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List of works by Diethard Mattanovich

1,3-Propanediol production from glycerol with Lactobacillus diolivorans ⬇️

scientific article published on May 30, 2012

16 years research on lactic acid production with yeast - ready for the market?

scientific article published on January 2010

A gene optimization strategy that enhances production of fully functional P-glycoprotein in Pichia pastoris

scientific article

A multi-level study of recombinant Pichia pastoris in different oxygen conditions.

scientific article

A single Gal4-like transcription factor activates the Crabtree effect in Komagataella phaffii

scientific article published in Nature Communications

A yeast for all seasons - Is Pichia pastoris a suitable chassis organism for future bioproduction?

scientific article published on 01 September 2018

Accurate quantification of the redox-sensitive GSH/GSSG ratios in the yeast Pichia pastoris by HILIC-MS/MS.

scientific article published on 22 December 2012

Adaptive laboratory evolution – principles and applications for biotechnology ⬇️

scientific article published on July 1, 2013

Amino-acid sequence comparison of nepovirus coat proteins

scientific article published in April 1992

An efficient tool for metabolic pathway construction and gene integration for Aspergillus niger.

scientific article

Analysis of the structure-function relationship of the S-layer protein SbsC of Bacillus stearothermophilus ATCC 12980 by producing truncated forms.

scientific article published in May 2001

Applications of cell sorting in biotechnology

scientific article

Assessing viability and cell-associated product of recombinant protein producing Pichia pastoris with flow cytometry

scientific article published in May 2003

Bacterial expression and refolding of human trypsinogen.

scientific article published in April 2004

Biochemistry of microbial itaconic acid production

scientific article

Biomarkers allow detection of nutrient limitations and respective supplementation for elimination in Pichia pastoris fed-batch cultures.

scientific article

Biosynthesis of vitamin C by yeast leads to increased stress resistance

scientific article

CRISPR/Cas9-Mediated Homology-Directed Genome Editing in Pichia pastoris

scientific article published on 01 January 2019

Characterization of methanol utilization negative Pichia pastoris for secreted protein production: New cultivation strategies for current and future applications

scientific article published on 08 February 2020

Characterizing MttA as a mitochondrial cis-aconitic acid transporter by metabolic engineering

scientific article published on 10 February 2016

Cloning, disruption and protein secretory phenotype of the GAS1 homologue of Pichia pastoris.

scientific article published in November 2006

Coat protein mediated resistance to Plum Pox Virus in Nicotiana clevelandii and N. benthamiana

scientific article published in February 1992

Complete genome sequence and transcriptome regulation of the pentose utilizing yeast Sugiyamaella lignohabitans.

scientific article

Corrigendum: Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan.

scientific article published on 11 May 2016

Creation of stable heterothallic strains of Komagataella phaffii enables dissection of mating gene regulation.

scientific article published on 23 October 2017

Curation of the genome annotation of Pichia pastoris (Komagataella phaffii) CBS7435 from gene level to protein function.

scientific article published on 6 July 2016

Detection and Elimination of Cellular Bottlenecks in Protein-Producing Yeasts

scientific article published on 01 January 2019

Detection of the trans activity of the plum pox virus NIa-like protease in infected plants

scientific article published in July 1990

Directed gene copy number amplification in Pichia pastoris by vector integration into the ribosomal DNA locus.

scientific article

Disruption of genes involved in CORVET complex leads to enhanced secretion of heterologous carboxylesterase only in protease deficient Pichia pastoris.

scientific article published on 23 February 2017

Disruption of vacuolar protein sorting components of the HOPS complex leads to enhanced secretion of recombinant proteins in Pichia pastoris

scientific article published on 03 July 2019

Divergent genetic control of protein solubility and conformational quality in Escherichia coli

scientific article published on 8 September 2007

Downscaling screening cultures in a multifunctional bioreactor array-on-a-chip for speeding up optimization of yeast-based lactic acid bioproduction

scientific article published on 19 March 2020

Early screening for anti-plum pox virus monoclonal antibodies with different epitope specificities by means of gold-labelled immunosorbent electron microscopy

scientific article published in December 1988

Editorial: metabolic modeling in biotechnology and medical research

scientific article

Effect of increased expression of protein disulfide isomerase and heavy chain binding protein on antibody secretion in a recombinant CHO cell line

scientific article

Effects of gene dosage, promoters, and substrates on unfolded protein stress of recombinant Pichia pastoris

scientific article published in February 2004

Engineering of Pichia pastoris for improved production of antibody fragments.

