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List of works by Paul Brindle

A specific CBP/p300-dependent gene expression programme drives the metabolic remodelling in late stages of spermatogenesis.

scientific article published on 13 February 2014

A transcription factor-binding domain of the coactivator CBP is essential for long-term memory and the expression of specific target genes

scientific article published on 15 September 2006

A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis

scientific article published in Nature

CBP/p300 double null cells reveal effect of coactivator level and diversity on CREB transactivation ⬇️

scientific article published on September 21, 2010

CREBBP mutations in relapsed acute lymphoblastic leukaemia

scientific article

Combinatorial regulation of a signal-dependent activator by phosphorylation and acetylation

scientific article

Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development

scientific article published in February 2006

Crebbp loss cooperates with Bcl2 overexpression to promote lymphoma in mice.

scientific article

Differential role for CBP and p300 CREB-binding domain in motor skill learning

scientific article

Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control

scientific article

Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation

scientific article

Double null cells reveal that CBP and p300 are dispensable for p53 targets p21 and Mdm2 but variably required for target genes of other signaling pathways

scientific article published on 15 January 2011

Functional interaction of STAT5 and nuclear receptor co-repressor SMRT: implications in negative regulation of STAT5-dependent transcription

scientific article

Genetic interaction between mutations in c-Myb and the KIX domains of CBP and p300 affects multiple blood cell lineages and influences both gene activation and repression

scientific article (publication date: 2013)

Genome-wide and single-cell analyses reveal a context dependent relationship between CBP recruitment and gene expression

scientific article

Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells

scientific article

Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8+ T-cell development

scientific article published on 11 May 2009

Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation

scientific article

Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300.

scientific article published on 12 September 2013

Inactivating mutations of acetyltransferase genes in B-cell lymphoma

scientific article (publication date: 10 March 2011)

Individual CREB-target genes dictate usage of distinct cAMP-responsive coactivation mechanisms

scientific article

Inhibition of p300 impairs Foxp3⁺ T regulatory cell function and promotes antitumor immunity.

scientific article published on 18 August 2013

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

scientific article

Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency.

scientific article published in February 2004

Multiple protein kinase A-regulated events are required for transcriptional induction by cAMP.

scientific article

Mutation of the CH1 Domain in the Histone Acetyltransferase CREBBP Results in Autism-Relevant Behaviors in Mice

scientific article (publication date: 2016)

Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment.

scientific article published on February 2014

Subregion-specific p300 conditional knock-out mice exhibit long-term memory impairments

scientific article

T-cells null for the MED23 subunit of mediator express decreased levels of KLF2 and inefficiently populate the peripheral lymphoid organs

scientific journal article

Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases.

scientific article published on 27 January 2010

The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism

scientific journal article

The CREB family of transcription activators

scientific article published on April 1, 1992

The CREBBP Acetyltransferase Is a Haploinsufficient Tumor Suppressor in B-cell Lymphoma

scientific article published on 9 January 2017

Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB.

scientific article published in July 1992

Transcriptional regulation by an upstream repression sequence from the yeast enolase gene ENO1.

scientific article published in September 1995

Two histone/protein acetyltransferases, CBP and p300, are indispensable for Foxp3+ T-regulatory cell development and function

scientific article

Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression.

scientific article

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