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List of works by Jordan S. Orange

1. Lymphocytes.

scientific article published on February 2008

7th International Immunoglobulin Conference: Foreword

scientific article published in December 2014

A custom 148 gene-based resequencing chip and the SNP explorer software: new tools to study antibody deficiency

scientific article

A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene

scientific article

A novel missense mutation in the nuclear factor-κB essential modulator (NEMO) gene resulting in impaired activation of the NF-κB pathway and a unique clinical phenotype presenting as MRSA subdural empyema

scientific article published on 23 July 2010

Acute chylothorax in children: selective retention of memory T cells and natural killer cells

scientific article

Allogeneic transplantation successfully corrects immune defects, but not susceptibility to colitis, in a patient with nuclear factor-kappaB essential modulator deficiency

scientific article

Antibody deficiency associated with an inherited autosomal dominant mutation in TWEAK.

scientific article published on 14 March 2013

Antibody targeting of anaplastic lymphoma kinase induces cytotoxicity of human neuroblastoma

scientific article published on 23 January 2012

Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity.

scientific article published on 02 October 2013

Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells

scientific article published on 20 April 2015

Asymmetric T lymphocyte division in the initiation of adaptive immune responses.

scientific article published in March 2007

Autoimmune regulator (AIRE) contributes to Dectin-1-induced TNF-α production and complexes with caspase recruitment domain-containing protein 9 (CARD9), spleen tyrosine kinase (Syk), and Dectin-1.

scientific article published on 29 September 2011

Bi-allelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes

Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity.

scientific article

Bilateral adrenal EBV-associated smooth muscle tumors in a child with a natural killer cell deficiency

scientific article

Bioavailability of IgG administered by the subcutaneous route.

scientific article published on March 2013

Bringing immunoglobulin knowledge up to date: how should we treat today?

scientific article published on 15 July 2011

Burden of copy number variation in common variable immunodeficiency

scientific article published on 01 July 2014

CD2 promotes human natural killer cell membrane nanotube formation

scientific article published in 2012

CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia

scientific article published on 24 December 2011

Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors

scientific article published on 11 May 2009

Cdc42-interacting protein-4 functionally links actin and microtubule networks at the cytolytic NK cell immunological synapse.

scientific article

Cell biological steps and checkpoints in accessing NK cell cytotoxicity

scientific article

Challenges in the use of allogeneic hematopoietic SCT for ectodermal dysplasia with immune deficiency

scientific article

Characteristics of mycobacterial infection in patients with immunodeficiency and nuclear factor-kappaB essential modulator mutation, with or without ectodermal dysplasia

scientific article published on 01 November 2004

Class switch recombination defects: impact on b cell maturation and antibody responses

scientific article published on 01 December 2020

Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation

scientific article published on 25 March 2012

Comparison of American and European practices in the management of patients with primary immunodeficiencies.

scientific article published on July 2012

Complications of tumor necrosis factor-α blockade in chronic granulomatous disease-related colitis

scientific article

Compound heterozygous CORO1A mutations in siblings with a mucocutaneous-immunodeficiency syndrome of epidermodysplasia verruciformis-HPV, molluscum contagiosum and granulomatous tuberculoid leprosy

scientific article

Comèl-Netherton syndrome defined as primary immunodeficiency

scientific article

Congenital alterations of NEMO glutamic acid 223 result in hypohidrotic ectodermal dysplasia and immunodeficiency with normal serum IgG levels

scientific article

Congenital immunodeficiencies and sepsis

scientific article

Considering the demand for and prioritization of intravenous immunoglobulin

scientific article published on 01 December 2014

Current treatment options with immunoglobulin G for the individualization of care in patients with primary immunodeficiency disease.

scientific article

Cutting edge: association with I kappa B kinase beta regulates the subcellular localization of Homer3.

scientific article

Cytoskeletal abnormalities and neutrophil dysfunction in WDR1 deficiency

scientific article

DOCK8 deficiency: clinical and immunological phenotype and treatment options - a review of 136 patients

scientific article

Decreased Natural Killer (NK) Cell Function in Chronic NK Cell Lymphocytosis Associated with Decreased Surface Expression of CD11b

scientific article published in April 2001

Dedicator of cytokinesis 8-deficient CD4+ T cells are biased to a TH2 effector fate at the expense of TH1 and TH17 cells.

