List of works - Thomas Thatcher

A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation

scientific article

AT-RvD1 Mitigates Secondhand Smoke-Exacerbated Pulmonary Inflammation and Restores Secondhand Smoke-Suppressed Antibacterial Immunity

scientific article published on 08 February 2021

Activated Human Lung Fibroblasts Produce Extracellular Vesicles with Anti-Fibrotic Prostaglandins

scientific article published on 01 March 2019

Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB.

scientific article published on March 2007

Attenuation of inflammatory mediator production by the NF-κB member RelB is mediated by microRNA-146a in lung fibroblasts

scientific article published on 05 April 2013

Autologous T-lymphocytes stimulate proliferation of orbital fibroblasts derived from patients with Graves' ophthalmopathy.

scientific article

Bacterial protease treatment of natural rubber latex alters its primary immunogenicity in a mouse model of sensitization

scientific article published on 01 October 2002

Cigarette Smoke Dampens Anti-viral Signaling in Small Airway Epithelial Cells by Disrupting TLR3 Cleavage.

scientific article published on 14 December 2017

Cigarette smoke exposure exacerbates lung inflammation and compromises immunity to bacterial infection

scientific article

Crystalline and amorphous silica differentially regulate the cyclooxygenase-prostaglandin pathway in pulmonary fibroblasts: implications for pulmonary fibrosis

scientific article published on 21 January 2005

Dung biomass smoke activates inflammatory signaling pathways in human small airway epithelial cells.

scientific article published on 11 November 2016

Electrophilic PPARγ Ligands Attenuate IL-1β and Silica-Induced Inflammatory Mediator Production in Human Lung Fibroblasts via a PPARγ-Independent Mechanism

scientific article

Electrophilic peroxisome proliferator-activated receptor-gamma ligands have potent antifibrotic effects in human lung fibroblasts.

scientific article

Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases

scientific article

Endogenous ligands of the aryl hydrocarbon receptor regulate lung dendritic cell function.

scientific article published on 10 November 2015

High-dose but not low-dose mainstream cigarette smoke suppresses allergic airway inflammation by inhibiting T cell function ⬇️

scientific article published on 20 June 2008

Human lung fibroblasts produce proresolving peroxisome proliferator-activated receptor-γ ligands in a cyclooxygenase-2-dependent manner

scientific article published on 9 September 2016

Increasing the frequency of T-cell precursors specific for a cryptic epitope of hen-egg lysozyme converts it to an immunodominant epitope

scientific article published on 01 February 2000

Inhibition of transglutaminase 2, a novel target for pulmonary fibrosis, by two small electrophilic molecules

scientific article

Ionizing radiation induces myofibroblast differentiation via lactate dehydrogenase

scientific article

Lipoxin B Enhances Human Memory B Cell Antibody Production via Upregulating Cyclooxygenase-2 Expression

article

Lung-targeted overexpression of the NF-κB member RelB inhibits cigarette smoke-induced inflammation

scientific article

Neu-164 and Neu-107, two novel antioxidant and anti-myeloperoxidase compounds, inhibit acute cigarette smoke-induced lung inflammation

scientific article

Normal Human Lung Epithelial Cells Inhibit Transforming Growth Factor-β Induced Myofibroblast Differentiation via Prostaglandin E2

scientific article published on 6 August 2015

Oropharyngeal aspiration of a silica suspension produces a superior model of silicosis in the mouse when compared to intratracheal instillation

scientific article published on 01 May 2006

PPAR-γ ligands repress TGFβ-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: implications for therapy of fibrosis

scientific article

PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis

scientific article published on 25 February 2005

Peroxisome proliferator-activated receptor γ B cell-specific-deficient mice have an impaired antibody response

scientific article

Pharmacologic inhibition of lactate production prevents myofibroblast differentiation

scientific article

Resolvin D1 Dampens Pulmonary Inflammation and Promotes Clearance of Nontypeable Haemophilus influenzae

scientific article published on 3 February 2016

Resolvin D1 Reduces Emphysema and Chronic Inflammation.

scientific article published on 12 October 2015

Resolvin D1 attenuates polyinosinic-polycytidylic acid-induced inflammatory signaling in human airway epithelial cells via TAK1

scientific article

Resolvins attenuate inflammation and promote resolution in cigarette smoke-exposed human macrophages

scientific article

Role of CXCR2 in cigarette smoke-induced lung inflammation

scientific article published on 15 April 2005

Secondhand Smoke Induces Inflammation and Impairs Immunity to Respiratory Infections.

scientific article

Sensitivity to bleomycin-induced lung injury is not moderated by an antigen-limited T-cell repertoire

scientific article published in September 2005

Specialized Proresolving Mediators Overcome Immune Suppression Induced by Exposure to Secondhand Smoke

scientific article published on 28 October 2020

Specialized proresolving mediators (SPMs) inhibit human B-cell IgE production

scientific article

Spiruchostatin A Inhibits Proliferation and Differentiation of Fibroblasts from Patients with Pulmonary Fibrosis ⬇️

scientific article published on January 12, 2012

The Role of PPARs in Lung Fibrosis

scientific article published in January 2007

The Self-fulfilling Prophecy of Pulmonary Fibrosis: A Selective Inspection of Pathologic Signaling Loops

scientific article published on 17 September 2020

The triterpenoid CDDO-Me inhibits bleomycin-induced lung inflammation and fibrosis

scientific article

Thy1 (CD90) controls adipogenesis by regulating activity of the Src family kinase, Fyn

scientific article published on 21 November 2014

Transglutaminase 2 and its role in pulmonary fibrosis.

