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List of works by Karl-Norbert Klotz

2',3'-Dideoxy-N6-cyclohexyladenosine: an adenosine derivative with antagonist properties at adenosine receptors.

scientific article published on October 1988

2-(Benzimidazol-2-yl)quinoxalines: a novel class of selective antagonists at human A(1) and A(3) adenosine receptors designed by 3D database searching

scientific article published in December 2005

2-(N-acyl) and 2-N-acyl-N(6)-substituted analogues of adenosine and their affinity at the human adenosine receptors

scientific article published in March 2004

2-Chloro-N6-[3H]cyclopentyladenosine ([3H]CCPA)--a high affinity agonist radioligand for A1 adenosine receptors

scientific article

2-Chloro-N6-cyclopentyladenosine: a highly selective agonist at A1 adenosine receptors

scientific article

2-Substituted N-ethylcarboxamidoadenosine derivatives as high-affinity agonists at human A3 adenosine receptors

scientific article

2-substituted 5'-N-methylcarboxamidoadenosine (MECA) derivatives as A3 adenosine receptor ligands

scientific article

5'-C-Ethyl-tetrazolyl-N(6)-substituted adenosine and 2-chloro-adenosine derivatives as highly potent dual acting A1 adenosine receptor agonists and A3 adenosine receptor antagonists

scientific article published on 27 February 2015

5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 receptor from different species

scientific article published on 22 September 2007

5,7-Disubstituted-[1,2,4]triazolo[1,5- a ][1,3,5]triazines as pharmacological tools to explore the antagonist selectivity profiles toward adenosine receptors

scientific article published on 15 December 2015

7-Amino-2-aryl/hetero-aryl-5-oxo-5,8-dihydro[1,2,4]triazolo[1,5-a]pyridine-6-carbonitriles: Synthesis and adenosine receptor binding studies

scientific article published on 15 May 2019

7-Deazaadenines Bearing Polar Substituents: Structure−Activity Relationships of New A1and A3Adenosine Receptor Antagonists†

scientific article published on 01 November 2000

7-Nitrobenzofurazan (NBD) derivatives of 5'-N-ethylcarboxamidoadenosine (NECA) as new fluorescent probes for human A(3) adenosine receptors.

scientific article published in December 2001

8-(2-Furyl)adenine derivatives as A₂A adenosine receptor ligands.

scientific article published on 17 October 2013

8-(Sulfostyryl)xanthines: water-soluble A2A-selective adenosine receptor antagonists.

scientific article

8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands

scientific article published on 23 February 2009

9-Ethyladenine derivatives as adenosine receptor antagonists: 2- and 8-substitution results in distinct selectivities

scientific article published on 7 May 2003

A facile and novel synthesis of N2-, C6-substituted pyrazolo[3,4-d]pyrimidine-4 carboxylate derivatives as adenosine receptor antagonists

scientific article published on 22 January 2015

A new synthesis of sulfonamides by aminolysis of p-nitrophenylsulfonates yielding potent and selective adenosine A2B receptor antagonists

scientific article published in July 2006

A1 adenosine receptor antagonists, 3-aryl[1,2,4]triazino[4,3-a]benzimidazol-4-(10H)-ones (ATBIs) andN-alkyl andN-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs): Different recognition of bovine and human binding sites

A2B adenosine receptor agonists: synthesis and biological evaluation of 2-phenylhydroxypropynyl adenosine and NECA derivatives

scientific article published in January 2004

Activation of the A3 adenosine receptor affects cell cycle progression and cell growth

scientific article

Adenosine A2A receptor antagonists: new 8-substituted 9-ethyladenines as tools for in vivo rat models of Parkinson's disease

scientific article

Adenosine receptors and cancer.

scientific article published on January 2009

Adenosine receptors and their ligands.

scientific article

Adenosine receptors as mediators of both cell proliferation and cell death of cultured human melanoma cells.

