Search filters

List of works by Thomas Dever

A network of hydrophobic residues impeding helix alphaC rotation maintains latency of kinase Gcn2, which phosphorylates the alpha subunit of translation initiation factor 2.

scientific article published on 29 December 2008

Amino acid substrates impose polyamine, eIF5A, or hypusine requirement for peptide synthesis

scientific article published on 16 June 2017

An eIF2α-binding motif in protein phosphatase 1 subunit GADD34 and its viral orthologs is required to promote dephosphorylation of eIF2α.

scientific article published on 22 June 2015

Analysis of eIF-2 alpha kinases in yeast

scientific article published on 01 January 1998

Archaeal aIF2B interacts with eukaryotic translation initiation factors eIF2alpha and eIF2Balpha: Implications for aIF2B function and eIF2B regulation.

scientific article

Association of initiation factor eIF-4E in a cap binding protein complex (eIF-4F) is critical for and enhances phosphorylation by protein kinase C.

scientific article published in June 1990

Baculovirus protein PK2 subverts eIF2α kinase function by mimicry of its kinase domain C-lobe.

scientific article

Binding of double-stranded RNA to protein kinase PKR is required for dimerization and promotes critical autophosphorylation events in the activation loop.

scientific article

Biochemical evidence supporting a mechanism for cap-independent and internal initiation of eukaryotic mRNA.

scientific article

Biochemical mechanisms for translational regulation in synaptic plasticity

scientific article

Biosynthetic incorporation of [3H]ethanolamine into protein synthesis elongation factor 1 alpha reveals a new post-translational protein modification

scientific article published in Journal of Biological Chemistry

Characterization of a ranavirus inhibitor of the antiviral protein kinase PKR

scientific article

Characterization of protein synthesis factors from rabbit reticulocytes

article

Characterization of the 46,000-dalton subunit of eIF-4F.

scientific article

Conserved intermolecular salt bridge required for activation of protein kinases PKR, GCN2, and PERK.

scientific article

Control of alpha subunit of eukaryotic translation initiation factor 2 (eIF2 alpha) phosphorylation by the human papillomavirus type 18 E6 oncoprotein: implications for eIF2 alpha-dependent gene expression and cell death

scientific article published on April 2004

Coupled release of eukaryotic translation initiation factors 5B and 1A from 80S ribosomes following subunit joining.

scientific article

Crystal Structure of Hypusine-Containing Translation Factor eIF5A Bound to a Rotated Eukaryotic Ribosome

scientific article

Direct binding of translation initiation factor eIF2gamma-G domain to its GTPase-activating and GDP-GTP exchange factors eIF5 and eIF2B epsilon

scientific article published on 7 March 2006

Disruption of cellular translational control by a viral truncated eukaryotic translation initiation factor 2alpha kinase homolog

scientific article

Dissociation of double-stranded polynucleotide helical structures by eukaryotic initiation factors, as revealed by a novel assay

scientific article published in May 1989

Double-stranded RNA-activated protein kinase PKR of fishes and amphibians: varying the number of double-stranded RNA binding domains and lineage-specific duplications

scientific article

EIF2S3 Mutations Associated with Severe X-Linked Intellectual Disability Syndrome MEHMO.

scientific article published on 5 January 2017

Engaging the ribosome: universal IFs of translation.

scientific article published in December 2001

Enhanced antiviral and antiproliferative properties of a STAT1 mutant unable to interact with the protein kinase PKR

scientific article (publication date: 27 April 2001)