scientific article published on 23 June 2011

List of works by Thomas Thatcher

A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation

AT-RvD1 Mitigates Secondhand Smoke-Exacerbated Pulmonary Inflammation and Restores Secondhand Smoke-Suppressed Antibacterial Immunity

Activated Human Lung Fibroblasts Produce Extracellular Vesicles with Anti-Fibrotic Prostaglandins

Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB.

Attenuation of inflammatory mediator production by the NF-κB member RelB is mediated by microRNA-146a in lung fibroblasts

Autologous T-lymphocytes stimulate proliferation of orbital fibroblasts derived from patients with Graves' ophthalmopathy.

Bacterial protease treatment of natural rubber latex alters its primary immunogenicity in a mouse model of sensitization

Cigarette Smoke Dampens Anti-viral Signaling in Small Airway Epithelial Cells by Disrupting TLR3 Cleavage.

Cigarette smoke exposure exacerbates lung inflammation and compromises immunity to bacterial infection

Crystalline and amorphous silica differentially regulate the cyclooxygenase-prostaglandin pathway in pulmonary fibroblasts: implications for pulmonary fibrosis

Dung biomass smoke activates inflammatory signaling pathways in human small airway epithelial cells.

Electrophilic PPARγ Ligands Attenuate IL-1β and Silica-Induced Inflammatory Mediator Production in Human Lung Fibroblasts via a PPARγ-Independent Mechanism

Electrophilic peroxisome proliferator-activated receptor-gamma ligands have potent antifibrotic effects in human lung fibroblasts.

Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases

Endogenous ligands of the aryl hydrocarbon receptor regulate lung dendritic cell function.

High-dose but not low-dose mainstream cigarette smoke suppresses allergic airway inflammation by inhibiting T cell function ⬇️

Human lung fibroblasts produce proresolving peroxisome proliferator-activated receptor-γ ligands in a cyclooxygenase-2-dependent manner

Increasing the frequency of T-cell precursors specific for a cryptic epitope of hen-egg lysozyme converts it to an immunodominant epitope

Inhibition of transglutaminase 2, a novel target for pulmonary fibrosis, by two small electrophilic molecules

Ionizing radiation induces myofibroblast differentiation via lactate dehydrogenase

Lipoxin B Enhances Human Memory B Cell Antibody Production via Upregulating Cyclooxygenase-2 Expression

Lung-targeted overexpression of the NF-κB member RelB inhibits cigarette smoke-induced inflammation

Neu-164 and Neu-107, two novel antioxidant and anti-myeloperoxidase compounds, inhibit acute cigarette smoke-induced lung inflammation

Normal Human Lung Epithelial Cells Inhibit Transforming Growth Factor-β Induced Myofibroblast Differentiation via Prostaglandin E2

Oropharyngeal aspiration of a silica suspension produces a superior model of silicosis in the mouse when compared to intratracheal instillation

PPAR-γ ligands repress TGFβ-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: implications for therapy of fibrosis

PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis

Peroxisome proliferator-activated receptor γ B cell-specific-deficient mice have an impaired antibody response

Pharmacologic inhibition of lactate production prevents myofibroblast differentiation

Resolvin D1 Dampens Pulmonary Inflammation and Promotes Clearance of Nontypeable Haemophilus influenzae

Resolvin D1 Reduces Emphysema and Chronic Inflammation.

Resolvin D1 attenuates polyinosinic-polycytidylic acid-induced inflammatory signaling in human airway epithelial cells via TAK1

Resolvins attenuate inflammation and promote resolution in cigarette smoke-exposed human macrophages

Role of CXCR2 in cigarette smoke-induced lung inflammation

Secondhand Smoke Induces Inflammation and Impairs Immunity to Respiratory Infections.

Sensitivity to bleomycin-induced lung injury is not moderated by an antigen-limited T-cell repertoire

Specialized Proresolving Mediators Overcome Immune Suppression Induced by Exposure to Secondhand Smoke

Specialized proresolving mediators (SPMs) inhibit human B-cell IgE production

Spiruchostatin A Inhibits Proliferation and Differentiation of Fibroblasts from Patients with Pulmonary Fibrosis ⬇️

The Role of PPARs in Lung Fibrosis

The Self-fulfilling Prophecy of Pulmonary Fibrosis: A Selective Inspection of Pathologic Signaling Loops

The triterpenoid CDDO-Me inhibits bleomycin-induced lung inflammation and fibrosis

Thy1 (CD90) controls adipogenesis by regulating activity of the Src family kinase, Fyn

Transglutaminase 2 and its role in pulmonary fibrosis.