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List of works by Maurizio D'Incalci

"The Art of Successful Publication" ECCO 13 workshop report.

scientific article published on 7 February 2006

3-methyladenine-DNA-glycosylase and O6-alkyl guanine-DNA-alkyltransferase activities and sensitivity to alkylating agents in human cancer cell lines.

scientific article

3D Mass Spectrometry Imaging Reveals a Very Heterogeneous Drug Distribution in Tumors

scientific article

A Nanostructured Matrices Assessment to Study Drug Distribution in Solid Tumor Tissues by Mass Spectrometry Imaging.

scientific article

A biodistribution study of PEGylated PCL-based nanoparticles in C57BL/6 mice bearing B16/F10 melanoma.

scientific article

A comprehensive safety analysis confirms rhabdomyolysis as an uncommon adverse reaction in patients treated with trabectedin.

scientific article

A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action.

scientific article

A filter incubation method for the determination of potentially crosslinkable sites in DNA in mammalian cells.

scientific article published in October 1985

A first in human phase I study of the proteasome inhibitor CEP-18770 in patients with advanced solid tumours and multiple myeloma

scientific article published on 08 October 2012

A gas chromatographic mass spectrometric assay for the determination of aphidicolin in plasma of cancer patients

scientific article published in May 1989

A limited sampling model for the pharmacokinetics of etoposide given orally

scientific article published in January 1993

A novel taxane active against an orthotopically growing human glioma xenograft ⬇️

scientific article published on December 15, 2001

A pharmacological study on pegylated asparaginase used in front-line treatment of children with acute lymphoblastic leukemia

scientific article published in January 2006

A phase II randomised (calibrated design) study on the activity of the single-agent trabectedin in metastatic or locally relapsed uterine leiomyosarcoma.

scientific article published on 30 July 2018

A prognostic regulatory pathway in stage I epithelial ovarian cancer: new hints for the poor prognosis assessment.

scientific article

A review of trabectedin (ET-743): a unique mechanism of action.

scientific article

A specific miRNA signature correlates with complete pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer.

scientific article

A systems biology approach to characterize the regulatory networks leading to trabectedin resistance in an in vitro model of myxoid liposarcoma

scientific article

A systems biology approach to investigate the mechanism of action of trabectedin in a model of myelomonocytic leukemia

scientific article published on 13 December 2016

AACR special conference in cancer research. Membrane transport in multidrug resistance, development, and disease. American Association for Cancer Research

scientific article published on 01 October 1991

AACR-NCI-EORTC International conference--molecular targets and cancer therapeutics

scientific article published in December 2001

Activity and pharmacokinetics of teniposide in Lewis lung carcinoma-bearing mice

scientific article published in June 1983

Activity and unexpected lung toxicity of the sequential administration of two alkylating agents--dacarbazine and fotemustine--in patients with melanoma

scientific article

Activity of 1-p-(3,3-dimethyl-1-triazeno) benzoic acid potassium salt in M 5076/73A ovarian reticular cell sarcoma of the mouse.

scientific article published on November 1982

Adjuvant 5-FU based chemotherapy for colon cancer: match or miss the mismatch?

scientific article

Allelic expression of p73 in human ovarian cancers

scientific article published on 01 August 1999

Alpha-bromoacryloyl derivative of distamycin A (PNU 151807): a new non-covalent minor groove DNA binder with antineoplastic activity.

scientific article published on June 1999

Alpha1 acid glycoprotein binds to imatinib (STI571) and substantially alters its pharmacokinetics in chronic myeloid leukemia patients

scientific article

Analysis of differential miRNA expression in primary tumor and stroma of colorectal cancer patients.

scientific article

Analysis of gene expression in early-stage ovarian cancer.

scientific article

Antagonism of 5-aza-2'-deoxycytidine antileukemic activity by concomitant treatment with cytarabine

scientific article published in December 1986

Anti-inflammatory properties of the novel antitumor agent yondelis (trabectedin): inhibition of macrophage differentiation and cytokine production

scientific article

Antiangiogenic activity of aplidine, a new agent of marine origin

scientific article published on June 2004

Antiangiogenic activity of trabectedin in myxoid liposarcoma: Involvement of host TIMP-1 and TIMP-2 and tumor thrombospondin-1

scientific article published on 19 June 2014

Antimetastatic and antiangiogenic activity of trabectedin in cutaneous melanoma

scientific article published on 01 April 2019

Antiproliferative properties of flavone acetic acid (NSC 347512) (LM 975), a new anticancer agent

scientific article

Antitumor activity and pharmacokinetics of oral gimatecan on pediatric cancer xenografts

scientific article

Antitumor activity of 1,4-bis (2'-chloroethyl)-1,4-diazabicyclo-[2.2.1] heptane dimaleate (Dabis Maleate) in M5076 and its subline resistant to cyclophosphamide M5/CTX.

scientific article

Antitumor activity of the novel nitrosourea S10036 in rodent tumors

scientific article published on 01 November 1988

Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells.

scientific article

Antitumour activity of trabectedin in myelodysplastic/myeloproliferative neoplasms.

scientific article published on 10 January 2017

Aplidine, a new anticancer agent of marine origin, inhibits vascular endothelial growth factor (VEGF) secretion and blocks VEGF-VEGFR-1 (flt-1) autocrine loop in human leukemia cells MOLT-4.

scientific article published on January 2003

Application of 3D Mass Spectrometry Imaging to TKIs

scientific article

Application of RNA-Seq transcriptome analysis: CD151 is an Invasion/Migration target in all stages of epithelial ovarian cancer

scientific article published on 24 January 2012

Are we close to the clinical development of novel drugs targeting telomeres and telomerase?

scientific article published on 01 May 2005

Ascites interferes with the activity of lurbinectedin and trabectedin: Potential role of their binding to alpha 1-acid glycoprotein

scientific article published on 3 August 2017

Assessing the anti-tumour properties of Iraqi propolis in vitro and in vivo

scientific article published on 28 January 2012

Assessment of proportional hazard assumption in aggregate data: a systematic review on statistical methodology in clinical trials using time-to-event endpoint

scientific article published on 13 November 2018

Association between miR-200c and the survival of patients with stage I epithelial ovarian cancer: a retrospective study of two independent tumour tissue collections.

scientific article published on 21 February 2011

Bcr-Abl mutations, resistance to imatinib, and imatinib plasma levels

scientific article published in September 2003

Bevacizumab-Induced Inhibition of Angiogenesis Promotes a More Homogeneous Intratumoral Distribution of Paclitaxel, Improving the Antitumor Response.

scientific article published on 22 October 2015

Binding of imatinib by alpha(1)-acid glycoprotein

scientific article published in July 2002

Biochemical studies on the ability of pentamethylmelamine to interact in vivo with DNA and proteins in a sensitive murine ovarian reticular cell sarcoma

scientific article published on 01 September 1984

Biological activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) is associated with telomere capping alteration

scientific article

Blockade of the IL-1R1/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy.

scientific article published on 9 December 2016

Bone marrow fibroblasts overexpress miR-27b and miR-214 in step with multiple myeloma progression, dependent on tumour cell-derived exosomes

scientific article published on 01 February 2019

Bortezomib-induced peripheral neurotoxicity: a neurophysiological and pathological study in the rat.

