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List of works by Pavel Gershkovich

A novel nucleoside rescue metabolic pathway may be responsible for therapeutic effect of orally administered cordycepin

scientific article published on 31 October 2019

A novel tropically stable oral amphotericin B formulation (iCo-010) exhibits efficacy against visceral Leishmaniasis in a murine model.

scientific article

A review of the application of lipid-based systems in systemic, dermal/ transdermal, and ocular drug delivery.

scientific article published on January 2008

A simple and sensitive method for determination of vitamins D3 and K1 in rat plasma: application for an in vivo pharmacokinetic study.

scientific article published on 4 February 2013

Analytical ultracentrifugation in saliva research: Impact of green tea astringency and its significance on the in-vivo aroma release

scientific article published in Scientific Reports

Application of biorelevant saliva-based dissolution for optimisation of orally disintegrating formulations of felodipine

scientific article published on 19 November 2018

Assessment of cholesterol absorption inhibitors nanostructured aluminosilicate and cholestyramine using in vitro lipolysis model

scientific article published on 20 September 2011

Assessment of novel oral lipid-based formulations of amphotericin B using an in vitro lipolysis model.

scientific article published on 18 February 2012

Biodistribution and tissue toxicity of amphotericin B in mice following multiple dose administration of a novel oral lipid-based formulation (iCo-009).

scientific article published on 22 September 2010

Cardiac glycoside cerberin exerts anticancer activity through PI3K/AKT/mTOR signal transduction inhibition

scientific article published on 28 March 2019

Chain length affects pancreatic lipase activity and the extent and pH-time profile of triglyceride lipolysis.

scientific article published in May 2015

Characterisation of human saliva as a platform for oral dissolution medium development.

scientific article published on 17 January 2015

Codrug Approach for the Potential Treatment of EML4-ALK Positive Lung Cancer

scientific article published on 27 September 2019

Delivery of Temozolomide and N3-Propargyl Analog to Brain Tumors Using an Apoferritin Nanocage

scientific article published on 04 March 2020

Development and characterization of oral lipid-based amphotericin B formulations with enhanced drug solubility, stability and antifungal activity in rats infected with Aspergillus fumigatus or Candida albicans

scientific article published on 17 January 2009

Development and validation of a cost-effective and sensitive bioanalytical HPLC-UV method for determination of lopinavir in rat and human plasma

scientific article published on 29 June 2020

Development of Cordycepin Formulations for Preclinical and Clinical Studies

scientific article published on 30 May 2017

Development of a simple and sensitive HPLC-UV method for the simultaneous determination of cannabidiol and Δ(9)-tetrahydrocannabinol in rat plasma.

scientific article published on 22 May 2015

Dietary fats and pharmaceutical lipid excipients increase systemic exposure to orally administered cannabis and cannabis-based medicines

scientific article published on 15 August 2016

Different impacts of intestinal lymphatic transport on the oral bioavailability of structurally similar synthetic lipophilic cannabinoids: dexanabinol and PRS-211,220

scientific article published on 05 May 2007

Dissolution methodology for taste masked oral dosage forms.

scientific article published on 31 October 2013

Dual physiologically based pharmacokinetic model of liposomal and nonliposomal amphotericin B disposition

scientific article published on 21 June 2013

Effect of a high-fat meal on absorption and disposition of lipophilic compounds: the importance of degree of association with triglyceride-rich lipoproteins

scientific article

Effect of abdominal surgery on the intestinal absorption of lipophilic drugs: possible role of the lymphatic transport.

scientific article published on 31 March 2009

Effect of hypertriglyceridemia on the pharmacokinetics and blood-brain barrier penetration of clozapine and norclozapine following administration to rats

scientific article published on 16 February 2010

Effect of variations in treatment regimen and liver cirrhosis on exposure to benzodiazepines during treatment of alcohol withdrawal syndrome.

scientific article published on 7 August 2015

Efficacy and toxicity of a tropically stable lipid-based formulation of amphotericin B (iCo-010) in a rat model of invasive candidiasis

scientific article published on 06 July 2012

Evaluation of the effect of plant sterols on the intestinal processing of cholesterol using an in vitro lipolysis model.

scientific article published on 28 July 2012

Highly effective oral amphotericin B formulation against murine visceral leishmaniasis

scientific article

Hyperlipidaemia alone and in combination with acidosis can increase the incidence and severity of statin-induced myotoxicity

scientific article published on 16 January 2017

In vitro anticancer properties and biological evaluation of novel natural alkaloid jerantinine B.

scientific article published on 26 October 2015

In vitro cytotoxicity of two novel oral formulations of Amphotericin B (iCo-009 and iCo-010) against Candida albicans, human monocytic and kidney cell lines

scientific article

Inhibition of cholesterol absorption: targeting the intestine.

