List of works - José Córdoba-Chacón

A novel human ghrelin variant (In1-ghrelin) and ghrelin-O-acyltransferase are overexpressed in breast cancer: potential pathophysiological relevance

scientific article

Adiponectin in mice with altered GH action: links to insulin sensitivity and longevity?

scientific article published on 25 February 2013

Adult-onset hepatocyte GH resistance promotes NASH in male mice, without severe systemic metabolic dysfunction

scientific article published on 01 November 2018

Autophagy Differentially Regulates Insulin Production and Insulin Sensitivity

scientific article published on 01 June 2018

Cortistatin Is a Key Factor Regulating the Sex-Dependent Response of the GH and Stress Axes to Fasting in Mice

scientific article

Cortistatin is not a somatostatin analogue but stimulates prolactin release and inhibits GH and ACTH in a gender-dependent fashion: potential role of ghrelin.

scientific article published on 4 October 2011

Differential impact of selective GH deficiency and endogenous GH excess on insulin-mediated actions in muscle and liver of male mice.

scientific article

Does the pituitary somatotrope play a primary role in regulating GH output in metabolic extremes?

scientific article

Elevated GH/IGF-I promotes mammary tumors in high-fat, but not low-fat, fed mice

scientific article

Elevated GH/IGF-I, due to somatotrope-specific loss of both IGF-I and insulin receptors, alters glucose homeostasis and insulin sensitivity in a diet-dependent manner

scientific article published on 11 October 2011

Endogenous somatostatin is critical in regulating the acute effects of L-arginine on growth hormone and insulin release in mice.

scientific article published on 21 May 2013

Expression of the ghrelin and neurotensin systems is altered in the temporal lobe of Alzheimer's disease patients.

scientific article published on January 2010

Fasting modulates GH/IGF-I axis and its regulatory systems in the mammary gland of female mice: Influence of endogenous cortistatin.

scientific article published on 9 June 2016

Growth Hormone Control of Hepatic Lipid Metabolism

scientific article published on 27 September 2016

Growth Hormone Inhibits Hepatic De Novo Lipogenesis in Adult Mice

scientific article

Hepatic HKDC1 Expression Contributes to Liver Metabolism

scientific article published on 01 February 2019

Hepatic PPARγ Is Not Essential for the Rapid Development of Steatosis After Loss of Hepatic GH Signaling, in Adult Male Mice

scientific article published on 7 March 2016

Hepatic hexokinase domain containing 1 (HKDC1) improves whole body glucose tolerance and insulin sensitivity in pregnant mice

scientific article published on 10 December 2018

Hepatocyte-specific, PPARγ-regulated mechanisms to promote steatosis in adult mice

scientific article published on 31 October 2016

Homologous and heterologous in vitro regulation of pituitary receptors for somatostatin, growth hormone (GH)-releasing hormone, and ghrelin in a nonhuman primate (Papio anubis).

scientific article published on 22 November 2011

Impact of gsp Oncogene on the mRNA Content for Somatostatin and Dopamine Receptors in Human Somatotropinomas

scientific article published on 13 November 2010

Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms.

scientific article published on 13 May 2013

Islet insulin content and release are increased in male mice with elevated endogenous GH and IGF-I, without evidence of systemic insulin resistance or alterations in β-cell mass.

scientific article published on 17 April 2015

Kisspeptin regulates gonadotroph and somatotroph function in nonhuman primate pituitary via common and distinct signaling mechanisms

scientific article

Long- but not short-term adult-onset, isolated GH deficiency in male mice leads to deterioration of β-cell function, which cannot be accounted for by changes in β-cell mass.

scientific article published on 16 December 2013

Loss of Hepatocyte-Specific PPARγ Expression Ameliorates Early Events of Steatohepatitis in Mice Fed the Methionine and Choline-Deficient Diet

scientific article published on 01 May 2020

Melatonin regulates somatotrope and lactotrope function through common and distinct signaling pathways in cultured primary pituitary cells from female primates

scientific article

Metabolic impact of adult-onset, isolated, growth hormone deficiency (AOiGHD) due to destruction of pituitary somatotropes

scientific article

Metabolic regulation of ghrelin O-acyl transferase (GOAT) expression in the mouse hypothalamus, pituitary, and stomach.