scientific article published on 9 January 2007

Breast and renal cancer-Derived endothelial colony forming cells share a common gene signature.

scientific article

Brostallicin, a novel anticancer agent whose activity is enhanced upon binding to glutathione.

scientific article

Cell cycle effects of gemcitabine

scientific article

Cell cycle-related phosphatases CDC25A and B expression correlates with survival in ovarian cancer patients

scientific article published in November 2000

Cell signaling and cancer treatment ⬇️

scientific article published on 01 May 1997

Central side effects of pentamethylmelamine: biochemical and behavioural studies.

scientific article published in December 1984

Cerebrospinal fluid levels of hexamethylmelamine and N-demethylated metabolites

scientific article published on 01 March 1981

Changes in cyclins and cyclin-dependent kinases induced by DNA damaging agents in a human ovarian cancer cell line expressing mutated or wild-type P53.

scientific article published on September 1996

Changes in doxorubicin distribution and toxicity in mice pretreated with the cyclosporin analogue SDZ PSC 833.

scientific article

Changes in gene expression profile induced by the anticancer agent Aplidine in Molt-4 leukemic cell lines.

scientific article published on July 2002

Changes in the synthesis of histone H1(0) and H1 in rat FRTL-5 thyroid cells exposed to thyrotropin

scientific article published on 01 January 1989

Characterization of a new trabectedin-resistant myxoid liposarcoma cell line that shows collateral sensitivity to methylating agents.

scientific article

Characterization of a novel mouse reticular cell sarcoma M5076 subline resistant to cisplatin

scientific article published in June 1989

Chemical characterization of Iraqi propolis samples and assessing their antioxidant potentials

article

Chinese hamster ovary cells deficient or proficient in O6-alkylguanine-DNA alkyltransferase activity are equally sensitive to X-rays

scientific article published on 01 October 1992

Chronic oral etoposide in small-cell lung cancer: clinical and pharmacokinetic results

scientific article published on 01 August 1993

Circulating miRNA landscape identifies miR-1246 as promising diagnostic biomarker in high-grade serous ovarian carcinoma: A validation across two independent cohorts

scientific article published on 22 December 2016

Cis-diamminedichloroplatinum sensitivity of murine reticulum sarcoma cells in primary culture and after in vitro passages

scientific article published in August 1993

Cisplatin-induced peripheral neuropathy: Neuroprotection by erythropoietin without affecting tumour growth

scientific article published on 23 January 2007

Clindamycin-paclitaxel pharmacokinetic interaction in ovarian cancer patients

scientific article published on 13 December 2005

Clinical and pathological factors influencing survival in a large cohort of triple-negative breast cancer patients

scientific article published on 8 January 2018

Clinical and pharmacokinetic study of oral NK611, a new podophyllotoxin derivative.

scientific article

Clinical pharmacokinetics of altretamine

scientific article

Clinical pharmacokinetics of the new oral camptothecin gimatecan: the inter-patient variability is related to alpha1-acid glycoprotein plasma levels.

scientific article published on 16 December 2009

Clinical pharmacology of chronic oral etoposide in patients with small cell and non-small cell lung cancer.

scientific article

Combination of PPARγ Agonist Pioglitazone and Trabectedin Induce Adipocyte Differentiation to Overcome Trabectedin Resistance in Myxoid Liposarcomas

scientific article published on 03 September 2019

Combination of the new minor groove alkylator tallimustine and melphalan

scientific article published in February 1997

Combination of trabectedin and irinotecan is highly effective in a human rhabdomyosarcoma xenograft

scientific article published on September 2005

Comparison between VP 16 and VM 26 in Lewis lung carcinoma of the mouse

scientific article published on 01 February 1986

Comparison of histone variant synthesis in human lymphocytic leukemia cells and in normal lymphocytes

scientific article published on 01 July 1988

Comparison of in vitro and in vivo biological effects of trabectedin, lurbinectedin (PM01183) and Zalypsis® (PM00104).

scientific article

Comparison of intracellular drug retention, DNA damage and cytotoxicity of derivatives of doxorubicin and daunorubicin in a human colon adenocarcinoma cell line (LoVo)

scientific article published on 01 November 1989

Comparison of paclitaxel and docetaxel activity on human ovarian carcinoma xenografts

scientific article published on 01 January 1994

Concentrations of VP16 and VM26 in human brain tumors

scientific article published on 01 January 1991

Concerted escalation of dose and dosing duration in a phase I study of the oral camptothecin gimatecan (ST1481) in patients with advanced solid tumors

scientific article

Correlation of ErbB2 gene status, mRNA and protein expression

scientific article published on 12 June 2006

Cyclosporin A markedly changes the distribution of doxorubicin in mice and rats.

scientific article

Cytotoxicity and DNA damage caused by 4-demethoxydaunorubicin and its metabolite 4-demethoxy-13-hydroxydaunorubicin in human acute myeloid leukemia cells

scientific article published on January 1990

DDP-induced cytotoxicity is not influenced by p53 in nine human ovarian cancer cell lines with different p53 status.

scientific article

DNA damage and cytotoxicity of mitoxantrone and doxorubicin in doxorubicin-sensitive and -resistant human colon carcinoma cells

scientific article published in January 1990

DNA damage induced by alachlor after in vitro activation by rat hepatocytes

scientific article published on 01 January 1992

DNA damage, cytotoxic effect and cell-cycle perturbation of Hoechst 33342 on L1210 cells in vitro ⬇️

scientific article published on January 1, 1988

DNA interstrand cross-links induced by cis-dichlorodiammine platinum in ovarian cancer cells growing in primary culture

scientific article published on 01 May 1988

DNA topoisomerase II poisons and inhibitors

scientific article published on 01 January 1997

DNA topoisomerase inhibitors

scientific article published on 01 January 1993

DNA-minor-groove alkylators, a new class of anticancer agents ⬇️

scientific article published on 01 December 1994

DNA-topoisomerase I activity and content in epithelial ovarian cancer

scientific article published on 01 March 1998

DNA-topoisomerase inhibitors.

scientific article published on November 1993

Decreased cytotoxic effects of doxorubicin in a human ovarian cancer-cell line expressing wild-type p53 and WAF1/CIP1 genes.

scientific article published on May 1995

Decreased half life of cyclophosphamide in patients under continual treatment ⬇️

scientific article published on January 1, 1979

Depletion of tumor-associated macrophages switches the epigenetic profile of pancreatic cancer infiltrating T cells and restores their anti-tumor phenotype

scientific article published on 13 November 2017

Determination of L-asparagine in biological samples in the presence of L-asparaginase

scientific article published on 01 July 1994

Determination of aplidin, a marine-derived anticancer drug, in human plasma, whole blood and urine by liquid chromatography with electrospray ionisation tandem mass spectrometric detection.

scientific article

Determination of paclitaxel distribution in solid tumors by nano-particle assisted laser desorption ionization mass spectrometry imaging

scientific article (publication date: 2013)