scientific article published in June 2006

Engineering of alcohol dehydrogenase 2 hybrid-promoter architectures in Pichia pastoris to enhance recombinant protein expression on ethanol

scientific article published on 09 July 2019

Engineering of biotin-prototrophy in Pichia pastoris for robust production processes

scientific article published on 3 August 2010

Engineering of bottlenecks in Rhizopus oryzae lipase production in Pichia pastoris using the nitrogen source-regulated FLD1 promoter

scientific article published on 01 September 2009

Engineering of protein folding and secretion-strategies to overcome bottlenecks for efficient production of recombinant proteins

scientific article published on 24 March 2014

Engineering of the citrate exporter protein enables high citric acid production in Aspergillus niger

scientific article published on 13 December 2018

Enhanced glutathione production by evolutionary engineering of Saccharomyces cerevisiae strains.

scientific article published on 24 April 2015

Expression of the plum pox virus coat protein region in Escherichia coli

scientific article

Flow Cytometric Analysis of Metabolic Stress Effects Due to Recombinant Plasmids and Proteins in Escherichia coli Production Strains

article

Flow cytometric analysis of bacterial physiology during induction of foreign protein synthesis in recombinant Escherichia coli cells

scientific article published on 01 February 1998

From rumen to industry ⬇️

scientific article published on September 10, 2012

Functional inclusion bodies produced in the yeast Pichia pastoris.

scientific article published on October 2016

Gas Chromatography-Quadrupole Time-of-Flight Mass Spectrometry-Based Determination of Isotopologue and Tandem Mass Isotopomer Fractions of Primary Metabolites for (13)C-Metabolic Flux Analysis.

scientific article published on 29 October 2015

Genetic engineering of Lactobacillus diolivorans.

scientific article published on 23 May 2013

Genome sequence of the ruminal bacterium Megasphaera elsdenii

scientific article published on October 2011

Genome, secretome and glucose transport highlight unique features of the protein production host Pichia pastoris.

scientific article

Genome-scale analysis of library sorting (GALibSo): Isolation of secretion enhancing factors for recombinant protein production in Pichia pastoris

scientific article

Genome-scale metabolic model of methylotrophic yeast Pichia pastoris and its use for in silico analysis of heterologous protein production.

scientific article published in July 2010

GoldenPiCS: a Golden Gate-derived modular cloning system for applied synthetic biology in the yeast Pichia pastoris

scientific article published on 8 December 2017

Heading for an economic industrial upgrading of crude glycerol from biodiesel production to 1,3-propanediol by Lactobacillus diolivorans.

scientific article published on 27 November 2013

High level expression of a promising anti-idiotypic antibody fragment vaccine against HIV-1 in Pichia pastoris

article

Hypoxic fed-batch cultivation of Pichia pastoris increases specific and volumetric productivity of recombinant proteins

scientific article published in May 2008

Identification and characterization of the Komagataella phaffii mating pheromone genes.

scientific article

Identification and deletion of the major secreted protein of Pichia pastoris

scientific article

Identification of microRNAs specific for high producer CHO cell lines using steady-state cultivation

scientific article

Impact of glutathione metabolism on zinc homeostasis in Saccharomyces cerevisiae.

scientific article published on 12 May 2017

Implications of evolutionary engineering for growth and recombinant protein production in methanol-based growth media in the yeast Pichia pastoris.

scientific article

Improvement of lactic acid production in Saccharomyces cerevisiae by cell sorting for high intracellular pH.

scientific article published on August 2006

In Pichia pastoris, growth rate regulates protein synthesis and secretion, mating and stress response.

scientific article published on 14 January 2014

Increased dosage of AOX1 promoter-regulated expression cassettes leads to transcription attenuation of the methanol metabolism in Pichia pastoris

scientific article published on 15 March 2017

Increasing pentose phosphate pathway flux enhances recombinant protein production in Pichia pastoris.

scientific article published on 28 March 2016

Induction and measurement of UPR and osmotic stress in the yeast Pichia pastoris.

scientific article

Induction without methanol: novel regulated promoters enable high-level expression in Pichia pastoris.

scientific article published on 24 January 2013

Influence of growth temperature on the production of antibody Fab fragments in different microbes: a host comparative analysis

scientific article published on 23 December 2010

Integrative Analysis of -Omics Data: A Method Comparison

scientific article

Interlaboratory comparison for quantitative primary metabolite profiling in Pichia pastoris

scientific article published on 19 April 2013

Intracellular interactome of secreted antibody Fab fragment in Pichia pastoris reveals its routes of secretion and degradation

scientific article published on 18 February 2012

Intracellular pH distribution in Saccharomyces cerevisiae cell populations, analyzed by flow cytometry

scientific article published on March 2005

Kinetics studies for the optimization of recombinant protein formation.

