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List of works by Anne Blangy

A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway

scientific article

A murine sequence-specific DNA binding protein shows extensive local similarities to the amyloid precursor protein

scientific article published on December 30, 1992

A receptor-interacting protein 1 (RIP1)-independent necrotic death under the control of protein phosphatase PP2A that involves the reorganization of actin cytoskeleton and the action of cofilin-1.

scientific article published on 5 August 2014

Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule

scientific article published on 31 October 2017

Biogenesis of N-cadherin-dependent cell-cell contacts in living fibroblasts is a microtubule-dependent kinesin-driven mechanism

scientific article

Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42

scientific article

Cibler l’activité de l’ostéoclaste

Cofilin activation during podosome belt formation in osteoclasts

scientific article

Combined strategy of siRNA and osteoclast actin cytoskeleton automated imaging to identify novel regulators of bone resorption shows a non-mitotic function for anillin

Combined strategy of siRNA and osteoclast actin cytoskeleton automated imaging to identify novel regulators of bone resorption shows a non-mitotic function for anillin

scientific article published on 31 October 2018

Dock-family exchange factors in cell migration and disease

scientific article published on 24 June 2014

Dock5 is a new regulator of microtubule dynamic instability in osteoclasts

scientific article published on 06 September 2019

Dynamic changes in nuclear architecture during mitosis: on the role of protein phosphorylation in spindle assembly and chromosome segregation.

scientific article

Expression profile of RhoGTPases and RhoGEFs during RANKL-stimulated osteoclastogenesis: identification of essential genes in osteoclasts

scientific article

Identification of TRIO-GEFD1 chemical inhibitors using the yeast exchange assay

scientific article

Identification of a bipartite focal adhesion localization signal in RhoU/Wrch-1, a Rho family GTPase that regulates cell adhesion and migration

scientific article

Induction of lamellipodia by Kalirin does not require its guanine nucleotide exchange factor activity

scientific article published on 21 April 2005

Interaction of ezrin with the novel guanine nucleotide exchange factor PLEKHG6 promotes RhoG-dependent apical cytoskeleton rearrangements in epithelial cells

scientific article

Interaction of the mitotic inhibitor monastrol with human kinesin Eg5.

scientific article published in January 2003

Interferon-alpha and -beta differentially regulate osteoclastogenesis: role of differential induction of chemokine CXCL11 expression.

scientific article

Kinectin is a key effector of RhoG microtubule-dependent cellular activity

scientific article

Mammalian and viral DNA sequences which interfere with the maintenance of a centromeric vector in yeast

scientific article published in September 1992

Methods to Investigate the Role of Rho GTPases in Osteoclast Function

scientific article published on 01 January 2018

Modulation of osteoclast differentiation and bone resorption by Rho GTPases

scientific article

N-cadherin-dependent cell-cell contact regulates Rho GTPases and beta-catenin localization in mouse C2C12 myoblasts

scientific article

Novel 2,7-Diazaspiro[4,4]nonane Derivatives to Inhibit Mouse and Human Osteoclast Activities and Prevent Bone Loss in Ovariectomized Mice without Affecting Bone Formation

scientific article published on 11 November 2020

Osteoclast Biology and Mechanosensing

Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO

scientific article

Pharmacological inhibition of Dock5 prevents osteolysis by affecting osteoclast podosome organization while preserving bone formation

scientific article published in Nature Communications

Phosphorylation by p34cdc2 protein kinase regulates binding of the kinesin-related motor HsEg5 to the dynactin subunit p150

scientific article (publication date: August 1997)

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

scientific article

Podosome organization drives osteoclast-mediated bone resorption.

scientific article

Podosomes are dispensable for osteoclast differentiation and migration

scientific article published on 26 March 2013

Primary myeloid cell proteomics and transcriptomics: importance of ß tubulin isotypes for osteoclast function

scientific article published on 07 April 2020

Promyelocytic leukemia zinc-finger induction signs mesenchymal stem cell commitment: identification of a key marker for stemness maintenance?

scientific article

Recognition of the CDEl motif GTCACATG by mouse nuclear proteins and interference with the early development of the mouse embryo ⬇️

scientific article published on December 1, 1991

Rho GTPases in osteoclasts: orchestrators of podosome arrangement

scientific article published on 23 April 2008

RhoA GTPase regulates M-cadherin activity and myoblast fusion

scientific article

RhoE controls myoblast alignment prior fusion through RhoA and ROCK.

scientific article published on 28 March 2008

Rigor-type mutation in the kinesin-related protein HsEg5 changes its subcellular localization and induces microtubule bundling

scientific article published in January 1998

Signalling pathways controlled by the GTPase RhoG

Targeting the Dbl and dock-family RhoGEFs: a yeast-based assay to identify cell-active inhibitors of Rho-controlled pathways

scientific article published on 08 August 2013

Tensin 3 is a new partner of Dock5 that controls osteoclast podosome organization and activity

scientific article published on 2 August 2016

Tensins are versatile regulators of Rho GTPase signalling and cell adhesion

scientific article

The Beta-Tubulin Isotype TUBB6 Controls Microtubule and Actin Dynamics in Osteoclasts

scientific article published on 18 November 2021

The DH-PH region of the giant protein UNC-89 activates RHO-1 GTPase in Caenorhabditis elegans body wall muscle

scientific article published on 09 September 2008

The Evolutionary Landscape of Dbl-Like RhoGEF Families: Adapting Eukaryotic Cells to Environmental Signals

scientific article

The GTP/GDP cycling of rho GTPase TCL is an essential regulator of the early endocytic pathway

scientific article

The Human Rho-GEF trio and its target GTPase RhoG are involved in the NGF pathway, leading to neurite outgrowth

scientific article (publication date: 19 February 2002)

The Rac1 exchange factor Dock5 is essential for bone resorption by osteoclasts

scientific article

The Rho GTPase Wrch1 regulates osteoclast precursor adhesion and migration

scientific article

The RhoE/ROCK/ARHGAP25 signaling pathway controls cell invasion by inhibition of Rac activity

scientific article published on 13 July 2016

The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo

scientific article

The atypical Rho GTPase RhoU interacts with intersectin-2 to regulate endosomal recycling pathways

scientific article published on 31 July 2020

The atypical RhoU/Wrch1 Rho GTPase controls cell proliferation and apoptosis in the gut epithelium

scientific article published on 12 March 2019

The gene for a new brain specific RhoA exchange factor maps to the highly unstable chromosomal region 1p36.2-1p36.3.

scientific article published in November 2001

The mineral dissolution function of osteoclasts is dispensable for hypertrophic cartilage degradation during long bone development and growth

scientific article published on 30 June 2014

The osteoclast cytoskeleton - current understanding and therapeutic perspectives for osteoporosis

scientific article published on 01 July 2020

The yeast exchange assay, a new complementary method to screen for Dbl-like protein specificity: identification of a novel RhoA exchange factor

scientific article published on 01 September 2000

Using a Modified Yeast Two-Hybrid System to Screen for Chemical GEF Inhibitors ⬇️

scientific article published on January 1, 2012

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