List of works - Carsten Janke

A Family of Protein-Deglutamylating Enzymes Associated with Neurodegeneration ⬇️

scientific article published on November 12, 2010

A targeted multienzyme mechanism for selective microtubule polyglutamylation

scientific article published in May 2007

A unified reviewing format for grant applications and evaluations

scientific article published on 27 December 2017

A versatile toolbox for PCR-based tagging of yeast genes: new fluorescent proteins, more markers and promoter substitution cassettes

scientific article (publication date: August 2004)

ATAT1-enriched vesicles promote microtubule acetylation via axonal transport

scientific article published on 18 December 2019

ATAT1/MEC-17 acetyltransferase and HDAC6 deacetylase control a balance of acetylation of alpha-tubulin and cortactin and regulate MT1-MMP trafficking and breast tumor cell invasion.

scientific article published on 16 August 2012

Activation of mitogen-activated protein kinase cascade and phosphorylation of cytoskeletal proteins after neurone-specific activation of p21ras. II. Cytoskeletal proteins and dendritic morphology

scientific article

Alterations in the balance of tubulin glycylation and glutamylation in photoreceptors leads to retinal degeneration

scientific article published on 19 January 2017

An essential role for α4A-tubulin in platelet biogenesis

scientific article published on 13 February 2019

Analysis of the molecular heterogeneity of the microtubule-associated protein tau by two-dimensional electrophoresis and RT-PCR

scientific article published on 01 July 2000

Bacterial kinesin light chain (Bklc) links the Btub cytoskeleton to membranes.

scientific article

Bug22 influences cilium morphology and the post-translational modification of ciliary microtubules

scientific article

CLIP-170 tracks growing microtubule ends by dynamically recognizing composite EB1/tubulin-binding sites.

scientific article published on 22 December 2008

Causes and Consequences of Microtubule Acetylation

scientific article published in December 2017

Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis.

scientific article published in February 2018

Characterisation of PGs1, a subunit of a protein complex co-purifying with tubulin polyglutamylase.

scientific article published in October 2003

Characterisation of polyglutamylases in trypanosomatids

scientific article published on 13 November 2014

Cytoskeleton stability is essential for the integrity of the cerebellum and its motor- and affective-related behaviors.

scientific article published on 15 February 2018

Direct induction of microtubule branching by microtubule nucleation factor SSNA1

scientific article published on 24 September 2018

Direct observation of dynamic protein interactions involving human microtubules using solid-state NMR spectroscopy

scientific article published on 02 January 2020

Drosophila DSP1 and rat HMGB1 have equivalent DNA binding properties and share a similar secondary fold.

scientific article published in April 2003

Ependymal cell differentiation, from monociliated to multiciliated cells.

scientific article published on 07 March 2015

Evidence for new C-terminally truncated variants of α- and β-tubulins

scientific article published on 6 January 2016

Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections

scientific article (publication date: 8 February 2002)

Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation

scientific article

Excessive tubulin polyglutamylation causes neurodegeneration and perturbs neuronal transport

scientific article published on 12 November 2018

Generation of Differentially Polyglutamylated Microtubules ⬇️

scientific article published on January 1, 2011

Glutamylation on alpha-tubulin is not essential but affects the assembly and functions of a subset of microtubules in Tetrahymena thermophila

scientific article published on 27 June 2008

H-ABC- and dystonia-causing <i>TUBB4A</i> mutations show distinct pathogenic effects

scientific article published on 11 March 2022

Investigating tubulin posttranslational modifications with specific antibodies.

scientific article published on January 2013

Involvement of the tubulin tyrosine ligase-like family member 4 polyglutamylase in PELP1 polyglutamylation and chromatin remodeling in pancreatic cancer cells

scientific article

Kinesin-3 Responds to Local Microtubule Dynamics to Target Synaptic Cargo Delivery to the Presynapse

scientific article published on 03 January 2019

Knocking Out Multiple Genes in Cultured Primary Neurons to Study Tubulin Posttranslational Modifications

scientific article published on 01 January 2020

Loss of alpha-tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function

scientific journal article

Loss of the deglutamylase CCP5 perturbs multiple steps of spermatogenesis and leads to male infertility

scientific article published on 07 February 2019

Loss of tubulin deglutamylase CCP1 causes infantile-onset neurodegeneration

scientific article published on 12 November 2018

Measuring the Impact of Tubulin Posttranslational Modifications on Axonal Transport

scientific article published on 01 January 2020

Microtubule-Associated Proteins: Structuring the Cytoskeleton

scientific article published on 12 August 2019

Microtubules: 50 years on from the discovery of tubulin

scientific article published on April 2016

Mitosis. Microtubule detyrosination guides chromosomes during mitosis

scientific article published on 23 April 2015

Molecular interactions between tubulin tails and glutamylases reveal determinants of glutamylation patterns

scientific article

Mutation of the α-tubulin Tuba1a leads to straighter microtubules and perturbs neuronal migration

scientific article

Nsl1p is essential for the establishment of bipolarity and the localization of the Dam-Duo complex

scientific article

Optochemistry to control the microtubule cytoskeleton

scientific article published on 17 July 2015

Polyglutamylation is a post-translational modification with a broad range of substrates.