scientific article published on 23 December 2009

Not So Giants: Mice Lacking Both Somatostatin and Cortistatin Have High GH Levels but Show No Changes in Growth Rate or IGF-1 Levels

scientific article published in April 2015

Obesity alters gene expression for GH/IGF-I axis in mouse mammary fat pads: differential role of cortistatin and somatostatin

scientific article

Obesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice

scientific article

Obestatin plays an opposite role in the regulation of pituitary somatotrope and corticotrope function in female primates and male/female mice.

scientific article published on 31 January 2014

Obestatin regulates adipocyte function and protects against diet-induced insulin resistance and inflammation.

scientific article published on 17 May 2012

Peripubertal-onset but not adult-onset obesity increases IGF-I and drives development of lean mass, which may lessen the metabolic impairment in adult obesity ⬇️

scientific article published on August 28, 2012

Role of endogenous cortistatin in the regulation of ghrelin system expression at pancreatic level under normal and obese conditions

scientific article

Role of ghrelin system in neuroprotection and cognitive functions: implications in Alzheimer's disease.

scientific article published on October 2011

Somatostatin and its receptors contribute in a tissue-specific manner to the sex-dependent metabolic (fed/fasting) control of growth hormone axis in mice ⬇️

scientific article published on October 13, 2010

Somatostatin and its receptors from fish to mammals.

scientific article

Somatostatin dramatically stimulates growth hormone release from primate somatotrophs acting at low doses via somatostatin receptor 5 and cyclic AMP.

scientific article

The rise in growth hormone during starvation does not serve to maintain glucose levels or lean mass but is required for appropriate adipose tissue response in female mice

scientific article

Tissue-dependent effects of cis-9,trans-11- and trans-10,cis-12-CLA isomers on glucose and lipid metabolism in adult male mice

scientific article published on 10 February 2019

Truncated somatostatin receptors as new players in somatostatin–cortistatin pathophysiology ⬇️

scientific article published on March 1, 2011

Understanding the multifactorial control of growth hormone release by somatotropes: lessons from comparative endocrinology.

scientific article published on April 2009

Use of the metallothionein promoter-human growth hormone-releasing hormone (GHRH) mouse to identify regulatory pathways that suppress pituitary somatotrope hyperplasia and adenoma formation due to GHRH-receptor hyperactivation.

scientific article published on 02 April 2009

p110γ deficiency protects against pancreatic carcinogenesis yet predisposes to diet-induced hepatotoxicity

scientific article published on 02 July 2019

List of works by José Córdoba-Chacón

A novel human ghrelin variant (In1-ghrelin) and ghrelin-O-acyltransferase are overexpressed in breast cancer: potential pathophysiological relevance

Adiponectin in mice with altered GH action: links to insulin sensitivity and longevity?

Adult-onset hepatocyte GH resistance promotes NASH in male mice, without severe systemic metabolic dysfunction

Autophagy Differentially Regulates Insulin Production and Insulin Sensitivity

Cortistatin Is a Key Factor Regulating the Sex-Dependent Response of the GH and Stress Axes to Fasting in Mice

Cortistatin is not a somatostatin analogue but stimulates prolactin release and inhibits GH and ACTH in a gender-dependent fashion: potential role of ghrelin.

Differential impact of selective GH deficiency and endogenous GH excess on insulin-mediated actions in muscle and liver of male mice.

Does the pituitary somatotrope play a primary role in regulating GH output in metabolic extremes?

Elevated GH/IGF-I promotes mammary tumors in high-fat, but not low-fat, fed mice

Elevated GH/IGF-I, due to somatotrope-specific loss of both IGF-I and insulin receptors, alters glucose homeostasis and insulin sensitivity in a diet-dependent manner

Endogenous somatostatin is critical in regulating the acute effects of L-arginine on growth hormone and insulin release in mice.

Expression of the ghrelin and neurotensin systems is altered in the temporal lobe of Alzheimer's disease patients.

