List of works - Tracy Hussell

A critical function for CD200 in lung immune homeostasis and the severity of influenza infection

scientific article published on 27 July 2008

A critical role for ICOS co-stimulation in immune containment of pulmonary influenza virus infection

scientific article

A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation

scientific article

A critical role for OX40 in T cell-mediated immunopathology during lung viral infection

scientific article

Accumulation of human-adapting mutations during circulation of A(H1N1)pdm09 influenza virus in humans in the United Kingdom.

scientific article

Airway immune homeostasis and implications for influenza-induced inflammation

scientific article published on 24 May 2011

Airway structural cells regulate TLR5-mediated mucosal adjuvant activity.

scientific article published on 25 September 2013

Altered regulation of Toll-like receptor responses impairs antibacterial immunity in the allergic lung

scientific article

Alveolar macrophages: plasticity in a tissue-specific context

scientific article published on 21 January 2014

Amelioration of influenza-induced pathology in mice by coinfection with Trichinella spiralis

scientific article published in March 2006

An absence of reactive oxygen species improves the resolution of lung influenza infection.

scientific article

An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action

scientific article

An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness.

scientific article published in August 2018

Axl and MerTK receptor tyrosine kinases maintain human macrophage efferocytic capacity in the presence of viral triggers

scientific article published on 5 February 2018

Bacterial complications during pandemic influenza infection.

scientific article

Bacterial superinfection following lung inflammatory disorders.

scientific article published on February 2013

Benzodiazepine augmented γ-amino-butyric acid signaling increases mortality from pneumonia in mice

scientific article published in July 2013

Boosting of cellular immunity against Mycobacterium tuberculosis and modulation of skin cytokine responses in healthy human volunteers by Mycobacterium bovis BCG substrain Moreau Rio de Janeiro oral vaccine.

scientific article

CD8+ T cells control Th2-driven pathology during pulmonary respiratory syncytial virus infection

scientific article published in December 1997

Chronic bacterial infections: living with unwanted guests

scientific article

Co-stimulation: novel methods for preventing viral-induced lung inflammation

scientific article published in August 2004

Colonic bacterial infection abrogates eosinophilic pulmonary disease

scientific article published on 14 December 2005

Differential chemokine expression following respiratory virus infection reflects Th1- or Th2-biased immunopathology.

scientific article

Diminished airway macrophage expression of the Axl receptor tyrosine kinase is associated with defective efferocytosis in asthma

scientific article published on 12 April 2017

Discovery of a vaccine antigen that protects mice from Chlamydia pneumoniae infection.

scientific article published on 13 December 2006

Eliminating a region of respiratory syncytial virus attachment protein allows induction of protective immunity without vaccine-enhanced lung eosinophilia.

scientific article

Endothelin-1 mediates Aspergillus fumigatus-induced airway inflammation and remodelling

scientific article published on 18 March 2019

Epidemiological isolation causing variable mortality in Island populations during the 1918-1920 influenza pandemic

scientific article

Evidence for a DC-specific inhibitory mechanism that depends on MyD88 and SIGIRR

scientific article

Flow cytometric measurement of intracellular cytokines.

scientific article

Functional group/guild modelling of inter-specific pathogen interactions: a potential tool for predicting the consequences of co-infection

scientific article

IL-17 boosts proinflammatory outcome of antiviral response in human cells

scientific article published on 30 September 2011

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

scientific article

Immune homeostasis in the respiratory tract and its impact on heterologous infection.

scientific article published on 15 February 2009

Immune modulatory strategies: a playground with a swing and a seesaw

scientific article published on 01 March 2012

Immunopathology of lung diseases: introduction for the special issue.

scientific article

Influenza virus lung infection protects from respiratory syncytial virus-induced immunopathology

scientific article

Inhibition of T1/ST2 during respiratory syncytial virus infection prevents T helper cell type 2 (Th2)- but not Th1-driven immunopathology

scientific article

Inhibition of tumor necrosis factor reduces the severity of virus-specific lung immunopathology

scientific article published in September 2001

Long-term persistence and reactivation of T cell memory in the lung of mice infected with respiratory syncytial virus.

scientific article published in September 2001

Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19

scientific article published on 01 September 2020

Lowering the threshold of lung innate immune cell activation alters susceptibility to secondary bacterial superinfection

scientific article

Macrophage-mediated inflammation and disease: a focus on the lung

scientific article published on 12 December 2012

Manipulation of acute inflammatory lung disease.

scientific article published on 07 May 2008

Mucosal immunisation of murine neonates using whole cell and acellular Pertussis vaccines.

scientific article

Ménage à trois of bacterial and viral pulmonary pathogens delivers coup de grace to the lung

scientific article published in July 2004

Nasal vaccination induces protective immunity without immunopathology.