scientific article

Affinities of barbiturates for the GABA-receptor complex and A1 adenosine receptors: a possible explanation of their excitatory effects

scientific article published in August 1987

Agonist-Induced Internalization and Recycling of the Human A3 Adenosine Receptors

scientific article published on 01 October 2000

Agonists activate different A2B adenosine receptor signaling pathways in MBA-MD-231 breast cancer cells with distinct potencies

scientific article published on 23 July 2019

Analysis of receptor oligomerization by FRAP microscopy.

scientific article

Binding thermodynamics at the human A(3) adenosine receptor

scientific article published in January 2002

Carbamazepine distinguishes between adenosine receptors that mediate different second messenger responses

scientific article published in April 1991

Chalcone-based derivatives as new scaffolds for hA3 adenosine receptor antagonists

scientific article

Characterization of [3H]phenobarbital binding to rat brain membranes

scientific article published in November 1984

Characterization of the K(+)-channel-coupled adenosine receptor in guinea pig atria

scientific article published in December 1989

Combining selectivity and affinity predictions using an integrated Support Vector Machine (SVM) approach: An alternative tool to discriminate between the human adenosine A(2A) and A(3) receptor pyrazolo-triazolo-pyrimidine antagonists binding sites.

scientific article

Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells.

scientific article published on January 1998

Comparative pharmacology of human beta-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cells

scientific article

Cytotoxic purine nucleoside analogues bind to A1, A2A, and A3 adenosine receptors

scientific article published on 17 January 2012

Design, Synthesis and Evaluation of New Indolylpyrimidylpiperazines for Gastrointestinal Cancer Therapy

scientific article published on 11 October 2019

Development of novel adenosine receptor ligands based on the 3-amidocoumarin scaffold

scientific article published on 22 May 2015

Different efficacy of adenosine and NECA derivatives at the human A3 adenosine receptor: insight into the receptor activation switch.

scientific article

Discovery of Novel Adenosine Receptor Antagonists through a Combined Structure- and Ligand-Based Approach Followed by Molecular Dynamics Investigation of Ligand Binding Mode

scientific article published on 27 February 2018

Discovery of indolylpiperazinylpyrimidines with dual-target profiles at adenosine A2A and dopamine D2 receptors for Parkinson's disease treatment

scientific article

Discovery of novel A3 adenosine receptor ligands based on chromone scaffold

scientific article

Discovery of simplified N²-substituted pyrazolo[3,4-d]pyrimidine derivatives as novel adenosine receptor antagonists: efficient synthetic approaches, biological evaluations and molecular docking studies.

scientific article published on 31 January 2014

Discovery of the first A1 adenosine receptor ligand based on the chromone scaffold

article

Does the combination of optimal substitutions at the C²-, N⁵- and N⁸-positions of the pyrazolo-triazolo-pyrimidine scaffold guarantee selective modulation of the human A₃ adenosine receptors?

scientific article published on 23 August 2011

Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity.

scientific article published on 3 June 2011

Effector coupling of stably transfected human A3 adenosine receptors in CHO cells

scientific article published in July 2002

Effects of adenosine on histamine release from human lung fragments

scientific article published on January 1, 1992

Erratum to: Molecular modelling study of 2-phenylethynyladenosine (PEAdo) derivatives as highly selective A(3) adenosine receptor ligands

scientific article

Exploring potency and selectivity receptor antagonist profiles using a multilabel classification approach: the human adenosine receptors as a key study

scientific article published in December 2009

Exploring the directionality of 5-substitutions in a new series of 5-alkylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine as a strategy to design novel human a(3) adenosine receptor antagonists

scientific article published on 9 November 2012

Expression, pharmacological profile, and functional coupling of A2B receptors in a recombinant system and in peripheral blood cells using a novel selective antagonist radioligand, [3H]MRE 2029-F20.

scientific article

G-protein-coupled A1 adenosine receptors in coated vesicles of mammalian brain: characterization by radioligand binding and photoaffinity labelling

scientific article published in November 1992

Guanosine exerts antiplatelet and antithrombotic properties through an adenosine-related cAMP-PKA signaling

scientific article published on 7 August 2017

Human breast cancer cell line MDA-MB-231 expresses endogenous A2B adenosine receptors mediating a Ca2+ signal.

