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List of works by Maureane Hoffman

A mouse bleeding model to study oral anticoagulants.

scientific article

A rationally designed heparin, M118, has anticoagulant activity similar to unfractionated heparin and different from Lovenox in a cell-based model of thrombin generation.

scientific article published in August 2009

A systematic evaluation of the effect of temperature on coagulation enzyme activity and platelet function

scientific article published in June 2004

A unique protein kinase C-dependent pathway for tissue factor downregulation in pericytes

scientific article published on 01 March 2019

Abnormal joint and bone wound healing in hemophilia mice is improved by extending factor IX activity after hemarthrosis.

scientific article published on 30 December 2016

Activated protein C cleaves factor Va more efficiently on endothelium than on platelet surfaces

scientific article published on 01 July 2002

Adaptation to hyperoxia in the neonatal rat: Kinetic parameters of the oxygen-mediated induction of lung superoxide dismutases, catalase and glutathione peroxidase

scientific article published on 01 January 1980

Alpha-macroglobulin secreted by alveolar macrophages serves as a binding protein for a macrophage-derived homologue of platelet-derived growth factor.

scientific article

An activated factor VII variant with enhanced tissue factor-independent activity speeds wound healing in a mouse hemophilia B model.

scientific article published on 8 March 2016

Analyzing fibrin clot structure using a microplate reader.

scientific article published in September 2002

Animal models of bleeding and tissue repair

scientific article

Bleeding risk in warfarinized patients with a therapeutic international normalized ratio: the effect of low factor IX levels.

scientific article published in June 2013

Celecoxib does not delay cutaneous wound healing in haemophilia B mice

scientific article

Circulating and binding characteristics of wild-type factor IX and certain Gla domain mutants in vivo

scientific article

Circulating tissue factor accumulates in thrombi, but not in hemostatic plugs

scientific article published on 01 September 2006

Coagulation 2006: a modern view of hemostasis.

scientific article

Coagulation disorders and hemostasis in liver disease: pathophysiology and critical assessment of current management

scientific article

Coagulation factor XI is a contaminant in intravenous immunoglobulin preparations

scientific article published on 01 September 2000

Coagulation in Liver Disease.

scientific article published on 06 June 2015

Comparison of the effects of IL-1 alpha and TNF-alpha on phagocyte accumulation and murine antibacterial immunity

scientific article published in October 1989

Consequences of intra-articular bleeding in haemophilia: science to clinical practice and beyond

scientific article

Cutaneous wound healing is impaired in hemophilia B.

scientific article published on 6 July 2006

Deencryption of cellular tissue factor is independent of its cytoplasmic domain.

scientific article

Dysregulation of hemostasis by cancer.

scientific article published on January 2009

Effect of cyclooxygenase inhibitors and protease inhibitors on phorbol-induced stimulation of oxygen consumption and superoxide production by rat pulmonary macrophages ⬇️

scientific article published on March 1, 1982

Effect of interferon-γ and human α2-macroglobulin on peritoneal macrophage morphology and Ia antigen expression

scientific article published on 01 February 1990

Elevated plasma homocysteine leads to alterations in fibrin clot structure and stability: implications for the mechanism of thrombosis in hyperhomocysteinemia

scientific article published in February 2003

Elevated prothrombin level and shortened clotting times in subjects with type 2 diabetes

scientific article published on 13 December 2006

Elevated prothrombin results in clots with an altered fiber structure: a possible mechanism of the increased thrombotic risk

scientific article published on 27 December 2002

Engineering a new generation of hemostatic agents: highlights of the Scientific Session on Hemostasis at the 2013 meeting of the American Society of Hematology

scientific article published on 24 March 2014

Exposure of mice to topical bovine thrombin induces systemic autoimmunity

scientific article

FVIIa: you've come a long way, baby!

scientific article published on 01 October 2008

From antiphospholipid syndrome to antibody-mediated thrombosis

scientific article published in The Lancet

Hemostasis: Old System, New Players, New Directions

scholarly article by Maureane Hoffman & Rafal Pawlinski published May 2014 in Thrombosis Research

Hemostatic properties of the FVIIa analog NN1731 ⬇️

scientific article published on March 23, 2012

Heparin cofactor II and thrombin Heparin-binding proteins linking hemostasis and inflammation

scientific article published on May 1994

High dose factor VIIa improves clot structure and stability in a model of haemophilia B.

scientific article published in December 2005

High-dose factor VIIa increases initial thrombin generation and mediates faster platelet activation in thrombocytopenia-like conditions in a cell-based model system.

scientific article

Homocysteinylated fibrinogen forms disulfide-linked complexes with albumin

scientific article published on 12 February 2011

Human platelets express endothelial protein C receptor, which can be utilized to enhance localization of factor VIIa activity

scientific article published on 27 June 2018

Hypercoagulation and thrombophilia in liver disease

scientific article

Hypothesis: Hyperhomocysteinemia is an indicator of oxidant stress ⬇️

scientific article published on 02 October 2011

Impact of procoagulant concentration on rate, peak and total thrombin generation in a model system

scientific article published in March 2004

Inflammation does not predispose to bleeding in hemophilia

scientific article published in November 2010

Laboratory Monitoring of High-Dose Factor VIIa Therapy

scientific article published on 01 November 2003

Localization of heparin cofactor II in injured human skin: a potential role in wound healing.

scientific article

Low intensity laser therapy speeds wound healing in hemophilia by enhancing platelet procoagulant activity.

