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List of works by Kazuhiro Irie

1,2-Di-O-α-linolenoyl-3-O-β-galactosyl-sn-glycerol as a superoxide generation inhibitor from Perilla frutescens var. crispa

scientific article published on 07 November 2011

A Toxic Conformer of Aβ42 with a Turn at 22-23 is a Novel Therapeutic Target for Alzheimer's Disease

scientific article published on 18 September 2017

A new class of simplified phorbol ester analogues: synthesis and binding to PKC and eta PKC-C1B (eta PKC-CRD2).

scientific article published on October 1999

A new lyngbyatoxin from the Hawaiian cyanobacterium Moorea producens ⬇️

scientific article

A simple analogue of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: development of a synthetically accessible protein kinase C activator with bryostatin-like activity.

scientific article

Aggregation and neurotoxicity of mutant amyloid beta (A beta) peptides with proline replacement: importance of turn formation at positions 22 and 23.

scientific article published in July 2002

Amyloid β toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques

scientific article published in Scientific Reports

An App knock-in mouse inducing the formation of a toxic conformer of Aβ as a model for evaluating only oligomer-induced cognitive decline in Alzheimer's disease

scientific article published on 01 June 2019

An RNA aptamer with potent affinity for a toxic dimer of amyloid β42 has potential utility for histochemical studies of Alzheimer's disease

scientific article published on 02 March 2020

Analysis of the non-covalent interaction between metal ions and the cysteine-rich domain of protein kinase C eta by electrospray ionization mass spectrometry

scientific article published in November 2003

Analysis of the secondary structure of beta-amyloid (Abeta42) fibrils by systematic proline replacement

scientific article published on 30 September 2004

Auraptene attenuates gastritis via reduction of Helicobacter pylori colonization and pro-inflammatory mediator production in C57BL/6 mice

scientific article published on 03 April 2012

Binding mode prediction of aplysiatoxin, a potent agonist of protein kinase C, through molecular simulation and structure-activity study on simplified analogs of the receptor-recognition domain

scientific article published on 7 July 2016

Binding selectivity of conformationally restricted analogues of (-)-indolactam-V to the C1 domains of protein kinase C isozymes

scientific article published on 01 July 2002

Biological activities and cellular uptake studies of fluorescent derivatives of indole alkaloid tumor promoter teleocidin

scientific article

Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism of protein kinase Cδ.

scientific article

Change of Amyloid-β 1-42 Toxic Conformer Ratio After Cerebrospinal Fluid Diversion Predicts Long-Term Cognitive Outcome in Patients with Idiopathic Normal Pressure Hydrocephalus.

scientific article published in January 2018

Comparison of chemical characteristics of the first and the second cysteine-rich domains of protein kinase C gamma

scientific article published on 01 August 1997

Control of the toxic conformation of amyloid β42 by intramolecular disulfide bond formation

scientific article published on 01 April 2020

Design and physicochemical properties of new fluorescent ligands of protein kinase C isozymes focused on CH/pi interaction

scientific article published on 22 October 2007

Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta.

scientific article

Diacylglycerol kinase gamma is one of the specific receptors of tumor-promoting phorbol esters.

scientific article

Distance measurement between Tyr10 and Met35 in amyloid beta by site-directed spin-labeling ESR spectroscopy: implications for the stronger neurotoxicity of Abeta42 than Abeta40.

scientific article published in December 2007

Downregulation of programmed cell death 4 by inflammatory conditions contributes to the generation of the tumor promoting microenvironment

scientific article

E22Δ Mutation in Amyloid β-Protein Promotes β-Sheet Transformation, Radical Production, and Synaptotoxicity, But Not Neurotoxicity.

scientific article published on 19 December 2010

Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation

scientific article

Effects of the methoxy group in the side chain of debromoaplysiatoxin on its tumor-promoting and anti-proliferative activities.

