List of works by Rhonda D Kineman

A cellular basis for growth hormone deficiency in the dwarf rat: analysis of growth hormone and prolactin release by reverse hemolytic plaque assay.

scientific article

A mutant allele of BARA/LIN-9 rescues the cdk4-/- phenotype by releasing the repression on E2F-regulated genes.

scientific article

A novel human ghrelin variant (In1-ghrelin) and ghrelin-O-acyltransferase are overexpressed in breast cancer: potential pathophysiological relevance

scientific article

Ablation of leptin signaling to somatotropes: changes in metabolic factors that cause obesity

scientific article

Adipokines (Leptin, Adiponectin, Resistin) Differentially Regulate All Hormonal Cell Types in Primary Anterior Pituitary Cell Cultures from Two Primate Species

scientific article published on 6 March 2017

Adiponectin in mice with altered GH action: links to insulin sensitivity and longevity?

scientific article published on 25 February 2013

Adult-onset hepatocyte GH resistance promotes NASH in male mice, without severe systemic metabolic dysfunction

scientific article published on 01 November 2018

Authors’ Response: Isolated Familial Somatotropinomas: Does the Disease Map to 11q13 or to 2p16?

scientific article published on 01 December 2000

BIM-23A760 influences key functional endpoints in pituitary adenomas and normal pituitaries: molecular mechanisms underlying the differential response in adenomas

scientific article published on 09 February 2017

Both estrogen receptor α and β stimulate pituitary GH gene expression.

scientific article published on January 2013

Bovine pituitary cells exhibit a unique form of somatotrope secretory heterogeneity

scientific article

Cdk4 is indispensable for postnatal proliferation of the anterior pituitary.

scientific article published on 28 September 2004

Cortistatin is not a somatostatin analogue but stimulates prolactin release and inhibits GH and ACTH in a gender-dependent fashion: potential role of ghrelin.

scientific article published on 4 October 2011

Differential impact of selective GH deficiency and endogenous GH excess on insulin-mediated actions in muscle and liver of male mice.

scientific article

Differential responses of the growth hormone axis in two rat models of streptozotocin-induced insulinopenic diabetes

scientific article published in February 2006

Disruption of growth hormone signaling retards prostate carcinogenesis in the Probasin/TAg rat

scientific article published on 13 December 2007

Does the pituitary somatotrope play a primary role in regulating GH output in metabolic extremes?

scientific article

Dynamic fluctuations in the secretory activity of individual lactotropes as demonstrated by a modified sequential plaque assay

scientific article published on 01 November 1994

Dynamic monitoring and quantification of gene expression in single, living cells: a molecular basis for secretory cell heterogeneity.

scientific article

Dysregulation of the Splicing Machinery Is Associated to the Development of Nonalcoholic Fatty Liver Disease

scientific article published on 01 August 2019

Effects of antagonists of growth hormone-releasing hormone (GHRH) on GH and insulin-like growth factor I levels in transgenic mice overexpressing the human GHRH gene, an animal model of acromegaly

scientific journal article

Effects of leptin replacement on hypothalamic-pituitary growth hormone axis function and circulating ghrelin levels in ob/ob mice.

scientific article

Elevated GH/IGF-I promotes mammary tumors in high-fat, but not low-fat, fed mice

scientific article

Elevated GH/IGF-I, due to somatotrope-specific loss of both IGF-I and insulin receptors, alters glucose homeostasis and insulin sensitivity in a diet-dependent manner

scientific article published on 11 October 2011

Endogenous somatostatin is critical in regulating the acute effects of L-arginine on growth hormone and insulin release in mice.

scientific article published on 21 May 2013

Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

scientific article

Evidence that endogenous SST inhibits ACTH and ghrelin expression by independent pathways.

scientific article published in August 2006

Evidence that ghrelin is as potent as growth hormone (GH)-releasing hormone (GHRH) in releasing GH from primary pituitary cell cultures of a nonhuman primate (Papio anubis), acting through intracellular signaling pathways distinct from GHRH.

scientific article

Examination of the direct effects of metabolic factors on somatotrope function in a non-human primate model, Papio anubis.

