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List of works by Xavier Langlois

5-HT3 receptors in the rat central nervous system are mainly located on nerve fibres and terminals

scientific article published in May 1993

Activator of G protein signaling type 3 mRNA is widely distributed in the rat brain and is particularly abundant in the subventricular zone-olfactory bulb system of neural precursor cell proliferation, migration and differentiation

scientific article

Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist

scientific article

Adjunctive alpha2-adrenoceptor blockade enhances the antipsychotic-like effect of risperidone and facilitates cortical dopaminergic and glutamatergic, NMDA receptor-mediated transmission

scientific article published on 19 October 2009

Aminergic receptors in astrogliotic plaques from patients with multiple sclerosis

scientific article published in October 2002

Antidepressant profile in rodents of SR 58611A, a new selective agonist for atypical beta-adrenoceptors

scientific article published on 01 August 1992

Anxiolytic- and antidepressant-like profile of a new CRF1 receptor antagonist, R278995/CRA0450.

scientific article published on February 2004

BiDiFuse: a FIJI plugin for fusing bi-directionally recorded microscopic image volumes.

scientific article published on 8 August 2016

Bilateral control of brain activity by dopamine D1 receptors: evidence from induction patterns of regulator of G protein signaling 2 and c-fos mRNA in D1-challenged hemiparkinsonian rats

scientific article published in January 2005

Central pre- and postsynaptic 5-HT1A receptors in rats treated chronically with a novel antidepressant, cericlamine.

scientific article

Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule

scientific article

Chronic alcoholization alters the expression of 5-HT1A and 5-HT1B receptor subtypes in rat brain

scientific article published on 01 August 1995

Co-localization of 5-HT1B- and 5-HT1D receptor mRNA in serotonergic cell bodies in guinea pig dorsal raphé nucleus: a double labeling in situ hybridization histochemistry study

scientific article published in September 1998

Combined alpha2 and D2/3 receptor blockade enhances cortical glutamatergic transmission and reverses cognitive impairment in the rat.

scientific article published on 28 April 2005

Comparison of the ex vivo receptor occupancy profile of ketamine to several NMDA receptor antagonists in mouse hippocampus.

scientific article

Corrigendum to acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist.

scientific article

Detailed distribution of Neurokinin 3 receptors in the rat, guinea pig and gerbil brain: a comparative autoradiographic study

scientific article published in January 2001

Detailed localization of regulator of G protein signaling 2 messenger ribonucleic acid and protein in the rat brain.

scientific article

Differential addressing of 5-HT1A and 5-HT1B receptors in transfected LLC-PK1 epithelial cells: a model of receptor targeting in neurons

scientific article published on 01 September 1996

Differential interaction of neuroleptics with apomorphine-induced behavior in rats as a function of changing levels of dopamine receptor stimulation

scientific article published on 26 September 2013

Differential membrane targeting and pharmacological characterization of chimeras of rat serotonin 5-HT1A and 5-HT1B receptors expressed in epithelial LLC-PK1 cells.

scientific article published on December 1998

Discovery of a new series of [1,2,4]triazolo[4,3-a]quinoxalines as dual phosphodiesterase 2/phosphodiesterase 10 (PDE2/PDE10) inhibitors

scientific article published in December 2012

Discovery of a potent, selective, and orally active phosphodiesterase 10A inhibitor for the potential treatment of schizophrenia

scientific article

Dominant role of the cytosolic C-terminal domain of the rat 5-HT1B receptor in axonal-apical targeting.

scientific article

Dopamine receptor-mediated regulation of RGS2 and RGS4 mRNA differentially depends on ascending dopamine projections and time

scientific article published in April 2004

Effect of stress and peripheral immune activation on astrocyte activation in transgenic bioluminescent Gfap-luc mice

scientific article published on 17 February 2015

Effects of chronic infusion of neurotensin and a neurotensin NT1 selective analogue PD149163 on amphetamine-induced hyperlocomotion

scientific article published on 21 January 2008

Erratum to: Preclinical Comparison of the Amyloid-β Radioligands [11C]Pittsburgh compound B and [18F]florbetaben in Aged APPPS1-21 and BRI1-42 Mouse Models of Cerebral Amyloidosis

scholarly article published in Molecular Imaging and Biology

Examining dopamine D3 receptor occupancy by antipsychotic drugs via [3H]7-OH-DPAT ex vivo autoradiography and its cross-validation via c-fos immunohistochemistry in the rat brain

scientific article published on 23 June 2014

Gene expression profiles highlight adaptive brain mechanisms in corticotropin releasing factor overexpressing mice.

