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List of works by Zoe Hughes

3-(Pyridin-2-yl-ethynyl)benzamide metabotropic glutamate receptor 5 negative allosteric modulators: Hit to lead studies

article

5-HT(1A) receptor antagonism reverses and prevents fluoxetine-induced sexual dysfunction in rats

scientific article

5-Piperazinyl-3-sulfonylindazoles as potent and selective 5-hydroxytryptamine-6 antagonists

scientific article

A partial noradrenergic lesion induced by DSP-4 increases extracellular noradrenaline concentration in rat frontal cortex: a microdialysis study in vivo

scientific article published in April 1998

Ablation of the locus coeruleus increases oxidative stress in tg-2576 transgenic but not wild-type mice.

scientific article published on 11 October 2010

Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1

scientific article published on 19 May 2015

BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes

scientific article

Central effects of urotensin-II following ICV administration in rats

scientific article (publication date: June 2001)

Characterisation of the selective 5-HT1B receptor antagonist SB-616234-A (1-[6-(cis-3,5-dimethylpiperazin-1-yl)-2,3-dihydro-5-methoxyindol-1-yl]-1-[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride): in vivo neurochem

scientific article published on 31 March 2006

Comparison of changes in the extracellular concentration of noradrenaline in rat frontal cortex induced by sibutramine or d-amphetamine: modulation by alpha2-adrenoceptors

scientific article

Correlating efficacy in rodent cognition models with in vivo 5-hydroxytryptamine1a receptor occupancy by a novel antagonist, (R)-N-(2-methyl-(4-indolyl-1-piperazinyl)ethyl)-N-(2-pyridinyl)-cyclohexane carboxamide (WAY-101405).

scientific article published on 8 January 2008

Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor.

scientific article

Development of a liquid chromatography/tandem mass spectrometry method for the quantitation of acetylcholine and related neurotransmitters in brain microdialysis samples

scientific article published on 23 February 2007

Differential autoreceptor control of extracellular 5-HT in guinea pig and rat: species and regional differences

scientific article published on 30 September 2003

Differentiating antidepressants of the future: efficacy and safety

scientific article published on 27 September 2006

Effects of a Balanced Translocation between Chromosomes 1 and 11 Disrupting the DISC1 Locus on White Matter Integrity

scientific article

Effects of atomoxetine and methylphenidate on attention and impulsivity in the 5-choice serial reaction time test

scientific article published on 27 June 2007

Evidence for sustained elevation of IL-6 in the CNS as a key contributor of depressive-like phenotypes.

scientific article published on 4 December 2012

Evidence from microdialysis and synaptosomal studies of rat cortex for noradrenaline uptake sites with different sensitivities to SSRIs ⬇️

scientific article published on July 1, 1998

Flow cytometric analysis of BrdU incorporation as a high-throughput method for measuring adult neurogenesis in the mouse

scientific article published on 14 December 2008

Future Viable Models of Psychiatry Drug Discovery in Pharma ⬇️

scientific article published on 07 February 2013

High-performance liquid chromatography/tandem mass spectrometry assay for the rapid high sensitivity measurement of basal acetylcholine from microdialysates

scientific article published in November 2002

Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice

scientific article

In vivo characterization of basal amino acid levels in subregions of the rat nucleus accumbens: effect of a dopamine D(3)/D(2) agonist

scientific article published in September 2001

Increased noradrenaline efflux induced by local infusion of fluoxetine in the rat frontal cortex

scientific article published in December 1996

Increased responsiveness of dopamine to atypical, but not typical antipsychotics in the medial prefrontal cortex of rats reared in isolation

scientific article

Innovations in CNS drug discovery: differentiating strategies to treat depression ⬇️

scientific article published on October 1, 2007

Innovative approaches for the development of antidepressant drugs: current and future strategies

scientific article

LPA1 receptor-deficient mice have phenotypic changes observed in psychiatric disease

scientific article published in December 2003

Negative allosteric modulation of metabotropic glutamate receptor 5 results in broad spectrum activity relevant to treatment resistant depression.

scientific article

Neurochemical changes in LPA1 receptor deficient mice--a putative model of schizophrenia

scientific article published in March 2005

Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone.

scientific article

PDE4B as a microglia target to reduce neuroinflammation.

scientific article published on April 2016

Pharmacological disruption of mouse social approach behavior: relevance to negative symptoms of schizophrenia

scientific article published on 25 June 2013

Prefrontal Cortical Kappa Opioid Receptors Attenuate Responses to Amygdala Inputs.

scientific article published on 14 May 2015

Receptor and behavioral pharmacology of WAY-267464, a non-peptide oxytocin receptor agonist

scientific article

Simultaneous blockade of 5-HT1A/B receptors and 5-HT transporters results in acute increases in extracellular 5-HT in both rats and guinea pigs: in vivo characterization of the novel 5-HT1A/B receptor antagonist/5-HT transport inhibitor SB-649915-B.

scientific article

Temporal dysregulation of cortical gene expression in the isolation reared Wistar rat.

scientific article published on 24 January 2010

The BTBR Mouse Model of Autism Spectrum Disorders Has Learning and Attentional Impairments and Alterations in Acetylcholine and Kynurenic Acid in Prefrontal Cortex ⬇️

scientific article published on April 24, 2013

The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise?

scientific article published on 20 April 2011

The orphan GPCR, GPR88, modulates function of the striatal dopamine system: a possible therapeutic target for psychiatric disorders?

scientific article published on 29 September 2009

The synthesis and biological evaluation of quinolyl-piperazinyl piperidines as potent serotonin 5-HT1A antagonists

scientific article published in May 2010

Use of Arc expression as a molecular marker of increased postsynaptic 5-HT function after SSRI/5-HT1A receptor antagonist co-administration

scientific article

WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent

scientific article

WAY-318068: a novel, potent and selective noradrenaline re-uptake inhibitor with activity in rodent models of pain and depression

scientific article

WS-50030 [7-{4-[3-(1H-inden-3-yl)propyl]piperazin-1-yl}-1,3-benzoxazol-2(3H)-one]: a novel dopamine D2 receptor partial agonist/serotonin reuptake inhibitor with preclinical antipsychotic-like and antidepressant-like activity

scientific article published on 14 October 2009

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