Development and validation of a LC-MS/MS method for the determination of the novel oral 1,14 substituted taxane derivatives, IDN 5738 and IDN 5839, in mouse plasma and its application to the pharmacokinetic study

scientific article published on 23 October 2009

Development and validation of a high-performance liquid chromatography-tandem mass spectrometry method for the determination of the novel inhibitor of angiogenesis E-3810 in human plasma and its application in a clinical pharmacokinetic study

scientific article published on 01 October 2011

Development and validation of a high-performance liquid chromatography-tandem mass spectrometry method for the determination of the novel proteasome inhibitor CEP-18770 in human plasma and its application in a clinical pharmacokinetic study

scientific article published on 25 September 2010

Development and validation of a liquid chromatography-tandem mass spectrometry method for the determination of ST1926, a novel oral antitumor agent, adamantyl retinoid derivative, in plasma of patients in a Phase I study

scientific article published on 7 August 2009

Development of distamycin-related DNA binding anticancer drugs.

scientific article

Development of novel cancer chemopreventive agents in Europe – Neglected Cinderella or rising phoenix?

article

Dietary agent indole-3-carbinol protects female rats against the hepatotoxicity of the antitumor drug ET-743 (trabectidin) without compromising efficacy in a rat mammary carcinoma

scientific article

Differences between in vivo and in vitro sensitivity to imatinib of Bcr/Abl+ cells obtained from leukemic patients.

scientific article published in May 2002

Differences in DNA damage produced by incorporation of 5-aza-2'-deoxycytidine or 5,6-dihydro-5-azacytidine into DNA of mammalian cells.

scientific article

Differences in cyclin B1 expression in cells blocked in the G2M phase after treatment with anticancer agent. New three-parametric flow cytometric analysis

scientific article published on 01 January 1997

Differences in docetaxel and paclitaxel activity in resistant tumor cells which express MRP: Need of comparative clinical trials in resistant patients ⬇️

scientific article published on 01 December 1997

Differential expression of c-fos proto-oncogene in two subclones derived from a human ovarian cancer cell line.

scientific article published on March 1995

Differential inhibition of the DNA binding of transcription factors NF kappa B and OTF-1 by nitrogen mustard and quinacrine mustard: transcriptional implications.

scientific article published on September 1993

Distamycin A and tallimustine inhibit TBP binding and basal in vitro transcription. ⬇️

scientific article published on May 1995

Distribution of daunorubicin and daunorubicinol in human glioma tumors after administration of liposomal daunorubicin

scientific article

Distribution of paclitaxel within the nervous system of the rat after repeated intravenous administration

scientific article published on 01 June 2000

Distribution, metabolism, and irreversible binding of hexamethylmelamine in mice bearing ovarian carcinoma

scientific article published in January 1983

Dose-dependent pharmacokinetics of PMM in the rat

scientific article published on 01 January 1981

Dose-dependent pharmacokinetics of flavone acetic acid in mice

scientific article published in January 1988

Doxorubicin distribution in human breast cancer.

scientific article published in December 1987

Doxorubicin induces the acetylation of histone H1 in a human colon cancer cell line (LoVo/DX) selected for resistance to the drug, but not in the sensitive parental line (LoVo).

scientific article published in September 1988

Driving p53 response to Bax activation greatly enhances sensitivity to taxol by inducing massive apoptosis.

scientific article

Drug homogeneity index in mass spectrometry imaging (MSI)

scientific article published on 08 November 2018

Dynamics of cell cycle phase perturbations by trabectedin (ET-743) in nucleotide excision repair (NER)-deficient and NER-proficient cells, unravelled by a novel mathematical simulation approach.

scientific article

E-3810 is a potent dual inhibitor of VEGFR and FGFR that exerts antitumor activity in multiple preclinical models

scientific article published on 6 January 2011

Early DNA damage induced in cells exposed to N10-propargyl 5,8-dideazafolic acid (CB 3717) or methotrexate

scientific article published on 01 May 1988

Ecteinascidin-743 (ET-743), a natural marine compound, with a unique mechanism of action.

scientific article

Ecteinascidin-743, a new marine natural product with potent antitumor activity on human ovarian carcinoma xenografts

scientific article published on 01 August 1998

Editorial comment on "In vitro toxicity of ET-743 and Aplidine, two marine-derived antineoplastics, on human bone marrow haematopoietic progenitors: comparison with the clinical results" by Albella and colleagues

scientific article published in July 2002

Effect of Aplidin in acute lymphoblastic leukaemia cells.

scientific article published on August 2003

Effect of ecteinascidin-743 on the interaction between DNA binding proteins and DNA.

scientific article

Effect of phenobarbital pretreatment on the metabolism and antitumor activity of hexamethylmelamine

scientific article published in April 1986

Effective combination of ET-743 and doxorubicin in sarcoma: preclinical studies

scientific article published on 29 May 2003

Effectiveness of Ecteinascidin-743 against drug-sensitive and -resistant bone tumor cells.

scientific article

Effects of DNA damaging agents on gene expression in two human cancer cell lines

scientific article published on 01 December 1993

Effects of a novel DNA-damaging agent on the budding yeast Saccharomyces cerevisiae cell cycle

scientific article published on 01 March 1996

Effects of cancer disease on the metabolism of anticancer agents.

scientific article published on January 1988

Efficacy of trabectedin (ecteinascidin-743) in advanced pretreated myxoid liposarcomas: a retrospective study

scientific article published on July 2007

Enhanced cell cycle perturbation and apoptosis mediate the synergistic effects of ST1926 and ATRA in neuroblastoma preclinical models

scientific article published on 3 June 2011

Epidoxorubicin and docetaxel as first-line chemotherapy in patients with advanced breast cancer: a multicentric phase I-II study

scientific article published on 01 August 2000

Epithelioid Pleural Mesothelioma Is Characterized by Tertiary Lymphoid Structures in Long Survivors: Results from the MATCH Study

scientific article published on 21 May 2022

Establishment and characterisation of a new patient-derived model of myxoid liposarcoma with acquired resistance to trabectedin

scientific article published on 14 August 2019

Establishment of L1210 leukemia cells resistant to the distamycin-A derivative (FCE 24517): characterization and cross-resistance studies.

scientific article published on January 1993

Estimation of the haematological toxicity of minor groove alkylators using tests on human cord blood cells

scientific article

Etoposide (VP-16-213) in malignant brain tumors: a phase II study

scientific article published in May 1984

European School of Oncology Task Force Report. New approaches in cancer pharmacology: drug design and development (Part 2).

scientific article

Expression of genes involved in nucleotide excision repair and sensitivity to cisplatin and melphalan in human cancer cell lines.

scientific article

Expression of genes of potential importance in the response to chemotherapy and DNA repair in patients with ovarian cancer

scientific article published on 01 April 1997

FOXM1 expression is significantly associated with chemotherapy resistance and adverse prognosis in non-serous epithelial ovarian cancer patients

scientific article

Failure to detect the P-glycoprotein multidrug resistant phenotype in cases of resistant childhood acute lymphocytic leukaemia

scientific article

Fate of PLA and PCL-Based Polymeric Nanocarriers in Cellular and Animal Models of Triple-Negative Breast Cancer.

