytic leukaemia

scientific article published in Nature

Non-nodal type of mantle cell lymphoma is a specific biological and clinical subgroup of the disease

scientific article

PRDM1/BLIMP1 is commonly inactivated in anaplastic large T-cell lymphoma

scientific article published on 4 September 2013

Pathogenic role of B-cell receptor signaling and canonical NF-κB activation in mantle cell lymphoma

scientific article published on 28 April 2016

Pathway discovery in mantle cell lymphoma by integrated analysis of high-resolution gene expression and copy number profiling

scientific article

Role of SOX11 and Genetic Events Cooperating with Cyclin D1 in Mantle Cell Lymphoma

scientific article published on June 2017

SNP-based mapping arrays reveal high genomic complexity in monoclonal gammopathies, from MGUS to myeloma status

scientific article published on 08 May 2012

SOX11 regulates PAX5 expression and blocks terminal B-cell differentiation in aggressive mantle cell lymphoma

scientific article published on 15 January 2013

Secondary genomic alterations in non-Hodgkin's lymphomas: tumor-specific profiles with impact on clinical behavior

scientific article published on 01 May 2008

Specific secondary genetic alterations in mantle cell lymphoma provide prognostic information independent of the gene expression-based proliferation signature

scientific article published on 12 February 2007

Sporadic and reversible chromothripsis in chronic lymphocytic leukemia revealed by longitudinal genomic analysis.

scientific article published on 24 April 2013

Sporadic and reversible chromothripsis in chronic lymphocytic leukemia revealed by longitudinal genomic analysis.

scientific article published in March 2015

The complex landscape of genetic alterations in mantle cell lymphoma

scientific article

The prognostic impact of minimal residual disease in patients with chronic lymphocytic leukemia requiring first-line therapy

scientific article

The reference epigenome and regulatory chromatin landscape of chronic lymphocytic leukemia

scientific article published on 21 May 2018

Unbalanced expression of licensing DNA replication factors occurs in a subset of mantle cell lymphomas with genomic instability

scientific article published on 01 December 2006

Uniparental disomies, homozygous deletions, amplifications, and target genes in mantle cell lymphoma revealed by integrative high-resolution whole-genome profiling.

scientific article

Update on the molecular pathogenesis and clinical treatment of Mantle Cell Lymphoma (MCL): minutes of the 9th European MCL Network conference.

scientific article published on September 2010

Update on the molecular pathogenesis and clinical treatment of mantle cell lymphoma: report of the 10th annual conference of the European Mantle Cell Lymphoma Network

scientific article published on 18 August 2011

Update on the molecular pathogenesis and clinical treatment of mantle cell lymphoma: report of the 11th annual conference of the European Mantle Cell Lymphoma Network

scientific article

microRNA expression profiles identify subtypes of mantle cell lymphoma with different clinicobiological characteristics

scientific article published on 02 May 2013

List of works by Sílvia Beà

A B-cell epigenetic signature defines three biologic subgroups of chronic lymphocytic leukemia with clinical impact.

A cyclin D1-dependent transcriptional program predicts clinical outcome in mantle cell lymphoma

A gene signature that distinguishes conventional and leukemic nonnodal mantle cell lymphoma helps predict outcome

ATM gene inactivation in mantle cell lymphoma mainly occurs by truncating mutations and missense mutations involving the phosphatidylinositol-3 kinase domain and is associated with increasing numbers of chromosomal imbalances

Amplifications and target genes in diffuse large B-cell lymphoma: real targets or consequences of structural features of the genome?

Analysis of Aurora-A and hMPS1 mitotic kinases in mantle cell lymphoma

Assessment of SOX11 expression in routine lymphoma tissue sections: characterization of new monoclonal antibodies for diagnosis of mantle cell lymphoma.

CCND2 and CCND3 hijack immunoglobulin light-chain enhancers in cyclin D1- mantle cell lymphoma

CCND2 rearrangements are the most frequent genetic events in cyclin D1(-) mantle cell lymphoma

CDK4andMDM2Gene Alterations Mainly Occur in Highly Proliferative and Aggressive Mantle Cell Lymphomas with Wild-typeINK4a/ARFLocus

CHK2-decreased protein expression and infrequent genetic alterations mainly occur in aggressive types of non-Hodgkin lymphomas

Check'-ing DLBCL

Checkpoint kinase 1 (CHK1) protein and mRNA expression is downregulated in aggressive variants of human lymphoid neoplasms

Chromosomal alterations detected by comparative genomic hybridization in subgroups of gene expression-defined Burkitt's lymphoma

Clinical impact of clonal and subclonal TP53, SF3B1, BIRC3, NOTCH1, and ATM mutations in chronic lymphocytic leukemia.

Clinicopathologic significance and prognostic value of chromosomal imbalances in diffuse large B-cell lymphomas

Clinicopathological characteristics and genomic profile of primary sinonasal tract diffuse large B cell lymphoma (DLBCL) reveals gain at 1q31 and RGS1 encoding protein; high RGS1 immunohistochemical expression associates with poor overall survival i

Comprehensive characterization of complex structural variations in cancer by directly comparing genome sequence reads

Cyclin D1 transcriptional activation in MCL

Decoding the DNA Methylome of Mantle Cell Lymphoma in the Light of the Entire B Cell Lineage.

Detection of chromothripsis-like patterns with a custom array platform for chronic lymphocytic leukemia.