Fasting modulates GH/IGF-I axis and its regulatory systems in the mammary gland of female mice: Influence of endogenous cortistatin.

Growth Hormone Control of Hepatic Lipid Metabolism

Growth Hormone Inhibits Hepatic De Novo Lipogenesis in Adult Mice

Hepatic HKDC1 Expression Contributes to Liver Metabolism

Hepatic PPARγ Is Not Essential for the Rapid Development of Steatosis After Loss of Hepatic GH Signaling, in Adult Male Mice

Hepatic hexokinase domain containing 1 (HKDC1) improves whole body glucose tolerance and insulin sensitivity in pregnant mice

Hepatocyte-specific, PPARγ-regulated mechanisms to promote steatosis in adult mice

Homologous and heterologous in vitro regulation of pituitary receptors for somatostatin, growth hormone (GH)-releasing hormone, and ghrelin in a nonhuman primate (Papio anubis).

Impact of gsp Oncogene on the mRNA Content for Somatostatin and Dopamine Receptors in Human Somatotropinomas

Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms.

Islet insulin content and release are increased in male mice with elevated endogenous GH and IGF-I, without evidence of systemic insulin resistance or alterations in β-cell mass.

Kisspeptin regulates gonadotroph and somatotroph function in nonhuman primate pituitary via common and distinct signaling mechanisms

Long- but not short-term adult-onset, isolated GH deficiency in male mice leads to deterioration of β-cell function, which cannot be accounted for by changes in β-cell mass.

Loss of Hepatocyte-Specific PPARγ Expression Ameliorates Early Events of Steatohepatitis in Mice Fed the Methionine and Choline-Deficient Diet

Melatonin regulates somatotrope and lactotrope function through common and distinct signaling pathways in cultured primary pituitary cells from female primates

Metabolic impact of adult-onset, isolated, growth hormone deficiency (AOiGHD) due to destruction of pituitary somatotropes

Metabolic regulation of ghrelin O-acyl transferase (GOAT) expression in the mouse hypothalamus, pituitary, and stomach.

Not So Giants: Mice Lacking Both Somatostatin and Cortistatin Have High GH Levels but Show No Changes in Growth Rate or IGF-1 Levels

Obesity alters gene expression for GH/IGF-I axis in mouse mammary fat pads: differential role of cortistatin and somatostatin

Obesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice

Obestatin plays an opposite role in the regulation of pituitary somatotrope and corticotrope function in female primates and male/female mice.

Obestatin regulates adipocyte function and protects against diet-induced insulin resistance and inflammation.

Peripubertal-onset but not adult-onset obesity increases IGF-I and drives development of lean mass, which may lessen the metabolic impairment in adult obesity ⬇️

Role of endogenous cortistatin in the regulation of ghrelin system expression at pancreatic level under normal and obese conditions

Role of ghrelin system in neuroprotection and cognitive functions: implications in Alzheimer's disease.

Somatostatin and its receptors contribute in a tissue-specific manner to the sex-dependent metabolic (fed/fasting) control of growth hormone axis in mice ⬇️

Somatostatin and its receptors from fish to mammals.

Somatostatin dramatically stimulates growth hormone release from primate somatotrophs acting at low doses via somatostatin receptor 5 and cyclic AMP.

The rise in growth hormone during starvation does not serve to maintain glucose levels or lean mass but is required for appropriate adipose tissue response in female mice

Tissue-dependent effects of cis-9,trans-11- and trans-10,cis-12-CLA isomers on glucose and lipid metabolism in adult male mice

Truncated somatostatin receptors as new players in somatostatin–cortistatin pathophysiology ⬇️

Understanding the multifactorial control of growth hormone release by somatotropes: lessons from comparative endocrinology.

Use of the metallothionein promoter-human growth hormone-releasing hormone (GHRH) mouse to identify regulatory pathways that suppress pituitary somatotrope hyperplasia and adenoma formation due to GHRH-receptor hyperactivation.

p110γ deficiency protects against pancreatic carcinogenesis yet predisposes to diet-induced hepatotoxicity