scientific article published on 7 June 2013

Enzymatic production of (-)-indolactam V by LtxB, a cytochrome P450 monooxygenase

scientific article published in January 2010

Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity

scientific article

Evaluation of Toxic Amyloid 42 Oligomers in Rat Primary Cerebral Cortex Cells and Human iPS-derived Neurons Treated with 10-Me-Aplog-1, a New PKC Activator

scientific article published on 11 February 2020

Formation and stabilization model of the 42-mer Abeta radical: implications for the long-lasting oxidative stress in Alzheimer's disease

scientific article

Generation of 'Unnatural Natural Product' library and identification of a small molecule inhibitor of XIAP.

scientific article

Geranyl modification on the tryptophan residue of ComXRO-E-2 pheromone by a cell-free system.

scientific article published on 17 December 2011

Identification and biological activities of bryostatins from Japanese bryozoan.

scientific article

Identification and characterization of PKCγ, a kinase associated with SCA14, as an amyloidogenic protein.

scientific article published on 12 September 2014

Identification of 6-octadecynoic acid from a methanol extract of Marrubium vulgare L. as a peroxisome proliferator-activated receptor γ agonist.

scientific article published on 8 September 2013

Identification of a New Type of Covalent PPARγ Agonist using a Ligand-Linking Strategy

scientific article published on 28 September 2015

Identification of physiological and toxic conformations in Abeta42 aggregates.

scientific article

Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-Methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in several cancer cell lines

scientific article published on 9 November 2017

Identification, activity, and structural studies of peptides incorporating the phorbol ester-binding domain of protein kinase C.

scientific article

In vivo Neuroprotective Activity of Epopeptide AB Against Ischemic Damage

scientific article

Indolactam and benzolactam compounds as new medicinal leads with binding selectivity for C1 domains of protein kinase C isozymes.

scientific article published on January 2004

Indolactam-V is involved in the CH/pi interaction with Pro-11 of the PKCdelta C1B domain: application for the structural optimization of the PKCdelta ligand.

scientific article

Inhibition of amyloid β aggregation by acteoside, a phenylethanoid glycoside

scientific article published on 7 June 2013

Insulin deficiency promotes formation of toxic amyloid-β42 conformer co-aggregating with hyper-phosphorylated tau oligomer in an Alzheimer's disease model

scientific article published on 10 January 2020

Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice

scientific article published on 28 April 2011

Intracellular Accumulation of Toxic Turn Amyloid-β is Associated with Endoplasmic Reticulum Stress in Alzheimer's Disease ⬇️

scientific article published on January 1, 2013

Isolation of (-)-14-O-Malonylindolactam-V as a Possible Precursor of (-)-Indolactam-V and (-)-14-O-Acetylindolactam-V from Streptomyces blastmyceticum. ⬇️

scientific article

Isolation, identification, and biological evaluation of Nrf2-ARE activator from the leaves of green perilla (Perilla frutescens var. crispa f. viridis).

scientific article published on 27 June 2012

Isomerization and/or racemization at Asp23 of Abeta42 do not increase its aggregative ability, neurotoxicity, and radical productivity in vitro

scientific article published on 17 December 2007

Lack of the consensus sequence necessary for tryptophan prenylation in the ComX pheromone precursor.

scientific article published on 7 August 2012

Loss of the Phenolic Hydroxyl Group and Aromaticity from the Side Chain of Anti-Proliferative 10-Methyl-aplog-1, a Simplified Analog of Aplysiatoxin, Enhances Its Tumor-Promoting and Proinflammatory Activities.