scientific article

Manipulation of prothrombin concentration improves response to high-dose factor VIIa in a cell-based model of haemophilia

scientific article published on 20 June 2006

Mechanisms and monitoring of bypassing agent therapy

scientific article published on August 2012

Modification of fibrinogen by homocysteine thiolactone increases resistance to fibrinolysis: a potential mechanism of the thrombotic tendency in hyperhomocysteinemia

scientific article published in February 2006

New insights into the coagulation system and implications for new therapeutic options with recombinant factor VIIa

scientific article

Novel oral anticoagulants and reversal agents: Considerations for clinical development

scientific article published on 26 March 2015

One more way that mice and men are different

scientific article published on 01 March 2005

PDGF-stimulated fibroblast proliferation is enhanced synergistically by receptor-recognized ?2-Macroglobulin ⬇️

scientific article published on October 1, 1990

Perivascular tissue factor is down-regulated following cutaneous wounding: implications for bleeding in hemophilia

scientific article published on 30 November 2007

Platelet Heterogeneity

scientific article published on 13 January 2005

Platelet activation in patients with thrombotic thrombocytopenic purpura.

scientific article

Platelet activity of high-dose factor VIIa is independent of tissue factor

scientific article

Platelet binding and activity of a factor VIIa variant with enhanced tissue factor independent activity.

scientific article published in April 2011

Platelet functions beyond hemostasis

scientific article

Platelet procoagulant complex assembly in a tissue factor-initiated system

scientific article published on 01 October 1994

Platelets and thrombin generation

scientific article

Platelets from thrombocytopenic ponies acutely infected with equine infectious anemia virus are activated in vivo and hypofunctional.

scientific article

Practical coagulation for the blood banker

scientific article published on 08 April 2013

Pro-thrombotic and pro-oxidant effects of diet-induced hyperhomocysteinemia

scientific article published on 18 September 2006

Production of superoxide anion by an nadph-oxidase from rat pulmonary macrophages

article

Progressive improvement in wound healing with increased therapy in haemophilia B mice

scientific article published on 23 July 2013

Protease-activated receptor-2 signaling triggers dendritic cell development

scientific article published on June 2003

Protein C inhibitor (plasminogen activator inhibitor-3) expression in the CWR22 prostate cancer xenograft.

scientific article

Restoring hemostatic thrombin generation at the time of cutaneous wounding does not normalize healing in hemophilia B.

scientific article published in August 2007

Reticulated platelet counts in patients undergoing autologous bone marrow transplantation: an aid in assessing marrow recovery.

scientific article

Reversal of dabigatran effects in models of thrombin generation and hemostasis by factor VIIa and prothrombin complex concentrate.

scientific article published on February 2015

Reversing the new oral anticoagulants with prothrombin complex concentrates (PCCs): what is the evidence?

scientific article

Review article: the prothrombin time test as a measure of bleeding risk and prognosis in liver disease.

scientific article published on July 2007

Safety profile of recombinant factor VIIa

scientific article published on January 2004

Some things I thought I knew about tissue factor that turn out to be wrong.

scientific article published on January 2008

Superactivated platelets: thrombus regulators, thrombin generators, and potential clinical targets

scientific article published on August 2013

Synergistic effect of aptamers that inhibit exosites 1 and 2 on thrombin.

scientific article published on 21 October 2009

The Coagulation Cascade in Cirrhosis

scientific article published on 01 February 2009

The Effect of Alpha2Macroglobulin-Proteinase Complexes on Macrophage IA Expression in Vivo

scientific article published on 01 February 1991

The Effect of Temperature and pH on the Activity of Factor VIIa: Implications for the Efficacy of High-Dose Factor VIIa in Hypothermic and Acidotic Patients

scientific article published on 01 November 2003

The Monocyte Monolayer Assay: A Noninvasive Technique for Predicting the Severity of in Utero Hemolysis

scientific article published on 01 May 1995

The action of high-dose factor VIIa (FVIIa) in a cell-based model of hemostasis.

scientific article

The action of high-dose factor Vlla (FVIIa) in a cell-based model of hemostasis

scientific article published on 01 January 2003

The clotting system – a major player in wound healing ⬇️

scientific article published on July 1, 2012

The effects of heparin cofactor II-derived chemotaxins on neutrophil actin conformation and cyclic AMP levels

scientific article published in October 1991

The factor VII-platelet interplay: effectiveness of recombinant factor VIIa in the treatment of bleeding in severe thrombocytopathia.

scientific article

The impact of prothrombin complex concentrates when treating DOAC-associated bleeding: a review

article

The macrophage-mediated regulation of hepatocyte synthesis of antithrombin III and α1-proteinase inhibitor

scientific article published on 01 March 1986

The multiple roles of tissue factor in wound healing

scientific article published on January 2012

The next best thing in factor VIIa

scientific article published on 16 August 2018

Tissue factor around dermal vessels has bound factor VII in the absence of injury

scientific article published on 09 April 2007

Tissue factor in brain is not saturated with factor VIIa: implications for factor VIIa dosing in intracerebral hemorrhage

scientific article

Variability in platelet procoagulant activity in healthy volunteers

article

Wound healing in haemophilia--breaking the vicious cycle.

scientific article published on May 2010

Wound healing in hemophilia B mice and low tissue factor mice

scientific article published on 19 February 2010

α 2Macroglobulin-proteinase complexes stimulate prostaglandin E2 synthesis by peritoneal macrophages

scientific article published on 01 December 1988

α2-macroglobulin ‘fast’ forms inhibit superoxide production by activated macrophages

article

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