scientific article published on 20 August 2016

Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency.

scientific article published on 4 February 2013

Development of a clinical assay to evaluate toll-like receptor function.

scientific article published on January 2006

Differential localization of T-bet and Eomes in CD8 T cell memory populations.

scientific article published on March 2013

Disseminated varicella infection due to the vaccine strain of varicella-zoster virus, in a patient with a novel deficiency in natural killer T cells

scientific article

Distinct integrin-dependent signals define requirements for lytic granule convergence and polarization in natural killer cells

scientific article published on 7 October 2014

Early murine cytomegalovirus (MCMV) infection induces liver natural killer (NK) cell inflammation and protection through macrophage inflammatory protein 1alpha (MIP-1alpha)-dependent pathways

scientific article

Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin

scientific article

Efficacy and safety of a new 20% immunoglobulin preparation for subcutaneous administration, IgPro20, in patients with primary immunodeficiency

scientific article

Emerging insights into human health and NK cell biology from the study of NK cell deficiencies

scientific article published on 01 January 2019

Eosinophilic fasciitis mimicking angioedema and treatment response to infliximab in a pediatric patient

scientific article published on 23 February 2011

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

scientific article (publication date: July 2008)

Evaluation of correlation between dose and clinical outcomes in subcutaneous immunoglobulin replacement therapy.

scientific article

Evaluation of prolonged fatigue post-West Nile virus infection and association of fatigue with elevated antiviral and proinflammatory cytokines

scientific article

FiloQuant reveals increased filopodia density during breast cancer progression.

scientific article

Finding NEMO: genetic disorders of NF-κB activation ⬇️

scientific article published on October 1, 2003

Food allergy in patients with primary immunodeficiency diseases: prevalence within the US Immunodeficiency Network (USIDNET).

scientific article

Formation and function of the lytic NK-cell immunological synapse

scientific article published on September 2008

Formation of a WIP-, WASp-, actin-, and myosin IIA-containing multiprotein complex in activated NK cells and its alteration by KIR inhibitory signaling

scientific article

Function and Regulation of Natural Killer (NK) Cells during Viral Infections: Characterization of Responses in Vivo

scientific article published on 01 April 1996

GATA2 deficiency underlying severe blastomycosis and fatal herpes simplex virus-associated hemophagocytic lymphohistiocytosis

scientific article published on 19 September 2015

GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics, and immunity.

scientific article

Genetic sharing and heritability of paediatric age of onset autoimmune diseases.

scientific article

Genome-wide association identifies diverse causes of common variable immunodeficiency

scientific article published on 17 April 2011

Global study of primary immunodeficiency diseases (PI)--diagnosis, treatment, and economic impact: an updated report from the Jeffrey Modell Foundation.

scientific article published on October 2011

HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease

scientific article published on 01 July 2020

High Incidence of Autoimmune Disease after Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease

scientific article published on 6 April 2018

High-resolution phenotyping identifies NK cell subsets that distinguish healthy children from adults

scientific article

How I Manage Natural Killer Cell Deficiency

scientific article published on 22 November 2019

Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential

scientific article

Human disease resulting from gene mutations that interfere with appropriate nuclear factor-kappaB activation

scientific article

Human immunodeficiency-causing mutation defines CD16 in spontaneous NK cell cytotoxicity

scientific article

Human natural killer cell deficiencies

scientific article published on December 2006

Human natural killer cell deficiencies and susceptibility to infection

scientific article

Human nuclear factor kappa B essential modulator mutation can result in immunodeficiency without ectodermal dysplasia

article by Jordan Orange et al published September 2004 in The Journal of Allergy and Clinical Immunology

Hypogammaglobulinemia in a pediatric tertiary care setting

scientific article published in October 2007

Hypohidrotic ectodermal dysplasia and immunodeficiency with coincident NEMO and EDA mutations.

scientific article published on 8 November 2011

Hypomorphic nuclear factor-kappaB essential modulator mutation database and reconstitution system identifies phenotypic and immunologic diversity

scientific article published on 11 October 2008

IKBKG (nuclear factor-kappa B essential modulator) mutation can be associated with opportunistic infection without impairing Toll-like receptor function

scientific article

IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function.