scientific article

Improving Potency, Selectivity, and Water Solubility of Adenosine A1 Receptor Antagonists: Xanthines Modified at Position 3 and Related Pyrimido[1,2,3-cd]purinediones

scientific article published on 01 August 2006

Inhibitors of membranous adenylyl cyclases with affinity for adenosine receptors

scientific article published on 14 December 2015

Insight into the interactions between novel coumarin derivatives and human A3 adenosine receptors

scientific article

Introduction of alkynyl chains on C-8 of adenosine led to very selective antagonists of the A(3) adenosine receptor.

scientific article

Involvement of mitogen protein kinase cascade in agonist-mediated human A(3) adenosine receptor regulation

scientific article published in August 2002

Linear and nonlinear 3D-QSAR approaches in tandem with ligand-based homology modeling as a computational strategy to depict the pyrazolo-triazolo-pyrimidine antagonists binding site of the human adenosine A2A receptor

scientific article published on 24 January 2008

N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands

scientific article (publication date: 18 July 2002)

N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine receptor with antinociceptive effects in mice

scientific article

N6-Cycloalkyl- andN6-Bicycloalkyl-C5′(C2′)-modified Adenosine Derivatives as High-Affinity and Selective Agonists at the Human A1Adenosine Receptor with Antinociceptive Effects in Mice

N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor

scientific article published on 20 February 2007

Navigating in chromone chemical space: discovery of novel and distinct A3 adenosine receptor ligands

article

New insight into adenosine receptors selectivity derived from a novel series of [5-substituted-4-phenyl-1,3-thiazol-2-yl] benzamides and furamides

scientific article published on 22 March 2013

New substituted 9-alkylpurines as adenosine receptor ligands

scientific article

Novel 8-(p-substituted-phenyl/benzyl)xanthines with selectivity for the A2A adenosine receptor possess bronchospasmolytic activity

scientific article published on 30 January 2014

Novel chiral isoxazole derivatives: synthesis and pharmacological characterization at human beta-adrenergic receptor subtypes

scientific article published on 2 February 2007

Novel mutants of the human beta1-adrenergic receptor reveal amino acids relevant for receptor activation

scientific article published on 28 April 2006

Novel thiazole-thiophene conjugates as adenosine receptor antagonists: synthesis, biological evaluation and docking studies

scientific article published on 28 January 2015

Organoruthenium antagonists of human A₃ adenosine receptors.

scientific article published on 23 April 2013

Peptide G protein agonists from a phage display library.

scientific article

Pharmacological characterization of novel adenosine ligands in recombinant and native human A2B receptors.

scientific article published on 10 October 2005

Physical coupling of N-formyl peptide chemoattractant receptors to G protein is unaffected by desensitization.

scientific article

Pyrazolo-triazolo-pyrimidines as adenosine receptor antagonists: Effect of the N-5 bond type on the affinity and selectivity at the four adenosine receptor subtypes

scientific article published on 25 July 2007

Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists

scientific article published on 01 November 1999

Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine Derivatives as Highly Potent and Selective Human A3Adenosine Receptor Antagonists: Influence of the Chain at the N8Pyrazole Nitrogen

scientific article published on 01 December 2000

Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines to develop functionalized ligands to target adenosine receptors: fluorescent ligands as an example

scientific article published on 18 February 2019

Radiation inactivation analysis of the A1 adenosine receptor of rat brain. Decrease in radiation inactivation size in the presence of guanine nucleotide

scientific article published in July 1989

Receptor crosstalk: haloperidol treatment enhances A2A adenosine receptor functioning in a transfected cell model ⬇️

scientific article published on October 12, 2010

Regulation of p42/p44 mitogen-activated protein kinase by the human adenosine A3 receptor in transfected CHO cells

scientific article published in May 2001

Revisiting a receptor-based pharmacophore hypothesis for human A(2A) adenosine receptor antagonists

scientific article published on 20 June 2013

Role of the beta1-adrenergic pathway in anesthetic and ischemic preconditioning against myocardial infarction in the rabbit heart in vivo

scientific article published in September 2006

Scaffold Decoration at Positions 5 and 8 of 1,2,4-Triazolo[1,5-c]Pyrimidines to Explore the Antagonist Profiling on Adenosine Receptors: A Preliminary Structure–Activity Relationship Study

scientific article published on 11 July 2014

Separation of solubilized A2 adenosine receptors of human platelets from non-receptor [3H]NECA binding sites by gel filtration

scientific article published on 01 January 1988

Signaling by extracellular nucleotides and nucleosides

scientific article published on 01 November 2000

Structure-Based Design, Synthesis, and In Vivo Antinociceptive Effects of Selective A1 Adenosine Receptor Agonists.