scientific article

Mechanistic analyses of the suppression of amyloid β42 aggregation by apomorphine

scientific article published on 2 February 2018

Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness

scientific article published on 21 February 2013

Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23

scientific article

Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease

scientific article published on 27 August 2003

New diagnostic method for Alzheimer's disease based on the toxic conformation theory of amyloid β

scientific article published on 20 September 2019

New teleocidin-related metabolites, (-)-7-geranylindolactam V and blastmycetin F, from Streptoverticillium blastmyceticum

scientific article published on 01 March 1994

Non-specific protein modifications by a phytochemical induce heat shock response for self-defense

scientific article

Non-toxic conformer of amyloid β may suppress amyloid β-induced toxicity in rat primary neurons: implications for a novel therapeutic strategy for Alzheimer's disease

scientific article published on 4 June 2013

Photocytotoxicity of water-soluble fullerene derivatives

scientific article published on 01 August 1996

Photocytotoxicity of water-soluble metalloporphyrin derivatives

scientific article published on 01 April 1993

Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid β-protein.

scientific article published on 12 August 2012

Role of the carboxy groups of triterpenoids in their inhibition of the nucleation of amyloid β42 required for forming toxic oligomers

scientific article published on 01 June 2018

Role of the phenolic hydroxyl group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity ⬇️

scientific article published on August 13, 2010

SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer disease

scientific article published on 9 November 2011

Selective binding of bryostatin analogues to the cysteine rich domains of protein kinase C isozymes

scientific article published on 01 June 1999

Semisynthesis and Structure-Activity Studies of Uncarinic Acid C Isolated from Uncaria rhynchophylla as a Specific Inhibitor of the Nucleation Phase in Amyloid β42 Aggregation

scientific article published on 4 October 2016

Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model

scientific article published on 7 November 2010

Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues

scientific article

Solid-phase synthesis, mass spectrometric analysis of the zinc-folding, and phorbol ester-binding studies of the 116-mer peptide containing the tandem cysteine-rich C1 domains of protein kinase C gamma

scientific article published on 01 June 1999

Solid-state NMR analysis of interaction sites of curcumin and 42-residue amyloid β-protein fibrils

scientific article published on 27 August 2011

Solid-state NMR analysis of the β-strand orientation of the protofibrils of amyloid β-protein.

scientific article

Stimulation of insulin secretion by acetylenic fatty acids in insulinoma MIN6 cells through FFAR1

scientific article published on 15 November 2019

Stimulation of the amyloidogenic pathway by cytoplasmic superoxide radicals in an Alzheimer's disease mouse model

scientific article published on 7 June 2012

Stomatal density is controlled by a mesophyll-derived signaling molecule

scientific article published on 9 December 2009

Structural insights into mechanisms for inhibiting amyloid β42 aggregation by non-catechol-type flavonoids

scientific article published on 12 December 2015

Structural optimization of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, as an anticancer lead

scientific article published on 9 October 2015

Structure of beta-amyloid fibrils and its relevance to their neurotoxicity: implications for the pathogenesis of Alzheimer's disease.

scientific article

Structure-activity relationship for (+)-taxifolin isolated from silymarin as an inhibitor of amyloid β aggregation

scientific article published on 7 May 2013

Structure-activity relationship in the induction of Epstein-Barr virus by teleocidin derivatives

scientific article

Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity.

scientific article published on 25 March 2013

Structure-activity studies on the spiroketal moiety of a simplified analogue of debromoaplysiatoxin with antiproliferative activity.

scientific article published on 6 June 2012

Suppression of CD74 expression and Helicobacter pylori adhesion by auraptene targeting serum starvation-activated ERK1/2 in NCI-N87 gastric carcinoma cells.

scientific article

Syntheses and biological activities of photolabile indolactam derivatives; new probes for the receptor analysis of tumor promoters

scientific article published on 01 July 1990

Synthesis and Characterization of New Photolabile Phorbol Esters for Affinity Labeling of Protein Kinase C