scientific article published on 25 August 2012

Inhibition of intestinal absorption of cholesterol by surface-modified nanostructured aluminosilicate compounds

scientific article

Is rat a good model for assessment of particulate-based taste-masked formulations?

scientific article published on 11 November 2019

Linking in Vitro Lipolysis and Microsomal Metabolism for the Quantitative Prediction of Oral Bioavailability of BCS II Drugs Administered in Lipidic Formulations

scientific article published on 2 September 2016

Lipid-lowering Activity of Natural and Semi-Synthetic Sterols and Stanols

scientific article

Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system

scientific article published on 18 July 2018

Long-circulating non-toxic blood pool imaging agent based on hyperbranched polyglycerols

scientific article published on 21 October 2011

Novel oral amphotericin B formulation (iCo-010) remains highly effective against murine systemic candidiasis following exposure to tropical temperature.

scientific article published on 29 August 2014

Oral administration of cannabis with lipids leads to high levels of cannabinoids in the intestinal lymphatic system and prominent immunomodulation.

scientific article published on 6 November 2017

Pharmacokinetics and biodistribution of amphotericin B in rats following oral administration in a novel lipid-based formulation.

scientific article published on 27 April 2009

Pharmacokinetics and tissue distribution of amphotericin B following oral administration of three lipid-based formulations to rats

scientific article published on 18 September 2012

Physiologically based pharmacokinetic model of amphotericin B disposition in rats following administration of deoxycholate formulation (Fungizone®): pooled analysis of published data.

scientific article

Protonated nanostructured aluminosilicate (NSAS) reduces plasma cholesterol concentrations and atherosclerotic lesions in Apolipoprotein E deficient mice fed a high cholesterol and high fat diet

scientific article published on 28 July 2009

Quantitative Prediction of Oral Bioavailability of a Lipophilic Antineoplastic Drug Bexarotene Administered in Lipidic Formulation Using a Combined In Vitro Lipolysis/Microsomal Metabolism Approach

scientific article published on 28 September 2018

Quantitative analysis of lab-to-lab variability in Caco-2 permeability assays.

scientific article

Reduced variability in tacrolimus pharmacokinetics following intramuscular injection compared to oral administration in cynomolgus monkeys: Investigating optimal dosing regimens

scientific article published on 11 December 2018

Rifampicin-induced CYP3A4 activation in CTX patients cannot replace chenodeoxycholic acid treatment

scientific article published in May 2007

Self-Assembling Benzothiazole-Based Gelators: A Mechanistic Understanding of in Vitro Bioactivation and Gelation.

scientific article published on 5 March 2018

Simple and sensitive HPLC-UV method for determination of bexarotene in rat plasma.

scientific article

Simultaneous determination of a novel antitrypanosomal compound (OSU-36) and its ester derivative (OSU-40) in plasma by HPLC: application to first pharmacokinetic study in rats.

scientific article published in January 2011

Solid lipid nanoparticles self-assembled from spray dried microparticles

scientific article published on 30 October 2019

Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols: Effect of core substitutions and salt formation

scientific article published in 2011

Synthesis of micellar-like terpolymer nanoparticles with reductively-cleavable cross-links and evaluation of efficacy in 2D and 3D models of triple negative breast cancer

scientific article published on 01 May 2020

Targeted delivery of lopinavir to HIV reservoirs in the mesenteric lymphatic system by lipophilic ester prodrug approach

scientific article published on 19 October 2020

The effect of a high-fat meal on the pharmacodynamics of a model lipophilic compound that binds extensively to triglyceride-rich lipoproteins

scientific article published on 19 January 2007

The role of acid-base imbalance in statin-induced myotoxicity

scientific article published on 29 March 2016

The role of molecular physicochemical properties and apolipoproteins in association of drugs with triglyceride-rich lipoproteins: in-silico prediction of uptake by chylomicrons

scientific article published on 01 January 2009

The role of the lymphatic system in subcutaneous absorption of macromolecules in the rat model

scientific article published on 07 April 2007

The use of the United States FDA programs as a strategy to advance the development of drug products for neglected tropical diseases

scientific article published on 11 February 2014

Translational insight into statin-induced muscle toxicity: from cell culture to clinical studies.

scientific article published on 25 January 2014

Tropically stable novel oral lipid formulation of amphotericin B (iCo-010): biodistribution and toxicity in a mouse model

scientific article

Uptake of lipophilic drugs by plasma derived isolated chylomicrons: linear correlation with intestinal lymphatic bioavailability

scientific article

Visceral leishmaniasis affects liver and spleen concentrations of amphotericin B following administration to mice

scientific article published on 21 December 2009

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