scientific article published on 19 December 2017

Structure-Based Optimization of Coumarin hA3 Adenosine Receptor Antagonists

scientific article published on 04 December 2019

Synthesis and adenosine receptors binding affinities of a series of 3-arylcoumarins

scientific article published on 22 August 2013

Synthesis and biological activity of trisubstituted adenines as A 2A adenosine receptor antagonists

scientific article published in January 2007

Synthesis and biological evaluation of 2-alkynyl-N6-methyl-5'-N-methylcarboxamidoadenosine derivatives as potent and highly selective agonists for the human adenosine A3 receptor

scientific article published in December 2009

Synthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A preliminary inspection of ligand-receptor recognition process

scientific article

Synthesis and pharmacological characterization of novel xanthine carboxylate amides as A2A adenosine receptor ligands exhibiting bronchospasmolytic activity.

scientific article published on 21 January 2016

Synthesis of enantiopure Delta2-isoxazoline derivatives and evaluation of their affinity and efficacy profiles at human beta-adrenergic receptor subtypes

scientific article published on 10 March 2006

Synthesis, adenosine receptor binding and molecular modelling studies of novel thieno[2,3-d]pyrimidine derivatives.

scientific article published in December 2017

Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists

scientific article published in February 2002

Synthesis, biological and modeling studies of 1,3-di-n-propyl-2,4-dioxo-6-methyl-8-(substituted) 1,2,3,4-tetrahydro [1,2,4]-triazolo [3,4-f]-purines as adenosine receptor antagonists

scientific article published in August 2005

Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists

scientific article published in March 2005

Synthesis, biological studies and molecular modeling investigation of 1,3-dimethyl-2,4-dioxo-6-methyl-8-(substituted) 1,2,3,4-tetrahydro [1,2,4]-triazolo [3,4-f]-purines as potential adenosine receptor antagonists

scientific article

Targeting adenosine receptors with coumarins: synthesis and binding activities of amide and carbamate derivatives

scientific article published in January 2013

The A2B adenosine receptor in MDA-MB-231 breast cancer cells diminishes ERK1/2 phosphorylation by activation of MAPK-phosphatase-1

scientific article published in PLoS ONE

The Influence of the 1-(3-Trifluoromethyl-Benzyl)-1H-Pyrazole-4-yl Moiety on the Adenosine Receptors Affinity Profile of Pyrazolo[4,3-e][1,2,4]Triazolo[1,5-c]Pyrimidine Derivatives

scientific article

The Length and Flexibility of the 2-Substituent of 9-Ethyladenine Derivatives Modulate Affinity and Selectivity for the Human A2A Adenosine Receptor

scientific article published on April 2016

The application of a 3D-QSAR (autoMEP/PLS) approach as an efficient pharmacodynamic-driven filtering method for small-sized virtual library: application to a lead optimization of a human A3 adenosine receptor antagonist

scientific article published on 29 March 2006

The glycoprotein nature of A1 adenosine receptors

scientific article

The interaction of N-formyl peptide chemoattractant receptors with the membrane skeleton is energy-dependent

scientific article published on 01 November 1994

The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA(3) adenosine receptors antagonists: new insights into structure-affinity relation

scientific article published in April 2010

The small antitumoral immune response modifier imiquimod interacts with adenosine receptor signaling in a TLR7- and TLR8-independent fashion

scientific article published on June 2006

Water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, A(2A)-selective adenosine receptor antagonists

scientific article

[3H]HEMADO--a novel tritiated agonist selective for the human adenosine A3 receptor

scientific article published on 27 October 2006

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