scientific article published in December 2002

Neurturin regulates the lung-resident macrophage inflammatory response to viral infection

scientific article published on 05 October 2020

OX40 ligand fusion protein delivered simultaneously with the BCG vaccine provides superior protection against murine Mycobacterium tuberculosis infection

scientific article published on 7 February 2012

OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis.

scientific article published on 27 January 2014

Overexpression of heat-shock proteins reduces survival of Mycobacterium tuberculosis in the chronic phase of infection

scientific article published on 01 June 2001

Parenteral fluids do not affect pulmonary immune responses to influenza or susceptibility to secondary bacterial pneumonia in mice.

scientific article

Partners in crime: co-infections in the developing world

article

Prior exposure to live Mycobacterium bovis BCG decreases Cryptococcus neoformans-induced lung eosinophilia in a gamma interferon-dependent manner

scientific article

Progress and prospects of early detection in lung cancer

scientific article published on September 2017

Properties of human thymic B cells ⬇️

scientific article published on April 1, 1992

Protection against tetanus toxin using a plant-based vaccine

scientific article published on 01 April 2005

Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin

scientific article published in June 2009

Respiratory infections: do we ever recover?

scientific article

Respiratory syncytial virus infection provokes airway remodelling in allergen-exposed mice in absence of prior allergen sensitization.

scientific article

Respiratory viral infections: knowledge based therapeutics.

scientific article published on 05 July 2012

Reversal of TREM-1 ectodomain shedding and improved bacterial clearance by intranasal metalloproteinase inhibitors

scientific article published on 14 December 2016

Role of CCL11 in eosinophilic lung disease during respiratory syncytial virus infection

scientific article

Role of CCL5 (RANTES) in viral lung disease.

scientific article

Sedation & immunomodulation

scientific article published on July 2009

Sedation & immunomodulation

scientific article published in December 2011

Sensing of apoptotic cells through Axl causes lung basal cell proliferation in inflammatory diseases

scientific article published on 09 July 2019

Sequence analysis of immunoglobulin variable region genes that encode autoantibodies expressed by lymphomas of mucosa associated lymphoid tissue.

scientific article

Structured regulation of inflammation during respiratory viral infection

scientific article published on 01 May 2010

Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection.

scientific article

TGF-beta prevents eosinophilic lung disease but impairs pathogen clearance.

scientific article published on 24 February 2005

The Axl receptor tyrosine kinase is a discriminator of macrophage function in the inflamed lung.

scientific article published on 21 January 2015

The chemokine MIP1alpha/CCL3 determines pathology in primary RSV infection by regulating the balance of T cell populations in the murine lung.

scientific article

The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice

scientific article

The innate immune rheostat: influence on lung inflammatory disease and secondary bacterial pneumonia

scientific article published on August 2009

The microbiology of asthma

scientific article published on 06 June 2012

The response of cells from low-grade B-cell gastric lymphomas of mucosa-associated lymphoid tissue to Helicobacter pylori

scientific article published on 01 September 1993

The role of airway macrophages in apoptotic cell clearance following acute and chronic lung inflammation

scientific article

The therapeutic potential of positive and negative immune cell co-stimulation during inflammation

scientific article published on December 2006

Themis2/ICB1 is a signaling scaffold that selectively regulates macrophage Toll-like receptor signaling and cytokine production

scientific article published on 13 July 2010

Tumour infiltrating T-cells in gastric lymphoma

scientific article published on 01 January 1995

List of works by Tracy Hussell

A critical function for CD200 in lung immune homeostasis and the severity of influenza infection

A critical role for ICOS co-stimulation in immune containment of pulmonary influenza virus infection

A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation

A critical role for OX40 in T cell-mediated immunopathology during lung viral infection

Accumulation of human-adapting mutations during circulation of A(H1N1)pdm09 influenza virus in humans in the United Kingdom.

Airway immune homeostasis and implications for influenza-induced inflammation

Airway structural cells regulate TLR5-mediated mucosal adjuvant activity.

Altered regulation of Toll-like receptor responses impairs antibacterial immunity in the allergic lung

Alveolar macrophages: plasticity in a tissue-specific context

Amelioration of influenza-induced pathology in mice by coinfection with Trichinella spiralis

An absence of reactive oxygen species improves the resolution of lung influenza infection.

An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action

An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness.

Axl and MerTK receptor tyrosine kinases maintain human macrophage efferocytic capacity in the presence of viral triggers

Bacterial complications during pandemic influenza infection.

Bacterial superinfection following lung inflammatory disorders.

Benzodiazepine augmented γ-amino-butyric acid signaling increases mortality from pneumonia in mice

Boosting of cellular immunity against Mycobacterium tuberculosis and modulation of skin cytokine responses in healthy human volunteers by Mycobacterium bovis BCG substrain Moreau Rio de Janeiro oral vaccine.