scientific article published on 20 January 2016

First International Conference on Reversal of Multi-Drug Resistance, St. Gallen, 1–3 September 1994 ⬇️

scientific article published on December 1, 1994

Flavone acetic acid antitumour activity against a mouse pancreatic adenocarcinoma is mediated by natural killer cells.

scientific article

Flavone acetic acid distribution in human malignant tumors

scientific article published on 01 January 1990

Flavone acetic acid pharmacokinetics in nude mice

scientific article

Flow cytometric analysis of cell cycle phase perturbations induced by Thiocoraline, a new marine-derived anticancer compound

scientific article published on 01 January 1997

Flow cytometric analysis of multidrug-resistance-associated antigen (P-glycoprotein) and DNA ploidy in human colon cancer

scientific article published on January 1, 1992

Flow-cytometric analysis of DNA distribution after VP16-213 treatment of Lewis lung carcinoma

scientific article published on 01 January 1983

G-quadruplex ligand RHPS4 potentiates the antitumor activity of camptothecins in preclinical models of solid tumors.

scientific article

Gas chromatographic determination of hexamethylmelamine in mouse plasma ⬇️

scientific article published on November 1, 1979

Genetic instability influences drug response in cancer cells.

scientific article published on October 2010

Genome-wide study of salivary miRNAs identifies miR-423-5p as promising diagnostic and prognostic biomarker in oral squamous cell carcinoma

scientific article published on 01 January 2021

Glutathione S-transferase activity and glutathione content in human bladder carcinoma associated with schistosomiasis: comparison with uninvolved surrounding tissues

scientific article published in December 1997

Glutathione S-transferase activity in epithelial ovarian cancer: Association with response to chemotherapy and disease outcome

scientific article published in April 1997

H1 variant synthesis in proliferating and quiescent human cells

scientific article published on 01 January 1986

HMGA1/E2F1 axis and NFkB pathways regulate LPS progression and trabectedin resistance

scientific article published on 06 July 2018

HPLC-MS/MS method to measure trabectedin in tumors: preliminary PK study in a mesothelioma xenograft model

scientific article published on August 2015

Hematopoietic toxicity and cell cycle perturbations induced by new DNA minor groove-alkylating agents

scientific article published in September 1997

Hematotoxicity on human bone marrow- and umbilical cord blood-derived progenitor cells and in vitro therapeutic index of methoxymorpholinyldoxorubicin and its metabolites

scientific article published on 01 January 1998

Heterogeneous interaction of interferon-beta and taxol in human ovarian cancer cells in vitro

scientific article published on 01 January 1994

Hexamethylmelamine and pentamethylmelamine tissue distribution in M5076/73A ovarian cancer-bearing mice

scientific article

Hexamethylmelamine distribution in patients with ovarian and other pelvic cancers

scientific article published on 01 February 1982

Hexamethylmelamine in ovarian cancer resistant to cyclophosphamide and adriamycin

scientific article published on August 1, 1979

Hexamethylmelamine tissue concentrations in pelvic cancer patients

scientific article published on 01 January 1980

Hexamethylmelamine, adriamycin, and cyclophosphamide (HAC) versus cis-dichlorodiamineplatinum, adriamycin, and cyclophosphamide (PAC) in advanced ovarian cancer: a randomized clinical trial

scientific article published on 01 January 1985

Hexamethylmelamine, doxorubicin, and cyclophosphamide in advanced ovarian cancer resistant to previous chemotherapy.

scientific article

Hexamethylmelamine-CAF (cyclophosphamide, methotrexate, and 5-FU) and cisplatin-CAF in refractory ovarian cancer

scientific article published on 01 May 1982

High Penetration of Paclitaxel in Abdominal Wall of Rabbits after Hyperthermic Intraperitoneal Administration of Nab-Paclitaxel Compared to Standard Paclitaxel Formulation.

scientific article

High-dose medroxyprogesterone acetate (MPA) in advanced epithelial ovarian cancer resistant to first- or second-line chemotherapy.

scientific article published in December 1981

High-dose vitamin C enhances cancer immunotherapy

scientific article published on 01 February 2020

High-performance liquid chromatographic assay for the determination of Aloe Emodin in mouse plasma.

scientific article published in October 2003

High-performance liquid chromatographic assay for the determination of p-(3,3-dimethyl-1-triazeno)benzoic acid in mouse plasma

High-performance liquid chromatographic assay for the determination of the novel C-Seco-taxane derivative (IDN 5390) in mouse plasma

scientific article published on 01 November 2002

High-performance liquid chromatographic assay for the determination of the novel etoposide derivative dimethylaminoetoposide (NK611) and its metabolites in urine of cancer patients

scientific article published on 01 February 1995

High-performance liquid chromatographic assay for the determination of the novel podophyllotoxin derivative dimethylaminoetoposide (NK611) in human plasma

scientific article published on 01 March 1994

High-performance liquid chromatographic assay for the determination of the novel taxane derivative IDN5109 in mouse plasma

scientific article published on 01 December 1999

High-performance liquid chromatographic determination of 5-bromodeoxyuridine in human plasma

scientific article published on 01 June 1989

High-performance liquid chromatography determination of 4'-demethyl-epipodophyllotoxin-9-(4,6-O-ethylidene beta-D-glucopyranoside) (VP 16-213) in human plasma

scientific article published on 01 January 1981

High-performance liquid chromatography tandem mass spectrometry procedure with automated solid phase extraction sample preparation for the quantitative determination of paclitaxel (Taxol) in human plasma

scientific article published on 01 January 1998

High-performance liquid chromatography/tandem mass spectrometry for the quantitative analysis of a novel taxane derivative (BAY59-8862) in biological samples and characterisation of its metabolic profile in rat bile samples

scientific article published in January 2001

Histone H1(0) is synthesized by human lymphocytic leukemia cells but not by normal lymphocytes

scientific article published on 01 October 1987

Horseradish peroxidase/hydrogen peroxide-catalyzed oxidation of VP16-213. Identification of a new metabolite

scientific article

Human malignant mesothelioma is recapitulated in immunocompetent BALB/c mice injected with murine AB cells.

scientific article

Human monocytic leukemia expresses low levels of asparagine synthase and is potentially sensitive to L-asparaginase

scientific article published on 01 February 1995

Human ovarian tumors in primary culture: growth, characterization and initial evaluation of the response to cis platinum treatment in vitro

scientific article published on 01 June 1988

Human tumor cell lines with pleiotropic drug resistance are efficiently killed by interleukin-2 activated killer cells and by activated monocytes

scientific article

ICRF 159 plus radiation versus radiation therapy alone in cervical carcinoma. A double-blind study

scientific article published on 01 January 1983

IDN 5390: an oral taxane candidate for protracted treatment schedules

scientific article published on March 2003

IDN5109, a taxane with oral bioavailability and potent antitumor activity.

scientific article

IFN-β Partially Counteracts Inhibition of Natural Killer Activity Induced by Some Antitumor Agents ⬇️

scientific article published on February 1, 1998

IGFBP-4 tumor and serum levels are increased across all stages of epithelial ovarian cancer

scientific article published on 20 January 2012

Idarubicinol myelotoxicity: a comparison of in vitro data with clinical outcome in patients treated with high-dose idarubicin

scientific article

Identification of a gene expression driven progression pathway in myxoid liposarcoma

scientific article

Identification of high-grade serous ovarian cancer miRNA species associated with survival and drug response in patients receiving neoadjuvant chemotherapy: a retrospective longitudinal analysis using matched tumor biopsies.