scientific article published on 28 November 2007

Polyglutamylation: a fine-regulator of protein function? 'Protein Modifications: beyond the usual suspects' review series.

scientific article

Post-translational modifications of tubulin.

scientific article

Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions

scientific article

Purification of tubulin with controlled post-translational modifications by polymerization-depolymerization cycles

scientific article published on 17 April 2019

Reorganization of Synaptic Connections and Perineuronal Nets in the Deep Cerebellar Nuclei of Purkinje Cell Degeneration Mutant Mice.

scientific article published on 27 December 2015

SnapShot: Functions of Tubulin Posttranslational Modifications

scientific article published on 31 May 2018

Spindle asymmetry drives non-Mendelian chromosome segregation.

scientific article

Structural basis of tubulin tyrosination by tubulin tyrosine ligase

scientific article

Synaptic activation modifies microtubules underlying transport of postsynaptic cargo

scientific article

TTLL3 Is a tubulin glycine ligase that regulates the assembly of cilia.

scientific article

TUBB1 mutations cause thyroid dysgenesis associated with abnormal platelet physiology

scientific article published on 01 December 2018

Tau phosphorylation impedes functionality of protective tau envelopes

The budding yeast proteins Spc24p and Spc25p interact with Ndc80p and Nuf2p at the kinetochore and are important for kinetochore clustering and checkpoint control

scientific article

The comeback of hand drawing in modern life sciences.

scientific article published on 20 December 2017

The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids

scientific article

The emerging role of the tubulin code: From the tubulin molecule to neuronal function and disease.

scientific article published on 2 March 2016

The tubulin code and its role in controlling microtubule properties and functions

scientific article published on 27 February 2020

The tubulin code at a glance

scientific article published on 21 March 2017

The tubulin code: molecular components, readout mechanisms, and functions

scientific article

The use of okadaic acid in vivo and the induction of molecular changes typical for Alzheimer's disease ⬇️

scientific article published on August 1, 1998

Towards elucidating the tubulin code

scientific article published on 01 April 2014

Tubulin Posttranslational Modifications and Emerging Links to Human Disease

scientific article published on 31 May 2018

Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia

scientific journal article

Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon.

scientific article

Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility

scientific article

Tubulin glycylation controls primary cilia length.

scientific article

Tubulin polyglutamylase enzymes are members of the TTL domain protein family

scientific article

Tubulin polyglutamylation is a general traffic-control mechanism in hippocampal neurons

scientific article published on 13 February 2020

Tubulin polyglutamylation stimulates spastin-mediated microtubule severing

scientific journal article

Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton

scientific article published on 11 June 2010

[Microtubule polyglutamylation and neurodegeneration]

scientific article published on 25 May 2011

α-Tubulin Tyrosination and CLIP-170 Phosphorylation Regulate the Initiation of Dynein-Driven Transport in Neurons

scientific article

αTAT1 controls longitudinal spreading of acetylation marks from open microtubules extremities.

scientific article

List of works by Carsten Janke

A Family of Protein-Deglutamylating Enzymes Associated with Neurodegeneration ⬇️

A targeted multienzyme mechanism for selective microtubule polyglutamylation

A unified reviewing format for grant applications and evaluations

A versatile toolbox for PCR-based tagging of yeast genes: new fluorescent proteins, more markers and promoter substitution cassettes

ATAT1-enriched vesicles promote microtubule acetylation via axonal transport

ATAT1/MEC-17 acetyltransferase and HDAC6 deacetylase control a balance of acetylation of alpha-tubulin and cortactin and regulate MT1-MMP trafficking and breast tumor cell invasion.

Activation of mitogen-activated protein kinase cascade and phosphorylation of cytoskeletal proteins after neurone-specific activation of p21ras. II. Cytoskeletal proteins and dendritic morphology

Alterations in the balance of tubulin glycylation and glutamylation in photoreceptors leads to retinal degeneration

An essential role for α4A-tubulin in platelet biogenesis

Analysis of the molecular heterogeneity of the microtubule-associated protein tau by two-dimensional electrophoresis and RT-PCR

Bacterial kinesin light chain (Bklc) links the Btub cytoskeleton to membranes.

Bug22 influences cilium morphology and the post-translational modification of ciliary microtubules

CLIP-170 tracks growing microtubule ends by dynamically recognizing composite EB1/tubulin-binding sites.