Enhanced interaction between pseudokinase and kinase domains in Gcn2 stimulates eIF2α phosphorylation in starved cells

scientific article

Eukaryotic translation initiation factors and regulators

scientific article

Evidence That Base-pairing Interaction between Intron and mRNA Leader Sequences Inhibits Initiation of HAC1 mRNA Translation in Yeast

scientific article

Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein

scientific article

Further Biochemical Characterization of Rabbit Reticulocyte eIF-4B

scientific article published on 01 March 1993

GCN2 whets the appetite for amino acids

scientific article

GTP-binding domain: three consensus sequence elements with distinct spacing

scientific article

Gene-specific regulation by general translation factors

scientific journal article

Getting the message in protein synthesis. Keystone Symposium on Translational Regulatory Mechanisms

scientific article published on 29 August 2008

Higher-Order Substrate Recognition of eIF2α by the RNA-Dependent Protein Kinase PKR

scientific article published on 01 September 2005

Hypusine-containing protein eIF5A promotes translation elongation

scientific article

Impaired EIF2S3 function associated with a novel phenotype of X-linked hypopituitarism with glucose dysregulation

scientific article published on 14 March 2019

Initiation factor eIF2γ promotes eIF2-GTP-Met-tRNAi(Met) ternary complex binding to the 40S ribosome

scientific article published on 16 October 2011

Initiation factor eIF5B catalyzes second GTP-dependent step in eukaryotic translation initiation

scientific article

Initiation factors that bind mRNA. A comparison of mammalian factors with wheat germ factors ⬇️

scientific article published in Journal of Biological Chemistry

Interaction between eukaryotic initiation factors 1A and 5B is required for efficient ribosomal subunit joining.

scientific article

Kinetic analysis of late steps of eukaryotic translation initiation

scientific article published on 19 October 2008

Linking the 3' poly(A) tail to the subunit joining step of translation initiation: relations of Pab1p, eukaryotic translation initiation factor 5b (Fun12p), and Ski2p-Slh1p

scientific article

Location of seven post-translational modifications in rabbit elongation factor 1 alpha including dimethyllysine, trimethyllysine, and glycerylphosphorylethanolamine.

scientific article published in December 1989

MEHMO syndrome mutation EIF2S3-I259M impairs initiator Met-tRNAiMet binding to eukaryotic translation initiation factor eIF2

scientific article published on 01 January 2019

Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast

scientific article

Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae

scientific article published on May 2016

Mechanistic Link between PKR Dimerization, Autophosphorylation, and eIF2α Substrate Recognition

scientific article published on 01 September 2005

Molecular Genetic Structure–Function Analysis of Translation Initiation Factor eIF5B

article

Molecular biology. A new start for protein synthesis

scientific article

Molecular insights into protein synthesis with proline residues.

scientific article published on 8 November 2016

Myxoma virus immunomodulatory protein M156R is a structural mimic of eukaryotic translation initiation factor eIF2alpha

scientific article

Novel membrane-bound eIF2alpha kinase in the flagellar pocket of Trypanosoma brucei

scientific article

PK4, a eukaryotic initiation factor 2α(eIF2α) kinase, is essential for the development of the erythrocytic cycle of Plasmodium

scientific article published on 21 February 2012

PKR and GCN2 kinases and guanine nucleotide exchange factor eukaryotic translation initiation factor 2B (eIF2B) recognize overlapping surfaces on eIF2alpha

scientific article

Phosphorylation of eIF-4F by protein kinase C or multipotential S6 kinase stimulates protein synthesis at initiation.

scientific article published in March 1991

Phosphorylation of eukaryotic initiation factor 2 by heme-regulated inhibitor kinase-related protein kinases in Schizosaccharomyces pombe is important for fesistance to environmental stresses

scientific article

Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

scientific article

Physical and functional interaction between the eukaryotic orthologs of prokaryotic translation initiation factors IF1 and IF2

scientific article

Polyamine Control of Translation Elongation Regulates Start Site Selection on Antizyme Inhibitor mRNA via Ribosome Queuing

scientific article published on 01 April 2018

Promotion of met-tRNAiMet binding to ribosomes by yIF2, a bacterial IF2 homolog in yeast

scientific article

Protein kinase PKR mutants resistant to the poxvirus pseudosubstrate K3L protein

scholarly article

Protein phosphatase PP1/GLC7 interaction domain in yeast eIF2γ bypasses targeting subunit requirement for eIF2α dephosphorylation

scientific article published on 24 March 2014

Purification and characterization of a new eukaryotic protein translation factor. Eukaryotic initiation factor 4H

scientific article

RNA unwinding in translation: assembly of helicase complex intermediates comprising eukaryotic initiation factors eIF-4F and eIF-4B ⬇️

scientific article published on December 1, 1991

Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors.