scientific article published on 17 January 2016

Identification of microsomal metabolites of spirogermanium

scientific article published on 01 March 1989

Importance of the DNA repair enzyme O6-alkyl guanine alkyltransferase (AT) in cancer chemotherapy.

scientific article published on December 1988

In vitro and in vivo effects of cisplatin on the generation of lymphokine-activated killer cells

scientific article published on 01 January 1990

In vitro and in vivo methazolastone-induced DNA damage and repair in L-1210 leukemia sensitive and resistant to chloroethylnitrosoureas.

scientific article

In vitro cytotoxicity of GC sequence directed alkylating agents related to distamycin

scientific article published on 01 April 1993

In vitro cytotoxicity of VP 16 on primary tumor and metastasis of Lewis lung carcinoma

scientific article published on 01 April 1982

In vivo anti-tumor activity of synthetic ether lipids is not enhanced by pharmacological modulation of tumor lipid composition

scientific article published on 01 November 1994

In vivo studies with the novel anticancer agent mitozolomide (NSC 353451) on Lewis lung carcinoma

scientific article published on 01 January 1986

Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth.

scientific article published on 29 November 2017

Inactivation of p53 in a Human Ovarian Cancer Cell Line Increases the Sensitivity to Paclitaxel by Inducing G2/M Arrest and Apoptosis ⬇️

scientific article published on May 25, 1998

Increase in etoposide-induced topoisomerase II-mediated DNA breaks after cell synchronization induced by low doses of methotrexate

scientific article published on 01 May 1988

Increased sensitivity to platinum drugs of cancer cells with acquired resistance to trabectedin

scientific article

Induction of partial synchronization of leukemia cells by continuous infusion of low-dose methotrexate followed by citrovorum factor

scientific article published on 01 October 1989

Influence of ascites on the pharmacokinetics of hexamethylmelamine and N-demethylated metabolites in ovarian cancer patients

scientific article

Integrated multiplatform method for in vitro quantitative assessment of cellular uptake for fluorescent polymer nanoparticles.

scientific article published on January 2014

Interference of transcriptional activation by the antineoplastic drug ecteinascidin-743.

scientific article published on June 2000

Interferon-beta can induce progesterone receptors in human endometrial adenocarcinoma

scientific article published on 01 August 1996

Interferon-beta does not change the level of O6-alkylguanine-DNA alkyltransferase in cancer patients' lymphocytes

scientific article published on 01 October 1994

Intracellular doxorubicin concentrations and drug-induced DNA damage in a human colon adenocarcinoma cell line and in a drug-resistant subline.

scientific article published in December 1988

Intracellular drug concentration and DNA damage in human childhood leukemic cells exposed to doxorubicin

scientific article published on 01 May 1988

Intracellular glutathione heterogeneity in L1210 murine leukemia sublines made resistant to DNA-interacting anti-neoplastic agents.

scientific article published on May 1993

Intraperitoneal and subcutaneous xenografts of human ovarian carcinoma in nude mice and their potential in experimental therapy

scientific article published on 01 September 1989

Intratumor heterogeneity and its impact on drug distribution and sensitivity

scientific article published on 14 May 2014

Investigation of size, surface charge, PEGylation degree and concentration on the cellular uptake of polymer nanoparticles

scientific article

Isolated bilateral anterior chamber eye relapse in a child with acute lymphoblastic leukemia

scientific article published on 01 August 1995

Karyotype instability and anchorage-independent growth in telomerase-immortalized fibroblasts from two centenarian individuals

scientific article published in September 2003

L-Asparagine depletion in plasma and cerebro-spinal fluid of children with acute lymphoblastic leukemia during subsequent exposures to Erwinia L-asparaginase

scientific article published on 01 September 1996

L-asparagine depletion and L-asparaginase activity in children with acute lymphoblastic leukemia receiving i.m. or i.v. Erwinia C. or E. coli L-asparaginase as first exposure

scientific article published on 01 February 2000

L1210 cells selected for resistance to methoxymorpholinyl doxorubicin appear specifically resistant to this class of morpholinyl derivatives

scientific article

Lack of activity of cyclophosphamide in ovarian cancer patients refractory to cis-dichlorodiammine platinum.

scientific article

Lack of bone marrow toxicity of high-dose cyclophosphamide associated with inefficient drug metabolism

scientific article published on 01 December 1993

Lack of effect of cisplatin on i.v. L-PAM plasma pharmacokinetics in ovarian cancer patients

scientific article published on 01 January 1988

Limbic seizures induce P-glycoprotein in rodent brain: functional implications for pharmacoresistance.

scientific article

Low-dose cyclophosphamide versus adriamycin plus cyclophosphamide in advanced ovarian cancer. A randomized clinical study

scientific article published on 01 January 1980

Low-dose oral etoposide in epithelial cancer of the ovary

scientific article published on 01 June 1993

Lurbinectedin Inactivates the Ewing Sarcoma Oncoprotein EWS-FLI1 by Redistributing It within the Nucleus.

scientific article published on 3 October 2016

Lurbinectedin reduces tumour-associated macrophages and the inflammatory tumour microenvironment in preclinical models

scientific article published on 6 July 2017

Lymphokine-activated killer (LAK) and monocyte-mediated cytotoxicity on tumor cell lines resistant to antitumor agents

scientific article

MAL gene overexpression as a marker of high-grade serous ovarian carcinoma stem-like cells that predicts chemoresistance and poor prognosis

scientific article

Mass spectrometric identification and analysis of some aphidicolin metabolites in cancer patients

scientific article published on 01 June 1993

Mechanism of action of trabectedin in desmoplastic small round cell tumor cells.

scientific article

Mechanisms of resistance to alkylating agents

scientific article

Metabolic approach to the enhancement of antitumor effect of chemotherapy: a key role of acetyl-L-carnitine

scientific article published on 18 June 2010

Metabolic studies of a podophyllotoxin derivative (VP16) in the isolated perfused liver

scientific article published in April 1985

Metabolism of the anticancer agent 1-(4-acetylphenyl)-3,3-dimethyltriazene.

scientific article published on August 1983

Metabolism of triazine anticancer agents.

scientific article published on January 1987

Metoclopramide treatment in DBA patients: no complete response in a French prospective study

article

MiRNA landscape in stage I epithelial ovarian cancer defines the histotype specificities.

scientific article published on 13 June 2013

Microsatellite instability and frameshift mutations in genes involved in cell cycle progression or apoptosis in ovarian cancer.

scientific article

Mode of action of trabectedin in myxoid liposarcomas.

scientific article published on 11 November 2013

Modulation of gene transcription by natural products--a viable anticancer strategy.

scientific article published on January 2007

Modulation of response to cancer chemotherapeutic agents by diet constituents: is the available evidence sufficiently robust for rational advice for patients?

scientific article published on 27 February 2007

Modulation of transcription factor--DNA interactions by anticancer drugs.