scientific article

Komagataella phaffii YPS1-5 encodes the alpha-factor degrading protease Bar1

scientific article published on 06 May 2020

Lactate production yield from engineered yeasts is dependent from the host background, the lactate dehydrogenase source and the lactate export.

scientific article

Macromolecular and elemental composition analysis and extracellular metabolite balances of Pichia pastoris growing at different oxygen levels.

scientific article published on 9 December 2009

Mass spectrometry based analysis of nucleotides, nucleosides, and nucleobases--application to feed supplements

scientific article published on 30 June 2012

Measurement uncertainty of isotopologue fractions in fluxomics determined via mass spectrometry

scientific article

Metabolic engineering of Pichia pastoris

scientific article published on 25 April 2018

Metabolic profiling of amino acids in cellular samples via zwitterionic sub-2 μm particle size HILIC-MS/MS and a uniformly 13C labeled internal standard.

scientific article

Metabolomics integrated elementary flux mode analysis in large metabolic networks.

scientific article published on 10 March 2015

Metabolomics of Pichia pastoris: impact of buffering conditions on the kinetics and nature of metabolite loss during quenching

scientific article published on 15 March 2017

Metabolomics sampling of Pichia pastoris revisited: rapid filtration prevents metabolite loss during quenching

scientific article published on 19 June 2015

Methanol regulated yeast promoters: production vehicles and toolbox for synthetic biology.

scientific article published on 2 December 2015

Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan.

scientific article published on 30 January 2015

Microbe Profile: Komagataella phaffii: a methanol devouring biotech yeast formerly known as Pichia pastoris

scientific article published on 01 July 2020

Microbial organic acid production as carbon dioxide sink

scientific article

Microbial production of 1,3-propanediol.

scientific article published on January 2008

Microbial production of organic acids: expanding the markets.

scientific article published on 11 January 2008

Microscale Perfusion-based Cultivation for Pichia pastoris Clone Screening Enables Accelerated and Optimized Recombinant Protein Production Processes

scientific article published on 15 September 2020

Model based engineering of Pichia pastoris central metabolism enhances recombinant protein production

scientific article

Modeling and measuring intracellular fluxes of secreted recombinant protein in Pichia pastoris with a novel 34S labeling procedure ⬇️

scientific article published on June 26, 2011

Monitoring intracellular redox conditions in the endoplasmic reticulum of living yeasts

scientific article published on 22 February 2010

Monitoring of transcriptional regulation in Pichia pastoris under protein production conditions

scientific article

Multistep processing of the secretion leader of the extracellular protein Epx1 in Pichia pastoris and implications for protein localization

scientific article published in May 2015

Non-genetic impact factors on chronological lifespan and stress resistance of baker's yeast

scientific article published on 12 April 2016

Novel insights into the unfolded protein response using Pichia pastoris specific DNA microarrays.

scientific article

Old obstacles and new horizons for microbial chemical production

scientific article published on 05 July 2014

Open access to sequence: browsing the Pichia pastoris genome

scientific article

Optimization of recombinant gene expression in Escherichia coli.

scientific article

Optimization of recombinant protein expression level in Escherichia coli by flow cytometry and cell sorting

scientific article

Organic acids from lignocellulose: Candida lignohabitans as a new microbial cell factory.

scientific article published on 5 February 2015

Overexpression of the transcription factor Yap1 modifies intracellular redox conditions and enhances recombinant protein secretion.

scientific article published on 31 October 2014

Oxidative protein folding and unfolded protein response elicit differing redox regulation in endoplasmic reticulum and cytosol of yeast

scientific article published on 8 March 2012

Pichia Pastoris : Protein Production Host and Model Organism for Biomedical Research ⬇️

scientific article published on February 1, 2013

Pichia pastoris Aft1--a novel transcription factor, enhancing recombinant protein secretion

scientific article published on 3 September 2014

Pichia pastoris Exhibits High Viability and a Low Maintenance Energy Requirement at Near-Zero Specific Growth Rates.

scientific article published on 20 May 2016

Pichia pastoris regulates its gene-specific response to different carbon sources at the transcriptional, rather than the translational, level.

scientific article published on 11 March 2015

Pichia pastoris secretes recombinant proteins less efficiently than Chinese hamster ovary cells but allows higher space-time yields for less complex proteins

scientific article published on 27 January 2014

Production of recombinant proteins and metabolites in yeasts: when are these systems better than bacterial production systems?