scientific article

Regulation of the protein kinase PKR by the vaccinia virus pseudosubstrate inhibitor K3L is dependent on residues conserved between the K3L protein and the PKR substrate eIF2alpha.

scientific article published on July 1997

Requirement for kinase-induced conformational change in eukaryotic initiation factor 2alpha (eIF2alpha) restricts phosphorylation of Ser51.

scientific article

Roles of polyamines in translation

scientific article published in Journal of Biological Chemistry

Sequence determination and cDNA cloning of eukaryotic initiation factor 4D, the hypusine-containing protein.

scientific article

Structural basis for the transition from translation initiation to elongation by an 80S-eIF5B complex

scientific article published on 06 October 2020

Structural characterization of ribosome recruitment and translocation by type IV IRES.

scientific article published on 9 May 2016

Structural integrity of {alpha}-helix H12 in translation initiation factor eIF5B is critical for 80S complex stability.

scientific article

Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing

scientific article

Suppression of protein synthesis in brain during hibernation involves inhibition of protein initiation and elongation

scientific article published on November 1998

The elongation, termination, and recycling phases of translation in eukaryotes

scientific article

The hypusine-containing translation factor eIF5A.

scientific article

The interferon-induced double-stranded RNA-activated protein kinase PKR will phosphorylate serine, threonine, or tyrosine at residue 51 in eukaryotic initiation factor 2alpha

scientific article (publication date: 5 November 1999)

The joining of ribosomal subunits in eukaryotes requires eIF5B.

scientific article

The protein kinase Gcn2p mediates sodium toxicity in yeast

scientific article published on 14 June 2001

The β-hairpin of 40S exit channel protein Rps5/uS7 promotes efficient and accurate translation initiation in vivo.

scientific article published on 2 July 2015

Tight binding of the phosphorylated alpha subunit of initiation factor 2 (eIF2alpha) to the regulatory subunits of guanine nucleotide exchange factor eIF2B is required for inhibition of translation initiation

scientific article

Translation Elongation and Recoding in Eukaryotes.

scientific article published on 2 April 2018

Translation initiation factor 2gamma mutant alters start codon selection independent of Met-tRNA binding.

scientific article published on 15 September 2008

Translation initiation factors that function as RNA helicases from mammals, plants and yeast

article

Translational regulation by the interferon-induced double-stranded-RNA-activated 68-kDa protein kinase

scientific article

Truncated protein phosphatase GLC7 restores translational activation of GCN4 expression in yeast mutants defective for the eIF-2 alpha kinase GCN2 ⬇️

scientific article published on December 1, 1992

Uncoupling of initiation factor eIF5B/IF2 GTPase and translational activities by mutations that lower ribosome affinity

scientific article

Universal conservation in translation initiation revealed by human and archaeal homologs of bacterial translation initiation factor IF2

scientific article

Universal translation initiation factor IF2/eIF5B.

scientific article

UsingGCN4as a Reporter of eIF2α Phosphorylation and Translational Regulation in Yeast

scientific article published on 01 April 1997

Variola virus E3L Zα domain, but not its Z-DNA binding activity, is required for PKR inhibition

scientific article published on 13 December 2013

X-Ray structures of the universal translation initiation factor IF2/eIF5B: conformational changes on GDP and GTP binding

scientific article

X-ray structure of translation initiation factor eIF2gamma: implications for tRNA and eIF2alpha binding

scientific article

eIF2γ mutation that disrupts eIF2 complex integrity links intellectual disability to impaired translation initiation

scientific article

eIF5A Functions Globally in Translation Elongation and Termination.

scientific article published on 30 March 2017

eIF5A promotes translation of polyproline motifs.

scientific article published on 30 May 2013

rRNA suppressor of a eukaryotic translation initiation factor 5B/initiation factor 2 mutant reveals a binding site for translational GTPases on the small ribosomal subunit.

scientific article

Paulina is supported by:

About Paulina

Help