scientific article published on August 1994

Molecular and Pharmacological Mechanisms of Drug Resistance:An Evolving Paradigm.

scientific article

Molecular characterisation of a panel of human ovarian carcinoma xenografts

scientific article published on 01 August 1998

Multicenter, randomised, open-label, non-comparative phase 2 trial on the efficacy and safety of the combination of bevacizumab and trabectedin with or without carboplatin in women with partially platinum-sensitive recurrent ovarian cancer

scientific article published on 20 September 2019

Multidrug resistance-reversing agents increase vinblastine distribution in normal tissues expressing the P-glycoprotein but do not enhance drug penetration in brain and testis.

scientific article published in June 1997

Multisite analysis of high-grade serous epithelial ovarian cancers identifies genomic regions of focal and recurrent copy number alteration in 3q26.2 and 8q24.3.

scientific article published on 26 April 2019

N-Hydroxymethylpentamethylmelamine, a major in vitro metabolite of hexamethylmelamine

scientific article published on 01 January 1980

Natural killer (NK) and lymphokine activated killer (LAK) cell activity in patients (PTS) treated with flavone acetic acid (FAA)

scientific article published on 01 February 1991

Nerve cell death induced in vivo by kainic acid and quinolinic acid does not involve apoptosis.

scientific article published in November 1991

New activities for the anti-tumor agent trabectedin: taking two birds with one stone

scientific article published in April 2013

New molecules and strategies in the field of anticancer agents.

scientific article published on May 2004

Not only tumor but also therapy heterogeneity

scientific article published on 12 October 2017

Notes on the use of in vitro systems to investigate the activity and the mechanism of action of antineoplastic agents

scientific article published on 01 February 1991

Novel models of myxoid liposarcoma xenografts mimicking the biological and pharmacologic features of human tumors.

scientific article published on 20 August 2010

O 6-Methylguanine-DNA methyltransferase activity and induction of novel immunogenicity in murine tumor cells treated with methylating agents

scientific article published on 01 January 1992

O6-alkylguanine DNA alkyltransferase is induced by human recombinant interferon-alpha A/D in mouse liver

scientific article published on 01 June 1992

O6-methylguanine and temozolomide can reverse the resistance to chloroethylnitrosoureas of a mouse L1210 leukemia

scientific article published on 01 January 1991

OTX015 (MK-8628), a novel BET inhibitor, exhibits antitumor activity in non-small cell and small cell lung cancer models harboring different oncogenic mutations

scientific article

On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts

scientific article published on 19 September 2013

One of the most interesting pro-apoptotic proteins recently identified is the TNF-related apoptosis-inducing ligand (TRAIL)

scientific article published on 01 January 2002

Oral efficacy and bioavailability of a novel taxane

scientific article published on 01 May 2000

PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy

scientific article published on 30 August 2010

PEGylated Nanoparticles Obtained through Emulsion Polymerization as Paclitaxel Carriers

scientific article published in December 2015

Paclitaxel induces significant changes in epidoxorubicin distribution in mice

scientific article published on 01 October 1996

Parallel Evaluation of Circulating Tumor DNA and Circulating Tumor Cells in Metastatic Colorectal Cancer

scientific article published in November 2017

Past-in-the-Future. Peak detection improves targeted mass spectrometry imaging

scientific article published on 28 June 2018

Patient-derived solitary fibrous tumour xenografts predict high sensitivity to doxorubicin/dacarbazine combination confirmed in the clinic and highlight the potential effectiveness of trabectedin or eribulin against this tumour.

scientific article published on 8 March 2017

Pharmacodynamic effects in the cerebrospinal fluid of rats after intravenous administration of different asparaginase formulations

scientific article

Pharmacokinetic and pharmacodynamic study of doxorubicin in children with cancer: results of a "European Pediatric Oncology Off-patents Medicines Consortium" trial

scientific article published on 21 October 2016

Pharmacokinetic approach to in vitro testing of ovarian cancer cell sensitivity.

scientific article published in January 1980

Pharmacokinetic interactions of paclitaxel, docetaxel and their vehicles with doxorubicin

scientific article published on 01 April 1999

Pharmacokinetic profile of imatinib mesylate and N-desmethyl-imatinib (CGP 74588) in children with newly diagnosed Ph+ acute leukemias

scientific article published on 3 June 2008

Pharmacokinetic studies of anticancer drugs in tumor-bearing animals.

scientific article published on February 1984

Pharmacokinetic study of VM26 given as a prolonged IV infusion to ovarian cancer patients

scientific article published on 01 January 1984

Pharmacokinetics and antineoplastic activity of galectin-1-targeting OTX008 in combination with sunitinib.

scientific article published on 24 August 2013

Pharmacokinetics and metabolism in mice of IDN 5390 (13-(N-Boc-3-i-butylisoserinoyl)-C-7,8-seco-10-deacetylbaccatin III), a new oral c-seco-taxane derivative with antiangiogenic property effective on paclitaxel-resistant tumors.

scientific article published on 8 September 2006

Pharmacokinetics of 4-demethoxydaunorubicin in cancer patients

scientific article published on 01 January 1990

Pharmacokinetics of 7-con-O-methylnogarol in patients with solid tumors

scientific article

Pharmacokinetics of Cyclophosphamide after prolonged low dose treatment in ovarian cancer patients ⬇️

scientific article published on January 1979

Pharmacokinetics of VM 26 given intrapericardially or intravenously in patients with malignant pericardial effusion

scientific article published on 01 January 1987

Pharmacokinetics of VP16-213 given by different administration methods

scientific article published on 01 January 1982

Pharmacokinetics of VP16-213 in Lewis lung carcinoma bearing mice

scientific article published in January 1982

Pharmacokinetics of anticancer agents in patients with impaired liver function

scientific article published on 01 January 1998

Pharmacokinetics of cisplatin during open and minimally-invasive secondary cytoreductive surgery plus HIPEC in women with platinum-sensitive recurrent ovarian cancer: a prospective study.

scientific article published in March 2019

Pharmacokinetics of concomitant cisplatin and paclitaxel administered by hyperthermic intraperitoneal chemotherapy to patients with peritoneal carcinomatosis from epithelial ovarian cancer

scientific article

Pharmacokinetics of etoposide in gestochoriocarcinoma

scientific article published on 01 January 1985

Pharmacokinetics of etoposide in patients with abnormal renal and hepatic function

scientific article published on 01 May 1986

Pharmacokinetics of hexamethylmelamine and pentamethylmelamine in mice

scientific article published on 01 July 1981

Pharmacokinetics of intrapleural versus intravenous etoposide (VP 16) and teniposide (VM 26) in patients with malignant pleural effusion

scientific article published on 01 January 1990

Pharmacokinetics of teniposide in patients with ovarian cancer

scientific article published on 01 January 1985

Phase I and clinical pharmacological evaluation of aphidicolin glycinate

scientific article published on 01 August 1991

Phase I clinical and pharmacokinetic study of the oral platinum analogue JM216 given daily for 14 days

scientific article

Phase I clinical and pharmacokinetic study of trabectedin and cisplatin in solid tumours.

scientific article published on 4 May 2009

Phase I clinical and pharmacokinetic study of trabectedin and doxorubicin in advanced soft tissue sarcoma and breast cancer.