CD8+ T cells control Th2-driven pathology during pulmonary respiratory syncytial virus infection

Chronic bacterial infections: living with unwanted guests

Co-stimulation: novel methods for preventing viral-induced lung inflammation

Colonic bacterial infection abrogates eosinophilic pulmonary disease

Differential chemokine expression following respiratory virus infection reflects Th1- or Th2-biased immunopathology.

Diminished airway macrophage expression of the Axl receptor tyrosine kinase is associated with defective efferocytosis in asthma

Discovery of a vaccine antigen that protects mice from Chlamydia pneumoniae infection.

Eliminating a region of respiratory syncytial virus attachment protein allows induction of protective immunity without vaccine-enhanced lung eosinophilia.

Endothelin-1 mediates Aspergillus fumigatus-induced airway inflammation and remodelling

Epidemiological isolation causing variable mortality in Island populations during the 1918-1920 influenza pandemic

Evidence for a DC-specific inhibitory mechanism that depends on MyD88 and SIGIRR

Flow cytometric measurement of intracellular cytokines.

Functional group/guild modelling of inter-specific pathogen interactions: a potential tool for predicting the consequences of co-infection

IL-17 boosts proinflammatory outcome of antiviral response in human cells

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

Immune homeostasis in the respiratory tract and its impact on heterologous infection.

Immune modulatory strategies: a playground with a swing and a seesaw

Immunopathology of lung diseases: introduction for the special issue.

Influenza virus lung infection protects from respiratory syncytial virus-induced immunopathology

Inhibition of T1/ST2 during respiratory syncytial virus infection prevents T helper cell type 2 (Th2)- but not Th1-driven immunopathology

Inhibition of tumor necrosis factor reduces the severity of virus-specific lung immunopathology

Long-term persistence and reactivation of T cell memory in the lung of mice infected with respiratory syncytial virus.

Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19

Lowering the threshold of lung innate immune cell activation alters susceptibility to secondary bacterial superinfection

Macrophage-mediated inflammation and disease: a focus on the lung

Manipulation of acute inflammatory lung disease.

Mucosal immunisation of murine neonates using whole cell and acellular Pertussis vaccines.

Ménage à trois of bacterial and viral pulmonary pathogens delivers coup de grace to the lung

Nasal vaccination induces protective immunity without immunopathology.

Neurturin regulates the lung-resident macrophage inflammatory response to viral infection

OX40 ligand fusion protein delivered simultaneously with the BCG vaccine provides superior protection against murine Mycobacterium tuberculosis infection

OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis.

Overexpression of heat-shock proteins reduces survival of Mycobacterium tuberculosis in the chronic phase of infection

Parenteral fluids do not affect pulmonary immune responses to influenza or susceptibility to secondary bacterial pneumonia in mice.

Partners in crime: co-infections in the developing world

Prior exposure to live Mycobacterium bovis BCG decreases Cryptococcus neoformans-induced lung eosinophilia in a gamma interferon-dependent manner

Progress and prospects of early detection in lung cancer

Properties of human thymic B cells ⬇️

Protection against tetanus toxin using a plant-based vaccine

Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin

Respiratory infections: do we ever recover?

Respiratory syncytial virus infection provokes airway remodelling in allergen-exposed mice in absence of prior allergen sensitization.

Respiratory viral infections: knowledge based therapeutics.

Reversal of TREM-1 ectodomain shedding and improved bacterial clearance by intranasal metalloproteinase inhibitors

Role of CCL11 in eosinophilic lung disease during respiratory syncytial virus infection

Role of CCL5 (RANTES) in viral lung disease.

Sedation & immunomodulation

Sedation & immunomodulation

Sensing of apoptotic cells through Axl causes lung basal cell proliferation in inflammatory diseases

Sequence analysis of immunoglobulin variable region genes that encode autoantibodies expressed by lymphomas of mucosa associated lymphoid tissue.

Structured regulation of inflammation during respiratory viral infection

Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection.

TGF-beta prevents eosinophilic lung disease but impairs pathogen clearance.

The Axl receptor tyrosine kinase is a discriminator of macrophage function in the inflamed lung.

The chemokine MIP1alpha/CCL3 determines pathology in primary RSV infection by regulating the balance of T cell populations in the murine lung.

The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice

The innate immune rheostat: influence on lung inflammatory disease and secondary bacterial pneumonia

The microbiology of asthma

The response of cells from low-grade B-cell gastric lymphomas of mucosa-associated lymphoid tissue to Helicobacter pylori

The role of airway macrophages in apoptotic cell clearance following acute and chronic lung inflammation

The therapeutic potential of positive and negative immune cell co-stimulation during inflammation