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List of works by Massimo Zucchetti

3D Mass Spectrometry Imaging Reveals a Very Heterogeneous Drug Distribution in Tumors

scientific article

A Nanostructured Matrices Assessment to Study Drug Distribution in Solid Tumor Tissues by Mass Spectrometry Imaging.

scientific article

A first in human phase I study of the proteasome inhibitor CEP-18770 in patients with advanced solid tumours and multiple myeloma

scientific article published on 08 October 2012

A gas chromatographic mass spectrometric assay for the determination of aphidicolin in plasma of cancer patients

scientific article published in May 1989

A limited sampling model for the pharmacokinetics of etoposide given orally

scientific article published in January 1993

A novel oral micellar fenretinide formulation with enhanced bioavailability and antitumour activity against multiple tumours from cancer stem cells

scientific article published on 22 August 2019

A novel taxane active against an orthotopically growing human glioma xenograft ⬇️

scientific article published on December 15, 2001

A pharmacological study on pegylated asparaginase used in front-line treatment of children with acute lymphoblastic leukemia

scientific article published in January 2006

Alpha1 acid glycoprotein binds to imatinib (STI571) and substantially alters its pharmacokinetics in chronic myeloid leukemia patients

scientific article

Antitumor activity and pharmacokinetics of oral gimatecan on pediatric cancer xenografts

scientific article

Application of 3D Mass Spectrometry Imaging to TKIs

scientific article

Ascites interferes with the activity of lurbinectedin and trabectedin: Potential role of their binding to alpha 1-acid glycoprotein

scientific article published on 3 August 2017

Asparagine levels in the cerebrospinal fluid of children with acute lymphoblastic leukemia treated with pegylated-asparaginase in the induction phase of the AIEOP-BFM ALL 2009 study

scientific article published on 31 January 2019

Bevacizumab-Induced Inhibition of Angiogenesis Promotes a More Homogeneous Intratumoral Distribution of Paclitaxel, Improving the Antitumor Response.

scientific article published on 22 October 2015

Binding of imatinib by alpha(1)-acid glycoprotein

scientific article published in July 2002

Bioreducible Hydrophobin-Stabilized Supraparticles for Selective Intracellular Release.

scientific article published on 14 August 2017

Blockade of the IL-1R1/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy.

scientific article published on 9 December 2016

Changes in doxorubicin distribution and toxicity in mice pretreated with the cyclosporin analogue SDZ PSC 833.

scientific article

Chemical characterization of Iraqi propolis samples and assessing their antioxidant potentials

article

Chronic oral etoposide in small-cell lung cancer: clinical and pharmacokinetic results

scientific article published on 01 August 1993

Clindamycin-paclitaxel pharmacokinetic interaction in ovarian cancer patients

scientific article published on 13 December 2005

Clinical and pharmacokinetic phase I trial of oral dimethylaminoetoposide (NK611) administered for 21 days every 35 days

scientific article published on 01 January 1996

Clinical and pharmacokinetic study of oral NK611, a new podophyllotoxin derivative.

scientific article

Clinical and pharmacological phase I study with accelerated titration design of a daily times five schedule of BBR3464, a novel cationic triplatinum complex

scientific article published on 01 August 2000

Clinical pharmacokinetics of the new oral camptothecin gimatecan: the inter-patient variability is related to alpha1-acid glycoprotein plasma levels.

scientific article published on 16 December 2009

Clinical pharmacology of chronic oral etoposide in patients with small cell and non-small cell lung cancer.

scientific article

Complete protection by high-dose dexamethasone against the hepatotoxicity of the novel antitumor drug yondelis (ET-743) in the rat ⬇️

scientific article published on September 15, 2003

Concentrations of VP16 and VM26 in human brain tumors

scientific article published on 01 January 1991

Concerted escalation of dose and dosing duration in a phase I study of the oral camptothecin gimatecan (ST1481) in patients with advanced solid tumors

scientific article

Cyclosporin A markedly changes the distribution of doxorubicin in mice and rats.

scientific article

Determination of L-asparagine in biological samples in the presence of L-asparaginase

scientific article published on 01 July 1994

Determination of aplidin, a marine-derived anticancer drug, in human plasma, whole blood and urine by liquid chromatography with electrospray ionisation tandem mass spectrometric detection.

scientific article

Determination of paclitaxel distribution in solid tumors by nano-particle assisted laser desorption ionization mass spectrometry imaging

scientific article (publication date: 2013)

Determination of total and lactone form of a new camptothecin derivative gimatecan (ST1481) and its metabolite ST1698 in human plasma by high-performance liquid chromatography with fluorimetric detection.