scientific article

Phase I clinical and pharmacological study of oral methoxymorpholinyl doxorubicin (PNU 152243)

scientific article published on 01 January 1999

Phase I study of the antifolate N10-propargyl-5,8-dideazafolic acid, CB 3717

scientific article published on 01 April 1988

Phase I study of the antipurine antifolate lometrexol (DDATHF) with folinic acid rescue.

scientific article

Phase I/IIa study evaluating the safety, efficacy, pharmacokinetics, and pharmacodynamics of lucitanib in advanced solid tumors

scientific article (publication date: November 2014)

Phase II trial of salvage therapy with trabectedin in metastatic pancreatic adenocarcinoma

scientific article

Podophyllotoxin derivatives

scientific article published on 01 January 1991

Podophyllotoxin derivatives

scientific article published on 01 January 1990

Podophyllotoxin derivatives VP-16 and VM-26.

scientific article

Potentiation of etoposide cytotoxicity against a human ovarian cancer cell line by pretreatment with non-toxic concentrations of methotrexate or aphidicolin ⬇️

scientific article published on January 1, 1992

Preclinical and clinical results with the natural marine product ET-743 ⬇️

scientific article published on November 1, 2003

Problems in dealing with very rare adverse effects of new anticancer drugs: the example of trabectedin.

scientific article

Professor Maurizio D'Incalci interviewed by Emma Cannell

scientific article published in August 2002

Profiling cancer gene mutations in longitudinal epithelial ovarian cancer biopsies by targeted next-generation sequencing: a retrospective study.

scientific article published on 6 April 2015

Promising in vivo efficacy of the BET bromodomain inhibitor OTX015/MK-8628 in malignant pleural mesothelioma xenografts

scientific article published on 4 September 2016

Prompt detection of L-asparaginase inactivation is crucial to optimize treatment efficacy also in aggressive lymphomas.

scientific article

Proneness to UV-induced apoptosis in human fibroblasts defective in transcription coupled repair is associated with the lack of Mdm2 transactivation

scientific article published in May 2000

Quantification of trabectedin in human plasma: validation of a high-performance liquid chromatography-mass spectrometry method and its application in a clinical pharmacokinetic study

scientific article published on 02 March 2014

Readily prepared biodegradable nanoparticles to formulate poorly water soluble drugs improving their pharmacological properties: The example of trabectedin

scientific article published on 7 March 2018

Reduced expression of the ROCK inhibitor Rnd3 is associated with increased invasiveness and metastatic potential in mesenchymal tumor cells

scientific article

Resistance to minor groove binders

scientific article published on 01 March 2014

Resistance to platinum-based chemotherapy is associated with epithelial to mesenchymal transition in epithelial ovarian cancer

article

Response to flavone acetic acid (NSC 347512) of primary and metastatic human colorectal carcinoma xenografts ⬇️

scientific article published on March 1, 1988

Restoring platinum sensitivity in recurrent ovarian cancer by extending the platinum-free interval: Myth or reality?

scientific article

Role of Macrophage Targeting in the Antitumor Activity of Trabectedin

scientific article published on 01 February 2013

Role of alpha1 acid glycoprotein in the in vivo resistance of human BCR-ABL(+) leukemic cells to the abl inhibitor STI571

scientific article published on 01 October 2000

Role of homologous recombination in trabectedin-induced DNA damage

scientific article

Role of membrane folate-binding protein in the cytotoxicity of 5,10-dideazatetrahydrofolic acid in human ovarian carcinoma cell lines in vitro

scientific article

Routes of elimination of hexamethylmelamine and pentamethylmelamine in the rat

scientific article published on 01 May 1982

Selective DNA interaction of the novel distamycin derivative FCE 24517.

scientific article published in January 1991

Self-Assembling PCL-Based Nanoparticles as PTX Solubility Enhancer Excipients

scientific article published on 25 July 2018

Sensitivity of CHO mutant cell lines with specific defects in nucleotide excision repair to different anti-cancer agents.

scientific article published on June 1996

Sequence-specific DNA interactions by novel alkylating anthracycline derivatives

scientific article published on 01 December 1995

Sequential administration of dacarbazine and fotemustine in patients with disseminated malignant melanoma--an effective combination with unexpected toxicity

scientific article published on January 1, 1992

Sequential administration of temozolomide and fotemustine: depletion of O6-alkyl guanine-DNA transferase in blood lymphocytes and in tumours.

scientific article published in July 1999

Simple and sensitive method for the determination of cyclophosphamide by means of a nitrogen--phosphorus-selective detector

scientific article published on 01 March 1978

Simultaneous determination of gemcitabine and its main metabolite, dFdU, in plasma of patients with advanced non-small-cell lung cancer by high-performance liquid chromatography-tandem mass spectrometry

scientific article published in February 2008

Small interfering RNA delivery through positively charged polymer nanoparticles.

scientific article published on 18 February 2016

Snail levels control the migration mechanism of mesenchymal tumor cells.

scientific article published on 30 May 2016

Some hope from marine natural products

scientific article

Spectrum of cellular responses to pyriplatin, a monofunctional cationic antineoplastic platinum(II) compound, in human cancer cells

scientific article

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway

scientific article published on 13 July 2009

Stepwise neoplastic transformation of a telomerase immortalized fibroblast cell line

scientific article published on December 2005

Steroid premedication markedly reduces liver and bone marrow toxicity of trabectedin in advanced sarcoma.

scientific article

Structural characterization of mono- and dihydroxylated metabolites of paclitaxel in rat bile using liquid chromatography/ion spray tandem mass spectrometry

scientific article published on 01 January 1997

Studies of the differentiation properties of camptothecin in the human leukaemic cells K562 ⬇️

scientific article published on January 1, 1991

Studies of the mode of action of antitumour triazenes and triazines--IV. The metabolism of 1-(4-acetylphenyl)-3,3-dimethyltriazene.

scientific article published on May 1982

Studies of the mode of action of antitumour triazenes and triazines-III. Metabolism studies on hexamethylmelamine

scientific article published on 01 March 1982

Synergism between 5-fluorouracil and N-methylformamide in HT29 human colon cancer line

scientific article published on March 1990

Synthesis of surfactant free PCL-PEG brushed nanoparticles with tunable degradation kinetics.

scientific article published on 21 June 2013

TRF2 inhibition triggers apoptosis and reduces tumourigenicity of human melanoma cells

scientific article

Targeting G-Quadruplex DNA Structures by EMICORON Has a Strong Antitumor Efficacy against Advanced Models of Human Colon Cancer

scientific article published on 24 August 2015

Targeting the EWS-FLI1 transcription factor in Ewing sarcoma.

scientific article published on 26 March 2015

Targeting triple negative breast cancer: is p53 the answer?

scientific article published on 12 January 2013

Taxoids in combination with anthracyclines and other agents: pharmacokinetic considerations

scientific article published on 01 December 1998

Telomerase expression in somatic cells: fountain of youth or Damocles' sword?