scientific article

Humanization of mouse 5-hydroxytryptamine1B receptor gene by homologous recombination: in vitro and in vivo characterization

scientific article

Identification of a Novel Orally Bioavailable Phosphodiesterase 10A (PDE10A) Inhibitor with Efficacy in Animal Models of Schizophrenia

scientific article published on 12 January 2015

Image Informatics Strategies for Deciphering Neuronal Network Connectivity

scientific article published on January 2016

Immunolabeling of central serotonin 5-HT1D beta receptors in the rat, mouse, and guinea pig with a specific anti-peptide antiserum

scientific article published on 01 December 1995

In vivo evidence for ligand-specific receptor activation in the central CRF system, as measured by local cerebral glucose utilization.

scientific article published on 22 January 2009

In vivo molecular neuroimaging of glucose utilization and its association with fibrillar amyloid-β load in aged APPPS1-21 mice

scientific article

JNJ-40255293, a novel adenosine A2A/A1 antagonist with efficacy in preclinical models of Parkinson's disease

scientific article published on 24 September 2014

Light and electron microscopic immunocytochemical visualization of 5-HT1B receptors in the rat brain ⬇️

scientific article published on June 20, 1997

MK-801 alters RGS2 levels and adenylyl cyclase sensitivity in the rat striatum

scientific article published in February 2005

Mapping of serotonin 5-HT(4) receptor mRNA and ligand binding sites in the post-mortem human brain

scientific article published on 01 April 2000

Memantine-induced brain activation as a model for the rapid screening of potential novel antipsychotic compounds: exemplified by activity of an mGlu2/3 receptor agonist

scientific article published on 31 October 2010

Metabotropic glutamate 1 receptor distribution and occupancy in the rat brain: a quantitative autoradiographic study using [3H]R214127.

scientific article published on April 2004

Metabotropic glutamate receptor 1 blockade impairs acquisition and retention in a spatial Water maze task.

scientific article published in October 2005

Molecular properties affecting fast dissociation from the D2 receptor

scientific article published on 26 February 2011

N-acetylcysteine- and MK-801-induced changes in glutamate levels do not affect in vivo binding of metabotropic glutamate 5 receptor radioligand 11C-ABP688 in rat brain

scientific article published on 19 September 2013

Negative versus positive allosteric modulation of metabotropic glutamate receptors (mGluR5): indices for potential pro-cognitive drug properties based on EEG network oscillations and sleep-wake organization in rats

scientific article published on 18 October 2014

Norpiperidine imidazoazepines as a new class of potent, selective, and nonsedative H1 antihistamines

scientific article

Patterns of brain glucose metabolism induced by phosphodiesterase 10A inhibitors in the mouse: a potential translational biomarker.

scientific article published on 8 July 2011

Peripheral Administration of Tumor Necrosis Factor-Alpha Induces Neuroinflammation and Sickness but Not Depressive-Like Behavior in Mice.

scientific article

Pharmacokinetic-pharmacodynamic modelling of fluvoxamine 5-HT transporter occupancy in rat frontal cortex

scientific article published on 19 May 2008

Pharmacological and pharmacokinetic properties of JNJ-40411813, a positive allosteric modulator of the mGlu2 receptor

scientific article

Pharmacology of JNJ-37822681, a specific and fast-dissociating D2 antagonist for the treatment of schizophrenia

scientific article

Pharmacology of JNJ-42314415, a centrally active phosphodiesterase 10A (PDE10A) inhibitor: a comparison of PDE10A inhibitors with D2 receptor blockers as potential antipsychotic drugs

scientific article published on 13 January 2014

Preclinical Comparison of the Amyloid-β Radioligands [(11)C]Pittsburgh compound B and [(18)F]florbetaben in Aged APPPS1-21 and BRI1-42 Mouse Models of Cerebral Amyloidosis

scientific article published on 21 February 2015

Preclinical evaluation of 18F-JNJ41510417 as a radioligand for PET imaging of phosphodiesterase-10A in the brain.

