List of works - Youcef Mehellou

An investigation into the anti-HIV activity of 2',3'-didehydro-2',3'-dideoxyuridine (d4U) and 2',3'-dideoxyuridine (ddU) phosphoramidate 'ProTide' derivatives.

scientific article

Aryloxy Triester Phosphoramidates as Phosphoserine Prodrugs: A Proof of Concept Study

scientific article published on 12 March 2020

Aryloxy phosphoramidate triesters: a technology for delivering monophosphorylated nucleosides and sugars into cells

scientific article

BTN3A1 Discriminates γδ T Cell Phosphoantigens from Nonantigenic Small Molecules via a Conformational Sensor in Its B30.2 Domain

scientific article

Chemical Strategies for Activating PINK1, a Protein Kinase Mutated in Parkinson's Disease

scientific article published on 07 November 2018

Design, synthesis, and anti-HIV activity of 2′,3′-didehydro-2′,3′-dideoxyuridine (d4U), 2′,3′-dideoxyuridine (ddU) phosphoramidate ‘ProTide’ derivatives

article

Kinetin Riboside and Its ProTides Activate the Parkinson's Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent of Mitochondrial Depolarization

scientific article published on 21 March 2017

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

scientific article

Niclosamide, a Drug with Many (Re)purposes.

scientific article

Nucleoside Phosphate and Phosphonate Prodrug Clinical Candidates

scientific article published on 25 August 2016

Organometallic Nucleoside Analogues: Effect of Hydroxyalkyl Linker Length on Cancer Cell Line Toxicity

article

Organometallic nucleoside analogues with ferrocenyl linker groups: synthesis and cancer cell line studies

scientific article

Phosphoramidate prodrugs deliver with potency against hepatitis C virus

scientific article published on November 2010

Phosphoramidates of 2'-beta-D-arabinouridine (AraU) as phosphate prodrugs; design, synthesis, in vitro activity and metabolism

scientific article published on March 2010

Phosphotyrosine prodrugs: design, synthesis and anti-STAT3 activity of ISS-610 aryloxy triester phosphoramidate prodrugs

scientific article published on 07 November 2018

Rafoxanide and Closantel Inhibit SPAK and OSR1 Kinases by Binding to a Highly Conserved Allosteric Site on Their C-terminal Domains

scientific article published on 31 March 2017

SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation

scientific article published on January 2012

Structural insights into the activation of MST3 by MO25

scientific article

Synthesis and Biological Evaluation of (E)-4-Hydroxy-3-Methylbut-2-enyl Phosphate (HMBP) Aryloxy Triester Phosphoramidate Prodrugs as Activators of Vγ9/Vδ2 T-Cells Immune Response.

scientific article published on 19 February 2018

Synthesis of pdCpAs and transfer RNAs activated with thiothreonine and derivatives

scientific article published on 15 February 2012

The Anthelmintic Drug Niclosamide and its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1.

scientific article published on 10 December 2017

The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

scientific article

The Cul4-DDB1-WDR3/WDR6 Complex Binds SPAK and OSR1 Kinases in a Phosphorylation-Dependent Manner

scientific article published on 15 October 2019

The Photosensitising Clinical Agent Verteporfin Is an Inhibitor of SPAK and OSR1 Kinases

scientific article published on 22 August 2018

The ProTide Prodrug Technology: From the Concept to the Clinic

scientific article published on 9 August 2017

The ProTides Boom

scientific article published on 9 May 2016

The design, synthesis and antiviral evaluation of a series of 5-trimethylsilyl-1-beta-D-(arabinofuranosyl)uracil phosphoramidate ProTides

scientific article published on 9 March 2010

Towards the Development of Small-Molecule MO25 Binders as Potential Indirect SPAK/OSR1 Kinase Inhibitors

scientific article

Twenty-six years of anti-HIV drug discovery: where do we stand and where do we go?

scientific article published on January 2010

WNK Signaling Inhibitors as Potential Antihypertensive Drugs

scientific article

List of works by Youcef Mehellou

An investigation into the anti-HIV activity of 2',3'-didehydro-2',3'-dideoxyuridine (d4U) and 2',3'-dideoxyuridine (ddU) phosphoramidate 'ProTide' derivatives.

Aryloxy Triester Phosphoramidates as Phosphoserine Prodrugs: A Proof of Concept Study

Aryloxy phosphoramidate triesters: a technology for delivering monophosphorylated nucleosides and sugars into cells

BTN3A1 Discriminates γδ T Cell Phosphoantigens from Nonantigenic Small Molecules via a Conformational Sensor in Its B30.2 Domain

Chemical Strategies for Activating PINK1, a Protein Kinase Mutated in Parkinson's Disease

Design, synthesis, and anti-HIV activity of 2′,3′-didehydro-2′,3′-dideoxyuridine (d4U), 2′,3′-dideoxyuridine (ddU) phosphoramidate ‘ProTide’ derivatives

Kinetin Riboside and Its ProTides Activate the Parkinson's Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent of Mitochondrial Depolarization

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

Niclosamide, a Drug with Many (Re)purposes.

Nucleoside Phosphate and Phosphonate Prodrug Clinical Candidates

Organometallic Nucleoside Analogues: Effect of Hydroxyalkyl Linker Length on Cancer Cell Line Toxicity

Organometallic nucleoside analogues with ferrocenyl linker groups: synthesis and cancer cell line studies

Phosphoramidate prodrugs deliver with potency against hepatitis C virus

Phosphoramidates of 2'-beta-D-arabinouridine (AraU) as phosphate prodrugs; design, synthesis, in vitro activity and metabolism

Phosphotyrosine prodrugs: design, synthesis and anti-STAT3 activity of ISS-610 aryloxy triester phosphoramidate prodrugs

Rafoxanide and Closantel Inhibit SPAK and OSR1 Kinases by Binding to a Highly Conserved Allosteric Site on Their C-terminal Domains

SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation

Structural insights into the activation of MST3 by MO25

Synthesis and Biological Evaluation of (E)-4-Hydroxy-3-Methylbut-2-enyl Phosphate (HMBP) Aryloxy Triester Phosphoramidate Prodrugs as Activators of Vγ9/Vδ2 T-Cells Immune Response.

Synthesis of pdCpAs and transfer RNAs activated with thiothreonine and derivatives

The Anthelmintic Drug Niclosamide and its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1.

The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

The Cul4-DDB1-WDR3/WDR6 Complex Binds SPAK and OSR1 Kinases in a Phosphorylation-Dependent Manner

The Photosensitising Clinical Agent Verteporfin Is an Inhibitor of SPAK and OSR1 Kinases

The ProTide Prodrug Technology: From the Concept to the Clinic

The ProTides Boom

The design, synthesis and antiviral evaluation of a series of 5-trimethylsilyl-1-beta-D-(arabinofuranosyl)uracil phosphoramidate ProTides

Towards the Development of Small-Molecule MO25 Binders as Potential Indirect SPAK/OSR1 Kinase Inhibitors

Twenty-six years of anti-HIV drug discovery: where do we stand and where do we go?

WNK Signaling Inhibitors as Potential Antihypertensive Drugs