scientific article published in August 2006

Expression analysis of dopamine receptor subtypes in normal human pituitaries, nonfunctioning pituitary adenomas and somatotropinomas, and the association between dopamine and somatostatin receptors with clinical response to octreotide-LAR in acrome

scientific article published on 17 March 2009

Expression analysis of hypothalamic and pituitary components of the growth hormone axis in fasted and streptozotocin-treated neuropeptide Y (NPY)-intact (NPY+/+) and NPY-knockout (NPY-/-) mice

scientific article published on 18 October 2005

Expression of growth hormone-releasing hormone (GHRH) messenger ribonucleic acid and the presence of biologically active GHRH in human breast, endometrial, and ovarian cancers

scientific article published in February 1999

Expression of the ghrelin and neurotensin systems is altered in the temporal lobe of Alzheimer's disease patients.

scientific article published on January 2010

Fluctuations in the proportions of growth hormone- and prolactin-secreting cells during the bovine estrous cycle

scientific article published in September 1991

Foreword

scientific article published on 29 March 2008

Gender-dependent role of endogenous somatostatin in regulating growth hormone-axis function in mice.

scientific article published on 30 August 2007

Glucocorticoids regulate pituitary growth hormone secretagogue receptor gene expression.

scientific article

Growth Hormone Inhibits Hepatic De Novo Lipogenesis in Adult Mice

scientific article

Growth hormone-releasing hormone and pituitary development, hyperplasia and tumorigenesis

scientific article

Growth hormone-releasing hormone receptor (GHRH-R) and growth hormone secretagogue receptor (GHS-R) mRNA levels during postnatal development in male and female rats

scientific article published in April 1999

Homologous and heterologous in vitro regulation of pituitary receptors for somatostatin, growth hormone (GH)-releasing hormone, and ghrelin in a nonhuman primate (Papio anubis).

scientific article published on 22 November 2011

Homologous and heterologous regulation of pituitary receptors for ghrelin and growth hormone-releasing hormone

scientific article published on 24 March 2004

Homologous down-regulation of growth hormone-releasing hormone receptor messenger ribonucleic acid levels

scientific article

Hypothalamic/pituitary-axis of the spontaneous dwarf rat: autofeedback regulation of growth hormone (GH) includes suppression of GH releasing-hormone receptor messenger ribonucleic acid

scientific journal article

Identification of a mouse ghrelin gene transcript that contains intron 2 and is regulated in the pituitary and hypothalamus in response to metabolic stress.

scientific article published on May 2007

Identification of the somatostatin receptor subtypes (sst) mediating the divergent, stimulatory/inhibitory actions of somatostatin on growth hormone secretion.

scientific article

Impact of gsp Oncogene on the mRNA Content for Somatostatin and Dopamine Receptors in Human Somatotropinomas

scientific article published on 13 November 2010

Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function

scientific journal article

Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms.

scientific article published on 13 May 2013

Islet insulin content and release are increased in male mice with elevated endogenous GH and IGF-I, without evidence of systemic insulin resistance or alterations in β-cell mass.

scientific article published on 17 April 2015

Kisspeptin regulates gonadotroph and somatotroph function in nonhuman primate pituitary via common and distinct signaling mechanisms

scientific article

Liver-Derived IGF-I Regulates GH Secretion at the Pituitary Level in Mice

article published in 2001

Liver-derived IGF-I regulates GH secretion at the pituitary level in mice

scientific article

Localization of Luteinizing Hormone-Releasing Hormone in the Forebrain of the Pig1

scientific article published on 01 October 1988

Localization of Proopiomelanocortin (POMC) Immunoreactive Neurons in the Forebrain of the Pig13

Long- but not short-term adult-onset, isolated GH deficiency in male mice leads to deterioration of β-cell function, which cannot be accounted for by changes in β-cell mass.

scientific article published on 16 December 2013

Loss of heterozygosity on chromosome 11q13 in two families with acromegaly/gigantism is independent of mutations of the multiple endocrine neoplasia type I gene.