Synthesis and PKC isozyme surrogate binding of indothiolactam-V, a new thioamide analogue of tumor promoting indolactam-V

scientific article published on 01 September 2000

Synthesis and binding selectivity of 7- and 15-decylbenzolactone-V8 for the C1 domains of protein kinase C isozymes

scientific article published on 01 September 2003

Synthesis and biological activities of (-)-6-n-octyl-indolactam-V, a new potent analogue of the tumor promoter (-)-indolactam-V

scientific article published on 01 August 1998

Synthesis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-)-indolactam-V

scientific article published on 01 August 1997

Synthesis and biological activities of simplified analogs of the natural PKC ligands, bryostatin-1 and aplysiatoxin

scientific article published on 20 February 2014

Synthesis and biological activities of the amide derivative of aplog-1, a simplified analog of aplysiatoxin with anti-proliferative and cytotoxic activities

scientific article

Synthesis and characterization of the amyloid β40 dimer model with a linker at position 30 adjacent to the intermolecular β-sheet region

scientific article published on 11 September 2015

Synthesis and characterization of the second cysteine-rich region of mouse skin PKCGh

article by Kazuhiro Irie et al published February 1996 in Bioorganic & Medicinal Chemistry Letters

Synthesis and phorbol ester binding of the cysteine-rich domains of diacylglycerol kinase (DGK) isozymes. DGKgamma and DGKbeta are new targets of tumor-promoting phorbol esters

scientific article

Synthesis and phorbol ester-binding studies of the individual cysteine-rich motifs of protein kinase D

scientific article published on 01 September 1999

Synthesis, aggregation, neurotoxicity, and secondary structure of various A beta 1-42 mutants of familial Alzheimer's disease at positions 21-23.

scientific article

Synthesis, conformational analysis, and biological evaluation of 1-hexylindolactam-V10 as a selective activator for novel protein kinase C isozymes

scientific article published on 12 December 2007

Synthetic Models of Quasi-Stable Amyloid β40 Oligomers with Significant Neurotoxicity

scientific article published on 27 December 2016

Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones

scientific article published on 14 April 2020

The C4 hydroxyl group of phorbol esters is not necessary for protein kinase C binding

scientific article

The amide hydrogen of (-)-indolactam-V and benzolactam-V8's plays a critical role in protein kinase C binding and tumor-promoting activities

scientific article

The toxic conformation of the 42-residue amyloid beta peptide and its relevance to oxidative stress in Alzheimer's disease.

scientific article published on October 2007

The turn formation at positions 22 and 23 in the 42-mer amyloid beta peptide: the emerging role in the pathogenesis of Alzheimer's disease

scientific article

Three Structural Features of Functional Food Components and Herbal Medicine with Amyloid β42 Anti-Aggregation Properties

scientific article published on 05 June 2019

Toward the development of new medicinal leads with selectivity for protein kinase C isozymes

scientific article published in January 2005

Toxicity in rat primary neurons through the cellular oxidative stress induced by the turn formation at positions 22 and 23 of Aβ42.

scientific article

Tumor promoter binding of the protein kinase C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s

scientific article

Two new lyngbyatoxin derivatives from the Cyanobacterium, Moorea producens. ⬇️

scientific article

Verification of the C-terminal intramolecular beta-sheet in Abeta42 aggregates using solid-state NMR: implications for potent neurotoxicity through the formation of radicals.

scientific article published on 26 April 2008

Verification of the intermolecular parallel beta-sheet in E22K-Abeta42 aggregates by solid-state NMR using rotational resonance: implications for the supramolecular arrangement of the toxic conformer of Abeta42.

scientific article published on 7 August 2008

Verification of the turn at positions 22 and 23 of the beta-amyloid fibrils with Italian mutation using solid-state NMR.

scientific article published on 22 September 2005

Vitamin C restores behavioral deficits and amyloid-β oligomerization without affecting plaque formation in a mouse model of Alzheimer's disease

scientific article published in January 2011

Zerumbone, an electrophilic sesquiterpene, induces cellular proteo-stress leading to activation of ubiquitin-proteasome system and autophagy.

scientific article published on 5 December 2012

[Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23].

scientific article published in November 2011

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