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List of works by Dirk Weuster-Botz

A new microfluidic concept for parallel operated milliliter-scale stirred tank bioreactors

scientific article published on 26 April 2011

A novel milliliter-scale chemostat system for parallel cultivation of microorganisms in stirred-tank bioreactors.

scientific article

A novel one-step expression and immobilization method for the production of biocatalytic preparations

scientific article published on 14 November 2015

A parallel bubble column system for the cultivation of phototrophic microorganisms

scientific article published on 17 May 2008

A two-stage biological gas to liquid transfer process to convert carbon dioxide into bioplastic

Advanced protein crystallization using water-soluble ionic liquids as crystallization additives

scientific article published in August 2007

Application of fuzzy-logic models for metabolic control analysis

scientific article published on 27 October 2006

Asymmetric synthesis of tert-butyl (3R, 5S) 6-chloro-dihydroxyhexanoate with Lactobacillus kefir

scientific article

Automated sampling device for monitoring intracellular metabolite dynamics

scientific article published on 01 May 1999

Bacterial Anaerobic Synthesis Gas (Syngas) and CO+H Fermentation

scientific article published on 16 March 2018

Biocatalytic process optimization based on mechanistic modeling of cholic acid oxidation with cofactor regeneration

scientific article published on 28 January 2011

Biochemical engineering science

scientific article published in April 2008

Biotechnological mass production of DNA origami

scientific article published in December 2017

Carbon monoxide conversion with Clostridium aceticum

scientific article published on 17 September 2018

Carbon storage in recombinant Escherichia coli during growth on glycerol and lactic acid

scientific article published on 29 July 2014

Characterization of stirrers for screening studies of enzymatic biomass hydrolyses on a milliliter scale

scientific article published on 26 September 2012

Chemostat studies of bacteriophage M13 infected Escherichia coli JM109 for continuous ssDNA production.

scientific article

Cofactor regeneration in phototrophic cyanobacteria applied for asymmetric reduction of ketones

scientific article published on 08 March 2007

Combined sulfite method for the measurement of the oxygen transfer coefficient k(L)a in bio-reactors

scientific article published on 10 August 2005

Comparative characterization of novel ene-reductases from cyanobacteria.

scientific article published on 21 January 2013

Comparative evaluation of Aspergillus niger strains for endogenous pectin-depolymerization capacity and suitability for D-galacturonic acid production

scientific article published on 23 April 2020

Comparative reaction engineering analysis of different acetogenic bacteria for gas fermentation

scientific article published on 20 April 2016

Comparative reaction engineering studies for succinic acid production from sucrose by metabolically engineered Escherichia coli in fed-batch-operated stirred tank bioreactors.

scientific article published on 14 June 2012

Comparison of genetic algorithms for experimental multi-objective optimization on the example of medium design for cyanobacteria

scientific article published in May 2006

Continuous gas fermentation by Acetobacterium woodii in a submerged membrane reactor with full cell retention

scientific article published on 31 July 2015

Development, parallelization, and automation of a gas-inducing milliliter-scale bioreactor for high-throughput bioprocess design (HTBD).

scientific article published in March 2005

Discrimination of riboflavin producing Bacillus subtilis strains based on their fed-batch process performances on a millilitre scale

scientific article published on 25 March 2009

Dynamic mechanistic modeling of the multienzymatic one-pot reduction of dehydrocholic acid to 12-keto ursodeoxycholic acid with competing substrates and cofactors

scientific article published on 2 February 2015

Effects of hydrogen partial pressure on autotrophic growth and product formation of Acetobacterium woodii

scientific article published on 9 April 2016

Efficient Production of Single-Stranded Phage DNA as Scaffolds for DNA Origami

scientific article published on 3 June 2015

Efficient whole-cell biotransformation in a biphasic ionic liquid/water system

scientific article published in August 2004

Enantioselective reduction of prochiral ketones by engineered bifunctional fusion proteins

scientific article published on 2 August 2010

Engineering of formate dehydrogenase: synergistic effect of mutations affecting cofactor specificity and chemical stability

scientific article published on 17 May 2012

Engineering solutions for open microalgae mass cultivation and realistic indoor simulation of outdoor environments.

scientific article

Estimation of optimal feeding strategies for fed-batch bioprocesses

scientific article published in June 2005

Evaluation of fluorimetric pH sensors for bioprocess monitoring at low pH.

scientific article published on 13 May 2015

Evaluation of parallel milliliter-scale stirred-tank bioreactors for the study of biphasic whole-cell biocatalysis with ionic liquids.

scientific article published on 3 November 2011

Evaluation of parallel operated small-scale bubble columns for microbial process development using Staphylococcus carnosus

scientific article

Experimental design for fermentation media development: statistical design or global random search?