Diffuse large B-cell lymphoma subgroups have distinct genetic profiles that influence tumor biology and improve gene-expression-based survival prediction

Diffuse large B-cell lymphoma: clinical and biological characterization and outcome according to the nodal or extranodal primary origin

Disregulation of p16MTS1/CDK4I protein and mRNA expression is associated with gene alterations in squamous-cell carcinoma of the larynx

Dynamics of genome architecture and chromatin function during human B cell differentiation and neoplastic transformation

Epigenetic activation of SOX11 in lymphoid neoplasms by histone modifications.

Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia.

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

Follicular lymphomas with and without translocation t(14;18) differ in gene expression profiles and genetic alterations

Gene expression profile and genomic changes in disease progression of early-stage chronic lymphocytic leukemia

Genetic Predisposition to Chronic Lymphocytic Leukemia Is Mediated by a BMF Super-Enhancer Polymorphism.

Genetic landscape and deregulated pathways in B-cell lymphoid malignancies

Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia

Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

Genome-wide methylation analyses identify a subset of mantle cell lymphoma with a high number of methylated CpGs and aggressive clinicopathological features.

Genomic and Gene Expression Profiling Defines Indolent Forms of Mantle Cell Lymphoma

Genomic and immunohistochemical profiles of enteropathy-associated T-cell lymphoma in Japan

Genomic complexity and IGHV mutational status are key predictors of outcome of chronic lymphocytic leukemia patients with TP53 disruption

Genomic imbalances and patterns of karyotypic variability in mantle-cell lymphoma cell lines

Genomic profiling reveals different genetic aberrations in systemic ALK-positive and ALK-negative anaplastic large cell lymphomas.

Identification of methylated genes associated with aggressive clinicopathological features in mantle cell lymphoma

IgCaller for reconstructing immunoglobulin gene rearrangements and oncogenic translocations from whole-genome sequencing in lymphoid neoplasms

Inactivation of RB1 in mantle-cell lymphoma detected by nonsense-mediated mRNA decay pathway inhibition and microarray analysis.

Incidence and prognostic impact of secondary cytogenetic aberrations in a series of 145 patients with mantle cell lymphoma.

Increased tumor cell proliferation in mantle cell lymphoma is associated with elevated insulin-like growth factor 2 mRNA-binding protein 3 expression

Insight into genetic predisposition to chronic lymphocytic leukemia from integrative epigenomics

Integrated genomic and expression profiling in mantle cell lymphoma: identification of gene-dosage regulated candidate genes.

International network of cancer genome projects

Is TCL1 overexpression a good or a bad player in mantle cell lymphoma?

Landscape of somatic mutations and clonal evolution in mantle cell lymphoma.

Leukemic involvement is a common feature in mantle cell lymphoma

Loss of major histocompatibility class II expression in non-immune-privileged site diffuse large B-cell lymphoma is highly coordinated and not due to chromosomal deletions.

MicroRNA expression, chromosomal alterations, and immunoglobulin variable heavy chain hypermutations in Mantle cell lymphomas.

Molecular subsets of mantle cell lymphoma defined by the IGHV mutational status and SOX11 expression have distinct biologic and clinical features

Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma in Asia Frequently Shows <i>SETD2</i> Alterations

Multiple recurrent chromosomal breakpoints in mantle cell lymphoma revealed by a combination of molecular cytogenetic techniques

Mutational Landscape and Tumor Burden Assessed by Cell-Free DNA in Diffuse Large B-Cell Lymphoma in a Population-based Study

NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome.

NOTCH1, TP53, and MAP2K1 Mutations in Splenic Diffuse Red Pulp Small B-cell Lymphoma Are Associated With Progressive Disease

Non-coding recurrent mutations in chronic lymphocytic leukaemia

Non-nodal type of mantle cell lymphoma is a specific biological and clinical subgroup of the disease

PRDM1/BLIMP1 is commonly inactivated in anaplastic large T-cell lymphoma

Pathogenic role of B-cell receptor signaling and canonical NF-κB activation in mantle cell lymphoma

Pathway discovery in mantle cell lymphoma by integrated analysis of high-resolution gene expression and copy number profiling

Role of SOX11 and Genetic Events Cooperating with Cyclin D1 in Mantle Cell Lymphoma

SNP-based mapping arrays reveal high genomic complexity in monoclonal gammopathies, from MGUS to myeloma status

SOX11 regulates PAX5 expression and blocks terminal B-cell differentiation in aggressive mantle cell lymphoma

Secondary genomic alterations in non-Hodgkin's lymphomas: tumor-specific profiles with impact on clinical behavior

Specific secondary genetic alterations in mantle cell lymphoma provide prognostic information independent of the gene expression-based proliferation signature

Sporadic and reversible chromothripsis in chronic lymphocytic leukemia revealed by longitudinal genomic analysis.

Sporadic and reversible chromothripsis in chronic lymphocytic leukemia revealed by longitudinal genomic analysis.

The complex landscape of genetic alterations in mantle cell lymphoma

The prognostic impact of minimal residual disease in patients with chronic lymphocytic leukemia requiring first-line therapy

The reference epigenome and regulatory chromatin landscape of chronic lymphocytic leukemia

Unbalanced expression of licensing DNA replication factors occurs in a subset of mantle cell lymphomas with genomic instability

Uniparental disomies, homozygous deletions, amplifications, and target genes in mantle cell lymphoma revealed by integrative high-resolution whole-genome profiling.

Update on the molecular pathogenesis and clinical treatment of Mantle Cell Lymphoma (MCL): minutes of the 9th European MCL Network conference.

Update on the molecular pathogenesis and clinical treatment of mantle cell lymphoma: report of the 10th annual conference of the European Mantle Cell Lymphoma Network

Update on the molecular pathogenesis and clinical treatment of mantle cell lymphoma: report of the 11th annual conference of the European Mantle Cell Lymphoma Network