scientific article

Protein folding and conformational stress in microbial cells producing recombinant proteins: a host comparative overview

scientific article published on 4 April 2008

Protein trafficking, ergosterol biosynthesis and membrane physics impact recombinant protein secretion in Pichia pastoris ⬇️

scientific article published on November 3, 2011

Quo vadis? The challenges of recombinant protein folding and secretion in Pichia pastoris

scientific article published on 27 February 2015

Recombinant expression of alliin lyase from garlic (Allium sativum) in bacteria and yeasts

scientific article published in May 1998

Recombinant protein production 6 (Vienna, February 2011).

scientific article

Recombinant protein production 6: a comparative view on host physiology

scientific article published on 13 October 2011

Recombinant protein production in the new Millennium

scientific article

Recombinant protein production in yeasts

scientific article published on 01 November 2005

Recombinant protein production in yeasts

scientific article published on 01 January 2012

Recombinant protein production in yeasts.

scientific article published in January 2004

Regeneration of transgenic plants of Prunus armeniaca containing the coat protein gene of Plum Pox Virus

scientific article published in February 1992

Reverse engineering of protein secretion by uncoupling of cell cycle phases from growth

scientific article published on 25 May 2011

S-layer gene sbsC of Bacillus stearothermophilus ATCC 12980: molecular characterization and heterologous expression in Escherichia coli

scientific article published in February 2000

Sample preparation workflow for the liquid chromatography tandem mass spectrometry based analysis of nicotinamide adenine dinucleotide phosphate cofactors in yeast

scientific article published on 20 June 2014

Six novel constitutive promoters for metabolic engineering of Aspergillus niger

scientific article

Stopping the DNA polymerase activity at a specific site with a dideoxyoligonucleotide: selective labelling of single stranded circular DNA

scientific article published on October 1989

Stress in recombinant protein producing yeasts.

scientific article published in September 2004

Superior protein titers in half the fermentation time: Promoter and process engineering for the glucose-regulated GTH1 promoter of Pichia pastoris

scientific article published on 08 August 2018

Systems biotechnology for protein production in Pichia pastoris.

scientific article published in November 2017

Systems metabolic engineering, industrial biotechnology and microbial cell factories ⬇️

scientific article published on December 11, 2012

Systems-level organization of yeast methylotrophic lifestyle.

scientific article published on 23 September 2015

Targeting enzymes to the right compartment: metabolic engineering for itaconic acid production by Aspergillus niger.

scientific article

The Degree and Length of O-glycosylation of Recombinant Proteins Produced in Pichia Pastoris Depends on the Nature of the Protein and the Process Type

scientific article published on 25 September 2020

The bud tip is the cellular hot spot of protein secretion in yeasts

scientific article

The effect of temperature on the proteome of recombinant Pichia pastoris

scientific article published in March 2009

The impact of ERAD on recombinant protein secretion in Pichia pastoris (syn Komagataella spp.).

scientific article published on 13 March 2018

The impact of oxygen on the transcriptome of recombinant S. cerevisiae and P. pastoris - a comparative analysis.

scientific article

The industrial yeast Pichia pastoris is converted from a heterotroph into an autotroph capable of growth on CO2

scientific article published on 16 December 2019

The lipidome and proteome of microsomes from the methylotrophic yeast Pichia pastoris

scientific article published on 01 February 2014

The metabolic growth limitations of petite cells lacking the mitochondrial genome

scientific article published in 2021

The response to unfolded protein is involved in osmotolerance of Pichia pastoris.

scientific article

The scientific impact of microbial cell factories.

scientific article published in December 2008

The secretome of Pichia pastoris in fed-batch cultivations is largely independent of the carbon source but changes quantitatively over cultivation time

scientific article published on 06 November 2019

The secretory pathway: exploring yeast diversity ⬇️

scientific article published on April 12, 2013

The vitamin-sensitive promoter PTHI11 enables pre-defined autonomous induction of recombinant protein production in Pichia pastoris.

scientific article published on 27 June 2016

Transcriptional engineering of the glyceraldehyde-3-phosphate dehydrogenase promoter for improved heterologous protein production in Pichia pastoris.

scientific article published on 26 June 2017

Transcriptomics-based identification of novel factors enhancing heterologous protein secretion in yeasts.

scientific article

U13C cell extract of Pichia pastoris--a powerful tool for evaluation of sample preparation in metabolomics

scientific article published on 22 October 2012

Unconventional microbial systems for the cost-efficient production of high-quality protein therapeutics.

scientific article published on 15 September 2012

Versatile modeling and optimization of fed batch processes for the production of secreted heterologous proteins with Pichia pastoris

scientific article published on 11 December 2006

Yeast biotechnology: teaching the old dog new tricks.

scientific article

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