scientific article published on 27 May 2009

Development and validation of a LC-MS/MS method for the determination of the novel oral 1,14 substituted taxane derivatives, IDN 5738 and IDN 5839, in mouse plasma and its application to the pharmacokinetic study

scientific article published on 23 October 2009

Development and validation of a high-performance liquid chromatography-tandem mass spectrometry method for the determination of the novel inhibitor of angiogenesis E-3810 in human plasma and its application in a clinical pharmacokinetic study

scientific article published on 01 October 2011

Development and validation of a high-performance liquid chromatography-tandem mass spectrometry method for the determination of the novel proteasome inhibitor CEP-18770 in human plasma and its application in a clinical pharmacokinetic study

scientific article published on 25 September 2010

Development and validation of a liquid chromatography-tandem mass spectrometry method for the determination of ST1926, a novel oral antitumor agent, adamantyl retinoid derivative, in plasma of patients in a Phase I study

scientific article published on 7 August 2009

Dietary agent indole-3-carbinol protects female rats against the hepatotoxicity of the antitumor drug ET-743 (trabectidin) without compromising efficacy in a rat mammary carcinoma

scientific article

Differences between in vivo and in vitro sensitivity to imatinib of Bcr/Abl+ cells obtained from leukemic patients.

scientific article published in May 2002

Distribution of daunorubicin and daunorubicinol in human glioma tumors after administration of liposomal daunorubicin

scientific article

Distribution of paclitaxel within the nervous system of the rat after repeated intravenous administration

scientific article published on 01 June 2000

Effective combination of ET-743 and doxorubicin in sarcoma: preclinical studies

scientific article published on 29 May 2003

Epidoxorubicin and docetaxel as first-line chemotherapy in patients with advanced breast cancer: a multicentric phase I-II study

scientific article published on 01 August 2000

HPLC-MS/MS method for quantitative determination of the novel dual inhibitor of FGF and VEGF receptors E-3810 in tumor tissues from xenograft mice and human biopsies.

scientific article

HPLC-MS/MS method to measure trabectedin in tumors: preliminary PK study in a mesothelioma xenograft model

scientific article published on August 2015

Heterogeneity of paclitaxel distribution in different tumor models assessed by MALDI mass spectrometry imaging

scientific article published on 21 December 2016

High Penetration of Paclitaxel in Abdominal Wall of Rabbits after Hyperthermic Intraperitoneal Administration of Nab-Paclitaxel Compared to Standard Paclitaxel Formulation.

scientific article

High-dose vitamin C enhances cancer immunotherapy

scientific article published on 01 February 2020

High-performance liquid chromatographic assay for the determination of Aloe Emodin in mouse plasma.

scientific article published in October 2003

High-performance liquid chromatographic assay for the determination of the novel C-Seco-taxane derivative (IDN 5390) in mouse plasma

scientific article published on 01 November 2002

High-performance liquid chromatographic assay for the determination of the novel etoposide derivative dimethylaminoetoposide (NK611) and its metabolites in urine of cancer patients

scientific article published on 01 February 1995

High-performance liquid chromatographic assay for the determination of the novel podophyllotoxin derivative dimethylaminoetoposide (NK611) in human plasma

scientific article published on 01 March 1994

High-performance liquid chromatographic assay for the determination of the novel taxane derivative IDN5109 in mouse plasma

scientific article published on 01 December 1999

High-performance liquid chromatography tandem mass spectrometry procedure with automated solid phase extraction sample preparation for the quantitative determination of paclitaxel (Taxol) in human plasma

scientific article published on 01 January 1998

High-performance liquid chromatography/tandem mass spectrometry for the quantitative analysis of a novel taxane derivative (BAY59-8862) in biological samples and characterisation of its metabolic profile in rat bile samples

scientific article published in January 2001

IDN 5390: an oral taxane candidate for protracted treatment schedules

scientific article published on March 2003

IDN5109, a taxane with oral bioavailability and potent antitumor activity.

scientific article

Idarubicinol myelotoxicity: a comparison of in vitro data with clinical outcome in patients treated with high-dose idarubicin

scientific article

Identification of microsomal metabolites of spirogermanium

scientific article published on 01 March 1989

Immediate cooling does not prevent the ex vivo hydrolysis of L-asparagine by asparaginase.

scientific article

In Vitro and In Vivo Activity of Lucitanib in FGFR1/2 Amplified or Mutated Cancer Models.

scientific article published on 15 December 2016

In vivo comparative study of the cytotoxicity of a liposomal formulation of cisplatin (lipoplatin™).