Causes and Consequences of Microtubule Acetylation

Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis.

Characterisation of PGs1, a subunit of a protein complex co-purifying with tubulin polyglutamylase.

Characterisation of polyglutamylases in trypanosomatids

Cytoskeleton stability is essential for the integrity of the cerebellum and its motor- and affective-related behaviors.

Direct induction of microtubule branching by microtubule nucleation factor SSNA1

Direct observation of dynamic protein interactions involving human microtubules using solid-state NMR spectroscopy

Drosophila DSP1 and rat HMGB1 have equivalent DNA binding properties and share a similar secondary fold.

Ependymal cell differentiation, from monociliated to multiciliated cells.

Evidence for new C-terminally truncated variants of α- and β-tubulins

Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections

Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation

Excessive tubulin polyglutamylation causes neurodegeneration and perturbs neuronal transport

Generation of Differentially Polyglutamylated Microtubules ⬇️

Glutamylation on alpha-tubulin is not essential but affects the assembly and functions of a subset of microtubules in Tetrahymena thermophila

H-ABC- and dystonia-causing <i>TUBB4A</i> mutations show distinct pathogenic effects

Investigating tubulin posttranslational modifications with specific antibodies.

Involvement of the tubulin tyrosine ligase-like family member 4 polyglutamylase in PELP1 polyglutamylation and chromatin remodeling in pancreatic cancer cells

Kinesin-3 Responds to Local Microtubule Dynamics to Target Synaptic Cargo Delivery to the Presynapse

Knocking Out Multiple Genes in Cultured Primary Neurons to Study Tubulin Posttranslational Modifications

Loss of alpha-tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function

Loss of the deglutamylase CCP5 perturbs multiple steps of spermatogenesis and leads to male infertility

Loss of tubulin deglutamylase CCP1 causes infantile-onset neurodegeneration

Measuring the Impact of Tubulin Posttranslational Modifications on Axonal Transport

Microtubule-Associated Proteins: Structuring the Cytoskeleton

Microtubules: 50 years on from the discovery of tubulin

Mitosis. Microtubule detyrosination guides chromosomes during mitosis

Molecular interactions between tubulin tails and glutamylases reveal determinants of glutamylation patterns

Mutation of the α-tubulin Tuba1a leads to straighter microtubules and perturbs neuronal migration

Nsl1p is essential for the establishment of bipolarity and the localization of the Dam-Duo complex

Optochemistry to control the microtubule cytoskeleton

Polyglutamylation is a post-translational modification with a broad range of substrates.

Polyglutamylation: a fine-regulator of protein function? 'Protein Modifications: beyond the usual suspects' review series.

Post-translational modifications of tubulin.

Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions

Purification of tubulin with controlled post-translational modifications by polymerization-depolymerization cycles

Reorganization of Synaptic Connections and Perineuronal Nets in the Deep Cerebellar Nuclei of Purkinje Cell Degeneration Mutant Mice.

SnapShot: Functions of Tubulin Posttranslational Modifications

Spindle asymmetry drives non-Mendelian chromosome segregation.

Structural basis of tubulin tyrosination by tubulin tyrosine ligase

Synaptic activation modifies microtubules underlying transport of postsynaptic cargo

TTLL3 Is a tubulin glycine ligase that regulates the assembly of cilia.

TUBB1 mutations cause thyroid dysgenesis associated with abnormal platelet physiology

Tau phosphorylation impedes functionality of protective tau envelopes

The budding yeast proteins Spc24p and Spc25p interact with Ndc80p and Nuf2p at the kinetochore and are important for kinetochore clustering and checkpoint control

The comeback of hand drawing in modern life sciences.

The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids

The emerging role of the tubulin code: From the tubulin molecule to neuronal function and disease.

The tubulin code and its role in controlling microtubule properties and functions

The tubulin code at a glance

The tubulin code: molecular components, readout mechanisms, and functions

The use of okadaic acid in vivo and the induction of molecular changes typical for Alzheimer's disease ⬇️

Towards elucidating the tubulin code

Tubulin Posttranslational Modifications and Emerging Links to Human Disease

Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia

Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon.

Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility

Tubulin glycylation controls primary cilia length.

Tubulin polyglutamylase enzymes are members of the TTL domain protein family

Tubulin polyglutamylation is a general traffic-control mechanism in hippocampal neurons

Tubulin polyglutamylation stimulates spastin-mediated microtubule severing

Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton

[Microtubule polyglutamylation and neurodegeneration]

α-Tubulin Tyrosination and CLIP-170 Phosphorylation Regulate the Initiation of Dynein-Driven Transport in Neurons

αTAT1 controls longitudinal spreading of acetylation marks from open microtubules extremities.