scientific article published in January 2000

Experimental design for the identification of macrokinetic models and model discrimination

scientific article published in December 1997

Experimental optimization of protein refolding with a genetic algorithm ⬇️

scientific article published on November 1, 2010

Experimental validation of in silico estimated biomass yields of Pseudomonas putida KT2440.

scientific article published on 14 March 2017

Fast sampling and quenching procedures for microbial metabolic profiling

scientific article published on 4 May 2007

Fed-batch production of l-tryptophan from glycerol using recombinant Escherichia coli

scientific article published on 06 October 2018

Fed-batch production of recombinant human calcitonin precursor fusion protein using Staphylococcus carnosus as an expression-secretion system

scientific article published on 01 September 2000

Feeding strategies enhance high cell density cultivation and protein expression in milliliter scale bioreactors

scientific article published on 8 September 2014

Fully automated single-use stirred-tank bioreactors for parallel microbial cultivations

scientific article published on 12 January 2008

General medium for the autotrophic cultivation of acetogens

scientific article

Genetic algorithm for multi-objective experimental optimization

scientific article

Growth and recombinant protein expression with Escherichia coli in different batch cultivation media.

scientific article published on 23 December 2010

High-performance recombinant protein production with Escherichia coli in continuously operated cascades of stirred-tank reactors

scientific article published in March 2017

Human chymotrypsinogen B production with Pichia pastoris by integrated development of fermentation and downstream processing. Part 1. Fermentation

scientific article published in May 2001

Identification, cloning, and characterization of a novel ketoreductase from the cyanobacterium Synechococcus sp. strain PCC 7942

scientific article published on 12 September 2008

Improvement of constraint-based flux estimation during L-phenylalanine production with Escherichia coli using targeted knock-out mutants.

scientific article

Influence of different packing methods on the hydrodynamic stability of chromatography columns.

scientific article published on 8 August 2017

Integrated L-phenylalanine separation in an E. coli fed-batch process: from laboratory to pilot scale

scientific article published on 26 March 2002

Integrated separation process for isolation and purification of biosuccinic acid.

scientific article

Kinetic studies on autohydrogenotrophic growth of Ralstonia eutropha with nitrate as terminal electron acceptor

scientific article published on 25 April 2007

Large-Scale Production of a Soluble Human β-1,4-Galactosyltransferase Using a Saccharomyces cerevisiae Expression System

scientific article published on 01 February 1995

Lipid production with Trichosporon oleaginosus in a membrane bioreactor using microalgae hydrolysate

scientific article

Macroscopic investigation of the transient hydrodynamic memory behavior of preparative packed chromatography beds

scientific article published on 28 December 2010

Metabolic engineering of Saccharomyces cerevisiae for the biotechnological production of succinic acid

scientific article published on 18 September 2010

Metabolic profiling of Escherichia coli cultivations: evaluation of extraction and metabolite analysis procedures

scientific article published on 4 May 2007

Methods and milliliter scale devices for high-throughput bioprocess design

scientific article published on 5 November 2005

Microbial production of homogeneously layered cellulose pellicles in a membrane bioreactor

scientific article published on 10 May 2011

Milliliter-scale stirred tank reactors for the cultivation of microorganisms.

scientific article published on January 2010

Miniature bioreactors for automated high-throughput bioprocess design (HTBD): reproducibility of parallel fed-batch cultivations with Escherichia coli

scientific article published in December 2005

Model-supported optimization of phototrophic growth in a stirred-tank photobioreactor

scientific article published in December 2006

Model-supported phototrophic growth studies with Scenedesmus obtusiusculus in a flat-plate photobioreactor.

scientific article

Modeling of transient flow through a viscoelastic preparative chromatography packing.

scientific article published on 25 June 2013

Modifying the product pattern of Clostridium acetobutylicum: physiological effects of disrupting the acetate and acetone formation pathways

scientific article published on 14 January 2012

Multi-enzymatic one-pot reduction of dehydrocholic acid to 12-keto-ursodeoxycholic acid with whole-cell biocatalysts.

scientific article published on 18 September 2012

Neutron and X-ray crystal structures of Lactobacillus brevis alcohol dehydrogenase reveal new insights into hydrogen-bonding pathways

scientific article published on 26 November 2018

New milliliter-scale stirred tank bioreactors for the cultivation of mycelium forming microorganisms

scientific article published in June 2010

New miniature stirred-tank bioreactors for parallel study of enzymatic biomass hydrolysis

scientific article published on 11 December 2011

New reactive extraction systems for separation of bio-succinic acid

scientific article published on 25 February 2011

Non-chromatographic preparative purification of enhanced green fluorescent protein.