scientific article published on 16 February 2011

Intratumor heterogeneity and its impact on drug distribution and sensitivity

scientific article published on 14 May 2014

L-Asparagine depletion in plasma and cerebro-spinal fluid of children with acute lymphoblastic leukemia during subsequent exposures to Erwinia L-asparaginase

scientific article published on 01 September 1996

L-asparagine depletion and L-asparaginase activity in children with acute lymphoblastic leukemia receiving i.m. or i.v. Erwinia C. or E. coli L-asparaginase as first exposure

scientific article published on 01 February 2000

Lack of bone marrow toxicity of high-dose cyclophosphamide associated with inefficient drug metabolism

scientific article published on 01 December 1993

Lack of effect of cisplatin on i.v. L-PAM plasma pharmacokinetics in ovarian cancer patients

scientific article published on 01 January 1988

Low-dose oral etoposide in epithelial cancer of the ovary

scientific article published on 01 June 1993

Mass spectrometric identification and analysis of some aphidicolin metabolites in cancer patients

scientific article published on 01 June 1993

Metabolic approach to the enhancement of antitumor effect of chemotherapy: a key role of acetyl-L-carnitine

scientific article published on 18 June 2010

Metoclopramide treatment in DBA patients: no complete response in a French prospective study

article

Monitoring the Fate of Orally Administered PLGA Nanoformulation for Local Delivery of Therapeutic Drugs

scientific article published on 06 December 2019

New class of squalene-based releasable nanoassemblies of paclitaxel, podophyllotoxin, camptothecin and epothilone A.

scientific article

Oral efficacy and bioavailability of a novel taxane

scientific article published on 01 May 2000

PEGylated Nanoparticles Obtained through Emulsion Polymerization as Paclitaxel Carriers

scientific article published in December 2015

Paclitaxel induces significant changes in epidoxorubicin distribution in mice

scientific article published on 01 October 1996

Pharmacodynamic effects in the cerebrospinal fluid of rats after intravenous administration of different asparaginase formulations

scientific article

Pharmacokinetic interactions of paclitaxel, docetaxel and their vehicles with doxorubicin

scientific article published on 01 April 1999

Pharmacokinetic profile of imatinib mesylate and N-desmethyl-imatinib (CGP 74588) in children with newly diagnosed Ph+ acute leukemias

scientific article published on 3 June 2008

Pharmacokinetic study of gemcitabine, given as prolonged infusion at fixed dose rate, in combination with cisplatin in patients with advanced non-small-cell lung cancer.

scientific article published on 6 February 2010

Pharmacokinetic study of intravesical gemcitabine in carcinoma in situ of the bladder refractory to bacillus Calmette-Guérin therapy.

scientific article published in January 2005

Pharmacokinetics and antineoplastic activity of galectin-1-targeting OTX008 in combination with sunitinib.

scientific article published on 24 August 2013

Pharmacokinetics and metabolism in mice of IDN 5390 (13-(N-Boc-3-i-butylisoserinoyl)-C-7,8-seco-10-deacetylbaccatin III), a new oral c-seco-taxane derivative with antiangiogenic property effective on paclitaxel-resistant tumors.

scientific article published on 8 September 2006

Pharmacokinetics of 4-demethoxydaunorubicin in cancer patients

scientific article published on 01 January 1990

Pharmacokinetics of anticancer agents in patients with impaired liver function

scientific article published on 01 January 1998

Pharmacokinetics of cisplatin during open and minimally-invasive secondary cytoreductive surgery plus HIPEC in women with platinum-sensitive recurrent ovarian cancer: a prospective study.

scientific article published in March 2019

Pharmacokinetics of concomitant cisplatin and paclitaxel administered by hyperthermic intraperitoneal chemotherapy to patients with peritoneal carcinomatosis from epithelial ovarian cancer

scientific article

Pharmacokinetics of etoposide in patients with abnormal renal and hepatic function

scientific article published on 01 May 1986

Pharmacokinetics of intrapleural versus intravenous etoposide (VP 16) and teniposide (VM 26) in patients with malignant pleural effusion

scientific article published on 01 January 1990

Pharmacokinetics of teniposide in patients with ovarian cancer

scientific article published on 01 January 1985

Phase I and clinical pharmacological evaluation of aphidicolin glycinate

scientific article published on 01 August 1991

Phase I clinical and pharmacokinetic study of oral etoposide phosphate

scientific article published on 01 January 1995

Phase I clinical and pharmacokinetic study of the oral platinum analogue JM216 given daily for 14 days

scientific article

Phase I clinical and pharmacokinetic study of trabectedin and cisplatin in solid tumours.