scientific article

IL12 in acute viral infectious disease.

scientific article published on September 1995

Identifying Genes Whose Mutant Transcripts Cause Dominant Disease Traits by Potential Gain-of-Function Alleles

article

Immunodeficiency disorders. Preface

scientific article published on 01 May 2008

Immunodeficiency in patients with 49,XXXXY chromosomal variation.

scientific article published on 23 January 2013

Immunoglobulins: current understanding and future directions

scientific article published on December 2014

Immunologic features of Cornelia de Lange syndrome

scientific article

Impact of trough IgG on pneumonia incidence in primary immunodeficiency: A meta-analysis of clinical studies

scientific article published on 01 August 2010

Interferon-alpha/beta inhibition of interleukin 12 and interferon-gamma production in vitro and endogenously during viral infection

scientific article

Interleukin-1-induced NF-kappaB activation is NEMO-dependent but does not require IKKbeta

scientific article

Intravenous immunoglobulins. Current understanding and future directions.

scientific article published on December 2009

Invariant natural killer T cells from children with versus without food allergy exhibit differential responsiveness to milk-derived sphingomyelin

scientific article

Latent herpesviruses: aligning human and murine NK cells

scientific article published on 01 June 2010

Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome.

scientific article

Lessons in gene hunting: a RAG1 mutation presenting with agammaglobulinemia and absence of B cells

scientific article published on 27 June 2014

Lessons learned from additional research analyses of unsolved clinical exome cases

scientific article published on 21 March 2017

Lytic immune synapse function requires filamentous actin deconstruction by Coronin 1A

scientific article

Management of an anaphylactoid reaction to methotrexate with a stepwise graded challenge

scientific article

Mechanism of interleukin 12-mediated toxicities during experimental viral infections: role of tumor necrosis factor and glucocorticoids

scientific article

Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases

scientific article

Modeling primary immunodeficiency disease epidemiology and its treatment to estimate latent therapeutic demand for immunoglobulin.

scientific article published on 12 December 2013

Molecular mechanisms of functional natural killer deficiency in patients with partial DiGeorge syndrome

scientific article

Monosomy 1p36 uncovers a role for OX40 in survival of activated CD4+ T cells.

scientific article published on 03 June 2008

Multiple distinct NK-cell synapses ⬇️

scientific article published on December 15, 2011

Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function.

scientific article published on 13 February 2013

Mutation in IRF2BP2 is responsible for a familial form of common variable immunodeficiency disorder.

scientific article published on 23 March 2016

Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome.

scientific article

Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56(bright) subset.

scientific article published on 30 January 2013

NK cell lytic granules are highly motile at the immunological synapse and require F-actin for post-degranulation persistence

scientific article

Natural killer cell deficiency

scientific article published on September 2013

Natural killer cell development is blocked in the context of aberrant T lymphocyte ontogeny

scientific article published on 01 June 1996

Natural killer cell lytic granule secretion occurs through a pervasive actin network at the immune synapse

scientific article (publication date: September 2011)

Natural killer cells inhibit hepatitis C virus expression

scientific article

Navigating barriers: the challenge of directed secretion at the natural killer cell lytic immunological synapse.

scientific article

New developments in primary immunodeficiencies: Report on the 2006 CIS Primary Immunodeficiency Diseases Consortium Conference, June 1, 2006

scientific article published in December 2006

New views of the human NK cell immunological synapse: recent advances enabled by super- and high-resolution imaging techniques

scientific article published on January 2012

Newborn screening for severe combined immunodeficiency in 11 screening programs in the United States

scientific article published in August 2014

Noncanonical NF-κB signaling is limited by classical NF-κB activity

scientific article published on 04 February 2014

Novel inborn error of folate metabolism: identification by exome capture and sequencing of mutations in the MTHFD1 gene in a single proband

scientific article (publication date: September 2011)

Novel mutation in STXBP2 prevents IL-2–induced natural killer cell cytotoxicity ⬇️

scientific article published on February 14, 2012

Outcomes after Allogeneic Transplant in Patients with Wiskott-Aldrich Syndrome

scientific article published on 28 November 2017

PGM3 mutations cause a congenital disorder of glycosylation with severe immunodeficiency and skeletal dysplasia

scientific article

PTEN is a negative regulator of NK cell cytolytic function.