scientific article published on 01 March 2006

Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect

scientific article

Telomere dysfunction increases cisplatin and ecteinascidin-743 sensitivity of melanoma cells

scientific article published in March 2003

Temozolomide induced differentiation of K562 leukemia cells is not mediated by gene hypomethylation

scientific article published on 01 July 1989

Teniposide in refractory ovarian cancer: a phase II study

scientific article published on 01 May 1984

The antitumour activity of alkylating agents is not correlated with the levels of glutathione, glutathione transferase and O6-alkylguanine-DNA-alkyltransferase of human tumour xenografts

scientific article published in October 1998

The bromodomain inhibitor OTX015 (MK-8628) exerts anti-tumor activity in triple-negative breast cancer models as single agent and in combination with everolimus

scientific article published on 07 December 2016

The combination of yondelis and cisplatin is synergistic against human tumor xenografts

scientific article published in September 2003

The effects of a benzoic acid mustard derivative of distamycin A (FCE 24517) and related minor groove-binding distamycin analogues on the activity of major groove-binding alkylating agents

scientific article published on 01 February 1993

The effects of vandetanib on paclitaxel tumor distribution and antitumor activity in a xenograft model of human ovarian carcinoma

scientific article

The impairment of the High Mobility Group A (HMGA) protein function contributes to the anticancer activity of trabectedin

article

The inhibition of supercoiling activity of DNA gyrase from Micrococcus luteus caused by rufloxacin (MF 934) and MF 961

scientific article published on 01 May 1991

The isothiocyanate produced from glucomoringin inhibits NF-kB and reduces myeloma growth in nude mice in vivo.

scientific article

The metalloproteinase inhibitor batimastat (BB-94) causes cell cycle phase perturbations in ovarian cancer cells

scientific article published on 01 May 1999

The molecular mechanisms responsible for resistance to ET-743 (Trabectidin; Yondelis) in the Ewing's sarcoma cell line, TC-71.

scientific article published on December 2005

The neuroprotective effect of erythropoietin in docetaxel-induced peripheral neuropathy causes no reduction of antitumor activity in 13762 adenocarcinoma-bearing rats

scientific article published on 30 October 2009

The novel atypical retinoid ST1926 is active in ATRA resistant neuroblastoma cells acting by a different mechanism

scientific article published on 7 November 2006

The novel lipophilic camptothecin analogue gimatecan is very active in vitro in human neuroblastoma: a comparative study with SN38 and topotecan

scientific article published on October 2005

The oestrogen receptor in epithelial ovarian carcinoma

scientific article published on 01 September 2000

The tyrosine kinase inhibitor E-3810 combined with paclitaxel inhibits the growth of advanced-stage triple-negative breast cancer xenografts

scientific article

The unique interaction with immunity of FCE 24517, an antitumor drug with a novel mode of action

scientific article published on 01 February 1992

The zinc finger gene ZIC2 has features of an oncogene and its overexpression correlates strongly with the clinical course of epithelial ovarian cancer

scientific article

Time dependence of the in vitro cytotoxicity of hexamethylmelamine and its metabolites.

scientific article

Towards a Model-Based Dose Recommendation for Doxorubicin in Children.

scientific article published on 19 September 2016

Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumors

scientific article

Trabectedin Followed by Irinotecan Can Stabilize Disease in Advanced Translocation-Positive Sarcomas with Acceptable Toxicity

scientific article published on 24 October 2016

Trabectedin and olaparib in patients with advanced and non-resectable bone and soft-tissue sarcomas (TOMAS): an open-label, phase 1b study from the Italian Sarcoma Group

article

Trabectedin and plitidepsin: drugs from the sea that strike the tumor microenvironment

scientific article

Trabectedin as a chemotherapy option for patients with BRCA deficiency

scientific article

Trabectedin efficacy in Ewing sarcoma is greatly increased by combination with anti-IGF signaling agents.

scientific article

Trabectedin for the treatment of breast cancer

scientific article

Trabectedin for women with ovarian carcinoma after treatment with platinum and taxanes fails.

scientific article

Trabectedin in advanced uterine leiomyosarcomas: A retrospective case series analysis from two reference centers

scientific article published on 13 September 2011

Trabectedin in myxoid liposarcomas (MLS): a long-term analysis of a single-institution series.

scientific article

Trabectedin in ovarian cancer: could we expect more?

scientific article published on 08 November 2010

Trabectedin is a novel chemotherapy agent for diffuse large B cell lymphoma.

scientific article published on 2 April 2018

Trabectedin mechanism of action: what's new?

scientific article published on December 2013

Trabectedin modulates the senescence-associated secretory phenotype and promotes cell death in senescent tumor cells by targeting NF-κB.

scientific article

Trabectedin therapy for sarcomas.

scientific article published on July 2010

Trabectedin, a drug acting on both cancer cells and the tumour microenvironment

scientific article published on 22 April 2014

Trabectedin: A drug from the sea that strikes tumor-associated macrophages

scientific article published on 16 April 2013

Transfer of a human chromosomal vector from a hamster cell line to a mouse embryonic stem cell line.

scientific article

Translocation-related sarcomas.

scientific article published on August 2009

Transplacental passage of cyclophosphamide

scientific article published on 01 August 1982

Transplacental passage of doxorubicin

scientific article published on 01 January 1983

Treatment with inhibitors of polyamine biosynthesis, which selectively lower intracellular spermine, does not affect the activity of alkylating agents but antagonizes the cytotoxicity of DNA topoisomerase II inhibitors.

scientific article

Tumor-associated macrophages and anti-tumor therapies: complex links

scientific article published on 8 March 2016

Tumour levels of O6-alkylguanine-DNA-alkyltransferase and sensitivity to BCNU of human xenografts.

scientific article published in November 1992

Unique features of the mode of action of ET-743.

scientific article

Unique features of trabectedin mechanism of action.

scientific article published on 14 December 2015

Unique pattern of ET-743 activity in different cellular systems with defined deficiencies in DNA-repair pathways

scientific article published in May 2001

Use of cancer chemopreventive phytochemicals as antineoplastic agents

scientific article published in November 2005

Variable oral absorption of hexamethylmelamine in man

scientific article published on December 1, 1978

Variolin B and its derivate deoxy-variolin B: new marine natural compounds with cyclin-dependent kinase inhibitor activity

scientific article published on 21 September 2005

Venetoclax penetrates in cerebrospinal fluid and may be effective in chronic lymphocytic leukemia with central nervous system involvement

scientific article published on 14 February 2019

Wiring miRNAs to pathways: a topological approach to integrate miRNA and mRNA expression profiles

scientific article

[Analysis of the concentration of VP 16 and VM 26 in human brain neoplasms]

scientific article published on 01 January 1985

hMLH1 and hMSH2 expression and BAX frameshift mutations in ovarian cancer cell lines and tumors.

scientific article published in April 1998

lncRNAs as Novel Indicators of Patients' Prognosis in Stage I Epithelial Ovarian Cancer: A Retrospective and Multicentric Study.

scientific article

microRNA-181a has a critical role in ovarian cancer progression through the regulation of the epithelial-mesenchymal transition.

scientific article published on January 2014

p21WAF1-derived peptides linked to an internalization peptide inhibit human cancer cell growth

scientific article published on 01 April 1997

p73 competes with p53 and attenuates its response in a human ovarian cancer cell line.

scientific article

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