scientific article published on 4 May 2009

Phase I clinical and pharmacokinetic study of trabectedin and doxorubicin in advanced soft tissue sarcoma and breast cancer.

scientific article

Phase I clinical and pharmacological study of oral methoxymorpholinyl doxorubicin (PNU 152243)

scientific article published on 01 January 1999

Phase I study of the antifolate N10-propargyl-5,8-dideazafolic acid, CB 3717

scientific article published on 01 April 1988

Phase I/IIa study evaluating the safety, efficacy, pharmacokinetics, and pharmacodynamics of lucitanib in advanced solid tumors

scientific article (publication date: November 2014)

Phase II trial of salvage therapy with trabectedin in metastatic pancreatic adenocarcinoma

scientific article

Phase ib of sorafenib in combination with everolimus in patients with advanced solid tumors, selected on the basis of molecular targets.

scientific article published on 27 March 2014

Prompt detection of L-asparaginase inactivation is crucial to optimize treatment efficacy also in aggressive lymphomas.

scientific article

Quantification of trabectedin in human plasma: validation of a high-performance liquid chromatography-mass spectrometry method and its application in a clinical pharmacokinetic study

scientific article published on 02 March 2014

Readily prepared biodegradable nanoparticles to formulate poorly water soluble drugs improving their pharmacological properties: The example of trabectedin

scientific article published on 7 March 2018

Role of Macrophage Targeting in the Antitumor Activity of Trabectedin

scientific article published on 01 February 2013

Role of alpha1 acid glycoprotein in the in vivo resistance of human BCR-ABL(+) leukemic cells to the abl inhibitor STI571

scientific article published on 01 October 2000

Safety and potential effectiveness of daunorubicin-containing liposomes in patients with advanced recurrent malignant CNS tumors.

scientific article

Self-Assembling PCL-Based Nanoparticles as PTX Solubility Enhancer Excipients

scientific article published on 25 July 2018

Sequence dependent antitumour efficacy of the vascular disrupting agent ZD6126 in combination with paclitaxel.

scientific article published on 11 September 2007

Short course infusional idarubicin plus intermittent cytarabine and etoposide for refractory hematologic malignancies: clinical and preliminary pharmacological results

scientific article published on 01 January 1998

Simultaneous determination of gemcitabine and its main metabolite, dFdU, in plasma of patients with advanced non-small-cell lung cancer by high-performance liquid chromatography-tandem mass spectrometry

scientific article published in February 2008

Structural characterization of mono- and dihydroxylated metabolites of paclitaxel in rat bile using liquid chromatography/ion spray tandem mass spectrometry

scientific article published on 01 January 1997

Susceptibility of different mouse strains to oxaliplatin peripheral neurotoxicity: Phenotypic and genotypic insights

scientific article published on 11 October 2017

Taxoids in combination with anthracyclines and other agents: pharmacokinetic considerations

scientific article published on 01 December 1998

Temozolomide induced differentiation of K562 leukemia cells is not mediated by gene hypomethylation

scientific article published on 01 July 1989

The novel lipophilic camptothecin analogue gimatecan is very active in vitro in human neuroblastoma: a comparative study with SN38 and topotecan

scientific article published on October 2005

The tyrosine kinase inhibitor E-3810 combined with paclitaxel inhibits the growth of advanced-stage triple-negative breast cancer xenografts

scientific article

Trabectedin and olaparib in patients with advanced and non-resectable bone and soft-tissue sarcomas (TOMAS): an open-label, phase 1b study from the Italian Sarcoma Group

article

Tumor delivery of chemotherapy combined with inhibitors of angiogenesis and vascular targeting agents

scientific article published on October 2013

Tumor progression and metastatic dissemination in ovarian cancer after dose-dense or conventional paclitaxel and cisplatin plus bevacizumab

scientific article published on 07 August 2018

Validated procedure for simultaneous trace level determination of the anti-cancer agent gemcitabine and its metabolite in human urine by high-performance liquid chromatography with tandem mass spectrometry

scientific article

Venetoclax penetrates in cerebrospinal fluid and may be effective in chronic lymphocytic leukemia with central nervous system involvement

scientific article published on 14 February 2019

[Analysis of the concentration of VP 16 and VM 26 in human brain neoplasms]

scientific article published on 01 January 1985

cis-Diamminedichloroplatinum(II) given in low-dose continuous infusion with concurrent radiotherapy to patients affected by inoperable lung carcinoma: a pharmacokinetic approach

scientific article published on 01 January 1998

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