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List of works by Julien Hanson

7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency

scientific article

A dynamic and screening-compatible nanoluciferase-based complementation assay enables profiling of individual GPCR-G protein interactions

scientific article published on 28 December 2018

Activation of the Orphan G Protein-Coupled Receptor GPR27 by Surrogate Ligands Promotes β-Arrestin 2 Recruitment

scientific article

Alternative glycosylation controls endoplasmic reticulum dynamics and tubular extension in mammalian cells

scientific article published in May 2021

An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81.

scientific article published in April 2010

BM-520, an original TXA2 modulator, inhibits the action of thromboxane A2 and 8-iso-prostaglandin F2alphain vitro and in vivo on human and rodent platelets, and aortic vascular smooth muscles from rodents

scientific article published on 13 March 2007

BM-573 inhibits the development of early atherosclerotic lesions in Apo E deficient mice by blocking TP receptors and thromboxane synthase

scientific article published on 21 March 2011

Capillary electrophoretic mobility shift displacement assay for the assessment of weak drug-protein interactions

scientific article published on 14 June 2018

Cardiovascular haemodynamics and ventriculo-arterial coupling in an acute pig model of coronary ischaemia-reperfusion

scientific article published on 12 October 2006

Characterization of an original model of myocardial infarction provoked by coronary artery thrombosis induced by ferric chloride in pig.

scientific article published on 23 March 2005

Chemokine neutralization as an innovative therapeutic strategy for atopic dermatitis.

scientific article published on 9 December 2016

Coxibs and cardiovascular side-effects: from light to shadow.

scientific article

Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis

scientific article

Design, synthesis, and SAR study of a series of N-alkyl-N'-[2-(aryloxy)-5-nitrobenzenesulfonyl]ureas and -cyanoguanidine as selective antagonists of the TPalpha and TPbeta isoforms of the human thromboxane A2 receptor.

scientific article

Different contribution of chemokine N-terminal features attest a different ligand binding mode and a bias towards activation of the atypical chemokine receptor ACKR3/CXCR7 compared to CXCR4 and CXCR3.

scientific article published on 22 December 2017

Effect of BM-573 [N-terbutyl-N'-[2-(4'-methylphenylamino)-5-nitro-benzenesulfonyl]urea], a dual thromboxane synthase inhibitor and thromboxane receptor antagonist, in a porcine model of acute pulmonary embolism

scientific article published on 30 April 2004

Effects of BM-573, a thromboxane A2 modulator on systemic hemodynamics perturbations induced by U-46619 in the pig.

scientific article

Effects of dobutamine on left ventriculoarterial coupling and mechanical efficiency in acutely ischemic pigs

scientific article published in February 2005

Enhancing Action of Positive Allosteric Modulators through the Design of Dimeric Compounds

scientific article published on 08 June 2018

Evaluation of BM-573, a novel TXA2 synthase inhibitor and receptor antagonist, in a porcine model of myocardial ischemia-reperfusion

scientific article published on 22 December 2005

Forskolin-free cAMP assay for Gi-coupled receptors.

scientific article published on 16 September 2015

From the design to the clinical application of thromboxane modulators

scientific article

GPCRs in immunity: Atypical receptors and novel concepts.

scientific article published on 29 June 2016

GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11

scientific article published on 21 September 2020

Heterologously expressed formyl peptide receptor 2 (FPR2/ALX) does not respond to lipoxin A₄.

scientific article published in May 2013

Human herpesvirus 8-encoded chemokine vCCL2/vMIP-II is an agonist of the atypical chemokine receptor ACKR3/CXCR7.

scientific article published on 26 May 2016

Identification and pharmacological characterization of succinate receptor agonists

scientific article

In vitro and in vivo pharmacological characterization of BM-613 [N-n-pentyl-N'-[2-(4'-methylphenylamino)-5-nitrobenzenesulfonyl]urea], a novel dual thromboxane synthase inhibitor and thromboxane receptor antagonist.

scientific article published on 30 December 2004

Insight into SUCNR1 (GPR91) structure and function.

scientific article

Mutational analysis of the extracellular disulphide bridges of the atypical chemokine receptor ACKR3/CXCR7 uncovers multiple binding and activation modes for its chemokine and endogenous non-chemokine agonists.

scientific article published on 9 March 2018

New developments on thromboxane modulators.

scientific article published in August 2004

Nicotinic acid (niacin): new lipid-independent mechanisms of action and therapeutic potentials

scientific article published on 22 September 2011

Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice

scientific article

Partial filling affinity capillary electrophoresis as a useful tool for fragment-based drug discovery: A proof of concept on thrombin.

scientific article published on 30 June 2017

Pharmacological characterization of N-tert-butyl-N'-[2-(4'-methylphenylamino)-5-nitrobenzenesulfonyl]urea (BM-573), a novel thromboxane, etc.

scientific article (publication date: May 2004)

Pharmacological evaluation of both enantiomers of (R,S)-BM-591 as thromboxane A2 receptor antagonists and thromboxane synthase inhibitors

scientific article published in October 2004

Progress in the field of GPIIb/IIIa antagonists

scientific article published in April 2004

Role of HCA₂ (GPR109A) in nicotinic acid and fumaric acid ester-induced effects on the skin

scientific article published on 26 June 2012

Synthesis and pharmacological evaluation of 2-aryloxy/arylamino-5-cyanobenzenesulfonylureas as novel thromboxane A₂ receptor antagonists.

scientific article published on 23 April 2013

Synthesis and pharmacological evaluation of novel nitrobenzenic thromboxane modulators as antiplatelet agents acting on both the alpha and beta isoforms of the human thromboxane receptor

scientific article published on 01 June 2006

The Distinct Roles of CXCR3 Variants and Their Ligands in the Tumor Microenvironment

scientific article published on 18 June 2019

The G Protein-Coupled Receptors deorphanization landscape

scientific article published on 15 February 2018

The causes and consequences of pituitary gigantism

scientific article published on 01 December 2018

Therapeutic applications of prostaglandins and thromboxane A2 inhibitors in abdominal aortic aneurysms

scientific article published on 27 December 2017

Thromboxane, prostacyclin and isoprostanes: therapeutic targets in atherogenesis

scientific article

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