scientific article

Luteinizing hormone secretion following intracerebroventricular administration of morphine in the prepuberal gilt

scientific article published on 01 January 1989

Mammary Growth Response of Holstein Heifers to Photoperiod

scientific article published on 01 January 1985

Mammosomatotropes are abundant in bovine pituitaries: influence of gonadal status

scientific article

Melatonin regulates somatotrope and lactotrope function through common and distinct signaling pathways in cultured primary pituitary cells from female primates

scientific article

Metabolic impact of adult-onset, isolated, growth hormone deficiency (AOiGHD) due to destruction of pituitary somatotropes

scientific article

Metabolic regulation of ghrelin O-acyl transferase (GOAT) expression in the mouse hypothalamus, pituitary, and stomach.

scientific article published on 23 December 2009

Nutritional, hormonal, and depot-dependent regulation of the expression of the small GTPase Rab18 in rodent adipose tissue.

scientific article

Obestatin plays an opposite role in the regulation of pituitary somatotrope and corticotrope function in female primates and male/female mice.

scientific article published on 31 January 2014

Paradoxical effects of dopamine (DA): Gi alpha 3 mediates DA inhibition of PRL release while masking its PRL-releasing activity

scientific article published on 01 August 1994

Pituitary hypoplasia and lactotroph dysfunction in mice deficient for cyclin-dependent kinase-4.

scientific article

Quantitative analysis of somatostatin receptor subtype (SSTR1–5) gene expression levels in somatotropinomas and non-functioning pituitary adenomas

article

Quantitative analysis of somatostatin receptor subtypes (1-5) gene expression levels in somatotropinomas and correlation to in vivo hormonal and tumor volume responses to treatment with octreotide LAR.

scientific article

Reporter expression, induced by a growth hormone promoter-driven Cre recombinase (rGHp-Cre) transgene, questions the developmental relationship between somatotropes and lactotropes in the adult mouse pituitary gland.

scientific article published on 8 February 2007

Role of endogenous somatostatin in regulating GH output under basal conditions and in response to metabolic extremes.

scientific article published on 14 December 2007

Role of ghrelin system in neuroprotection and cognitive functions: implications in Alzheimer's disease.

scientific article published on October 2011

Role of glucocorticoids in the regulation of pituitary somatostatin receptor subtype (sst1-sst5) mRNA levels: evidence for direct and somatostatin-mediated effects

scientific journal article

Severity of the catabolic condition differentially modulates hypothalamic expression of growth hormone-releasing hormone in the fasted mouse: potential role of neuropeptide Y and corticotropin-releasing hormone.

scientific article published on 12 October 2006

Somatostatin and its receptors contribute in a tissue-specific manner to the sex-dependent metabolic (fed/fasting) control of growth hormone axis in mice ⬇️

scientific article published on October 13, 2010

Targeted deletion of somatotroph insulin-like growth factor-I signaling in a cell-specific knockout mouse model

scientific article

The Pituitary Gland is a Novel Major Site of Action of Metformin in Non-Human Primates: a Potential Path to Expand and Integrate Its Metabolic Actions

scientific article published on 11 September 2018

The adult pituitary shows stem/progenitor cell activation in response to injury and is capable of regeneration

scientific article published on 19 April 2012

The effect of GHRH on somatotrope hyperplasia and tumor formation in the presence and absence of GH signaling.

scientific article published in September 2001

The growth hormone (GH)-axis of GH receptor/binding protein gene-disrupted and metallothionein-human GH-releasing hormone transgenic mice: hypothalamic neuropeptide and pituitary receptor expression in the absence and presence of GH feedback

scientific article published in March 2001

The ontogenic and functional relationships between growth hormone- and prolactin-releasing cells during the development of the bovine pituitary

scientific article published in July 1992

The rise in growth hormone during starvation does not serve to maintain glucose levels or lean mass but is required for appropriate adipose tissue response in female mice

scientific article

The role of pituitary ghrelin in growth hormone (GH) secretion: GH-releasing hormone-dependent regulation of pituitary ghrelin gene expression and peptide content

scientific article

The somatotrope as a metabolic sensor: deletion of leptin receptors causes obesity.

scientific article

Truncated somatostatin receptor variant sst5TMD4 confers aggressive features (proliferation, invasion and reduced octreotide response) to somatotropinomas

scientific article

Use of the metallothionein promoter-human growth hormone-releasing hormone (GHRH) mouse to identify regulatory pathways that suppress pituitary somatotrope hyperplasia and adenoma formation due to GHRH-receptor hyperactivation.

scientific article published on 02 April 2009

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