scientific article published on 17 December 2014

Non-water miscible ionic liquid improves biocatalytic production of geranyl glucoside with Escherichia coli overexpressing a glucosyltransferase

scientific article published on 3 May 2016

Novel whole-cell biocatalysts with recombinant hydroxysteroid dehydrogenases for the asymmetric reduction of dehydrocholic acid.

scientific article published on 15 May 2012

One-step synthesis of 12-ketoursodeoxycholic acid from dehydrocholic acid using a multienzymatic system

scientific article published on 17 August 2012

Parallel reactor systems for bioprocess development.

scientific article

Parallel steady state studies on a milliliter scale accelerate fed-batch bioprocess design for recombinant protein production with Escherichia coli

scientific article published on 7 September 2016

Parallel substrate feeding and pH-control in shaking-flasks

scientific article published in March 2001

Parallelized small-scale production of uniformly (13)C-labeled cell extract for quantitative metabolome analysis.

scientific article published on 12 March 2015

Perturbation Experiments: Approaches for Metabolic Pathway Analysis in Bioreactors.

scientific article published on 16 May 2015

Phosphoenolpyruvate Transporter Enables Targeted Perturbation During Metabolic Analysis of L-Phenylalanine Production With Escherichia coli

scientific article published on 8 December 2017

Population heterogeneity in microbial bioprocesses: origin, analysis, mechanisms, and future perspectives.

scientific article published on 14 March 2018

Power consumption and maximum energy dissipation in a milliliter-scale bioreactor

scientific article published on 01 March 2010

Process intensification of whole-cell biocatalysis with ionic liquids

scientific article published on 01 January 2007

Process performance of parallel bioreactors for batch cultivation of Streptomyces tendae

scientific article published on 08 October 2010

Production of Lactobacillus kefir cells for asymmetric synthesis of a 3,5-dihydroxycarboxylate

scientific article published on 22 December 2004

Production of halophilic proteins using Haloferax volcanii H1895 in a stirred-tank bioreactor.

scientific article published in October 2015

Protein crystallization in stirred systems--scale-up via the maximum local energy dissipation

scientific article published on 09 February 2013

Purification of proteins from solutions containing residual host cell proteins via preparative crystallization

scientific article published on 26 May 2015

Rapid media transition: an experimental approach for steady state analysis of metabolic pathways

scientific article published in January 2010

Rational selection of biphasic reaction systems for geranyl glucoside production by Escherichia coli whole-cell biocatalysts

scientific article published on 08 November 2017

Reaction engineering analysis of L-lysine transport by Corynebacterium glutamicum

scientific article published on 01 July 1996

Reaction engineering analysis of Scenedesmus ovalternus in a flat-plate gas-lift photobioreactor

scientific article published on 11 November 2016

Reaction engineering analysis of cellulase production with Trichoderma reesei RUT-C30 with intermittent substrate supply

scientific article published on 26 September 2012

Reaction engineering analysis of the autotrophic energy metabolism of Clostridium aceticum

scientific article published on 23 October 2017

Reaction engineering methods to study intracellular metabolite concentrations.

scientific article published on January 1996

Reaction engineering studies for the production of 2-hydroxyisobutyric acid with recombinant Cupriavidus necator H 16.

scientific article published on 13 July 2010

Reaction engineering studies of acetone-butanol-ethanol fermentation with Clostridium acetobutylicum

scientific article published on 18 January 2012

Sampling tube device for monitoring intracellular metabolite dynamics.

scientific article

Selective enhancement of autotrophic acetate production with genetically modified Acetobacterium woodii

scientific article

Specific growth rate and multiplicity of infection affect high-cell-density fermentation with bacteriophage M13 for ssDNA production.

scientific article published on 17 October 2016

Statistical vs. stochastic experimental design: an experimental comparison on the example of protein refolding

scientific article published on 18 October 2012

Steady-state analysis of metabolic pathways: comparing the double modulation method and the lin-log approach

scientific article published on 14 August 2007

Studies on the scale-up of biomass production with Scenedesmus spp. in flat-plate gas-lift photobioreactors.

scientific article

Two stirred-tank bioreactors in series enable continuous production of alcohols from carbon monoxide with Clostridium carboxidivorans

scientific article published on 03 July 2018

Using gas mixtures of CO, CO2 and H2 as microbial substrates: the do's and don'ts of successful technology transfer from laboratory to production scale.

scientific article

Utilization of organophosphate:phosphate antiporter for isotope-labeling experiments in E. coli.

scientific article

Water immiscible ionic liquids as solvents for whole cell biocatalysis.

scientific article published on 18 January 2006

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