scientific article

Pediatric common variable immunodeficiency: immunologic and phenotypic associations with switched memory B cells

scientific article published on 19 March 2010

Phosphorylation of the myosin IIA tailpiece regulates single myosin IIA molecule association with lytic granules to promote NK-cell cytotoxicity

scientific article

Presentation of hemophagocytic lymphohistiocytosis due to a novel MUNC 13-4 mutation masked by partial therapeutic immunosuppression

scientific article

Prevalence of Toll-like receptor signalling defects in apparently healthy children who developed invasive pneumococcal infection

scientific article published on 06 December 2006

Primary immunodeficiency diseases consortium conference

scientific article published in September 2005

Primary immunodeficiency diseases: Genomic approaches delineate heterogeneous Mendelian disorders

scientific article

Prioritization of evidence-based indications for intravenous immunoglobulin

scientific article published on 14 June 2013

Pro-asthmatic cytokines regulate unliganded and ligand-dependent glucocorticoid receptor signaling in airway smooth muscle

scientific article

Quantitative measurement of F-actin accumulation at the NK cell immunological synapse.

scientific article published on 19 February 2010

Rapid activation receptor- or IL-2-induced lytic granule convergence in human natural killer cells requires Src, but not downstream signaling

scientific article

Rapid lytic granule convergence to the MTOC in natural killer cells is dependent on dynein but not cytolytic commitment

scientific article

Rapid up-regulation and granule-independent transport of perforin to the immunological synapse define a novel mechanism of antigen-specific CD8+ T cell cytotoxic activity.

scientific article published on May 2009

Rare variants at 16p11.2 are associated with common variable immunodeficiency

scientific article published on 10 February 2015

Recommendations for live viral and bacterial vaccines in immunodeficient patients and their close contacts

scientific article

Reply: To PMID 22935624

scientific article published on 28 December 2012

Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration

scientific article

Severe combined immunodeficiency resulting from mutations in MTHFD1.

scientific article published on 6 January 2013

Severe cutaneous human papillomavirus infection associated with natural killer cell deficiency following stem cell transplantation for severe combined immunodeficiency

scientific article published on 23 August 2014

Stem-cell gene therapy for the Wiskott-Aldrich syndrome

scientific article

Substance P inhibits natural killer cell cytotoxicity through the neurokinin-1 receptor

scientific article

The Wiskott-Aldrich syndrome

scientific article published on 01 September 2004

The adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation

scientific article published on 21 February 2013

The mature activating natural killer cell immunologic synapse is formed in distinct stages

scientific article

Therapeutic use of immunoglobulins

scientific article published on January 2010

Transcription of the activating receptor NKG2D in natural killer cells is regulated by STAT3 tyrosine phosphorylation.

scientific article

Tumorigenic adenovirus 12 cells evade NK cell lysis by reducing the expression of NKG2D ligands.

scientific article

Unraveling human natural killer cell deficiency ⬇️

scientific article published on February 22, 2012

Use and interpretation of diagnostic vaccination in primary immunodeficiency: a working group report of the Basic and Clinical Immunology Interest Section of the American Academy of Allergy, Asthma & Immunology

scientific article

Use of intravenous immunoglobulin and adjunctive therapies in the treatment of primary immunodeficiencies: A working group report of and study by the Primary Immunodeficiency Committee of the American Academy of Allergy Asthma and Immunology

scientific article published on 14 November 2009

Use of intravenous immunoglobulin in human disease: a review of evidence by members of the Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and Immunology

scientific article

Vaccine-associated varicella and rubella infections in severe combined immunodeficiency with isolated CD4 lymphocytopenia and mutations in IL7R detected by tandem whole exome sequencing and chromosomal microarray

scientific article published on December 2014

Variants of DENND1B associated with asthma in children

scientific article

Viral evasion of natural killer cells

scientific article

Wiskott-Aldrich syndrome protein is required for NK cell cytotoxicity and colocalizes with actin to NK cell-activating immunologic synapses

scientific article

miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta

scientific article

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