scientific article published on 16 September 2010

Preclinical evaluation of [(18)F]JNJ42259152 as a PET tracer for PDE10A

scientific article published on 09 May 2013

Preclinical evaluation of the antipsychotic potential of the mGlu2-positive allosteric modulator JNJ-40411813.

scientific article

Production and characterization of polyclonal antibodies recognizing the intracytoplasmic third loop of the 5-hydroxytryptamine1A receptor

scientific article published on 01 October 1994

Profiling of hepatic clearance pathways of Pittsburgh compound B and human liver cytochrome p450 phenotyping

scientific article published on 14 February 2013

Pyrido[4,3-e][1,2,4]triazolo[4,3-a]pyrazines as Selective, Brain Penetrant Phosphodiesterase 2 (PDE2) Inhibitors

scientific article published on 15 January 2015

Quantitative autoradiographic distribution of γ-hydroxybutyric acid binding sites in human and monkey brain

scientific article published on 01 May 2000

Quantitative μPET Imaging of Cerebral Glucose Metabolism and Amyloidosis in the TASTPM Double Transgenic Mouse Model of Alzheimer's Disease

scientific article

Reconsideration of 5-hydroxytryptamine (5-HT)(7) receptor distribution using [(3)H]5-carboxamidotryptamine and [(3)H]8-hydroxy-2-(di-n-propylamino)tetraline: analysis in brain of 5-HT(1A) knockout and 5-HT(1A/1B) double-knockout mice

scientific article

Selective inhibition of phosphodiesterase 10A impairs appetitive and aversive conditioning and incentive salience attribution

scientific article published on 22 August 2013

Self-assembling PEG-p(CL-co-TMC) copolymers for oral delivery of poorly water-soluble drugs: a case study with risperidone

scientific article

Serotonin1A receptors are expressed by a subpopulation of cholinergic neurons in the rat medial septum and diagonal band of Broca--a double immunocytochemical study

scientific article published in September 1996

Somatodendritic localization of 5-HT1A and preterminal axonal localization of 5-HT1B serotonin receptors in adult rat brain

scientific article published on 01 February 2000

Striatal gene expression of RGS2 and RGS4 is specifically mediated by dopamine D1 and D2 receptors: clues for RGS2 and RGS4 functions

scientific article published in March 2003

Structure-Based Design of a Potent, Selective, and Brain Penetrating PDE2 Inhibitor with Demonstrated Target Engagement

scientific article published on 22 July 2014

Synthesis and biodistribution of [(11)C]R116301, a promising PET ligand for central NK(1) receptors

scientific article published in March 2005

Synthesis and biodistribution of [11C]R107474, a new radiolabeled alpha2-adrenoceptor antagonist

scientific article published on 6 March 2006

Synthesis and biological evaluation of carbon-11 and fluorine-18 labeled tracers for in vivo visualization of PDE10A.

scientific article published on 24 May 2014

Synthesis, In Vivo Occupancy, and Radiolabeling of Potent Phosphodiesterase Subtype-10 Inhibitors as Candidates for Positron Emission Tomography Imaging ⬇️

scientific article published on August 2, 2011

Synthesis, evaluation, and radiolabeling of new potent positive allosteric modulators of the metabotropic glutamate receptor 2 as potential tracers for positron emission tomography imaging

scientific article published on 11 October 2012

The Effects of Physiological and Methodological Determinants on 18F-FDG Mouse Brain Imaging Exemplified in a Double Transgenic Alzheimer Model

scientific article

The [18F]FDG μPET readout of a brain activation model to evaluate the metabotropic glutamate receptor 2 positive allosteric modulator JNJ-42153605.

scientific article published on 4 June 2014

The differential effects of atypical antipsychotics on prolactin elevation are explained by their differential blood-brain disposition: a pharmacological analysis in rats

scientific article published in September 2002

Tricyclic isoxazolines: Identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and α2-adrenoceptor antagonism

scientific article published on 21 March 2007

Use of a beta microprobe system to measure arterial input function in PET via an arteriovenous shunt in rats.

scientific article published on 10 August 2011

Use of the beta-imager for rapid ex vivo autoradiography exemplified with central nervous system penetrating neurokinin 3 antagonists.

scientific article

What We Observe In Vivo Is Not Always What We See In Vitro: Development and Validation of 11C-JNJ-42491293, A Novel Radioligand for mGluR2.

scientific article published on 28 July 2016

[3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists.

scientific article

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